KR20250011913A - 효소 및 첨가제를 이용한 아미노산 및 펩타이드 화합물의 생성 방법 - Google Patents

효소 및 첨가제를 이용한 아미노산 및 펩타이드 화합물의 생성 방법 Download PDF

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Publication number
KR20250011913A
KR20250011913A KR1020247040257A KR20247040257A KR20250011913A KR 20250011913 A KR20250011913 A KR 20250011913A KR 1020247040257 A KR1020247040257 A KR 1020247040257A KR 20247040257 A KR20247040257 A KR 20247040257A KR 20250011913 A KR20250011913 A KR 20250011913A
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South Korea
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group
compound
residue
amino acid
chemical formula
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Pending
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KR1020247040257A
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English (en)
Korean (ko)
Inventor
시오리 이시야마
가즈히코 나카노
기요미치 시노다
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추가이 세이야쿠 가부시키가이샤
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Priority claimed from TW111149813A external-priority patent/TW202342741A/zh
Application filed by 추가이 세이야쿠 가부시키가이샤 filed Critical 추가이 세이야쿠 가부시키가이샤
Publication of KR20250011913A publication Critical patent/KR20250011913A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/28—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/01—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020247040257A 2022-05-13 2023-05-12 효소 및 첨가제를 이용한 아미노산 및 펩타이드 화합물의 생성 방법 Pending KR20250011913A (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
JP2022079712 2022-05-13
JPJP-P-2022-079712 2022-05-13
JPJP-P-2022-079711 2022-05-13
JP2022079711 2022-05-13
JPPCT/JP2022/047741 2022-12-23
EP22216504.5 2022-12-23
TW111149813 2022-12-23
TW111149813A TW202342741A (zh) 2021-12-28 2022-12-23 多胜肽及使用其之胺基酸的製造方法
EP22216504.5A EP4206322A3 (en) 2021-12-28 2022-12-23 Polypeptide and method for producing amino acid using same
PCT/JP2022/047741 WO2023127752A1 (ja) 2021-12-28 2022-12-23 ポリペプチド及びこれを用いたアミノ酸の製造方法
PCT/JP2023/017861 WO2023219156A1 (ja) 2022-05-13 2023-05-12 酵素及び添加剤を用いたアミノ酸及びペプチド化合物の製造方法

Publications (1)

Publication Number Publication Date
KR20250011913A true KR20250011913A (ko) 2025-01-22

Family

ID=88730279

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247040257A Pending KR20250011913A (ko) 2022-05-13 2023-05-12 효소 및 첨가제를 이용한 아미노산 및 펩타이드 화합물의 생성 방법

Country Status (5)

Country Link
US (1) US20250369029A1 (https=)
EP (1) EP4520829A1 (https=)
JP (1) JPWO2023219156A1 (https=)
KR (1) KR20250011913A (https=)
WO (1) WO2023219156A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
US12312379B2 (en) 2021-05-07 2025-05-27 Chugai Seiyaku Kabushiki Kaisha Methods for producing cyclic compounds comprising N-substituted amino acid residues

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003319788A (ja) 2002-02-28 2003-11-11 Mitsubishi Chemicals Corp 新規デヒドロゲナーゼ及びそれをコードする遺伝子
JP2005095167A (ja) 2003-08-26 2005-04-14 Mitsubishi Chemicals Corp 光学活性環状アミノ酸の製造方法
JP2012080878A (ja) 2010-09-15 2012-04-26 Sumitomo Chemical Co Ltd ビニルグリシン誘導体またはその塩の製造方法
JP2012080879A (ja) 2010-09-15 2012-04-26 Sumitomo Chemical Co Ltd ビニルグリシン誘導体またはその塩の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003211367A1 (en) * 2002-02-28 2003-09-09 Mitsubishi Chemical Corporation Novel dehydrogenase and gene encoding the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003319788A (ja) 2002-02-28 2003-11-11 Mitsubishi Chemicals Corp 新規デヒドロゲナーゼ及びそれをコードする遺伝子
JP2005095167A (ja) 2003-08-26 2005-04-14 Mitsubishi Chemicals Corp 光学活性環状アミノ酸の製造方法
JP2012080878A (ja) 2010-09-15 2012-04-26 Sumitomo Chemical Co Ltd ビニルグリシン誘導体またはその塩の製造方法
JP2012080879A (ja) 2010-09-15 2012-04-26 Sumitomo Chemical Co Ltd ビニルグリシン誘導体またはその塩の製造方法

Also Published As

Publication number Publication date
US20250369029A1 (en) 2025-12-04
EP4520829A1 (en) 2025-03-12
WO2023219156A1 (ja) 2023-11-16
JPWO2023219156A1 (https=) 2023-11-16

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PA0105 International application

Patent event date: 20241204

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application