KR20240101941A - 5'-구아닐산디나트륨·5'-이노신산디나트륨 혼정의 제조방법 - Google Patents
5'-구아닐산디나트륨·5'-이노신산디나트륨 혼정의 제조방법 Download PDFInfo
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- KR20240101941A KR20240101941A KR1020247019215A KR20247019215A KR20240101941A KR 20240101941 A KR20240101941 A KR 20240101941A KR 1020247019215 A KR1020247019215 A KR 1020247019215A KR 20247019215 A KR20247019215 A KR 20247019215A KR 20240101941 A KR20240101941 A KR 20240101941A
- Authority
- KR
- South Korea
- Prior art keywords
- disodium
- crystallization
- concentration
- aqueous solution
- inosinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013078 crystal Substances 0.000 title claims abstract description 116
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 31
- 239000004198 disodium guanylate Substances 0.000 title claims description 7
- 239000004194 disodium inosinate Substances 0.000 title description 3
- 238000002425 crystallisation Methods 0.000 claims abstract description 117
- 230000008025 crystallization Effects 0.000 claims abstract description 116
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 83
- 239000007864 aqueous solution Substances 0.000 claims abstract description 68
- 239000011780 sodium chloride Substances 0.000 claims abstract description 41
- AANLCWYVVNBGEE-IDIVVRGQSA-L Disodium inosinate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 AANLCWYVVNBGEE-IDIVVRGQSA-L 0.000 claims abstract description 27
- 235000013890 disodium inosinate Nutrition 0.000 claims abstract description 27
- PVBRXXAAPNGWGE-LGVAUZIVSA-L disodium 5'-guanylate Chemical compound [Na+].[Na+].C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O PVBRXXAAPNGWGE-LGVAUZIVSA-L 0.000 claims abstract description 25
- 235000013896 disodium guanylate Nutrition 0.000 claims abstract description 25
- 239000004193 disodium 5'-ribonucleotide Substances 0.000 claims abstract description 23
- 239000000243 solution Substances 0.000 claims abstract description 16
- 235000013928 guanylic acid Nutrition 0.000 claims description 75
- 235000013902 inosinic acid Nutrition 0.000 claims description 63
- 238000000034 method Methods 0.000 claims description 33
- 238000001816 cooling Methods 0.000 claims description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 238000010191 image analysis Methods 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- RQFCJASXJCIDSX-UHFFFAOYSA-N 14C-Guanosin-5'-monophosphat Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(COP(O)(O)=O)C(O)C1O RQFCJASXJCIDSX-UHFFFAOYSA-N 0.000 description 73
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 description 72
- GRSZFWQUAKGDAV-UHFFFAOYSA-N Inosinic acid Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-UHFFFAOYSA-N 0.000 description 62
- XKVWLLRDBHAWBL-UHFFFAOYSA-N imperatorin Natural products CC(=CCOc1c2OCCc2cc3C=CC(=O)Oc13)C XKVWLLRDBHAWBL-UHFFFAOYSA-N 0.000 description 29
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 238000003756 stirring Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 238000002347 injection Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000002002 slurry Substances 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 238000005192 partition Methods 0.000 description 6
- 238000004364 calculation method Methods 0.000 description 4
- 239000012453 solvate Substances 0.000 description 4
- 230000032683 aging Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000012527 feed solution Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000005070 ripening Effects 0.000 description 2
- AUHDWARTFSKSAC-HEIFUQTGSA-N (2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-(6-oxo-1H-purin-9-yl)oxolane-2-carboxylic acid Chemical compound [C@]1([C@H](O)[C@H](O)[C@@H](CO)O1)(N1C=NC=2C(O)=NC=NC12)C(=O)O AUHDWARTFSKSAC-HEIFUQTGSA-N 0.000 description 1
- GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004245 inosinic acid Substances 0.000 description 1
- 229940028843 inosinic acid Drugs 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPJP-P-2021-181884 | 2021-11-08 | ||
| JP2021181884 | 2021-11-08 | ||
| PCT/JP2022/041526 WO2023080253A1 (ja) | 2021-11-08 | 2022-11-08 | ５'－グアニル酸ジナトリウム・５'－イノシン酸ジナトリウム混晶の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240101941A true KR20240101941A (ko) | 2024-07-02 |
Family
ID=86241626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247019215A Pending KR20240101941A (ko) | 2021-11-08 | 2022-11-08 | 5'-구아닐산디나트륨·5'-이노신산디나트륨 혼정의 제조방법 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPWO2023080253A1 (https=) |
| KR (1) | KR20240101941A (https=) |
| CN (1) | CN118215670A (https=) |
| WO (1) | WO2023080253A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250118074A (ko) * | 2024-01-29 | 2025-08-05 | 씨제이제일제당 (주) | 다이소듐-5'-구아닐레이트 결정 제조 방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03215494A (ja) | 1989-09-04 | 1991-09-20 | Ajinomoto Co Inc | ５′―グアニル酸ジナトリウム・５′―イノシン酸ジナトリウム混晶の製造方法 |
| JPH03223299A (ja) | 1990-01-27 | 1991-10-02 | Ajinomoto Co Inc | ５’―グアニル酸ジナトリウム・５’―イノシン酸ジナトリウム混晶の製造方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5978665A (ja) * | 1982-10-28 | 1984-05-07 | Ajinomoto Co Inc | ５′−イノシン酸カルシウム及び５′−グアニル酸カルシウムの製造法 |
| JP2002284794A (ja) * | 2001-03-26 | 2002-10-03 | Ajinomoto Co Inc | ５’−グアニル酸ジナトリウム・５’−イノシン酸ジナトリウム混晶の製造法 |
| JP4453070B2 (ja) * | 2001-07-26 | 2010-04-21 | 味の素株式会社 | ５’−グアニル酸ジナトリウム・５’−イノシン酸ジナトリウム混晶の製造法 |
| JP4010230B2 (ja) * | 2002-11-22 | 2007-11-21 | 味の素株式会社 | プリン誘導体ヌクレオチドジナトリウム結晶の製造方法およびメタノール除去方法 |
-
2022
- 2022-11-08 KR KR1020247019215A patent/KR20240101941A/ko active Pending
- 2022-11-08 JP JP2023558102A patent/JPWO2023080253A1/ja active Pending
- 2022-11-08 WO PCT/JP2022/041526 patent/WO2023080253A1/ja not_active Ceased
- 2022-11-08 CN CN202280074240.9A patent/CN118215670A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03215494A (ja) | 1989-09-04 | 1991-09-20 | Ajinomoto Co Inc | ５′―グアニル酸ジナトリウム・５′―イノシン酸ジナトリウム混晶の製造方法 |
| JPH03223299A (ja) | 1990-01-27 | 1991-10-02 | Ajinomoto Co Inc | ５’―グアニル酸ジナトリウム・５’―イノシン酸ジナトリウム混晶の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2023080253A1 (https=) | 2023-05-11 |
| CN118215670A (zh) | 2024-06-18 |
| WO2023080253A1 (ja) | 2023-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20240607 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application |