KR20240079853A - Antioxidant effect and skin whitening composition containing extracts of Glochidion chodoense as an active ingredient - Google Patents

Abstract

The composition for antioxidant effect and skin whitening containing the Glochidion chodoense JS Lee & HT Im extract as an active ingredient according to an embodiment of the present invention contains the Glochidion chodoense JS Lee & HT Im extract as an active ingredient.
In the composition for antioxidant effect and skin whitening containing the extract of the mandu tree as an active ingredient according to an embodiment of the present invention, the extract of the mandu tree contains at least one of the leaves, stems, roots, and fruits of the tree. can do.

Description

Antioxidant effect and skin whitening composition containing extracts of Glochidion chodoense as an active ingredient}

The present invention relates to a composition for antioxidant effect and skin whitening containing extract of the mandu tree as an active ingredient.

In general, the Jodo Mandu tree (scientific name: Glochidion chodoense JS Lee & HT Im) was first discovered in Jodo, Jeollanam-do and its name means a tree of the Mandu genus. It is a deciduous shrub with leaves, and its height is 2~3m.

This Jodo dumpling tree is deciduous and has many gray hairs on its branches. The leaves are long oval and 5-8 cm long. The front of the leaf is green and the back is light green. Flowers bloom in August, with male and female flowers growing separately and blooming in the leaf axils. The fruit is a capsule, round in shape with a hollow center, and has six or more compartments. This species was reported as a new species in 1994 and is a plant endemic to Korea.

Meanwhile, active oxygen flowing in from outside the body or generated within the body causes many problems, such as accelerating aging of the body or causing cancer. Therefore, much development and research is being conducted on antioxidant substances that inhibit oxidation by active oxygen. Antioxidants are widely distributed in the animal and plant kingdoms, and many phenolic compounds, flavonoids, tocopherols, vitamin C, and selenium are known to be present in fruits and vegetables. However, antioxidant substances that exist in nature cannot be expected to have a substantially sufficient effect when applied to the skin. Therefore, synthetic antioxidants that have excellent antioxidant power and are inexpensive are widely used, but their use is limited due to safety concerns such as side effects on the human body.

Meanwhile, preference for whitening products is expanding from summer to all seasons, and consumers are also becoming segmented. As interest in whitening cosmetics increases, complex functional cosmetics that combine whitening, wrinkle improvement, whitening, and UV protection functions based on more advanced technology are appearing. However, there are a number of tasks that companies must take the lead in solving, such as preventing the limitation of raw materials in the functional cosmetics notification from acting as another obstacle to the growth of the whitening cosmetics market.

And, 'cosmetics with the function of helping whiten the skin by preventing the deposition of melanin pigment on the skin and suppressing the formation of blemishes and freckles. It helps whiten the skin by lightening the color of the melanin pigment deposited on the skin. Cosmetics with the function of giving whitening function are called whitening functional cosmetics. In a cosmetics-related survey, Korean women ranked skin pigmentation as the number one skin concern they wanted to solve first, which clearly shows how high women's interest in whitening cosmetics is.

The domestic whitening cosmetics market is expected to increase further in the future due to Asian women's preference for white skin. In this growing whitening cosmetics market, companies are accelerating the development of new ingredients with differentiated and excellent whitening effects in order to steadily increase sales, and are investing heavily in developing more stable and safe natural materials and products.

In this regard, in the past, Patent Publication No. 10-2021-0087405 (2021.07.12) “Composition containing plant extract” (hereinafter referred to as “Prior Art 1”) has been disclosed.

Prior art 1 has a skin whitening effect by reducing the total amount of melanin and tyrosinase activity in skin melanocytes, promotes collagen synthesis in skin fibroblasts and inhibits collagenase activity, thereby promoting skin regeneration and improving skin elasticity or skin It improves wrinkles, suppresses NO production to have an anti-inflammatory or skin soothing effect, promotes the production of hyaluronic acid in fibroblasts, increases skin moisture content and has a moisturizing effect, and has an antioxidant effect by scavenging free radicals. In addition, it was a technology that could be used as a cosmetic composition, pharmaceutical composition, external skin agent, or food composition by showing a wide range of antibacterial effects against various bacteria.

In addition, in the past, Registered Patent Publication No. 10-2452006 (2022.10.07.) “Cosmetic composition for whitening containing mixed extracts of tangerine, rapeseed, bracken and camellia” (hereinafter referred to as “Prior Art 2”) This has been disclosed.

Prior art 2 relates to a cosmetic composition for whitening. It uses mixed extracts of tangerine, rapeseed, fern, and camellia tree, which have excellent antioxidant effects, as active ingredients, and has excellent skin whitening effect. It also contains methyl, which improves stability when used with vitamin C. By using a solvent consisting of either pyrrolidone or ethylpyrrolidone, the functionality is maximized so that the excellent bioactive substances contained in the mixed extracts of tangerine, rapeseed, fern, and camellia tree can effectively penetrate into the skin, and the solvent causes It was a technology to provide a whitening cosmetic composition that can minimize skin irritation by minimizing phototoxicity and inflammation caused to the skin.

In addition, in the past, Registered Patent Publication No. 10-2376523 (2022.03.17) “Cosmetic composition containing Rose of Sharon bark extract” (hereinafter referred to as “Prior Art 3”) has been disclosed.

Prior art 3 relates to a cosmetic composition containing Rose of Sharon tree bark extract and cosmetics containing the same. More specifically, it has excellent skin absorption of active ingredients, improves skin wrinkles and skin troubles, and has antioxidant effects and anti-aging properties. It was a technology related to a cosmetic composition containing Rose of Sharon bark extract, which has excellent effects in removing skin wastes as well as moisturizing, whitening, and improving skin, and cosmetics containing the same.

In addition, in the past, Registered Patent Publication No. 10-2022-0110915 (2022.08.09.) “Cypress Jijangsu composition with whitening and antioxidant performance” (hereinafter referred to as “Prior Art 4”) was disclosed. there is.

Prior art 4 is to manufacture cypress jijangsu using red clay and cypress tree, ferment it and then concentrate it to produce a cypress jijangsu composition, which contains not only the efficacy of red clay but also the efficacy of cypress tree, thereby improving whitening and antioxidant performance. It was about a Cypress Jijangsu composition that has whitening and antioxidant properties.

In addition, in prior art 4, red clay and cypress leaves are mixed and aged, and cypress tree chips, cypress leaves, pine needles, bedrock water, and charcoal are mixed with the aged red clay to produce cypress tree, and then the prepared cypress tree is fermented. It was a technology to provide a Cypress Jijangsu composition with whitening and antioxidant properties that can effectively improve whitening and antioxidant performance by obtaining the supernatant, pasteurizing it at low temperature, and then concentrating it under reduced pressure.

In this way, technologies having antioxidant or whitening effects using various plant extracts have been disclosed, such as prior art 1 to 4, but the effects tended to fall short of expectations. Therefore, recently, there is a need for research and development on compositions that can further increase the antioxidant or whitening effect using extracts from the Korean mandu tree, a native Korean plant.

Public Patent Publication No. 10-2021-0087405 (2021.07.12) Registered Patent Publication No. 10-2452006 (2022.10.07.) Registered Patent Publication No. 10-2376523 (2022.03.17.) Public Patent Publication No. 10-2022-0110915 (2022.08.09.)

The present invention was created to solve the above problems, and the purpose of the present invention is to provide an anti-oxidant effect containing as an active ingredient the extract of the mandu tree, which can increase the antioxidant or whitening effect by using the stem and leaf extract of the mandu tree. and to provide compositions for skin whitening, pharmaceutical compositions for treatment, and health functional foods.

In addition, the purpose of the present invention is to provide extracts of the stems and leaves of Jodo Mandu tree, which have a high collagenase inhibition rate and are excellent for improving skin wrinkles.

However, the technical problems to be achieved in the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned will be clearly apparent to those skilled in the art from the description below. It will be understandable.

The composition for antioxidant effect and skin whitening containing the Glochidion chodoense JS Lee & HT Im extract as an active ingredient according to an embodiment of the present invention contains the Glochidion chodoense JS Lee & HT Im extract as an active ingredient.

In the composition for antioxidant effect and skin whitening containing the extract of the mandu tree as an active ingredient according to an embodiment of the present invention, the extract of the mandu tree contains at least one of the leaves, stems, roots, and fruits of the tree. can do.

In the composition for antioxidant effect and skin whitening containing the extract of Glochidion chodoense JS Lee & HT Im according to an embodiment of the present invention, the leaf extract of Glochidion chodoense JS Lee & HT Im contains gallic acid, It may include any one or more from the group consisting of norbergenin, ethyl gallate, isoorientin, and isovitexin.

In the composition for antioxidant effect and skin whitening containing the extract of Glochidion chodoense JS Lee & HT Im according to an embodiment of the present invention, the stem extract of Glochidion chodoense JS Lee & HT Im contains gallic acid, It may include any one or more from the group consisting of norbergenin, bergenin, ethyl gallate, isoorientin, and ellagic acid.

In addition, in the composition for antioxidant effect and skin whitening containing the extract of the mandu tree as an active ingredient according to an embodiment of the present invention, the stems and leaves of the tree are freeze-dried and prepared in powder form, then 30% to 30% of the composition is prepared in powder form. It may contain 70% ethanol extract or hot water extract.

In addition, the pharmaceutical composition for improving or treating antioxidant effect and skin whitening containing the extract of Glochidion chodoense JS Lee & HT Im as an active ingredient according to another embodiment of the present invention includes the extract of Glochidion chodoense JS Lee & HT Im. Contains as an active ingredient.

In addition, the health functional food containing Glochidion chodoense JS Lee & HT Im extract as an active ingredient according to another embodiment of the present invention contains Glochidion chodoense JS Lee & HT Im extract as an active ingredient.

The present invention provides 30% to 70% ethanol extract or hot water extract by pulverizing the stem and leaf extract of Jodo Mandu tree, thereby providing antioxidant effect due to DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS radical scavenging ability. and has excellent skin whitening effect.

In addition, the stem and leaf extract of Jodo Mandu tree according to an embodiment of the present invention has a high collagenase inhibition rate and is excellent for improving skin wrinkles.

Figure 1 is a graph showing the HPLC measurement results of 30% ethanol extract, 70% ethanol extract, and hot water extract using Jodo Mandu tree leaves.
Figure 2 is a graph showing the HPLC measurement results of 30% ethanol extract, 70% ethanol extract, and hot water extract using Jodo dumpling tree stems.

Below, with reference to the attached drawings, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, since the description of the present invention is only an example for structural or functional explanation, the scope of the present invention should not be construed as limited by the examples described in the text. In other words, since the embodiment can be modified in various ways and can have various forms, the scope of rights of the present invention should be understood to include equivalents that can realize the technical idea. In addition, the purpose or effect presented in the present invention does not mean that a specific embodiment must include all or only such effects, so the scope of the present invention should not be understood as limited thereby.

The meaning of terms described in the present invention should be understood as follows.

Terms such as “first” and “second” are used to distinguish one component from another component, and the scope of rights should not be limited by these terms. For example, a first component may be named a second component, and similarly, the second component may also be named a first component. When a component is referred to as being “connected” to another component, it should be understood that it may be directly connected to the other component, but that other components may also exist in between. On the other hand, when a component is referred to as being “directly connected” to another component, it should be understood that there are no other components in between. Meanwhile, other expressions that describe the relationship between components, such as "between" and "immediately between" or "neighboring" and "directly neighboring" should be interpreted similarly.

Singular expressions should be understood to include plural expressions unless the context clearly indicates otherwise, and terms such as “comprise” or “have” refer to installed features, numbers, steps, operations, components, parts, or combinations thereof. It is intended to specify the existence of one thing, and should be understood as not excluding in advance the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

All terms used herein, unless otherwise defined, have the same meaning as commonly understood by a person of ordinary skill in the field to which the present invention pertains. Terms defined in commonly used dictionaries should be interpreted as consistent with the meaning they have in the context of the related technology, and cannot be interpreted as having an ideal or excessively formal meaning unless clearly defined in the present invention.

In order to test the antioxidant and whitening effects of the crude dumpling tree, the inventors of the present invention used stem and leaf extracts of the crude dumpling tree by a certain method and recovered each extract as an excellent antioxidant and whitening active ingredient. By confirming the DPPH and ABTS radical scavenging effects of the dumpling tree extract, we intended to utilize the dumpling tree extract as a pharmaceutical composition and health functional food for antioxidant effects and skin whitening.

The composition for antioxidant effect and skin whitening containing the Glochidion chodoense JS Lee & HT Im extract as an active ingredient according to an embodiment of the present invention contains the Glochidion chodoense JS Lee & HT Im extract as an active ingredient.

In the composition for antioxidant effect and skin whitening containing the extract of the mandu tree as an active ingredient according to an embodiment of the present invention, the extract of the mandu tree contains at least one of the leaves, stems, roots, and fruits of the tree. can do.

In addition, in the composition for antioxidant effect and skin whitening containing the extract of the mandu tree as an active ingredient according to an embodiment of the present invention, the stems and leaves of the tree are freeze-dried and prepared in powder form, then 30% to 30% of the composition is prepared in powder form. It may contain 70% ethanol extract or hot water extract.

In addition, the pharmaceutical composition for antioxidant effect and skin whitening or treatment containing the extract of Glochidion chodoense JS Lee & HT Im as an active ingredient according to another embodiment of the present invention contains the extract of Glochidion chodoense JS Lee & HT Im. Contains as an ingredient.

In addition, the health functional food containing Glochidion chodoense JS Lee & HT Im extract as an active ingredient according to another embodiment of the present invention contains Glochidion chodoense JS Lee & HT Im extract as an active ingredient.

<Example 1>

The stem (branches) and leaves of Glochidion chodoense JS Lee & HT Im were separated and foreign substances were removed. The stems and leaves of the Jodo dumpling tree were freeze-dried, prepared in powder form, and subjected to 30% ethanol extraction, 70% ethanol extraction, and hot water extraction.

To confirm the antioxidant and skin whitening effects of each of these extracts, experiments were conducted on DPPH and ABTS radical scavenging abilities, and the results are shown in Table 1 below.

That is, the composition for antioxidant effect and skin whitening containing the extract of the mandu tree as an active ingredient according to an embodiment of the present invention divides the leaves and stems into 30% ethanol extract, 70% ethanol extract, and hot water extract, respectively, and contains DPPH, An experiment was conducted on ABTS radical scavenging ability, and the results are shown in Table 1 below.

Extraction method EC ₅₀ (μg/mL) ^a DPPH ABTS ^·+ stem
(branch) 30% EtOH 10.75 ± 0.31 14.94 ± 1.80 70% EtOH 8.16 ± 0.06 7.68 ± 0.37 thermal water 11.09 ± 0.21 8.18 ± 0.15 leaf 30% EtOH 4.62 ± 0.0.3 4.46 ± 0.53 70% EtOH 4.31 ± 0.09 5.69 ± 0.45 thermal water 6.20 ± 0.29 5.76 ± 0.25 control group L-Ascorbic acid 3.28 ± 0.11 3.47 ± 0.20

<EC ₅₀ : Half maximal effective concentration>

Referring to Table 1 above, it was found that L-Ascorbic acid, which is used as a control antioxidant, has excellent DPPH and ABTS radical scavenging ability.

Here, the leaves and stems of the present invention were divided into 30% ethanol extract, 70% ethanol extract, and hot water extract, respectively, and it was found that the DPPH and ABTS radical scavenging ability was lower than that of L-Ascorbic acid, an antioxidant, but satisfactory.

In particular, it was found that 30% ethanol extract and 70% ethanol extract using the leaves of Jodo Mandu tree had excellent DPPH and ABTS radical scavenging abilities, similar to the level of L-Ascorbic acid, which is used as an antioxidant.

Therefore, the present invention provides 30% to 70% ethanol extract or hot water extract by freeze-drying and powdering the stem and leaf extract of Jodo Mandu tree, which has excellent DPPH and ABTS radical scavenging ability, thereby providing antioxidant effect and skin whitening effect. I could tell it was high.

On the other hand, the composition for antioxidant effect and skin whitening containing the extract of the mandu tree as an active ingredient according to an embodiment of the present invention is divided into 30% ethanol extract, 70% ethanol extract, and hot water extract of the leaves and stems, respectively, to produce melanin. An experiment was conducted on the inhibition rate of Tyrosinase, an enzyme involved in , and Collagenase, an enzyme that decomposes collagen, at 50 μg/mL, and the results are shown in Table 2 below.

Extraction method Inhibition rate (%) at 50 μg/mL Tyrosinase Collagenase stem
(branch) 30% EtOH -2.40 ± 0.89 -5.13 ± 10.12 70% EtOH 11.29 ± 1.80 41.56 ± 5.97 thermal water 5.22 ± 2.70 2.69 ± 2.36 leaf 30% EtOH 18.39 ± 1.12 22.25 ± 3.81 70% EtOH 13.60 ± 1.57 63.33 ± 2.54 thermal water 24.21 ± 0.90 24.45 ± 3.67 control group Kojic acid 81.86 ± 0.39
(inhibition rate at 10 μg/mL) - Epigallocatechin gallate - 50.86 ± 1.94
(inhibition rate at 200 μg/mL)

Here, referring to Table 2, it was found that Kojic acid (10 μg/mL) and Epigallocatechin gallate (200 μg/mL), which were used as positive controls, had excellent inhibition rates (%) of Tyrosinase and Collagenase.

In addition, the inhibition rate (%) of Tyrosinase and Collagenase was measured at 50 μg/mL by dividing the leaves and stems of the present invention into 30% ethanol extract, 70% ethanol extract, and hot water extract, respectively, and it was found to be effective. there was.

In particular, it was found that the 70% ethanol extract of the leaves of the present invention had a better inhibition rate (%) of Collagenase at 50 μg/mL than Epigallocatechin gallate.

Therefore, the present invention provides 30% to 70% ethanol extract or hot water extract by freeze-drying and powdering the stem and leaf extract of Jodo Mandu tree, thereby producing Tyrosinase, an enzyme involved in melanin production, and Collagenase, an enzyme that decomposes collagen. Since the inhibition rate (%) was excellent at 50 μg/mL, it was found that the antioxidant effect and skin whitening effect were high. In addition, it can be seen that the collagenase inhibition rate is high, making it excellent for improving skin wrinkles.

<Example 2>

Figure 1 is a graph showing the HPLC-Q-TOF-MS measurement results of 30% ethanol extract, 70% ethanol extract, and hot water extract using Jodo Mandu tree leaves.

Figure 2 is a graph showing the HPLC-Q-TOF-MS measurement results of 30% ethanol extract, 70% ethanol extract, and hot water extract using Jodo dumpling tree stems.

The stem (branches) and leaves of Glochidion chodoense JS Lee & HT Im were separated and foreign substances were removed. The stems and leaves of the Jodo dumpling tree were freeze-dried, prepared in powder form, and subjected to 30% ethanol extraction, 70% ethanol extraction, and hot water extraction.

Using high-performance liquid chromatography (HPLC), HPLC-Q-TOF-MS analysis was performed on 30% ethanol extract, 70% ethanol extract, and hot water extract of the leaves and stems of Jodo Mandu tree, respectively. The results are shown in Figures 1 and 2 and Table 2.

RT (min) measured mass Error (ppm) fragment ion (m/z) molecular formula ingredient type 9.52 169.0146 [M - H] ^- 5.3 125.0247 C ₇ H ₆ O ₁₅ Gallic acid leaves, stems 10.32 313.0538 [M-H] ^- 5.7 193.0124 C ₁₃ H ₁₆ O ₉ Norbergenin leaves, stems 18.02 327.0736 [M - H] ^- -6.4 249.0380, 234.0177, 192.0055, 190.0247 C ₁₄ H ₁₆ O ₉ Bergenin stem 44.99 197.0439 [M - H] ^- -5.6 C ₉ H ₁₀ O ₅ Ethyl gallate leaves, stems 45.49 447.0927 [M - H] ^- 0.0 357.0612, 327.0490, 297.0391 C ₂₁ H ₂₀ O ₁₁ Isoorientin (luteolin-6-C-glucoside) leaves, stems 53.70 300.9964 [M - H] ^- -6.6 C ₁₄ H ₆ O ₈ Ellagic acid stem 60.06 431.0957 [M-H] ^- -4.9 341.0644, 311.0565, 283.0576 C ₂₁ H ₂₀ O ₁₀ Isovitexin (apigenin-6-C-glucoside) leaf

As a result of the component analysis in Figure 1 and Table 3, in the 30% ethanol extract, 70% ethanol extract, and hot water extract of the leaves of Jodo Mandu tree, gallic acid, norbergenin, ethyl gallate, Isoorientin and Isovitexin were detected.

As a result of component analysis in Figure 2 and Table 3, gallic acid, norbergenin, bergenin, and ethyl gall were found in the 30% ethanol extract, 70% ethanol extract, and hot water extract of the Jodo Mandu tree stem. Ethyl gallate, isoorientin, and ellagic acid were detected.

Through this analysis of the main compounds of the Jodo dumpling tree, it was possible to find out what components the leaves and stems of the Jodo dumpling tree are made of.

<Example 3>

Based on the results of component analysis of the leaves and stems of the Jodo dumpling tree, an experiment was conducted on the DPPH and ABTS radical scavenging effects of each component to confirm the antioxidant effect of the main compounds of the Jodo dumpling tree, and the results are presented below. It is shown in Table 3.

ingredient Clearance (%) at 20 μg/mL DPPH ABTS ^·+ Norbergenin 93.76 ± 0.87 78.53 ± 4.19 Bergenin - 50.68 ± 0.82 Gallic acid 91.79 ± 1.71 88.04 ± 4.12 Ethyl gallate 88.90 ± 2.45 88.45 ± 1.47 Isoorientin 85.24 ± 1.57 55.30 ± 2.53 Isovitexin 7.12 ± 0.66 8.49 ± 2.83 Ellagic acid 98.94 ± 0.37 80.91 ± 7.00

Referring to Table 4 above, as a result of measuring the scavenging activity of DDPH against norbergenin, gallic acid, ethyl gallate, isoorientin, isovitexin, and ellagic acid, which are the main compounds of Jodo mandu tree, DDPH It was found that the erasing ability was excellent.

In addition, referring to Table 4 above, the ABTS ^·+ for norbergenin, bergenin, gallic acid, ethyl gallate, isoorientin, isovitexin, and ellagic acid, which are the main compounds of the mandu tree. As a result of measuring the radical scavenging activity, it was found that ABTS ^·+ had excellent scavenging ability.

As described above, the specific description of the present invention has been made by way of examples, but since the above-described embodiments are only explained by referring to preferred examples of the present invention, it is understood that the present invention is limited to the above-described embodiments. It should not be denied, and the scope of rights of the present invention should be understood in terms of the claims described later and their equivalent concepts.

Claims (8)

A composition for antioxidant effect and skin whitening containing extract of Glochidion chodoense JS Lee & HT Im as an active ingredient.
According to claim 1,
The Jodo dumpling tree extract is characterized in that it contains at least one of the leaves, stems, roots, and fruits of the Jodo dumpling tree.
A composition for antioxidant effect and skin whitening containing extract of Glochidion chodoense JS Lee & HT Im as an active ingredient.
According to claim 2,
The leaf extract of Glochidion chodoense JS Lee & HT Im contains gallic acid, norbergenin, ethyl gallate, isoorientin, and isovitexin. ), characterized in that it contains one or more of the group consisting of
A composition for antioxidant effect and skin whitening containing extract of Glochidion chodoense JS Lee & HT Im as an active ingredient.
According to claim 2,
The stem extract of Glochidion chodoense JS Lee & HT Im contains gallic acid, norbergenin, bergenin, ethyl gallate, and isoorientin. , characterized in that it contains at least one from the group consisting of ellagic acid.
A composition for antioxidant effect and skin whitening containing extract of Glochidion chodoense JS Lee & HT Im as an active ingredient.
According to claim 1,
The stems and leaves of the Glochidion chodoense JS Lee & HT Im were prepared in powder form by freeze-drying and then containing Glochidion chodoense JS Lee & HT Im extract containing 30% to 70% ethanol extract or hot water extract as an active ingredient. A composition for antioxidant effect and skin whitening.
A pharmaceutical composition for improving antioxidant effect or skin whitening containing extract of Glochidion chodoense JS Lee & HT Im as an active ingredient.
A health functional food composition containing Glochidion chodoense JS Lee & HT Im extract as an active ingredient.
According to claim 1,
The antioxidant effect and skin whitening composition containing the Glochidion chodoense JS Lee & HT Im extract as an active ingredient is characterized in that it improves skin wrinkles by inhibiting collagenase.
A composition for antioxidant effect and skin whitening containing extract of Glochidion chodoense JS Lee & HT Im as an active ingredient.