KR20240046280A - 펩티드 조성물 및 사용 방법 - Google Patents
펩티드 조성물 및 사용 방법 Download PDFInfo
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| KR1020177034366A KR102652804B1 (ko) | 2015-05-01 | 2016-04-29 | 펩티드 조성물 및 사용 방법 |
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| KR1020177034366A KR102652804B1 (ko) | 2015-05-01 | 2016-04-29 | 펩티드 조성물 및 사용 방법 |
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| JP (2) | JP6884755B2 (ja) |
| KR (2) | KR20240046280A (ja) |
| CN (2) | CN113651873A (ja) |
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| HU (1) | HUE057883T2 (ja) |
| LT (1) | LT3288379T (ja) |
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| RS (1) | RS62866B1 (ja) |
| SI (1) | SI3288379T1 (ja) |
| WO (1) | WO2016178993A1 (ja) |
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| SI3288379T1 (sl) * | 2015-05-01 | 2022-06-30 | Onl Therapeutics, Inc. | Peptidne sestave in načini uporabe |
| EP3768301A4 (en) * | 2018-03-20 | 2022-06-08 | ONL Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR FAS INHIBITION |
| AU2019288296B2 (en) * | 2018-06-19 | 2022-11-24 | Cella Therapeutics, Llc | Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a CNP compound, an NPR-B compound, a Tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension |
| AU2020407072A1 (en) * | 2019-12-18 | 2022-07-07 | Cella Therapeutics, Llc | Drug delivery systems comprising a neurotrophic agent, an apoptosis signaling fragment inhibitor (FAS) or FAS ligand (FASL) inhibitor, a tumor necrosis factor-α (TNF-α) or TNF receptor inhibitor, a mitochondrial peptide, an oligonucleotide, a chemokine inhibitor, or a cysteine-aspartic protease inhibitor |
| WO2023129766A1 (en) * | 2021-12-27 | 2023-07-06 | Onl Therapeutics, Inc. | Sfasl for inhibiting rpe cell death and associated disorders |
| WO2024031022A2 (en) * | 2022-08-05 | 2024-02-08 | Onl Therapeutics, Inc. | Peptide compositions and methods of use |
| WO2024031024A1 (en) * | 2022-08-05 | 2024-02-08 | Onl Therapeutics, Inc. | Peptide compositions and methods of use |
Family Cites Families (38)
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| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
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| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
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| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| US5631237A (en) | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
| JP3460863B2 (ja) | 1993-09-17 | 2003-10-27 | 三菱電機株式会社 | 半導体装置の製造方法 |
| US5714353A (en) | 1994-05-24 | 1998-02-03 | Research Corporation Technologies, Inc. | Safe vectors for gene therapy |
| US5527928A (en) | 1994-09-30 | 1996-06-18 | Nantz; Michael H. | Cationic transport reagents |
| US5650096A (en) | 1994-12-09 | 1997-07-22 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
| US5719131A (en) | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
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| US5705385A (en) | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US6001962A (en) | 1996-11-15 | 1999-12-14 | The Regents Of The University Of California | Modified Fas ligands |
| US7091047B2 (en) * | 1997-05-23 | 2006-08-15 | A&G Pharmaceutical, Inc. | Methods and kits for diagnosing tumorigenicity |
| US6363020B1 (en) | 1999-12-06 | 2002-03-26 | Virage Logic Corp. | Architecture with multi-instance redundancy implementation |
| US6480428B2 (en) | 2000-12-19 | 2002-11-12 | Winbond Electronics Corporation | Redundant circuit for memory device |
| EP1730186A2 (en) * | 2004-03-31 | 2006-12-13 | Xencor, Inc. | Bmp-7 variants with improved properties |
| AU2005249383A1 (en) | 2004-04-23 | 2005-12-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Cell death modulation via antagonists of FasL and Fas activation |
| ES2322200T3 (es) * | 2005-05-10 | 2009-06-17 | Alcon, Inc. | Formulaciones en suspension que comprenden un principio activo, un tensioactivo poloxamero o meroxapol y un glicol, su uso para la fabricacion de un medicamento para tratar trastornos oftalmicos. |
| RU2008122978A (ru) * | 2005-11-09 | 2009-12-20 | Комбинаторкс, Инкорпорейтед (Us) | Способы, композиции и наборы для лечения медицинских состояний |
| EP1963364A2 (en) * | 2005-12-01 | 2008-09-03 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Compounds and methods for inhibiting apoptosis |
| JP5529754B2 (ja) * | 2007-12-21 | 2014-06-25 | ストライカー コーポレイション | Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体 |
| CN102449140B (zh) * | 2009-03-03 | 2014-11-26 | 密执安大学评议会 | 抑制光感受器凋亡的方法 |
| WO2010113753A1 (ja) * | 2009-03-30 | 2010-10-07 | 参天製薬株式会社 | ＪＮＫ（ｃ－Ｊｕｎアミノ末端キナーゼ）阻害ペプチドを用いた網膜疾患の予防または治療剤、網膜疾患の予防または治療方法、ならびに、その使用 |
| WO2011017350A2 (en) * | 2009-08-04 | 2011-02-10 | Amira Pharmaceuticals, Inc. | Compounds as lysophosphatidic acid receptor antagonists |
| CN103492574B (zh) | 2011-02-22 | 2015-12-09 | 加州理工学院 | 使用腺相关病毒（aav）载体递送蛋白 |
| EP2717899A4 (en) * | 2011-06-06 | 2015-07-29 | Kineta One Llc | PHARMACEUTICAL COMPOSITIONS BASED ON SHK AND METHODS OF MAKING AND USING THE SAME |
| WO2013106909A1 (en) | 2012-01-18 | 2013-07-25 | Governing Council Of The University Of Toronto | Novel peptides and methods and uses thereof for preventing retinal disorders |
| CN104394881B (zh) * | 2012-06-21 | 2016-10-26 | 韩诺生物制药株式会社 | 修饰的人肿瘤坏死因子受体-1多肽的新用途 |
| WO2014071183A1 (en) * | 2012-11-02 | 2014-05-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor |
| EP3254106A4 (en) | 2015-02-05 | 2018-10-03 | Immunarray USA, Inc. | Methods and compositions for diagnosing brain injury or neurodegeneration |
| US20190201500A1 (en) | 2015-05-01 | 2019-07-04 | Onl Therapeutics, Inc. | Compositions and methods of fas inhibition |
| SI3288379T1 (sl) * | 2015-05-01 | 2022-06-30 | Onl Therapeutics, Inc. | Peptidne sestave in načini uporabe |
| CN110177577A (zh) | 2016-07-05 | 2019-08-27 | 马萨诸塞大学 | Sfasl的aav2介导的基因递送作为青光眼的神经保护疗法 |
| EP3768301A4 (en) | 2018-03-20 | 2022-06-08 | ONL Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR FAS INHIBITION |
| AU2019288296B2 (en) | 2018-06-19 | 2022-11-24 | Cella Therapeutics, Llc | Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a CNP compound, an NPR-B compound, a Tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension |
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