BR112017023479A2 - composições peptídicas e métodos de uso - Google Patents
composições peptídicas e métodos de usoInfo
- Publication number
- BR112017023479A2 BR112017023479A2 BR112017023479-3A BR112017023479A BR112017023479A2 BR 112017023479 A2 BR112017023479 A2 BR 112017023479A2 BR 112017023479 A BR112017023479 A BR 112017023479A BR 112017023479 A2 BR112017023479 A2 BR 112017023479A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- peptide compositions
- photoreceptors
- fas
- therewith
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 108091008695 photoreceptors Proteins 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000034994 death Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000002207 retinal effect Effects 0.000 abstract 1
- 210000003583 retinal pigment epithelium Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
são aqui fornecidas composições incluindo peptídeos, suas preparações farmacêuticas, e métodos de prevenir a morte de fotorreceptor com as mesmas e proteger as células retinais, incluindo, mas não limitadas a fotorreceptores e epitélio pigmentar retinal, da apoptose mediada por fas ou trail.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562155711P | 2015-05-01 | 2015-05-01 | |
US62/155,711 | 2015-05-01 | ||
PCT/US2016/030098 WO2016178993A1 (en) | 2015-05-01 | 2016-04-29 | Peptide compositions and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017023479A2 true BR112017023479A2 (pt) | 2018-07-24 |
Family
ID=57217771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017023479-3A BR112017023479A2 (pt) | 2015-05-01 | 2016-04-29 | composições peptídicas e métodos de uso |
Country Status (22)
Country | Link |
---|---|
US (4) | US10508134B2 (pt) |
EP (2) | EP3997981A1 (pt) |
JP (2) | JP6884755B2 (pt) |
KR (2) | KR20240046280A (pt) |
CN (2) | CN113651873A (pt) |
AU (1) | AU2016258837B2 (pt) |
BR (1) | BR112017023479A2 (pt) |
CA (1) | CA2984154A1 (pt) |
CY (1) | CY1124911T1 (pt) |
DK (1) | DK3288379T3 (pt) |
EA (2) | EA202090184A3 (pt) |
ES (1) | ES2906173T3 (pt) |
HK (1) | HK1251979A1 (pt) |
HR (1) | HRP20220138T1 (pt) |
HU (1) | HUE057883T2 (pt) |
LT (1) | LT3288379T (pt) |
MX (1) | MX2017014075A (pt) |
PL (1) | PL3288379T3 (pt) |
PT (1) | PT3288379T (pt) |
RS (1) | RS62866B1 (pt) |
SI (1) | SI3288379T1 (pt) |
WO (1) | WO2016178993A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113651873A (zh) * | 2015-05-01 | 2021-11-16 | Onl医疗股份有限公司 | 肽组合物和使用方法 |
WO2019183246A1 (en) * | 2018-03-20 | 2019-09-26 | Onl Therapeutics, Inc. | Compositions and methods of fas inhibition |
EP3810082A1 (en) * | 2018-06-19 | 2021-04-28 | Cella Therapeutics, LLC | Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a cnp compound, an npr-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension |
EP4076495A4 (en) * | 2019-12-18 | 2023-12-20 | Cella Therapeutics, LLC | DRUG DELIVERY SYSTEMS INCLUDING NEUROTROPHIC AGENT, APOPTOSIS SIGNALING FRAGMENT (FAS) INHIBITOR OR FAS LIGAND INHIBITOR (FASL), TUMOR NECROSIS FACTOR INHIBITOR? (TNF-A) OR TNF RECEPTOR, MITOCHONDRIAL PEPTIDE, OLIGONUCLEOTIDE, CHEMOKINE INHIBITOR OR ASPARTIC CYSTEINE PROTEASE INHIBITOR |
WO2023129766A1 (en) * | 2021-12-27 | 2023-07-06 | Onl Therapeutics, Inc. | Sfasl for inhibiting rpe cell death and associated disorders |
WO2024031022A2 (en) * | 2022-08-05 | 2024-02-08 | Onl Therapeutics, Inc. | Peptide compositions and methods of use |
WO2024031024A1 (en) * | 2022-08-05 | 2024-02-08 | Onl Therapeutics, Inc. | Peptide compositions and methods of use |
Family Cites Families (38)
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US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US5532123A (en) * | 1990-07-11 | 1996-07-02 | New York University | Receptor-type phosphotyrosine phosphatase-γ |
US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
JP3187201B2 (ja) * | 1992-05-14 | 2001-07-11 | 三共株式会社 | C末端にプロリンアミドを有するペプチドの製法 |
US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
US5631237A (en) | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
JP3460863B2 (ja) | 1993-09-17 | 2003-10-27 | 三菱電機株式会社 | 半導体装置の製造方法 |
US5714353A (en) | 1994-05-24 | 1998-02-03 | Research Corporation Technologies, Inc. | Safe vectors for gene therapy |
US5527928A (en) | 1994-09-30 | 1996-06-18 | Nantz; Michael H. | Cationic transport reagents |
US5719131A (en) | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
US5650096A (en) | 1994-12-09 | 1997-07-22 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5711964A (en) | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
US5705385A (en) | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
US6001962A (en) * | 1996-11-15 | 1999-12-14 | The Regents Of The University Of California | Modified Fas ligands |
US7091047B2 (en) * | 1997-05-23 | 2006-08-15 | A&G Pharmaceutical, Inc. | Methods and kits for diagnosing tumorigenicity |
US6363020B1 (en) | 1999-12-06 | 2002-03-26 | Virage Logic Corp. | Architecture with multi-instance redundancy implementation |
US6480428B2 (en) | 2000-12-19 | 2002-11-12 | Winbond Electronics Corporation | Redundant circuit for memory device |
CA2561809A1 (en) * | 2004-03-31 | 2005-10-20 | Xencor, Inc. | Bmp-7 variants with improved properties |
EP1737483A2 (en) | 2004-04-23 | 2007-01-03 | University of Pittsburgh of the Commonwealth System of Higher Education | Cell death modulation via antagonists of fasl and fas activation |
KR20080011310A (ko) * | 2005-05-10 | 2008-02-01 | 알콘, 인코퍼레이티드 | 폴록사머 또는 메록사폴 계면활성제 및 글리콜을유효성분으로 함유하는 현탁제, 안질환 치료용 의약의제조를 위한 그의 용도 |
AU2006311577B2 (en) * | 2005-11-09 | 2013-02-07 | Zalicus Inc. | Methods, compositions, and kits for the treatment of medical conditions |
AU2006320327A1 (en) | 2005-12-01 | 2007-06-07 | Duke University | Compounds and methods for inhibiting apoptosis |
EP2222696A1 (en) * | 2007-12-21 | 2010-09-01 | Stryker Corporation | Bmp mutants with decreased susceptibility to noggin |
EP2403937B1 (en) | 2009-03-03 | 2015-05-06 | The Regents of the University of Michigan | Use of met peptide for inhibiting photoreceptor apoptosis |
KR20120022721A (ko) * | 2009-03-30 | 2012-03-12 | 산텐 세이야꾸 가부시키가이샤 | JNK(c-Jun 아미노 말단 키나제) 저해 펩티드를 이용한 망막 질환의 예방 또는 치료제, 망막 질환의 예방 또는 치료 방법, 및 이 펩티드의 용도 |
EP2462128B1 (en) * | 2009-08-04 | 2016-09-21 | Amira Pharmaceuticals, Inc. | Compounds as lysophosphatidic acid receptor antagonists |
JP6091435B2 (ja) | 2011-02-22 | 2017-03-08 | カリフォルニア インスティチュート オブ テクノロジー | アデノ随伴ウイルス(aav)ベクターを用いたタンパク質の送達 |
MX351353B (es) * | 2011-06-06 | 2017-10-11 | Kineta One Llc | Composiciones farmacéuticas basadas en shk y métodos para prepararlas y usarlas. |
WO2013106909A1 (en) | 2012-01-18 | 2013-07-25 | Governing Council Of The University Of Toronto | Novel peptides and methods and uses thereof for preventing retinal disorders |
BR112014031923B1 (pt) * | 2012-06-21 | 2022-02-08 | Daewoong Pharmaceutical Co., Ltd. | Uso de uma composição compreendendo pelo menos um tnfri modificado ou fragmento tnfri modificado, uso de uma formulação tópica e uso de uma composição |
WO2014071183A1 (en) * | 2012-11-02 | 2014-05-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor |
CN107533048A (zh) | 2015-02-05 | 2018-01-02 | 美国免疫阵列公司 | 用于诊断脑损伤或神经退行性变的方法和组合物 |
CN113651873A (zh) * | 2015-05-01 | 2021-11-16 | Onl医疗股份有限公司 | 肽组合物和使用方法 |
US20190201500A1 (en) | 2015-05-01 | 2019-07-04 | Onl Therapeutics, Inc. | Compositions and methods of fas inhibition |
CN110177577A (zh) | 2016-07-05 | 2019-08-27 | 马萨诸塞大学 | Sfasl的aav2介导的基因递送作为青光眼的神经保护疗法 |
WO2019183246A1 (en) | 2018-03-20 | 2019-09-26 | Onl Therapeutics, Inc. | Compositions and methods of fas inhibition |
EP3810082A1 (en) | 2018-06-19 | 2021-04-28 | Cella Therapeutics, LLC | Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a cnp compound, an npr-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension |
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2016
- 2016-04-29 CN CN202110665678.1A patent/CN113651873A/zh active Pending
- 2016-04-29 CN CN201680038258.8A patent/CN107708416B/zh active Active
- 2016-04-29 CA CA2984154A patent/CA2984154A1/en active Pending
- 2016-04-29 PL PL16789830T patent/PL3288379T3/pl unknown
- 2016-04-29 ES ES16789830T patent/ES2906173T3/es active Active
- 2016-04-29 AU AU2016258837A patent/AU2016258837B2/en active Active
- 2016-04-29 KR KR1020247010090A patent/KR20240046280A/ko not_active Application Discontinuation
- 2016-04-29 EP EP21200594.6A patent/EP3997981A1/en active Pending
- 2016-04-29 SI SI201631458T patent/SI3288379T1/sl unknown
- 2016-04-29 EA EA202090184A patent/EA202090184A3/ru unknown
- 2016-04-29 KR KR1020177034366A patent/KR102652804B1/ko active IP Right Grant
- 2016-04-29 JP JP2018508624A patent/JP6884755B2/ja active Active
- 2016-04-29 HR HRP20220138TT patent/HRP20220138T1/hr unknown
- 2016-04-29 WO PCT/US2016/030098 patent/WO2016178993A1/en active Application Filing
- 2016-04-29 RS RS20220095A patent/RS62866B1/sr unknown
- 2016-04-29 BR BR112017023479-3A patent/BR112017023479A2/pt active Search and Examination
- 2016-04-29 EA EA201792399A patent/EA035293B1/ru unknown
- 2016-04-29 HU HUE16789830A patent/HUE057883T2/hu unknown
- 2016-04-29 DK DK16789830.3T patent/DK3288379T3/da active
- 2016-04-29 EP EP16789830.3A patent/EP3288379B1/en active Active
- 2016-04-29 LT LTEPPCT/US2016/030098T patent/LT3288379T/lt unknown
- 2016-04-29 US US15/570,948 patent/US10508134B2/en active Active
- 2016-04-29 MX MX2017014075A patent/MX2017014075A/es unknown
- 2016-04-29 PT PT167898303T patent/PT3288379T/pt unknown
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2018
- 2018-09-04 HK HK18111301.1A patent/HK1251979A1/zh unknown
-
2019
- 2019-11-04 US US16/673,513 patent/US10829518B2/en active Active
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2020
- 2020-10-06 US US17/064,495 patent/US11597749B2/en active Active
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2021
- 2021-05-12 JP JP2021080927A patent/JP2021120400A/ja active Pending
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2022
- 2022-02-02 CY CY20221100088T patent/CY1124911T1/el unknown
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2023
- 2023-01-24 US US18/159,021 patent/US20230287052A1/en active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A01N 25/00 , A61K 38/00 Ipc: A61K 38/00 (2006.01), A61P 27/02 (2006.01) |
|
B25G | Requested change of headquarter approved |
Owner name: THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) ; ONL THERAPEUTICS, INC. (US) |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |