KR20240042148A - 간독성 및 지방간 질병을 치료하는 데 효과적인 화합물 및 이의 용도 - Google Patents

간독성 및 지방간 질병을 치료하는 데 효과적인 화합물 및 이의 용도 Download PDF

Info

Publication number
KR20240042148A
KR20240042148A KR1020247008968A KR20247008968A KR20240042148A KR 20240042148 A KR20240042148 A KR 20240042148A KR 1020247008968 A KR1020247008968 A KR 1020247008968A KR 20247008968 A KR20247008968 A KR 20247008968A KR 20240042148 A KR20240042148 A KR 20240042148A
Authority
KR
South Korea
Prior art keywords
liver
mannitol
combination
group
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247008968A
Other languages
English (en)
Korean (ko)
Inventor
올리버 요아-푸 후
퉁-위안 시
청-후이 셩
신-티엔 호
Original Assignee
시뉴 파마 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/078039 external-priority patent/WO2017084234A1/zh
Application filed by 시뉴 파마 인크. filed Critical 시뉴 파마 인크.
Publication of KR20240042148A publication Critical patent/KR20240042148A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
    • C07C51/215—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of saturated hydrocarbyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/42—Glutaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
KR1020247008968A 2015-09-24 2016-09-26 간독성 및 지방간 질병을 치료하는 데 효과적인 화합물 및 이의 용도 Pending KR20240042148A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201562222959P 2015-09-24 2015-09-24
US62/222,959 2015-09-24
US201562257697P 2015-11-19 2015-11-19
US62/257,697 2015-11-19
CNPCT/CN2016/078039 2016-03-31
PCT/CN2016/078039 WO2017084234A1 (zh) 2015-11-19 2016-03-31 预防或治疗脂肪肝的药物组合物
KR1020187011548A KR102891137B1 (ko) 2015-09-24 2016-09-26 간독성 및 지방간 질병을 치료하는 데 효과적인 화합물 및 이의 용도
PCT/CN2016/100187 WO2017050298A1 (en) 2015-09-24 2016-09-26 Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187011548A Division KR102891137B1 (ko) 2015-09-24 2016-09-26 간독성 및 지방간 질병을 치료하는 데 효과적인 화합물 및 이의 용도

Publications (1)

Publication Number Publication Date
KR20240042148A true KR20240042148A (ko) 2024-04-01

Family

ID=60047309

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020247008968A Pending KR20240042148A (ko) 2015-09-24 2016-09-26 간독성 및 지방간 질병을 치료하는 데 효과적인 화합물 및 이의 용도
KR1020187011548A Active KR102891137B1 (ko) 2015-09-24 2016-09-26 간독성 및 지방간 질병을 치료하는 데 효과적인 화합물 및 이의 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020187011548A Active KR102891137B1 (ko) 2015-09-24 2016-09-26 간독성 및 지방간 질병을 치료하는 데 효과적인 화합물 및 이의 용도

Country Status (20)

Country Link
US (4) US10456371B2 (https=)
EP (3) EP3991724B1 (https=)
JP (2) JP2018537517A (https=)
KR (2) KR20240042148A (https=)
CN (3) CN107614475A (https=)
AU (3) AU2016327930B2 (https=)
BR (1) BR112018005905B1 (https=)
CA (2) CA3232521A1 (https=)
EA (1) EA201890810A1 (https=)
ES (1) ES3044383T3 (https=)
HK (1) HK1244266A1 (https=)
HR (1) HRP20250899T1 (https=)
HU (1) HUE072982T2 (https=)
MX (2) MX395231B (https=)
MY (1) MY190647A (https=)
PH (1) PH12018500659A1 (https=)
SG (1) SG10202002573RA (https=)
TW (1) TWI781912B (https=)
WO (1) WO2017050298A1 (https=)
ZA (1) ZA201802373B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3069733T3 (pl) * 2013-11-13 2023-02-13 National Defense Education And Research Foundation Nowa kompozycja związku stanowiącego acetaminofen niepowodująca w wątrobie działań niepożądanych
WO2017084234A1 (zh) * 2015-11-19 2017-05-26 欣耀生医股份有限公司 预防或治疗脂肪肝的药物组合物
EA201890810A1 (ru) 2015-09-24 2018-11-30 Синью Фарма Инк. Соединения, эффективные для лечения гепатотоксичности и стеатоза печени, и их применение
CN111867572A (zh) * 2018-02-14 2020-10-30 欣耀生医股份有限公司 用于预防、减少或消除由对乙酰氨基酚(apap)引起的毒性的方法和组合物
CN110538187A (zh) * 2018-05-28 2019-12-06 北京大学 Cpt1激活剂
KR102136326B1 (ko) * 2018-09-06 2020-07-22 서울대학교산학협력단 가시박으로부터 분리한 플라보노이드 유도체를 유효성분으로 포함하는 간 질환 예방 또는 치료용 조성물
TWI691719B (zh) * 2018-10-19 2020-04-21 香港商阿瓦隆 海帕波有限公司 半乳糖快速定量檢測系統及其應用
CN109920550A (zh) * 2018-12-25 2019-06-21 天津大学 一种基于dMRI研究青少年肌阵挛性癫痫的方法
TWI858005B (zh) * 2019-01-21 2024-10-11 新加坡商新加坡保健服務私人有限公司 肝毒性之治療
CN110269855A (zh) * 2019-07-19 2019-09-24 辽宁大学 黄酮类小分子化合物在制备抑制胰脂肪酶活性药物中的应用
US12383191B1 (en) * 2020-05-04 2025-08-12 PathAI, Inc. Systems and methods for assessing liver pathology
CN113999272A (zh) * 2021-10-29 2022-02-01 广西医科大学 香蜂草苷的制备方法及其应用
CN113875982A (zh) * 2021-11-19 2022-01-04 武汉森澜生物科技有限公司 一种含二氢杨梅素的抗衰组合物及其应用
CN117482082A (zh) * 2023-11-27 2024-02-02 西北大学 金松双黄酮在制备抗慢性肾损伤药物中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661519A (en) * 1983-04-12 1987-04-28 Pola Chemical Industries Inc. Method for dermatological application
CH664150A5 (de) * 1985-01-15 1988-02-15 Peter Paul Prof Dr Speiser Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen.
JP3916685B2 (ja) * 1996-02-29 2007-05-16 第一製薬株式会社 ガラクトース誘導体
JP4677550B2 (ja) * 2002-08-14 2011-04-27 独立行政法人産業技術総合研究所 環状エステル化合物
TWI287990B (en) * 2004-01-08 2007-10-11 Nat Defense Medical Ct Inhibitors and enhancers of uridine diphosphate-glucuronosyl transferase 2B (UGT2B)
WO2006010083A2 (en) * 2004-07-08 2006-01-26 Molecular Therapeutics, Inc. Biodegradable nanoparticles
CN1939929A (zh) * 2005-09-29 2007-04-04 云南白药集团股份有限公司 一种偏诺皂苷类化合物酸式盐及制备方法
DE112011105169B4 (de) * 2011-04-20 2021-11-04 National Defense Education And Research Foundation Neue pharmazeutische orale Zusammensetzung mit geringen Nebenwirkungen enthaltend anti-Tuberkulose Arzneimittel
KR20150084897A (ko) * 2012-11-12 2015-07-22 세게티스, 인코포레이티드. 가교성 폴리케탈 에스터, 그의 제조 방법 및 용도
US9211298B2 (en) * 2012-11-16 2015-12-15 Song Gao Compositions containing enriched natural crocin and/or crocetin, and their therapeutic or nutraceutical uses
JP6194412B2 (ja) * 2013-04-29 2017-09-06 ハーシャ チグルパティ アルコール飲料の毒性低減
TWI552748B (zh) 2013-10-25 2016-10-11 The use of a compound for the removal of hepatotoxicity against Acetaminophen (APAP)
CN104623670A (zh) * 2013-11-06 2015-05-20 高松 一种含西红花素的组合物及其应用
PL3069733T3 (pl) * 2013-11-13 2023-02-13 National Defense Education And Research Foundation Nowa kompozycja związku stanowiącego acetaminofen niepowodująca w wątrobie działań niepożądanych
CN104292289B (zh) * 2014-07-10 2017-12-29 程怡 半乳糖配体及其在肝靶向脂质体中的应用
EA201890810A1 (ru) * 2015-09-24 2018-11-30 Синью Фарма Инк. Соединения, эффективные для лечения гепатотоксичности и стеатоза печени, и их применение
WO2017084234A1 (zh) * 2015-11-19 2017-05-26 欣耀生医股份有限公司 预防或治疗脂肪肝的药物组合物

Also Published As

Publication number Publication date
JP2018537517A (ja) 2018-12-20
BR112018005905A2 (pt) 2018-10-16
PH12018500659A1 (en) 2018-10-01
US11285123B2 (en) 2022-03-29
KR20180058795A (ko) 2018-06-01
SG10202002573RA (en) 2020-05-28
AU2016327930B2 (en) 2021-04-15
WO2017050298A1 (en) 2017-03-30
EP3353144A1 (en) 2018-08-01
EP3991724A3 (en) 2022-07-27
MX2022007816A (es) 2022-08-02
AU2024200963A1 (en) 2024-03-07
AU2016327930A1 (en) 2018-05-10
MX2018003700A (es) 2018-08-01
TW201722897A (zh) 2017-07-01
MY190647A (en) 2022-04-30
EP4609911A3 (en) 2025-11-19
EP3991724A2 (en) 2022-05-04
US20180256526A1 (en) 2018-09-13
EP3353144A4 (en) 2019-06-05
CN120349362A (zh) 2025-07-22
MX395231B (es) 2025-03-25
BR112018005905B1 (pt) 2023-03-21
EP3991724B1 (en) 2025-07-16
KR102891137B1 (ko) 2025-11-25
HUE072982T2 (hu) 2025-12-28
US12083088B2 (en) 2024-09-10
TWI781912B (zh) 2022-11-01
JP2022009680A (ja) 2022-01-14
EA201890810A1 (ru) 2018-11-30
CN120398980A (zh) 2025-08-01
EP4609911A2 (en) 2025-09-03
CN107614475A (zh) 2018-01-19
AU2021205040A1 (en) 2021-08-12
AU2024200963B2 (en) 2026-02-12
US10456371B2 (en) 2019-10-29
US20240335404A1 (en) 2024-10-10
AU2021205040B2 (en) 2023-11-16
HK1244266A1 (zh) 2018-08-03
US20200009097A1 (en) 2020-01-09
CA3232521A1 (en) 2017-03-30
US20220265587A1 (en) 2022-08-25
ES3044383T3 (en) 2025-11-26
HRP20250899T1 (hr) 2025-11-07
JP7261850B2 (ja) 2023-04-20
EP3991724C0 (en) 2025-07-16
CA2999368A1 (en) 2017-03-30
ZA201802373B (en) 2019-04-24

Similar Documents

Publication Publication Date Title
AU2024200963B2 (en) Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof
Křen et al. Silybin and its congeners: from traditional medicine to molecular effects
Wang et al. Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity
Yamamoto et al. Hesperidin metabolite hesperetin-7-O-glucuronide, but not hesperetin-3′-O-glucuronide, exerts hypotensive, vasodilatory, and anti-inflammatory activities
US20170360744A1 (en) Agent containing flavonoid derivatives for treating cancer and inflammation
US11643405B2 (en) Compound for treatment or prevention of liver diseases
HK40129564A (zh) 有效於治疗肝毒性及脂肪肝疾病的化合物及其用途
HK40128564A (zh) 有效於治疗肝毒性及脂肪肝疾病的化合物及其用途
Luo et al. Retracted Article: Stereoisomers of octahydrocurcumin, the hydrogenated metabolites of curcumin, display stereoselective activity on the CYP2E1 enzyme in L-02 cells
EA040650B1 (ru) Соединения, эффективные для лечения гепатотоксичности и стеатоза печени, и их применение
EP3225237A1 (en) Fatty acid amides for the prevention and/or treatment of steatohepatitis
CA2939592C (en) Compositions of selenoorganic compounds and methods of use thereof
Hmidene Study on Phytochemicals and Bioactivities of the Medicinal Halophyte Tamarix gallica
HK40046565A (en) Compounds for treatment or prevention of liver diseases

Legal Events

Date Code Title Description
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

D21 Rejection of application intended

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11 Administrative time limit extension requested

Free format text: ST27 STATUS EVENT CODE: U-3-3-T10-T11-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000