KR20230002419A - Bcl-2 억제제 - Google Patents

Bcl-2 억제제 Download PDF

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Publication number
KR20230002419A
KR20230002419A KR1020227035815A KR20227035815A KR20230002419A KR 20230002419 A KR20230002419 A KR 20230002419A KR 1020227035815 A KR1020227035815 A KR 1020227035815A KR 20227035815 A KR20227035815 A KR 20227035815A KR 20230002419 A KR20230002419 A KR 20230002419A
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KR
South Korea
Prior art keywords
azaspiro
isopropylphenyl
nonane
mmol
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020227035815A
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English (en)
Korean (ko)
Inventor
하이 슈에
윤항 구오
즈위 왕
Original Assignee
베이진 엘티디
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Application filed by 베이진 엘티디 filed Critical 베이진 엘티디
Publication of KR20230002419A publication Critical patent/KR20230002419A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020227035815A 2020-04-15 2021-04-14 Bcl-2 억제제 Pending KR20230002419A (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/084992 2020-04-15
CN2020084992 2020-04-15
CNPCT/CN2020/100472 2020-07-06
CN2020100472 2020-07-06
CN2020125580 2020-10-30
CNPCT/CN2020/125580 2020-10-30
CNPCT/CN2021/075831 2021-02-07
CN2021075831 2021-02-07
CNPCT/CN2021/086189 2021-04-09
CN2021086189 2021-04-09
PCT/CN2021/087225 WO2021208963A1 (en) 2020-04-15 2021-04-14 Bcl-2 inhibitor

Publications (1)

Publication Number Publication Date
KR20230002419A true KR20230002419A (ko) 2023-01-05

Family

ID=78083530

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227035815A Pending KR20230002419A (ko) 2020-04-15 2021-04-14 Bcl-2 억제제

Country Status (13)

Country Link
US (3) US12286430B2 (https=)
EP (1) EP4136084A4 (https=)
JP (1) JP7839962B2 (https=)
KR (1) KR20230002419A (https=)
CN (3) CN116969937B (https=)
AU (1) AU2021256580A1 (https=)
BR (1) BR112022019525A2 (https=)
CA (1) CA3172478A1 (https=)
IL (1) IL296582A (https=)
MX (1) MX2022013006A (https=)
TW (1) TW202200574A (https=)
WO (1) WO2021208963A1 (https=)
ZA (1) ZA202209891B (https=)

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US20250122191A1 (en) * 2021-11-20 2025-04-17 Fochon Biosciences, Ltd Compounds as bcl-2 inhibitors
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CN114292192A (zh) * 2022-01-17 2022-04-08 山东泓瑞医药科技股份公司 一种3,4-二甲氧基苯甲酸甲酯的合成方法
AU2023235233A1 (en) 2022-03-14 2024-09-12 Slap Pharmaceuticals Llc Multicyclic compounds
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Publication number Publication date
US12286430B2 (en) 2025-04-29
CN116802179A (zh) 2023-09-22
EP4136084A4 (en) 2023-11-01
CN116969937A (zh) 2023-10-31
EP4136084A1 (en) 2023-02-22
CN116969937B (zh) 2026-03-24
US20230159522A1 (en) 2023-05-25
JP2023520843A (ja) 2023-05-22
BR112022019525A2 (pt) 2023-11-14
AU2021256580A1 (en) 2022-09-29
CA3172478A1 (en) 2021-10-21
JP7839962B2 (ja) 2026-04-03
ZA202209891B (en) 2023-05-31
CN116969936A (zh) 2023-10-31
US20250270210A1 (en) 2025-08-28
IL296582A (en) 2022-11-01
MX2022013006A (es) 2023-01-11
TW202200574A (zh) 2022-01-01
US20240376097A1 (en) 2024-11-14
WO2021208963A1 (en) 2021-10-21

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