KR20220151038A - 코로나바이러스 감염 예방를 위한 조성물 - Google Patents
코로나바이러스 감염 예방를 위한 조성물 Download PDFInfo
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- KR20220151038A KR20220151038A KR1020227038215A KR20227038215A KR20220151038A KR 20220151038 A KR20220151038 A KR 20220151038A KR 1020227038215 A KR1020227038215 A KR 1020227038215A KR 20227038215 A KR20227038215 A KR 20227038215A KR 20220151038 A KR20220151038 A KR 20220151038A
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- oleandrin
- infection
- extract
- virus
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US11351149B2 (en) * | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
JP2024532149A (ja) * | 2021-08-16 | 2024-09-05 | フェニックス・バイオテクノロジー・インコーポレイテッド | 動物ウイルス感染を治療するための方法および組成物 |
WO2023212353A1 (en) * | 2022-04-29 | 2023-11-02 | Emory University | Viral entry inhibitors derived from botanicals |
CN115364136A (zh) * | 2022-09-05 | 2022-11-22 | 深圳市药品检验研究院(深圳市医疗器械检测中心) | 景天科植物提取物在制备抗新型冠状病毒和流感病毒感染药物中的应用 |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1394196A (en) | 1971-10-03 | 1975-05-14 | Hisamitsu Pharmaceutical Co | Process for isolating oleandrin from nerium odorum |
PT84857B (pt) | 1986-05-13 | 1990-02-08 | Huseyin Ziya Ozel | Processo para a preparacao de extractos de plantas da especie nerium e de composicoes farmaceuticas que os contem |
JPS6333341A (ja) * | 1986-07-28 | 1988-02-13 | Seitetsu Kagaku Co Ltd | 配糖体の処理方法 |
US5236132A (en) | 1992-01-03 | 1993-08-17 | Vortec, Inc. | Gradient-force comminuter/dehydrator apparatus and method |
US5598979A (en) | 1995-04-20 | 1997-02-04 | Vortec, Inc. | Closed loop gradient force comminuting and dehydrating system |
CA2191923C (en) | 1996-12-03 | 2000-10-24 | Ji-Won Yoon | Portulaca oleracea and tumor cell growth |
WO1999059578A1 (en) | 1998-05-19 | 1999-11-25 | Research Development Foundation | Triterpene compositions and methods for use thereof |
CA2354037A1 (en) | 1998-09-24 | 2000-03-30 | Ozelle Pharmaceuticals, Inc. | Extract of nerium species, pharmaceutical composition thereof and methods for preparation thereof |
US6517015B2 (en) | 2000-03-21 | 2003-02-11 | Frank F. Rowley, Jr. | Two-stage comminuting and dehydrating system and method |
AU2001284946B2 (en) | 2000-08-18 | 2007-02-01 | Advanced Life Sciences Inc. | Prodrugs of betulinic acid derivatives for the treatment of cancer and HIV |
US6715705B2 (en) | 2001-03-16 | 2004-04-06 | Frank F. Rowley, Jr. | Two-stage comminuting and dehydrating system and method |
DE60204078T2 (de) | 2001-04-09 | 2006-01-26 | Loders Croklaan B.V. | Konzentrat von Triterpenen |
EP2567625A1 (en) | 2001-05-11 | 2013-03-13 | University Of Ottawa | Preparation containing betulinic acid, obtained from a plant of the family Marcgraviaceae |
CA2443630A1 (en) | 2001-06-18 | 2002-12-27 | S.A.V. Virex Co Ltd. | Nerium oleander extract, compositions containing the nerium oleander l. extract and a method of preparation of this extract |
US20040082521A1 (en) | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
EP1585504A4 (en) | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | LIPOSOMAL PREPARATIONS OF PHARMACEUTICAL AGENTS STABILIZED BY PROTEINS |
US20050026849A1 (en) | 2003-03-28 | 2005-02-03 | Singh Chandra U. | Water soluble formulations of digitalis glycosides for treating cell-proliferative and other diseases |
MXPA06010592A (es) | 2004-03-17 | 2007-06-12 | Panacos Pharmaceuticals Inc | Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico. |
US7118508B2 (en) | 2004-07-28 | 2006-10-10 | General Motors Corporation | Planetary transmissions having three interconnected gear members and clutched input members |
WO2006036337A2 (en) | 2004-08-13 | 2006-04-06 | Biolase Technology, Inc. | Laser handpiece architecture and methods |
KR101068259B1 (ko) | 2005-02-09 | 2011-09-28 | 프레세니어스 카비 온콜로지 리미티드 | 헤테로사이클기에 고리-축합된 신규 베툴린산 유도체 |
US20090076290A1 (en) | 2005-03-29 | 2009-03-19 | Regents Of The University Of Minnesota | Selective oxidation of triterpenes employing tempo |
US20060252733A1 (en) | 2005-04-07 | 2006-11-09 | Novelix Pharmaceuticals, Inc. | Betulin, betulin derivatives, betulinic acid and betulinic acid derivatives as novel therapeutics in the treatment of disease of lipid and/or glucose metabolism |
US20090131714A1 (en) | 2005-06-08 | 2009-05-21 | Krasutsky Pavel A | Synthesis of betulonic and betulinic aldehydes |
US7718635B2 (en) | 2005-06-10 | 2010-05-18 | Pola Chemical Industries Inc. | Triterpenic acid derivative and preparation for external application for skin comprising the same |
US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
WO2007078848A2 (en) | 2005-12-16 | 2007-07-12 | Panacos Pharmaceuticals, Inc. | Preparation of pharmaceutical salts of 3-o-(3',3'-dimethlsuccinyl) betulinic acid |
EP1803461A1 (en) | 2005-12-27 | 2007-07-04 | Heinz-Herbert Fiebig | Therapeutic use of an extract from the leaves of Nerium oleander |
GB0604535D0 (en) | 2006-03-07 | 2006-04-12 | Sndv Sprl | Betulonic acid derivatives |
US20090203661A1 (en) | 2006-10-12 | 2009-08-13 | Safe Stephen H | Betulinic acid, derivatives and analogs thereof and uses therefor |
AR063546A1 (es) | 2006-11-03 | 2009-01-28 | Panacos Pharmaceuticals Inc | DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH. |
WO2008091532A1 (en) | 2007-01-19 | 2008-07-31 | Panacos Pharmaceuticals, Inc. | Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof |
US8987212B2 (en) | 2007-08-07 | 2015-03-24 | Muhammed Majeed | Oleanoyl peptide composition and method of treating skin aging |
RU2571687C2 (ru) | 2007-11-13 | 2015-12-20 | Феникс Байотекнолоджи Инк. | Набор для определения вероятности терапевтического ответа на противораковую химиотерапию сердечным гликозидом |
TW201004627A (en) | 2008-04-18 | 2010-02-01 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
KR101713140B1 (ko) | 2008-04-18 | 2017-03-08 | 리타 파마슈티컬스 잉크. | C-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체 |
DK2276493T3 (da) | 2008-04-18 | 2019-01-02 | Reata Pharmaceuticals Inc | Antioxidative inflammationsmodulatorer: oleanolsyrederivater med amino- og andre modifikationer ved c-17 |
CA2721666C (en) | 2008-04-18 | 2017-05-23 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
US20110224159A1 (en) | 2008-09-10 | 2011-09-15 | Universite du Quebec a Chicoutime | Bidesmosidic betulin and betulinic acid derivatives and uses thereof as antitumor agents |
AU2009303460B9 (en) | 2008-10-14 | 2014-12-18 | Nerium Biotechnology, Inc. | Process for extracting cardiac glycodides and compositions |
US8778990B2 (en) | 2008-11-04 | 2014-07-15 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
WO2010144611A2 (en) | 2009-06-10 | 2010-12-16 | 3-V Biosciences, Inc. | Antivirals that target transporters, carriers, and ion channels |
US8802727B2 (en) | 2009-07-14 | 2014-08-12 | Hetero Research Foundation, Hetero Drugs Limited | Pharmaceutically acceptable salts of betulinic acid derivatives |
CN101704872B (zh) | 2009-11-23 | 2012-06-27 | 张南 | 23-羟基白桦酸衍生物、其制备方法及应用 |
US8685469B2 (en) | 2009-11-30 | 2014-04-01 | University Of Kwazulu-Natal | In vitro anti-sickling activity of betulinic acid, oleanolic acid and their derivatives |
US9011937B2 (en) | 2010-11-22 | 2015-04-21 | Phoenix Biotechnology, Inc. | Method of treating neurological conditions with extract of Nerium species or Thevetia species |
KR101811462B1 (ko) | 2010-01-11 | 2018-01-25 | 피닉스 바이오테크놀러지 인코포레이티드. | 협죽도 추출물을 포함하는 신경질환 치료용 조성물 |
US10383886B2 (en) | 2010-01-11 | 2019-08-20 | Phoenix Biotechnology, Inc. | Method of treating neurological conditions with oleandrin |
TWI386415B (zh) | 2010-02-02 | 2013-02-21 | Univ Kaohsiung Medical | 熊果酸衍生物及其醫藥組合物 |
TWI410431B (zh) | 2010-12-22 | 2013-10-01 | Ind Tech Res Inst | 齊敦果酸衍生物在製備預防或治療c型肝炎之藥物的用途 |
WO2012095705A1 (en) | 2011-01-10 | 2012-07-19 | Hetero Research Foundation | Pharmaceutically acceptable salts of novel betulinic acid derivatives |
US8748415B2 (en) | 2011-01-31 | 2014-06-10 | Bristol-Myers Squibb Company | C-28 amines of C-3 modified betulinic acid derivatives as HIV maturation inhibitors |
CN102558280B (zh) | 2011-11-18 | 2014-09-17 | 温州大学 | 一种30-卤代桦木酸的生产方法 |
DK2787002T3 (en) | 2011-12-01 | 2016-08-29 | Hangzhou Bensheng Pharmaceutical Co Ltd | Oleanolsyreamidat derivatives, methods of making and uses thereof |
WO2013079018A1 (zh) | 2011-12-01 | 2013-06-06 | 杭州本生药业有限公司 | 2-位取代的齐墩果酸衍生物、及其制备方法和应用 |
WO2013160810A2 (en) | 2012-04-24 | 2013-10-31 | Hetero Research Foundation | Novel betulinic acid derivatives as hiv inhibitors |
US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
KR101889528B1 (ko) | 2012-08-14 | 2018-08-17 | 넥스올리고(주) | 신규한 우르솔릭산 유도체 및 이의 제조 방법 |
DK2892912T3 (da) | 2012-09-10 | 2019-06-24 | Reata Pharmaceuticals Inc | C17-alkandiyl og alkenediylderivater af oleanolsyre og fremgangsmåder til anvendelse deraf |
EP2892911B1 (en) | 2012-09-10 | 2017-08-30 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
WO2014040073A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
WO2014105926A1 (en) | 2012-12-31 | 2014-07-03 | Hetero Research Foundation | Novel betulinic acid proline derivatives as hiv inhibitors |
AU2014218754B2 (en) | 2013-02-25 | 2017-04-20 | VIIV Healthcare UK (No.5) Limited | C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of HIV |
WO2015195776A1 (en) | 2014-06-19 | 2015-12-23 | Bristol-Myers Squibb Company | Betulinic acid derivatives with hiv maturation inhibitory activity |
WO2017214080A1 (en) * | 2016-06-09 | 2017-12-14 | University Of Massachusetts | Inhibition of zika virus infection |
ES2874187T3 (es) | 2016-09-14 | 2021-11-04 | Phoenix Biotechnology Inc | Método y composiciones para el tratamiento de una infección viral |
US10702567B2 (en) * | 2016-09-14 | 2020-07-07 | Phoenix Biotechnology, Inc. | Method and compositions for treating viral infection |
US10596186B2 (en) | 2016-09-14 | 2020-03-24 | Phoenix Biotechnology, Inc. | Method and compositions for treating viral infections |
MX2020002883A (es) | 2017-09-14 | 2020-10-05 | Phoenix Biotechnology Inc | Método y composiciones para tratar la infección viral. |
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IL277315A (en) | 2021-09-30 |
KR20210124010A (ko) | 2021-10-14 |
RU2020130238A3 (zh) | 2022-03-14 |
TWI753747B (zh) | 2022-01-21 |
JP2022186737A (ja) | 2022-12-15 |
WO2021201903A1 (en) | 2021-10-07 |
IL277315B (en) | 2022-05-01 |
TW202137991A (zh) | 2021-10-16 |
TWI790048B (zh) | 2023-01-11 |
JP7153083B2 (ja) | 2022-10-13 |
MX2022009176A (es) | 2022-08-17 |
IL291727B1 (en) | 2023-03-01 |
SG11202105728YA (en) | 2021-11-29 |
IL291727A (en) | 2022-05-01 |
JP2022522074A (ja) | 2022-04-14 |
RU2020130238A (ru) | 2022-03-14 |
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