KR20220137057A - 조작된 류신 데카르복실라제 - Google Patents

조작된 류신 데카르복실라제 Download PDF

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Publication number
KR20220137057A
KR20220137057A KR1020227030236A KR20227030236A KR20220137057A KR 20220137057 A KR20220137057 A KR 20220137057A KR 1020227030236 A KR1020227030236 A KR 1020227030236A KR 20227030236 A KR20227030236 A KR 20227030236A KR 20220137057 A KR20220137057 A KR 20220137057A
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KR
South Korea
Prior art keywords
ala
polypeptide
leu
sequence
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020227030236A
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English (en)
Korean (ko)
Inventor
조이스 리우
리앤 퀠틴몬트 티트
리앤 ??틴몬트 티트
니키 델라스
스테판 젠느
페이 론 두
크리스틴 진 밸리우
커린 맥클루스키
Original Assignee
코덱시스, 인코포레이티드
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Application filed by 코덱시스, 인코포레이티드 filed Critical 코덱시스, 인코포레이티드
Publication of KR20220137057A publication Critical patent/KR20220137057A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01014—Valine decarboxylase (4.1.1.14)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020227030236A 2020-02-04 2021-02-03 조작된 류신 데카르복실라제 Pending KR20220137057A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062970039P 2020-02-04 2020-02-04
US62/970,039 2020-02-04
PCT/US2021/016450 WO2021158686A1 (en) 2020-02-04 2021-02-03 Engineered leucine decarboxylases

Publications (1)

Publication Number Publication Date
KR20220137057A true KR20220137057A (ko) 2022-10-11

Family

ID=77061734

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227030236A Pending KR20220137057A (ko) 2020-02-04 2021-02-03 조작된 류신 데카르복실라제

Country Status (12)

Country Link
US (2) US12241100B2 (enExample)
EP (1) EP4103711A4 (enExample)
JP (2) JP2023512683A (enExample)
KR (1) KR20220137057A (enExample)
CN (1) CN116113691A (enExample)
AU (1) AU2021216389A1 (enExample)
BR (1) BR112022015139A2 (enExample)
CA (1) CA3168922A1 (enExample)
IL (1) IL295169A (enExample)
MX (1) MX2022009531A (enExample)
PH (1) PH12022551776A1 (enExample)
WO (1) WO2021158686A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4103711A4 (en) 2020-02-04 2024-02-28 Codexis, Inc. Engineered leucine decarboxylases
JP2024540358A (ja) * 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
WO2023102499A1 (en) * 2021-12-02 2023-06-08 Codexis, Inc. Engineered threonine aldolases and amino acid decarboxylases

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Also Published As

Publication number Publication date
PH12022551776A1 (en) 2023-11-29
US20240018504A1 (en) 2024-01-18
EP4103711A1 (en) 2022-12-21
US12241100B2 (en) 2025-03-04
JP2025143444A (ja) 2025-10-01
MX2022009531A (es) 2022-09-09
JP2023512683A (ja) 2023-03-28
CN116113691A (zh) 2023-05-12
WO2021158686A1 (en) 2021-08-12
US20210238575A1 (en) 2021-08-05
IL295169A (en) 2022-09-01
CA3168922A1 (en) 2021-08-12
BR112022015139A2 (pt) 2022-10-11
WO2021158686A8 (en) 2022-03-17
EP4103711A4 (en) 2024-02-28
AU2021216389A1 (en) 2022-08-11

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