JP2023512683A - 操作されたロイシンデカルボキシラーゼ - Google Patents

操作されたロイシンデカルボキシラーゼ Download PDF

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Publication number
JP2023512683A
JP2023512683A JP2022547083A JP2022547083A JP2023512683A JP 2023512683 A JP2023512683 A JP 2023512683A JP 2022547083 A JP2022547083 A JP 2022547083A JP 2022547083 A JP2022547083 A JP 2022547083A JP 2023512683 A JP2023512683 A JP 2023512683A
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JP
Japan
Prior art keywords
polypeptide
engineered
seq
sequence
amino acid
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JP2022547083A
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English (en)
Japanese (ja)
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JP2023512683A5 (enExample
Inventor
ジョイス リウ，
リアン クエルティンモント テット，
ニッキ デラス，
スティーブン ジェンヌ，
ファイェ ロアン ドゥ，
クリステン ジーン ヴァリュウ，
ケリン マクラスキー，
Original Assignee
コデクシス， インコーポレイテッド
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Publication of JP2023512683A publication Critical patent/JP2023512683A/ja
Publication of JP2023512683A5 publication Critical patent/JP2023512683A5/ja
Priority to JP2025114444A priority Critical patent/JP2025143444A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01014—Valine decarboxylase (4.1.1.14)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2022547083A 2020-02-04 2021-02-03 操作されたロイシンデカルボキシラーゼ Withdrawn JP2023512683A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025114444A JP2025143444A (ja) 2020-02-04 2025-07-07 操作されたロイシンデカルボキシラーゼ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062970039P 2020-02-04 2020-02-04
US62/970,039 2020-02-04
PCT/US2021/016450 WO2021158686A1 (en) 2020-02-04 2021-02-03 Engineered leucine decarboxylases

Related Child Applications (1)

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JP2025114444A Division JP2025143444A (ja) 2020-02-04 2025-07-07 操作されたロイシンデカルボキシラーゼ

Publications (2)

Publication Number Publication Date
JP2023512683A true JP2023512683A (ja) 2023-03-28
JP2023512683A5 JP2023512683A5 (enExample) 2024-01-04

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JP2022547083A Withdrawn JP2023512683A (ja) 2020-02-04 2021-02-03 操作されたロイシンデカルボキシラーゼ
JP2025114444A Pending JP2025143444A (ja) 2020-02-04 2025-07-07 操作されたロイシンデカルボキシラーゼ

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Country Link
US (2) US12241100B2 (enExample)
EP (1) EP4103711A4 (enExample)
JP (2) JP2023512683A (enExample)
KR (1) KR20220137057A (enExample)
CN (1) CN116113691A (enExample)
AU (1) AU2021216389A1 (enExample)
BR (1) BR112022015139A2 (enExample)
CA (1) CA3168922A1 (enExample)
IL (1) IL295169A (enExample)
MX (1) MX2022009531A (enExample)
PH (1) PH12022551776A1 (enExample)
WO (1) WO2021158686A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4103711A4 (en) 2020-02-04 2024-02-28 Codexis, Inc. Engineered leucine decarboxylases
JP2024540358A (ja) * 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
WO2023102499A1 (en) * 2021-12-02 2023-06-08 Codexis, Inc. Engineered threonine aldolases and amino acid decarboxylases

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Also Published As

Publication number Publication date
PH12022551776A1 (en) 2023-11-29
US20240018504A1 (en) 2024-01-18
EP4103711A1 (en) 2022-12-21
US12241100B2 (en) 2025-03-04
JP2025143444A (ja) 2025-10-01
MX2022009531A (es) 2022-09-09
CN116113691A (zh) 2023-05-12
KR20220137057A (ko) 2022-10-11
WO2021158686A1 (en) 2021-08-12
US20210238575A1 (en) 2021-08-05
IL295169A (en) 2022-09-01
CA3168922A1 (en) 2021-08-12
BR112022015139A2 (pt) 2022-10-11
WO2021158686A8 (en) 2022-03-17
EP4103711A4 (en) 2024-02-28
AU2021216389A1 (en) 2022-08-11

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