KR20220103986A - 지정 접합 기술 - Google Patents
지정 접합 기술 Download PDFInfo
- Publication number
- KR20220103986A KR20220103986A KR1020227019529A KR20227019529A KR20220103986A KR 20220103986 A KR20220103986 A KR 20220103986A KR 1020227019529 A KR1020227019529 A KR 1020227019529A KR 20227019529 A KR20227019529 A KR 20227019529A KR 20220103986 A KR20220103986 A KR 20220103986A
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- South Korea
- Prior art keywords
- moiety
- amino acid
- binding moiety
- antibody
- independently
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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Applications Claiming Priority (5)
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| US201962937131P | 2019-11-18 | 2019-11-18 | |
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| US202063063902P | 2020-08-10 | 2020-08-10 | |
| US63/063,902 | 2020-08-10 | ||
| PCT/US2020/061127 WO2021102052A1 (en) | 2019-11-18 | 2020-11-18 | Directed conjugation technologies |
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| KR20220103986A true KR20220103986A (ko) | 2022-07-25 |
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| EP (1) | EP4061425A4 (https=) |
| JP (1) | JP2023501720A (https=) |
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| CN (1) | CN115066263A (https=) |
| AU (1) | AU2020388383A1 (https=) |
| BR (1) | BR112022009398A2 (https=) |
| CA (1) | CA3160681A1 (https=) |
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| MX (1) | MX2022005884A (https=) |
| PH (1) | PH12022551000A1 (https=) |
| WO (1) | WO2021102052A1 (https=) |
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| WO2022078566A1 (en) * | 2020-10-12 | 2022-04-21 | Debiopharm Research & Manufacturing S.A. | Reactive conjugates |
| MX2023013274A (es) * | 2021-05-17 | 2023-11-30 | Biohaven Therapeutics Ltd | Composiciones que incluyen potenciadores de tratamientos conjugados. |
| US20250108124A1 (en) * | 2021-05-19 | 2025-04-03 | Biohaven Therapeutics Ltd. | Antibody drug conjugates using mates technology for delivering cytotoxic agents |
| CN113636960A (zh) * | 2021-08-24 | 2021-11-12 | 上海皓元医药股份有限公司 | 一种2-(氯磺酰基)环己烷-1-烯甲酸乙酯衍生物的制备方法 |
| CN114085376B (zh) * | 2021-12-02 | 2022-12-20 | 中国科学院长春应用化学研究所 | 一种多肽及其制备方法、双特异性抗体及其应用 |
| WO2025158412A1 (en) | 2024-01-26 | 2025-07-31 | Biohaven Therapeutics Ltd. | BIFUNCTIONAL DEGRADERS OF IgG4 IMMUNOGLOBULINS |
| WO2025181697A1 (en) | 2024-02-26 | 2025-09-04 | Biohaven Therapeutics Ltd. | Bifunctional degraders of anti-pla2r antibody |
| WO2025210538A1 (en) | 2024-04-02 | 2025-10-09 | Biohaven Therapeutics Ltd. | Bifunctional degraders |
| WO2026028159A1 (en) | 2024-07-31 | 2026-02-05 | Biohaven Therapeutics Ltd. | Bifunctional degraders for the treatment of graves' disease |
| WO2026028158A1 (en) | 2024-07-31 | 2026-02-05 | Biohaven Therapeutics Ltd. | Targeted degradation of anti-aav antibodies to enable aav-based gene therapy |
| WO2026083257A1 (en) | 2024-10-14 | 2026-04-23 | Biohaven Therapeutics Ltd. | Antigen-specific degraders of immunoglobulin a and their uses |
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| EP2861261A2 (en) * | 2012-06-19 | 2015-04-22 | Polytherics Limited | Process for preparation of antibody conjugates and antibody conjugates |
| GB201506407D0 (en) * | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| WO2017139329A1 (en) * | 2016-02-09 | 2017-08-17 | Alexander Krantz | Site-selective functionalization of proteins using traceless affinity lables |
| US11135307B2 (en) * | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| AU2018259856B2 (en) * | 2017-04-28 | 2025-05-01 | Ajinomoto Co., Inc. | Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof |
| CA3069986A1 (en) * | 2017-07-26 | 2019-01-31 | Kleo Pharmaceuticals, Inc. | Universal abt compounds and uses thereof |
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- 2020-11-18 IL IL293095A patent/IL293095B1/en unknown
- 2020-11-18 MX MX2022005884A patent/MX2022005884A/es unknown
- 2020-11-18 BR BR112022009398A patent/BR112022009398A2/pt unknown
- 2020-11-18 AU AU2020388383A patent/AU2020388383A1/en active Pending
- 2020-11-18 KR KR1020227019529A patent/KR20220103986A/ko active Pending
- 2020-11-18 PH PH1/2022/551000A patent/PH12022551000A1/en unknown
- 2020-11-18 EP EP20891185.9A patent/EP4061425A4/en active Pending
- 2020-11-18 CA CA3160681A patent/CA3160681A1/en active Pending
- 2020-11-18 WO PCT/US2020/061127 patent/WO2021102052A1/en not_active Ceased
- 2020-11-18 US US17/769,924 patent/US20230128688A1/en active Pending
- 2020-11-18 CN CN202080093195.2A patent/CN115066263A/zh active Pending
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Also Published As
| Publication number | Publication date |
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| IL293095B1 (en) | 2026-01-01 |
| JP2023501720A (ja) | 2023-01-18 |
| WO2021102052A1 (en) | 2021-05-27 |
| CA3160681A1 (en) | 2021-05-27 |
| BR112022009398A2 (pt) | 2022-08-09 |
| IL325588A (en) | 2026-02-01 |
| EP4061425A4 (en) | 2024-06-05 |
| IL293095A (en) | 2022-07-01 |
| CN115066263A (zh) | 2022-09-16 |
| PH12022551000A1 (en) | 2023-10-02 |
| AU2020388383A1 (en) | 2022-03-31 |
| EP4061425A1 (en) | 2022-09-28 |
| US20230128688A1 (en) | 2023-04-27 |
| MX2022005884A (es) | 2022-08-15 |
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