CA3160681A1 - Directed conjugation technologies - Google Patents

Directed conjugation technologies

Info

Publication number
CA3160681A1
CA3160681A1 CA3160681A CA3160681A CA3160681A1 CA 3160681 A1 CA3160681 A1 CA 3160681A1 CA 3160681 A CA3160681 A CA 3160681A CA 3160681 A CA3160681 A CA 3160681A CA 3160681 A1 CA3160681 A1 CA 3160681A1
Authority
CA
Canada
Prior art keywords
moiety
amino acid
agent
binding moiety
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3160681A
Other languages
English (en)
French (fr)
Inventor
Luca Rastelli
David Adam SPIEGEL
Matthew Ernest WELSCH
Tetyana Berbasova
Michael C. CUKAN
Lawrence Gerald IBEN
Ada Margaret VAILL
Anna BUNIN
Christian Marcel VIDAL
Enrique Alvarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kleo Pharmaceuticals Inc
Original Assignee
Kleo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kleo Pharmaceuticals Inc filed Critical Kleo Pharmaceuticals Inc
Publication of CA3160681A1 publication Critical patent/CA3160681A1/en
Pending legal-status Critical Current

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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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WO2022078566A1 (en) * 2020-10-12 2022-04-21 Debiopharm Research & Manufacturing S.A. Reactive conjugates
MX2023013274A (es) * 2021-05-17 2023-11-30 Biohaven Therapeutics Ltd Composiciones que incluyen potenciadores de tratamientos conjugados.
US20250108124A1 (en) * 2021-05-19 2025-04-03 Biohaven Therapeutics Ltd. Antibody drug conjugates using mates technology for delivering cytotoxic agents
CN113636960A (zh) * 2021-08-24 2021-11-12 上海皓元医药股份有限公司 一种2-(氯磺酰基)环己烷-1-烯甲酸乙酯衍生物的制备方法
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WO2025158412A1 (en) 2024-01-26 2025-07-31 Biohaven Therapeutics Ltd. BIFUNCTIONAL DEGRADERS OF IgG4 IMMUNOGLOBULINS
WO2025181697A1 (en) 2024-02-26 2025-09-04 Biohaven Therapeutics Ltd. Bifunctional degraders of anti-pla2r antibody
WO2025210538A1 (en) 2024-04-02 2025-10-09 Biohaven Therapeutics Ltd. Bifunctional degraders
WO2026028159A1 (en) 2024-07-31 2026-02-05 Biohaven Therapeutics Ltd. Bifunctional degraders for the treatment of graves' disease
WO2026028158A1 (en) 2024-07-31 2026-02-05 Biohaven Therapeutics Ltd. Targeted degradation of anti-aav antibodies to enable aav-based gene therapy
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WO2017139329A1 (en) * 2016-02-09 2017-08-17 Alexander Krantz Site-selective functionalization of proteins using traceless affinity lables
US11135307B2 (en) * 2016-11-23 2021-10-05 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
AU2018259856B2 (en) * 2017-04-28 2025-05-01 Ajinomoto Co., Inc. Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof
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IL325588A (en) 2026-02-01
EP4061425A4 (en) 2024-06-05
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CN115066263A (zh) 2022-09-16
KR20220103986A (ko) 2022-07-25
PH12022551000A1 (en) 2023-10-02
AU2020388383A1 (en) 2022-03-31
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US20230128688A1 (en) 2023-04-27
MX2022005884A (es) 2022-08-15

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