IL293095B1 - Directed conjugation technologies - Google Patents

Directed conjugation technologies

Info

Publication number
IL293095B1
IL293095B1 IL293095A IL29309522A IL293095B1 IL 293095 B1 IL293095 B1 IL 293095B1 IL 293095 A IL293095 A IL 293095A IL 29309522 A IL29309522 A IL 29309522A IL 293095 B1 IL293095 B1 IL 293095B1
Authority
IL
Israel
Prior art keywords
nho
hno
onh
moiety
binding moiety
Prior art date
Application number
IL293095A
Other languages
English (en)
Hebrew (he)
Other versions
IL293095A (en
Inventor
Luca Rastelli
David Adam Spiegel
Matthew Ernest Welsch
Tetyana Berbasova
Michael C Cukan
Lawrence Gerald Iben
Ada Margaret Vaill
Anna Bunin
Christian Marcel Vidal
Enrique Alvarez
Original Assignee
Kleo Pharmaceuticals Inc
Luca Rastelli
David Adam Spiegel
Matthew Ernest Welsch
Tetyana Berbasova
Michael C Cukan
Lawrence Gerald Iben
Ada Margaret Vaill
Anna Bunin
Christian Marcel Vidal
Enrique Alvarez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kleo Pharmaceuticals Inc, Luca Rastelli, David Adam Spiegel, Matthew Ernest Welsch, Tetyana Berbasova, Michael C Cukan, Lawrence Gerald Iben, Ada Margaret Vaill, Anna Bunin, Christian Marcel Vidal, Enrique Alvarez filed Critical Kleo Pharmaceuticals Inc
Publication of IL293095A publication Critical patent/IL293095A/en
Publication of IL293095B1 publication Critical patent/IL293095B1/en

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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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WO2022078566A1 (en) * 2020-10-12 2022-04-21 Debiopharm Research & Manufacturing S.A. Reactive conjugates
MX2023013274A (es) * 2021-05-17 2023-11-30 Biohaven Therapeutics Ltd Composiciones que incluyen potenciadores de tratamientos conjugados.
US20250108124A1 (en) * 2021-05-19 2025-04-03 Biohaven Therapeutics Ltd. Antibody drug conjugates using mates technology for delivering cytotoxic agents
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WO2025158412A1 (en) 2024-01-26 2025-07-31 Biohaven Therapeutics Ltd. BIFUNCTIONAL DEGRADERS OF IgG4 IMMUNOGLOBULINS
WO2025181697A1 (en) 2024-02-26 2025-09-04 Biohaven Therapeutics Ltd. Bifunctional degraders of anti-pla2r antibody
WO2025210538A1 (en) 2024-04-02 2025-10-09 Biohaven Therapeutics Ltd. Bifunctional degraders
WO2026028159A1 (en) 2024-07-31 2026-02-05 Biohaven Therapeutics Ltd. Bifunctional degraders for the treatment of graves' disease
WO2026028158A1 (en) 2024-07-31 2026-02-05 Biohaven Therapeutics Ltd. Targeted degradation of anti-aav antibodies to enable aav-based gene therapy
WO2026083257A1 (en) 2024-10-14 2026-04-23 Biohaven Therapeutics Ltd. Antigen-specific degraders of immunoglobulin a and their uses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018199337A1 (ja) * 2017-04-28 2018-11-01 味の素株式会社 可溶性タンパク質に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩
WO2019023501A1 (en) * 2017-07-26 2019-01-31 Kleo Pharmaceuticals, Inc. UNIVERSAL ABT COMPOUNDS AND USES THEREOF

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2861261A2 (en) * 2012-06-19 2015-04-22 Polytherics Limited Process for preparation of antibody conjugates and antibody conjugates
GB201506407D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
WO2017139329A1 (en) * 2016-02-09 2017-08-17 Alexander Krantz Site-selective functionalization of proteins using traceless affinity lables
US11135307B2 (en) * 2016-11-23 2021-10-05 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018199337A1 (ja) * 2017-04-28 2018-11-01 味の素株式会社 可溶性タンパク質に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩
WO2019023501A1 (en) * 2017-07-26 2019-01-31 Kleo Pharmaceuticals, Inc. UNIVERSAL ABT COMPOUNDS AND USES THEREOF

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHRISTIAN VIDAL ET AL:, 635 A NOVEL SITE-DIRECTED CHEMICAL CONJUGATION TECHNOLOGY CONFERS ANTITUMOR ACTIVITY VIA NATIVE FC RECEPTOR TO PLASMA IMMUNOGLOBULIN BY ATTACHING TUMOR BINDERS | JOURNAL FOR IMMUNOTHERAPY OF CANCER, 1 November 2022 (2022-11-01) *
NELSON MICHELLE ET AL:, 633 DUAL-TARGETING OF 4-1BB AND OX40 WITH AN ADAPTIR(TM) BISPECIFIC ANTIBODY ENHANCES ANTI-TUMOR RESPONSES TO SOLID TUMOR, 1 November 2020 (2020-11-01) *
NICHOLAS VANCE ET AL:, DEVELOPMENT, OPTIMIZATION, AND STRUCTURAL CHARACTERIZATION OF AN EFFICIENT PEPTIDE-BASED PHOTOAFFINITY CROSS-LINKING REACTION FOR GENERATION OF HOMOGENEOUS CONJUGATES FROM WILD-TYPE ANTIBODIES, 19 December 2018 (2018-12-19) *
SATOSHI KISHIMOTO ET AL:, SITE-SPECIFIC CHEMICAL CONJUGATION OF ANTIBODIES BY USING AFFINITY PEPTIDE FOR THE DEVELOPMENT OF THERAPEUTIC ANTIBODY FORMAT, 4 January 2019 (2019-01-04) *
VIDAL CHRISTIAN ET AL:, KPMW135, A BIOSUPERIOR CDS BISPECIFIC VERSION OF RITUXIMAB CREATED BY A NOVEL CHEMICAL CONJUGATION TECHNOLOGY DEMONSTRATES INCREASED ANTI-TUMOR ACTIVITY BY ADDING T CELL-MEDIATED CYTOTOXICITY ACTIVITY TO THE EXISTING MECHANISMS OF RITUXIMAB | BLOOD |, 5 November 2020 (2020-11-05) *

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