BR112022009398A2 - Tecnologias de conjugação direcionadas - Google Patents

Tecnologias de conjugação direcionadas

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Publication number
BR112022009398A2
BR112022009398A2 BR112022009398A BR112022009398A BR112022009398A2 BR 112022009398 A2 BR112022009398 A2 BR 112022009398A2 BR 112022009398 A BR112022009398 A BR 112022009398A BR 112022009398 A BR112022009398 A BR 112022009398A BR 112022009398 A2 BR112022009398 A2 BR 112022009398A2
Authority
BR
Brazil
Prior art keywords
technologies
present disclosure
conjugation
conjugation technologies
targeted
Prior art date
Application number
BR112022009398A
Other languages
English (en)
Inventor
Rastelli Luca
Adam Spiegel David
Ernest Welsch Matthew
Berbasova Tetyana
C Cukan Michael
Gerald Iben Lawrence
Margaret Vaill Ada
Bunin Anna
Marcel Vidal Christian
Alvarez Enrique
Original Assignee
Kleo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kleo Pharmaceuticals Inc filed Critical Kleo Pharmaceuticals Inc
Publication of BR112022009398A2 publication Critical patent/BR112022009398A2/pt

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    • A—HUMAN NECESSITIES
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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Abstract

TECNOLOGIAS DE CONJUGAÇÃO DIRECIONADAS. Entre outros, a presente divulgação fornece tecnologias para conjugação direcionada a sítio de várias porções químicas de interesse para agentes-alvo. Em algumas modalidades, a presente divulgação utiliza porções químicas de ligação ao alvo para fornecer alta eficiência e seletividade de conjugação. Em algumas modalidades, as tecnologias fornecidas são úteis para preparar conjugados de anticorpos.
BR112022009398A 2019-11-18 2020-11-18 Tecnologias de conjugação direcionadas BR112022009398A2 (pt)

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PCT/US2020/061127 WO2021102052A1 (en) 2019-11-18 2020-11-18 Directed conjugation technologies

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IL293095A (en) 2022-07-01
CN115066263A (zh) 2022-09-16
WO2021102052A1 (en) 2021-05-27
EP4061425A4 (en) 2024-06-05
KR20220103986A (ko) 2022-07-25
US20230128688A1 (en) 2023-04-27
MX2022005884A (es) 2022-08-15
CA3160681A1 (en) 2021-05-27
AU2020388383A1 (en) 2022-03-31
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