MX2022005884A - Tecnologías de conjugación dirigida. - Google Patents

Tecnologías de conjugación dirigida.

Info

Publication number
MX2022005884A
MX2022005884A MX2022005884A MX2022005884A MX2022005884A MX 2022005884 A MX2022005884 A MX 2022005884A MX 2022005884 A MX2022005884 A MX 2022005884A MX 2022005884 A MX2022005884 A MX 2022005884A MX 2022005884 A MX2022005884 A MX 2022005884A
Authority
MX
Mexico
Prior art keywords
technologies
directed conjugation
present disclosure
conjugation technologies
directed
Prior art date
Application number
MX2022005884A
Other languages
English (en)
Inventor
Luca Rastelli
David Adam Spiegel
Matthew Ernest Welsch
Anna Bunin
Tetyana Berbasova
Michael C Cukan
Lawrence Gerald Iben
Ada Margaret Vaill
Christian Marcel Vidal
Enrique Alvarez
Original Assignee
Kleo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kleo Pharmaceuticals Inc filed Critical Kleo Pharmaceuticals Inc
Publication of MX2022005884A publication Critical patent/MX2022005884A/es

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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Entre otras cosas, la presente divulgación proporciona tecnologías para conjugación dirigida al sitio de diversas porciones de interés hacia agentes diana. En algunas formas de realización, la presente divulgación utiliza porciones de unión a la diana para proporcionar una alta eficiencia de conjugación y selectividad. En algunas formas de realización, las tecnologías proporcionadas son útiles para preparar conjugados de anticuerpo.
MX2022005884A 2019-11-18 2020-11-18 Tecnologías de conjugación dirigida. MX2022005884A (es)

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US201962937131P 2019-11-18 2019-11-18
US202063063902P 2020-08-10 2020-08-10
PCT/US2020/061127 WO2021102052A1 (en) 2019-11-18 2020-11-18 Directed conjugation technologies

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JP (1) JP2023501720A (es)
KR (1) KR20220103986A (es)
CN (1) CN115066263A (es)
AU (1) AU2020388383A1 (es)
BR (1) BR112022009398A2 (es)
CA (1) CA3160681A1 (es)
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WO2022078566A1 (en) * 2020-10-12 2022-04-21 Debiopharm Research & Manufacturing S.A. Reactive conjugates
EP4340859A1 (en) * 2021-05-19 2024-03-27 Biohaven Therapeutics Ltd. Antibody drug conjugates using mates technology for delivering cytotoxic agents
CN113636960A (zh) * 2021-08-24 2021-11-12 上海皓元医药股份有限公司 一种2-(氯磺酰基)环己烷-1-烯甲酸乙酯衍生物的制备方法
CN114085376B (zh) * 2021-12-02 2022-12-20 中国科学院长春应用化学研究所 一种多肽及其制备方法、双特异性抗体及其应用

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EP3617235A4 (en) * 2017-04-28 2020-12-16 Ajinomoto Co., Inc. ASSOCIATION WITH A SUBSTANCE WITH AFFINITY TO SOLUBLE PROTEIN, FITTABLE PART AND REACTIVE GROUP OR SALT THEREOF
MX2020000976A (es) * 2017-07-26 2020-07-22 Kleo Pharmaceuticals Inc Compuestos abt universales y usos de los mismos.

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KR20220103986A (ko) 2022-07-25
WO2021102052A1 (en) 2021-05-27
IL293095A (en) 2022-07-01
EP4061425A1 (en) 2022-09-28
AU2020388383A1 (en) 2022-03-31
BR112022009398A2 (pt) 2022-08-09
JP2023501720A (ja) 2023-01-18
EP4061425A4 (en) 2024-06-05
CA3160681A1 (en) 2021-05-27
CN115066263A (zh) 2022-09-16
US20230128688A1 (en) 2023-04-27

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