KR20220031732A - 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 - Google Patents

알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 Download PDF

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Publication number
KR20220031732A
KR20220031732A KR1020227006071A KR20227006071A KR20220031732A KR 20220031732 A KR20220031732 A KR 20220031732A KR 1020227006071 A KR1020227006071 A KR 1020227006071A KR 20227006071 A KR20227006071 A KR 20227006071A KR 20220031732 A KR20220031732 A KR 20220031732A
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KR
South Korea
Prior art keywords
compound
cancer
alkyl
chloro
salt
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Ceased
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KR1020227006071A
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English (en)
Korean (ko)
Inventor
왕 센
아이민 장
잭 마웅
샤오링 쩡
Original Assignee
뉴젠 세러퓨틱스 인코포레이티드
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Publication of KR20220031732A publication Critical patent/KR20220031732A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020227006071A 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 Ceased KR20220031732A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161449088P 2011-03-04 2011-03-04
US61/449,088 2011-03-04
KR1020217010767A KR20210043016A (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
PCT/US2012/027614 WO2012122058A2 (en) 2011-03-04 2012-03-02 Alkyne substituted quinazoline compound and methods of use

Related Parent Applications (1)

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KR1020217010767A Division KR20210043016A (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법

Publications (1)

Publication Number Publication Date
KR20220031732A true KR20220031732A (ko) 2022-03-11

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Family Applications (4)

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KR1020227006071A Ceased KR20220031732A (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
KR1020217010767A Ceased KR20210043016A (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
KR1020137026199A Active KR102061743B1 (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
KR1020197038395A Ceased KR20200003933A (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020217010767A Ceased KR20210043016A (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
KR1020137026199A Active KR102061743B1 (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
KR1020197038395A Ceased KR20200003933A (ko) 2011-03-04 2012-03-02 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법

Country Status (14)

Country Link
US (5) US9090588B2 (enExample)
EP (1) EP2680850B1 (enExample)
JP (1) JP6006242B2 (enExample)
KR (4) KR20220031732A (enExample)
CN (1) CN103998040B (enExample)
AU (3) AU2012225693A1 (enExample)
BR (1) BR112013022552B1 (enExample)
CA (1) CA2828713C (enExample)
IL (1) IL228072A (enExample)
MX (1) MX344302B (enExample)
RU (1) RU2013144571A (enExample)
SG (3) SG10201601711SA (enExample)
TW (1) TWI617556B (enExample)
WO (1) WO2012122058A2 (enExample)

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CN102898386B (zh) * 2011-07-27 2015-07-29 上海医药集团股份有限公司 喹唑啉衍生物、其制备方法、中间体、组合物及其应用
US9556191B2 (en) 2013-04-28 2017-01-31 Sunshine Lake Pharma Co., Ltd. Aminoquinazoline derivatives and their salts and methods of use thereof
CN103254156B (zh) * 2013-05-10 2015-08-26 苏州明锐医药科技有限公司 阿法替尼中间体的制备方法
CN103254183B (zh) * 2013-05-10 2015-11-11 苏州明锐医药科技有限公司 阿法替尼的制备方法
JP6983661B2 (ja) * 2015-12-24 2021-12-17 協和キリン株式会社 α、β不飽和アミド化合物
DE102016224889B4 (de) * 2016-12-14 2019-11-07 Airbus Defence and Space GmbH Verfahren zur Vorbeugung einer Ablösung einer Fluidströmung, Strömungskörpersystem und Luftfahrzeug
US11083492B2 (en) * 2018-06-06 2021-08-10 Lifetech Scientific (Shenzhen) Co., Ltd Method for implanting an interventional medical device
US10973321B2 (en) 2018-09-04 2021-04-13 Steelcase Inc. Workspace system and components and method for the use thereof
CA3113241A1 (en) 2018-09-25 2020-04-02 Black Diamond Therapeutics, Inc. Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use
US12435046B2 (en) * 2019-08-15 2025-10-07 Black Diamond Therapeutics, Inc. Alkynyl quinazoline compounds
TWI820414B (zh) * 2020-04-17 2023-11-01 大陸商北京賽特明強醫藥科技有限公司 喹唑啉類化合物、製備方法及其應用
CN113527215B (zh) * 2020-04-17 2023-12-05 北京赛特明强医药科技有限公司 一种喹唑啉类化合物、制备方法及其应用
MX2023004998A (es) * 2020-11-02 2023-05-12 Black Diamond Therapeutics Inc Metodo para tratar canceres con derivados de quinazolina sustituida con alquino.
CN120769850A (zh) * 2023-03-02 2025-10-10 江苏康缘药业股份有限公司 一种炔基取代的喹唑啉化合物的晶型、其制备方法和应用

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Also Published As

Publication number Publication date
WO2012122058A2 (en) 2012-09-13
WO2012122058A3 (en) 2014-04-24
MX2013010016A (es) 2013-11-20
TWI617556B (zh) 2018-03-11
US20140128417A1 (en) 2014-05-08
SG10201601711SA (en) 2016-04-28
AU2017200984A1 (en) 2017-03-02
SG193291A1 (en) 2013-10-30
AU2018267622B2 (en) 2020-05-14
US20180093975A1 (en) 2018-04-05
EP2680850A2 (en) 2014-01-08
US20190382382A1 (en) 2019-12-19
EP2680850A4 (en) 2015-01-28
JP2014518544A (ja) 2014-07-31
KR20210043016A (ko) 2021-04-20
AU2012225693A1 (en) 2013-09-19
KR102061743B1 (ko) 2020-01-03
BR112013022552A2 (pt) 2016-12-06
KR20140020955A (ko) 2014-02-19
BR112013022552B1 (pt) 2021-11-23
CA2828713A1 (en) 2012-09-13
CN103998040A (zh) 2014-08-20
MX344302B (es) 2016-12-13
KR20200003933A (ko) 2020-01-10
SG10201913982WA (en) 2020-03-30
US9090588B2 (en) 2015-07-28
IL228072A (en) 2016-08-31
RU2013144571A (ru) 2015-04-10
AU2018267622A1 (en) 2018-12-13
US20210047303A1 (en) 2021-02-18
US11524956B2 (en) 2022-12-13
US20160031860A1 (en) 2016-02-04
JP6006242B2 (ja) 2016-10-12
TW201249835A (en) 2012-12-16
EP2680850B1 (en) 2018-05-23
IL228072A0 (en) 2013-09-30
CA2828713C (en) 2022-08-16
CN103998040B (zh) 2017-03-29

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