KR20220019259A - Una 아미다이트 및 이의 용도 - Google Patents

Una 아미다이트 및 이의 용도 Download PDF

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KR20220019259A
KR20220019259A KR1020227000232A KR20227000232A KR20220019259A KR 20220019259 A KR20220019259 A KR 20220019259A KR 1020227000232 A KR1020227000232 A KR 1020227000232A KR 20227000232 A KR20227000232 A KR 20227000232A KR 20220019259 A KR20220019259 A KR 20220019259A
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substituted
unsubstituted
cases
oligonucleotide
formula
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벤카타 라마나 도팔라푸디
마이클 카라미안 코크런
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어비디티 바이오사이언시스 인크.
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
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    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/30—Chemical structure
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  • General Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
KR1020227000232A 2019-06-06 2020-06-05 Una 아미다이트 및 이의 용도 Ceased KR20220019259A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962858289P 2019-06-06 2019-06-06
US62/858,289 2019-06-06
PCT/US2020/036420 WO2020247818A1 (en) 2019-06-06 2020-06-05 Una amidites and uses thereof

Publications (1)

Publication Number Publication Date
KR20220019259A true KR20220019259A (ko) 2022-02-16

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KR1020227000232A Ceased KR20220019259A (ko) 2019-06-06 2020-06-05 Una 아미다이트 및 이의 용도

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US (2) US12006499B2 (https=)
EP (1) EP3980437A4 (https=)
JP (2) JP7581252B2 (https=)
KR (1) KR20220019259A (https=)
CN (1) CN114375297A (https=)
AU (1) AU2020287880B2 (https=)
CA (1) CA3142337A1 (https=)
WO (1) WO2020247818A1 (https=)

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