KR20210122713A - Cosmetic composition for anti-aging and anti-inlammation containing a combination of Citrus natsudaidai hayata, Boehmeria nipononivea, Humulus japonicus extract from jeju - Google Patents

Abstract

The present invention relates to an anti-aging and anti-inflammation cosmetic composition containing extracts of Citrus natsudaidai, Boehmeria niveafrom, Humulus japonicus from Jeju in combination. According to the present invention, formulation stability can be maintained even when the cosmetic composition contains 10 wt% or more of a natural product.

Description

TECHNICAL FIELD [0002] Cosmetic composition for anti-aging and anti-inlammation containing a combination of Citrus natsudaidai hayata, Boehmeria nipononivea, Humulus japonicus extract from jeju }

The present invention relates to a cosmetic composition containing an extract of golden tangerine, ciliate citrus, and ginseng vine extract as a complex and exhibiting anti-aging and anti-inflammatory effects.

Common basic cosmetics are meaningful in helping the skin to function normally, but most of the effects are limited to moisturizing. For this reason, in recent years, consumers' preference for functional cosmetics that can exhibit additional effects and functions compared to general basic cosmetics is increasing.

Functional cosmetics refer to those that have been given functionalities such as skin whitening, wrinkle improvement, and antioxidant. The antioxidant function inhibits oxidation in the skin and has effects such as anti-aging.

In addition, as problems such as the stability of antioxidants and skin irritation have recently emerged, interest in functional cosmetics using natural materials is increasing. However, since most of the natural raw materials used in the domestic cosmetic industry depend on foreign countries, there are limitations such as financial payment for the use and access of resources. Accordingly, the need to develop products using domestic resources is emerging.

Republic of Korea Patent No. 10-1236212 (2013.02.18.) describes a cosmetic composition for skin whitening containing a tangerine extract as an active ingredient. Republic of Korea Patent Registration No. 10-1504908 (2015.03.17.) describes a composition for strengthening the skin barrier containing ramie grass extract as an active ingredient. Korean Patent Application Laid-Open No. 10-2013-0062484 (2013.06.13.) describes a composition for external application to the skin that contains a ginseng vine extract.

In general, when a natural product is added to a cosmetic composition, there is a problem that the formulation is unstable. An object of the present invention is to provide a cosmetic composition in which the formulation is stable even when 10% by weight or more of a natural product is added to the cosmetic composition.

In addition, the present invention is to provide a cosmetic composition using rare plants and traditional plants from Jeju.

The present invention provides a cosmetic composition for anti-aging comprising a mixture of a golden tangerine extract, a ciliate saprum extract, and a ginseng vine extract.

In addition, the present invention provides a cosmetic composition for relieving irritation caused by inflammation, which includes a complex of a golden tangerine extract, a ciliate shamrock extract, and a ginseng vine extract.

In the present invention, the complex is preferably mixed in an amount of 35 to 55% by weight of the golden tangerine extract, 35 to 55% by weight of the ciliate saprum extract, and 0.01 to 20% by weight of the ginseng vine extract.

In the present invention, the composite may be preferably included in an amount of 0.001 to 30% by weight based on the entire cosmetic composition.

The present invention provides a cosmetic composition containing Jeju golden tangerine, ciliate saprum, and ginseng vine extract as a complex. Formulation stability is maintained even when the present invention contains 10% by weight or more of natural products.

1 is an example of a cosmetic composition of a gel formulation prepared using the complex of the present invention.

Jeju Special Self-Governing Province (濟州特別自治道) is a special self-governing province that has jurisdiction over islands in the South Sea of Korea. has been Thanks to the natural geography of Hallasan and a volcanic island, natural resources are abundant and unique rare plants are growing.

The present invention provides a cosmetic composition using a plant growing in Jeju. Specifically, the present invention provides a cosmetic composition for anti-aging comprising a complex in which a golden tangerine extract, a ciliate saprum extract, and a ginseng vine extract are mixed. In addition, the present invention provides a cosmetic composition for alleviating skin irritation induced by inflammation, comprising a complex of a golden tangerine extract, a ciliate shamrock extract, and a ginseng vine extract.

The hagwan of the present invention is an evergreen tree belonging to the family Unhyangaceae and is distributed in Jeju. It has a high sugar content, and the flesh is soft and juicy. It grows up to 3m in height, and the mouth is oval and the edge is flat without saw teeth. Tangerine contains a lot of vitamin C and flavonoids.

The ramie grass of the present invention is a perennial plant belonging to the nettle family, and grows well in warm regions with high temperature and humidity, and is mainly cultivated in Jeju, Jeonnam, Gyeongbuk, and Chungnam Hansan in Korea. Roots, stems, and leaves can be used individually, and since ancient times, they have been used as an antidote, a diuretic, and a pain reliever, and in addition, the leaves have been used to apply to cuts and blood clots.

The ginseng vine of the present invention is a vine and plant that lives in the fields or roadsides of the Hyeopjae region of Jeju Island. As one of the citrus fruits, carotenoids, bioflavonoids, pectins and terpenes are abundantly contained in the peel and fruit.

In the present invention, the complex is preferably mixed in an amount of 35 to 55% by weight of the golden tangerine extract, 35 to 55% by weight of the ciliate saprum extract, and 0.01 to 20% by weight of the ginseng vine extract. When mixed in the same way as above, skin irritation is the lowest, and skin absorption and moisture are excellent. In particular, when each extract was treated alone, there was a risk of skin irritation, but it was confirmed that the degree of skin irritation was significantly lowered when mixed as in the above-mentioned mixing ratio.

In the present invention, the composite was excellent in ABTS radical scavenging ability and DPPH radical scavenging ability, and from this, it was confirmed that there was a skin antioxidant effect. Antioxidants remove free radicals and prevent cell oxidation and aging. That is, the cosmetic composition comprising the complex of the present invention can prevent oxidation and aging of skin cells as it exerts an antioxidant effect, and can improve problems such as wrinkle generation and reduced elasticity due to skin aging.

On the other hand, in the cosmetic composition of the present invention, the cosmetic composition is, for example, a solution, suspension, emulsion, paste, lotion, gel, water-soluble liquid, cream, essence, surfactant-containing cleansing, oil, oil-in-water (O /W) type and water-in-oil (W/O) type of any one basic cosmetic formulation selected from; skin; Lotion; eye cream; soothing gel; Ointment; formulations for mask packs; formulations for body wash; peeling gel; Oil-in-water and water-in-oil makeup base; foundation; skin cover; Any one color cosmetic formulation selected from lipstick, lip gloss, face powder, two-way cake, eye shadow, cheek color and eyebrow pencil; formulations for the scalp; It may be any one selected from among.

Hereinafter, the present invention will be described in more detail in the following Examples and Experimental Examples. However, the scope of the present invention is not limited only to the following examples and experimental examples, and includes all modifications of the technical idea equivalent thereto.

[Example 1: Preparation of golden tangerine, ciliate, ginseng vine extract]

After washing with water, 1 kg of Jeju golden tangerine, ciliate, and ginseng vine are added to 20 kg of 70% (v/v) ethanol aqueous solution, respectively, extracted at room temperature for 3 days, and each is filtered with Whatman #5 filter paper. , was concentrated under reduced pressure and freeze-dried at 50 ℃ or less to prepare a golden tangerine extract, a ciliate saprum extract, and a ginseng vine extract. Each extract was prepared to be used as a cosmetic composition by dispersing and dissolving it using at least one solvent selected from purified water, ethanol, butylene glycol, and propylene glycol.

[Experimental Example 1: Confirmation of antioxidant effect of golden tangerine, ciliate shamrock, ginseng vine extract]

(1) ABTS radical scavenging ability

Antioxidative activity was measured using the principle that ABTS radical loses color due to the electron-donating ability of antioxidants. The ABTS solution was diluted with 7.0 mM 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 2.45 mM potassium persulfate, followed by ABTS radical morphology for 24 hours, and then diluted with distilled water so that the absorbance value was 0.70. did. The sample solution in which the extract was dissolved by concentration was mixed with ABTS solution, reacted at 37°C for 30 minutes, and then absorbance was measured at 700 nm with a Microplate reader (Epoch, BioTek). The ABTS radical scavenging ability was expressed as a percentage by comparing the sample addition group and the non-addition group, and ascorbic acid (Sigma) was used as a positive control group.

Extracts
(mg/ml) ABTS radical scavenging ability (%) ciliate extract ginseng vine extract golden tangerine extract Ascorbic acid 0.0625 17.4 ± 1.5 15.9 ± 1.2 14.9 ± 1.3 72.2 ± 3.5 0.125 48.4 ± 1.0 29.9 ± 1.1 27.9 ± 1.1 92.3 ± 0.3 0.25 78.2 ± 0.3 53.3 ± 1.5 63.3 ± 1.5 98.4 ± 0.1 0.5 95.3 ± 0.5 83.5 ± 1.0 85.5 ± 1.0 98.7 ± 0.3 1.0 96.9 ± 0.1 97.5 ± 0.3 97.8 ± 0.4 99.5 ± 0.7 IC ₅₀ 0.18 ± 0.5 0.23 ± 1.0 0.20 ± 0.8 0.004 ± 1.2

(2) DPPH radical scavenging ability

DPPH (2,2-diphenyl-1-picrylhydrazyl) assay is a method for measuring antioxidant activity and is a very stable radical. It is a purple mixture that exhibits characteristic light absorption at 519 nm, and loses its original color when reduced by antioxidants.

For the electron donating ability of each extract, the radical scavenging ability of the sample was measured using DPPH (1,1-diphenyl-2-picryl hydrazyl). The sample solution in which the extracts were dissolved by concentration was mixed with 0.2 mM DPPH and reacted in the dark for 15 minutes, and then absorbance was measured at 517 nm with a Microplate reader (Epoch, BioTek). The DPPH radical scavenging ability was expressed as a percentage by comparing the sample addition group and the non-addition group, and ascorbic acid (Sigma) was used as a positive control group.

Extracts
(mg/ml) DPPH radical scavenging ability (%) ciliate extract ginseng vine extract golden tangerine extract Ascorbic acid 0.0625 18.4 ± 0.6 5.2 ± 0.2 6.2 ± 0.2 32.6 ± 3.1 0.125 27.8 ± 2.2 9.6 ± 0.1 10.6 ± 0.3 41.1 ± 2.4 0.25 39.1 ± 2.3 21.1 ± 3.9 24.1 ± 3.5 69.3 ± 1.3 0.5 55.1 ± 3.6 40.1 ± 2.0 45.1 ± 1.5 80.3 ± 2.2 1.0 72.7 ± 2.3 53.2 ± 2.9 60.2 ± 1.9 90.2 ± 0.7 IC ₅₀ 0.52 ± 1.5 0.89 ± 1.1 0.87 ± 1.2 0.015 ± 2.5

[Example 2: Preparation of a complex of golden tangerine, ciliate and ginseng extract]

The golden tangerine extract obtained in Example 1, the ciliate saprum extract, and the ginseng vine extract were blended in the mixing ratios shown in Table 3 below.

golden tangerine extract ciliate extract ginseng vine extract Example 2 4.5 4.5 One Comparative Example 1 One 4.5 4.5 Comparative Example 2 4.5 One 4.5

[Experimental Example 2: Confirmation of skin irritation level of the complex]

In this experiment, the degree of skin irritation of the golden tangerine extract prepared in Example 1, the ciliate saprum extract, the ginseng vine extract, and the complex prepared in Example 2 was confirmed. The degree of skin irritation according to the mixing ratio of each extract and complex is shown in Table 4 below, and 15 adults in their 20s and 30s were randomly selected and the degree of irritation felt from each extract and complex was expressed as a number from 1 to 10.

golden tangerine extract ciliate extract ginseng vine extract stimulus degree Example 2 4.5 4.5 One 2.0 Comparative Example 3 10 0 0 4.0 Comparative Example 4 0 10 0 3.5 Comparative Example 5 0 0 10 2.5

As shown in Table 4, it was confirmed that the complex of the present invention had a lower degree of skin irritation than when each extract was treated alone. In particular, it was confirmed that the degree of skin irritation was significantly reduced in the case of the golden tangerine extract, but the degree of skin irritation was significantly reduced by combining the ciliate saprum extract and the ginseng vine extract as described above.

[Experimental Example 3: Confirmation of the antioxidant effect of the complex]

The antioxidant effect of the composite prepared according to Example 2 was confirmed. ABTS radical scavenging ability and DPPH radical scavenging ability were confirmed in the same manner as in Experimental Example 1.

Extracts
(mg/ml) ABTS radical scavenging ability (%) Example 2 Comparative Example 1 Comparative Example 2 0.0625 12.0 ± 1.7 11.4 ± 0.4 14.0 ± 0.7 0.125 30.5 ± 0.4 20.3 ± 1.2 26.2 ± 0.9 0.25 54.3 ± 2.1 40.4 ± 1.4 47.1 ± 1.5 0.5 85.2 ± 2.7 72.1 ± 1.4 76.2 ± 1.8 1.0 98.3 ± 0.1 95.1 ± 0.4 95.9 ± 0.8

Extracts
(mg/ml) DPPH radical scavenging ability (%) Example 2 Comparative Example 1 Comparative Example 2 0.0625 9.2 ± 0.8 5.6 ± 0.9 8.7 ± 0.1 0.125 16.3 ± 1.2 10.9 ± 1.7 13.3 ± 0.2 0.25 30.2 ± 3.6 16.8 ± 3.4 20.6 ± 2.7 0.5 49.7 ± 1.6 26.9 ± 2.3 29.7 ± 3.7 1.0 58.7 ± 2.2 41.2 ± 2.4 39.2 ± 2.3

As shown in Table 5, it was confirmed that the composite of Example 2 of the present invention had superior ABTS radical scavenging ability compared to the composite of Comparative Examples 1 and 2.

On the other hand, when comparing the DPPH radical scavenging ability of the complex according to Table 6 and the DPPH radical scavenging ability of each extract according to Table 2, the antioxidant effect of the complex of the present invention is lower than when each extract is treated alone. can However, when each extract was treated alone, there was a high risk of skin irritation as shown in Experimental Example 2, and thus, the present invention was able to significantly lower skin irritation by composing each extract as a complex.

[Experimental Example 3: Evaluation of composition use by mixing ratio]

In this experiment, the feeling of use of the composite prepared in Example 2 by mixing ratio was evaluated. 10 random adult males and 10 females in their 20's and 60's were evaluated for no skin irritation, absorption, and moisture on a 5-point scale (1: very bad, 5: very good). The usability evaluation results are shown in Table 7 below. The 'no skin irritation' item was given a higher score as no skin irritation was felt.

Example 2 Comparative Example 1 Comparative Example 2 No skin irritation 4.6 4.2 4.2 absorptivity 4.4 3.2 3.8 moisturizing 4.6 3.2 3.8

As a result of the evaluation, Example 2 was the most excellent in the absence of skin irritation. Example 2 was the most excellent in absorbency and moisturizing feeling, and Comparative Example 2 showed superior absorption and moisturizing feeling compared to Comparative Example 1.

[Preparation Example 1: Preparation of a cosmetic composition containing the composite]

In this preparation example, a soothing gel was prepared using the composite of Example 2. The purified water of this preparation example was added so that the total amount of the cosmetic composition was 100 ml.

In purified water heated to 50°C, 0.7 g of Carbomer, 0.1 g of Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyethylcellulose 0.06 g, PEG-60 Hydrogenated Castor Oil 0.2 g, PEG-40 Hydrogenated Castor Oil 0.1 g, Glycerin 7.0 g, 10.0 to 14.0 g of the compound of Example 2 and 2.0 g of 1,2-hexanediol were added. After it was completely dissolved by stirring, 0.7 g of arginine was administered in small portions while stirring at a constant speed. After cooling to room temperature and defoaming, a slightly acidic soothing gel having a pH of 5 to 6 was prepared. 1 shows a photograph of the prepared soothing gel.

[Preparation Example 2: Preparation of Cosmetic Composition Containing Composite]

In this preparation example, a lotion was prepared using the complex of Example 2. The purified water of this preparation example was added so that the total amount of the cosmetic composition was 100 ml.

Add 3.0 g of glycerin and 1.0 g of trehalose to purified water heated to 80° C. and stir to dissolve it completely, then stir at a constant speed to dissolve 1.0 g of cetyl alcohol, glyceryl stearate A mixture of 0.78 g of Glyceryl Stearate, 0.72 g of PEG-100 Stearate, and 4.0 g of Cetyl Ethylhexanoate is slowly added to emulsify. Then C13-14 isoparaffin (C13-14 Isoparaffin) 0.07 g, polyacrylamide (Polyacrylamide) 0.14 g, cyclopentasiloxane (Cyclopentasiloxane) 0.09 g, dimethicone (Dimethicone) 0.19 g, sebum / sebum-18 /18 dimethicone (PEG/PPG-18/18 Dimethicone) 0.01 g, Trideceth-6 (Trideceth-6) 0.06 g, sodium polyacrylate (Sodium Polyacrylate) 0.26 g slowly added, stirred to dissolve completely After that, 10.0 to 14.0 g of the compound of Example 2 and 2.0 g of 1,2-hexanediol (1,2-Hexanediol) were sequentially added at a constant rate at a temperature of 40 to 50° C. and administered with stirring. . Then, after cooling to room temperature and defoaming, a lotion was prepared.

[Preparation Example 3: Preparation of a cosmetic composition containing the composite]

In this preparation example, a cream was prepared using the complex of Example 2. The purified water of this preparation example was added so that the total amount of the cosmetic composition was 100 ml.

After adding 4.0 g of glycerin and 1.0 g of betaine to purified water heated to 80° C. and stirring to dissolve it completely, 0.52 g of cetyl palmitate dissolved while stirring at a constant speed, sorbitan palmitate (Sorbitan Palmitate) 0.39 g, Sorbitan Olivate 0.39 g, Behenyl Alcohol 0.36 g, Arachidyl Alcohol 0.6 g, Arachidyl Glucoside 0.24 g, Cetyl Alcohol ( Cetyl Alcohol 2.0 g, Triethylhexanoin 2.0 g, Cetyl Ethylhexanoate 5.0 g mixture is slowly added to emulsify. After that, 0.38 g of cyclopentasiloxane and 0.52 g of sodium polyacrylate are slowly added, stirred and completely dissolved, and the temperature is 40-50° C. at a constant rate of the compound of Example 2 10.0 ~ 14.0 g, 1,2-hexanediol (1,2-Hexanediol) 2.0 g was added in order and administered with stirring. Then, after cooling to room temperature and defoaming, a cream was prepared.

[Preparation Example 4: Preparation of Cosmetic Composition Containing Composite]

In this preparation example, a shampoo was prepared using the complex of Example 2. The purified water of this preparation example was added so that the total amount of the cosmetic composition was 100 ml.

Acrylates copolymer 8.0 g, Sodium Cocoyl Isethionate 4.0 g, Sodium Myristoyl Glutamate 2.0 g, coco-betaine in purified water heated to 50° C. (Coco-Betaine) 0.9 g, Potassium Cocoyl Glycinate (Potassium Cocoyl Glycinate) 10.0 g were added and completely dissolved by stirring, and after stirring at a constant speed, 10.0 to 14.0 g of the compound of Example 2, 1,2-hexane 2.0 g of diol (1,2-Hexanediol) was added in order. Then, after cooling to room temperature and defoaming, shampoo was prepared.

Claims (4)

A cosmetic composition for anti-aging comprising a complex containing a golden tangerine extract, a ciliate shamrock extract, and a ginseng vine extract.
A cosmetic composition for relieving irritation caused by inflammation, comprising a complex containing a mixture of golden tangerine extract, ciliate shamrock extract, and ginseng vine extract.
3. The method of claim 1 or 2,
The composite is
A cosmetic composition, characterized in that it is mixed in an amount of 35 to 55% by weight of golden tangerine extract, 35 to 55% by weight of ciliate extract, and 0.01 to 20% by weight of ginseng vine extract.
3. The method of claim 1 or 2,
The composite is
A cosmetic composition, characterized in that it is contained in an amount of 0.001 to 30% by weight based on the entire cosmetic composition.

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