KR102610177B1 - Cosmetic composition for anti-oxidation and irritation relief containing a combination of Citrus natsudaidai hayata, Boehmeria nipononivea, Humulus japonicus extract from jeju - Google Patents

Abstract

The present invention relates to a cosmetic composition for antioxidant and irritation relief containing a complex of extracts of golden hazelnuts from Jeju, cilium cilium, and ginseng vine.

Description

Cosmetic composition for anti-oxidation and irritation relief containing a combination of Citrus natsudaidai hayata, Boehmeria nipononivea, Humulus japonicus extract from jeju }

The present invention relates to a cosmetic composition that contains a complex of extracts of golden hazelnuts, cilium cilium, and ginseng vine, and has antioxidant and skin mild effects.

General basic cosmetics are meaningful in helping the skin function normally, but their effectiveness is mostly limited to moisturizing. For this reason, consumers' preference for functional cosmetics that can provide additional effects and functions compared to general basic cosmetics has recently been increasing.

Functional cosmetics refer to cosmetics with functionality such as skin whitening, wrinkle improvement, and antioxidant properties. Antioxidant function inhibits oxidation in the skin and has anti-aging effects. However, due to the nature of antioxidant substances, there is a problem that the substance is oxidized when exposed for a long time, reducing its effectiveness.

Additionally, as issues such as the stability of antioxidants and skin irritation have recently emerged, interest in functional cosmetics using natural materials is increasing. However, most of the natural raw materials used in the domestic cosmetics industry are dependent on foreign sources, which creates limitations such as financial payment for use and access to resources. Accordingly, the need to develop products using domestic resources is emerging.

Republic of Korea Patent No. 10-1236212 (February 18, 2013) discloses a cosmetic composition for skin whitening containing hazelnut extract as an active ingredient. Republic of Korea Patent No. 10-1504908 (2015.03.17.) describes a composition for strengthening the skin barrier containing ramie extract as an active ingredient. Republic of Korea Patent Publication No. 10-2013-0062484 (June 13, 2013) discloses a composition for external use on the skin containing extract of ginseng vine.

In general, when natural products are added to cosmetic compositions, there is a problem with the formulation being unstable. The present invention seeks to provide a cosmetic composition whose formulation is stable even when 10% by weight or more of natural products are added to the cosmetic composition.

Additionally, the present invention seeks to provide a cosmetic composition using rare and traditional plants from Jeju Island.

The present invention provides an anti-oxidant cosmetic composition comprising a mixture of golden hazelnut extract, ciliary extract, and ginseng vine extract.

In addition, the present invention provides a cosmetic composition for relieving irritation having a mild skin irritation effect, comprising a composite of golden hazelnut extract, ciliary extract, and ginseng vine extract.

In the present invention, the complex is preferably mixed with 35 to 55% by weight of golden hazelnut extract, 35 to 55% by weight of cilium ginseng extract, and 0.01 to 20% by weight of ginseng vine extract.

In the present invention, the composite may preferably be contained in an amount of 0.001 to 30% by weight based on the total cosmetic composition.

The present invention provides a cosmetic composition containing a complex of extracts of golden hazelnuts from Jeju, cilium cilium, and ginseng vine. In the present invention, formulation stability is maintained even if it contains 10% by weight or more of natural products.

Figure 1 is an example of a gel-type cosmetic composition prepared using the complex of the present invention.

Jeju Special Self-Governing Province (濟州牞特別自治道) is a special self-governing province that governs islands in the southern seas of Korea, including the main island of Jeju Island, the largest island in Korea, as well as 8 inhabited islands including Marado, Udo, and Chuja Archipelago, as well as uninhabited islands. Consists of 55 provinces It is done. Thanks to the natural geographical characteristics of the Hallasan area and volcanic islands, natural resources are abundant and unique rare plants grow.

The present invention provides a cosmetic composition using plants growing in Jeju. Specifically, the present invention provides an anti-oxidant cosmetic composition comprising a composite of golden hazelnut extract, ciliary extract, and ginseng vine extract. In addition, the present invention provides a cosmetic composition for relieving irritation having a mild skin irritation effect, comprising a composite of golden hazelnut extract, ciliary extract, and ginseng vine extract.

The summer tangerine of the present invention is an evergreen tree belonging to the Rutaceae family and is distributed in Jeju. The sugar content is high, and the flesh is soft and juicy. It grows up to 3m in height, and the outer ears are oval-shaped and the edges are plain without teeth. Red tangerines contain large amounts of vitamin C and flavonoids.

The ramie plant of the present invention is a perennial herb belonging to the nettle family and grows well in warm regions with high temperature and humidity. In Korea, it is mainly cultivated in Jeju, Jeonnam, Gyeongbuk, and Hansan, South Chungcheong. The roots, stems, and leaves can be used individually, and since ancient times, they have been used as a detoxifier, diuretic, and analgesic. In addition, the leaves have been used to treat cuts or stagnant blood.

The Hwansam vine of the present invention is a vine plant growing in fields or roadsides in the Hyeopjae area of Jeju Island. The leaves are palm-shaped and the stems have strong hairs. In the past, it was used as a medicinal herb under the name of Yulcho of Donguibogam. Hagyul is cultivated in Jeju Island. As one of the citrus fruits, the peel and fruit are rich in carotenoids, bioflavonoids, pectin, and terpenes.

In the present invention, the complex is preferably mixed with 35 to 55% by weight of golden hazelnut extract, 35 to 55% by weight of cilium ginseng extract, and 0.01 to 20% by weight of ginseng vine extract. When mixed in the above mixing ratio, skin irritation is lowest and skin absorption and moisturizing properties are excellent. In particular, there was a risk of skin irritation when each extract was treated alone, but it was confirmed that when mixed at the above mixing ratio, the degree of skin irritation was significantly reduced.

In the present invention, the complex had excellent ABTS radical scavenging ability and DPPH radical scavenging ability, and it was confirmed that it has a skin antioxidant effect. Antioxidants remove free radicals and prevent cell oxidation and aging. That is, the cosmetic composition containing the complex of the present invention prevents oxidation and aging of skin cells by exerting an antioxidant effect, and can improve problems such as wrinkle formation and loss of elasticity due to skin aging.

Meanwhile, in the cosmetic composition of the present invention, the cosmetic composition includes, for example, a solution, suspension, emulsion, paste, lotion, gel, water-soluble liquid, cream, essence, surfactant-containing cleansing, oil, oil-in-water (O A basic cosmetic formulation selected from /W) type and water-in-oil (W/O) type; skin; Lotion; eye cream; soothing gel; Ointment; Formulation for mask pack; Formulations for body wash; peeling gel; Oil-in-water and water-in-oil makeup bases; foundation; skin cover; A color cosmetic formulation selected from lipstick, lip gloss, face powder, two-way cake, eye shadow, cheek color, and eyebrow pencil; Formulations for scalp use; It may be any one selected from among.

Hereinafter, the present invention will be described in more detail in the following examples and experimental examples. However, the scope of the present invention is not limited to the following examples and experimental examples, and includes all modifications of the technical idea equivalent thereto.

[Example 1: Preparation of golden hazelnut, ciliary plant, and ginseng vine extract]

After washing 1kg of golden hazelnuts, cilantrophytes, and ginseng vines from Jeju with water, they were each added to 20kg of 70% (v/v) ethanol aqueous solution, extracted for 3 days at room temperature, and then filtered through Whatman #5 filter paper. , and concentrated under reduced pressure and freeze-dried at 50°C or lower to prepare golden hazelnut extract, cilium lanceolate extract, and ginseng vine extract. Each extract was prepared to be used as a cosmetic composition by dispersing and dissolving it in one or more solvents selected from purified water, ethanol, butylene glycol, and propylene glycol.

[Experimental Example 1: Confirmation of antioxidant effect of golden hazelnut, cilium cilium, and ginseng vine extracts]

(1) ABTS radical scavenging ability

Antioxidant activity was measured using the principle that ABTS radical loses coloring power due to the electron donating ability of antioxidant substances. The ABTS solution was mixed with 7.0mM 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 2.45mM potassium persulfate, subjected to ABTS radical analysis for 24 hours, and then diluted with distilled water to obtain an absorbance value of 0.70. did. The sample solution in which the extract was dissolved at each concentration was mixed with ABTS solution and reacted at 37°C for 30 minutes, and then the absorbance was measured at 700 nm with a Microplate reader (Epoch, BioTek). ABTS radical scavenging ability was expressed as a percentage by comparing the group with sample addition and the group without addition, and ascorbic acid (Sigma) was used as a positive control group.

Extracts
(mg/ml) ABTS radical scavenging ability (%) Ciliary plant extract Panax ginseng extract Golden hazelnut extract Ascorbic acid 0.0625 17.4 ± 1.5 15.9 ± 1.2 14.9 ± 1.3 72.2 ± 3.5 0.125 48.4 ± 1.0 29.9 ± 1.1 27.9 ± 1.1 92.3 ± 0.3 0.25 78.2 ± 0.3 53.3 ± 1.5 63.3 ± 1.5 98.4 ± 0.1 0.5 95.3 ± 0.5 83.5 ± 1.0 85.5 ± 1.0 98.7 ± 0.3 1.0 96.9 ± 0.1 97.5 ± 0.3 97.8 ± 0.4 99.5 ± 0.7 IC ₅₀ 0.18 ± 0.5 0.23 ± 1.0 0.20 ± 0.8 0.004 ± 1.2

(2) DPPH radical scavenging ability

DPPH (2,2-diphenyl-1-picrylhydrazyl) assay is a method for measuring antioxidant activity and is a very stable radical. It is a purple mixture that exhibits characteristic light absorption at 519 nm, and loses its original color when reduced by antioxidants.

The electron donating ability of each extract was measured using DPPH (1,1-diphenyl-2-picryl hydrazyl) to measure the radical scavenging ability of the sample. The sample solution in which the extract was dissolved at each concentration was mixed with 0.2 mM DPPH and reacted in the dark for 15 minutes, and then the absorbance was measured at 517 nm with a Microplate reader (Epoch, BioTek). DPPH radical scavenging ability was expressed as a percentage by comparing the group with and without sample addition, and ascorbic acid (Sigma) was used as a positive control group.

Extracts
(mg/ml) DPPH radical scavenging ability (%) Ciliary plant extract Panax ginseng extract Golden hazelnut extract Ascorbic acid 0.0625 18.4 ± 0.6 5.2 ± 0.2 6.2 ± 0.2 32.6 ± 3.1 0.125 27.8 ± 2.2 9.6 ± 0.1 10.6 ± 0.3 41.1 ± 2.4 0.25 39.1 ± 2.3 21.1 ± 3.9 24.1 ± 3.5 69.3 ± 1.3 0.5 55.1 ± 3.6 40.1 ± 2.0 45.1 ± 1.5 80.3 ± 2.2 1.0 72.7 ± 2.3 53.2 ± 2.9 60.2 ± 1.9 90.2 ± 0.7 IC ₅₀ 0.52 ± 1.5 0.89 ± 1.1 0.87 ± 1.2 0.015 ± 2.5

[Example 2: Preparation of a complex of golden hazelnuts, cilium cilium, and ginseng vine extracts]

The golden hazelnut extract, ciliary root extract, and ginseng vine extract obtained in Example 1 were mixed in the mixing ratio as shown in Table 3 below.

Golden hazelnut extract Ciliary plant extract Panax ginseng extract Example 2 4.5 4.5 One Comparative Example 1 One 4.5 4.5 Comparative Example 2 4.5 One 4.5

[Experimental Example 2: Confirmation of skin irritation level of complex]

In this experiment, the degree of skin irritation of the golden hazelnut extract, ciliary root extract, and ginseng vine extract prepared in Example 1 and the complex prepared in Example 2 was confirmed. The level of skin irritation according to the mixing ratio of each extract and complex is shown in Table 4 below. Fifteen adults in their 20s and 30s were randomly selected and the degree of irritation felt from each extract and complex was expressed as a number from 1 to 10.

Golden hazelnut extract Ciliary plant extract Panax ginseng extract stimulation Example 2 4.5 4.5 One 2.0 Comparative Example 3 10 0 0 4.0 Comparative Example 4 0 10 0 3.5 Comparative Example 5 0 0 10 2.5

As shown in Table 4, it was confirmed that the complex of the present invention had a lower degree of skin irritation compared to when each extract was treated alone. In particular, the degree of skin irritation was high in the case of the golden orange tangerine extract, but it was confirmed that the degree of skin irritation was significantly reduced by mixing the Ciliaceae extract and the ginseng vine extract as described above.

[Experimental Example 3: Confirmation of antioxidant effect of complex]

The antioxidant effect of the composite prepared according to Example 2 was confirmed. ABTS radical scavenging activity and DPPH radical scavenging activity were confirmed in the same manner as in Experimental Example 1 above.

Extracts
(mg/ml) ABTS radical scavenging ability (%) Example 2 Comparative Example 1 Comparative Example 2 0.0625 12.0 ± 1.7 11.4 ± 0.4 14.0 ± 0.7 0.125 30.5 ± 0.4 20.3 ± 1.2 26.2 ± 0.9 0.25 54.3 ± 2.1 40.4 ± 1.4 47.1 ± 1.5 0.5 85.2 ± 2.7 72.1 ± 1.4 76.2 ± 1.8 1.0 98.3 ± 0.1 95.1 ± 0.4 95.9 ± 0.8

Extracts
(mg/ml) DPPH radical scavenging ability (%) Example 2 Comparative Example 1 Comparative Example 2 0.0625 9.2 ± 0.8 5.6 ± 0.9 8.7 ± 0.1 0.125 16.3 ± 1.2 10.9 ± 1.7 13.3 ± 0.2 0.25 30.2 ± 3.6 16.8 ± 3.4 20.6 ± 2.7 0.5 49.7 ± 1.6 26.9 ± 2.3 29.7 ± 3.7 1.0 58.7 ± 2.2 41.2 ± 2.4 39.2 ± 2.3

As shown in Table 5, it was confirmed that the composite of Example 2 of the present invention had superior ABTS radical scavenging ability compared to the composites of Comparative Examples 1 and 2.

Meanwhile, comparing the DPPH radical scavenging ability of the complex according to Table 6 and the DPPH radical scavenging ability of each extract according to Table 2, it can be seen that the antioxidant effect of the complex of the present invention is lower than when each extract is treated alone. You can. However, when each extract was treated alone, there was a high risk of skin irritation, as shown in Experimental Example 2 above. Accordingly, the present invention was able to significantly reduce skin irritation by forming each extract into a composite.

[Experimental Example 3: Evaluation of composition use by mixing ratio]

In this experiment, the feeling of use of the composite prepared in Example 2 was evaluated for each mixing ratio. 10 random male and 10 female adults in their 20s to 60s were asked to evaluate the lack of skin irritation, absorption, and moisturizing sensation using a 5-point scale (1: very bad, 5: very good). The results of the usability evaluation are shown in Table 7 below. In the 'No skin irritation' item, a higher score was given as no skin irritation was felt.

Example 2 Comparative Example 1 Comparative Example 2 No skin irritation 4.6 4.2 4.2 absorptivity 4.4 3.2 3.8 Moisturizing 4.6 3.2 3.8

As a result of the evaluation, Example 2 was the best in terms of no skin irritation. Example 2 had the best absorbency and moisturizing sensation, and Comparative Example 2 showed superior absorption and moisturizing sensation compared to Comparative Example 1.

[Preparation Example 1: Preparation of a cosmetic composition containing a composite]

In this production example, a soothing gel was prepared using the composite of Example 2. Purified water in this production example was added to make a total of 100 ml of the cosmetic composition.

Purified water heated to 50℃ contains 0.7 g of Carbomer, 0.1 g of Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, and Hydroxyethylcellulose. 0.06 g, PEG-60 Hydrogenated Castor Oil 0.2 g, PEG-40 Hydrogenated Castor Oil 0.1 g, Glycerin 7.0 g, 10.0 to 14.0 g of the complex of Example 2 and 2.0 g of 1,2-hexanediol were added. After stirring to completely dissolve it, 0.7 g of arginine was administered in small amounts while stirring at a constant speed. It was cooled to room temperature and defoamed to prepare a slightly acidic soothing gel with a pH of 5 to 6. Figure 1 shows a photograph of the manufactured soothing gel.

[Preparation Example 2: Preparation of a cosmetic composition containing a composite]

In this production example, a lotion was prepared using the composite of Example 2. Purified water in this production example was added to make a total of 100 ml of the cosmetic composition.

Add 3.0 g of glycerin and 1.0 g of trehalose to purified water heated to 80℃ and stir to completely dissolve. Then, stir at a constant speed to dissolve 1.0 g of cetyl alcohol and glyceryl stear. Slowly add a mixture of 0.78 g of Glyceryl Stearate, 0.72 g of PEG-100 Stearate, and 4.0 g of Cetyl Ethylhexanoate to emulsify. Afterwards, C13-14 Isoparaffin 0.07 g, Polyacrylamide 0.14 g, Cyclopentasiloxane 0.09 g, Dimethicone 0.19 g, PEG/PPG-18 Slowly add 0.01 g of PEG/PPG-18/18 Dimethicone, 0.06 g of Trideceth-6, and 0.26 g of Sodium Polyacrylate, and stir to completely dissolve. After the temperature was 40 to 50°C, 10.0 to 14.0 g of the complex of Example 2 and 2.0 g of 1,2-hexanediol were sequentially added at a constant rate and stirred. . Afterwards, it was cooled to room temperature, degassed, and lotion was prepared.

[Preparation Example 3: Preparation of a cosmetic composition containing a composite]

In this production example, a cream was prepared using the complex of Example 2. Purified water in this production example was added to make a total of 100 ml of the cosmetic composition.

Add 4.0 g of glycerin and 1.0 g of betaine to purified water heated to 80℃ and stir to completely dissolve. Then, stir at a constant speed to dissolve 0.52 g of cetyl palmitate and sorbitan palmitate. (Sorbitan Palmitate) 0.39 g, Sorbitan Olivate 0.39 g, Behenyl Alcohol 0.36 g, Arachidyl Alcohol 0.6 g, Arachidyl Glucoside 0.24 g, Cetyl Alcohol ( Slowly add a mixture of 2.0 g of Cetyl Alcohol, 2.0 g of Triethylhexanoin, and 5.0 g of Cetyl Ethylhexanoate to emulsify. Afterwards, 0.38 g of Cyclopentasiloxane and 0.52 g of Sodium Polyacrylate were slowly added and stirred to completely dissolve, and then at a constant speed when the temperature was 40-50°C, the complex 10.0 of Example 2 was added. ~ 14.0 g and 2.0 g of 1,2-hexanediol were added in order and administered while stirring. Afterwards, it was cooled to room temperature, defoamed, and cream was prepared.

[Preparation Example 4: Preparation of a cosmetic composition containing a composite]

In this production example, shampoo was prepared using the complex of Example 2. Purified water in this production example was added to make a total of 100 ml of the cosmetic composition.

Purified water heated to 50℃ contains 8.0 g of Acrylates copolymer, 4.0 g of Sodium Cocoyl Isethionate, 2.0 g of Sodium Myristoyl Glutamate, and Coco-Betaine. (Coco-Betaine) 0.9 g and Potassium Cocoyl Glycinate (Potassium Cocoyl Glycinate) 10.0 g were added and stirred to completely dissolve, then stirred at a constant speed and 10.0 to 14.0 g of the complex of Example 2, 1,2-hexane. 2.0 g of diol (1,2-Hexanediol) was sequentially added. Afterwards, it was cooled to room temperature, degassed, and shampoo was prepared.

Claims (4)

An anti-oxidant cosmetic composition containing a mixture of golden hazelnut extract, ciliary extract, and ginseng vine extract.
A cosmetic composition for relieving irritation that has a mild skin irritation effect, comprising a mixture of golden hazelnut extract, ciliary extract, and ginseng vine extract.
According to claim 1 or 2,
The complex is,
A cosmetic composition characterized in that it is mixed with 35 to 55% by weight of golden hazelnut extract, 35 to 55% by weight of cilium ginseng extract, and 0.01 to 20% by weight of ginseng vine extract.
According to claim 1 or 2,
The complex is,
A cosmetic composition characterized in that it is contained in an amount of 0.001 to 30% by weight based on the total cosmetic composition.