KR20210116488A - 액티빈 수용체-유사 키나제-2의 억제제로서의 이미다조피리다진 및 이미다조피리딘 화합물 - Google Patents

액티빈 수용체-유사 키나제-2의 억제제로서의 이미다조피리다진 및 이미다조피리딘 화합물 Download PDF

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Publication number
KR20210116488A
KR20210116488A KR1020217022783A KR20217022783A KR20210116488A KR 20210116488 A KR20210116488 A KR 20210116488A KR 1020217022783 A KR1020217022783 A KR 1020217022783A KR 20217022783 A KR20217022783 A KR 20217022783A KR 20210116488 A KR20210116488 A KR 20210116488A
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KR
South Korea
Prior art keywords
alkyl
alkylene
independently selected
membered heterocycloalkyl
cycloalkyl
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Pending
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KR1020217022783A
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English (en)
Korean (ko)
Inventor
쥔 판
제레미 로치
쑹 메이
천훙 허
량싱 우
원칭 야오
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인사이트 코포레이션
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Publication of KR20210116488A publication Critical patent/KR20210116488A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020217022783A 2018-12-20 2019-12-19 액티빈 수용체-유사 키나제-2의 억제제로서의 이미다조피리다진 및 이미다조피리딘 화합물 Pending KR20210116488A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862782994P 2018-12-20 2018-12-20
US62/782,994 2018-12-20
US201962935891P 2019-11-15 2019-11-15
US62/935,891 2019-11-15
PCT/US2019/067403 WO2020132197A1 (en) 2018-12-20 2019-12-19 Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2

Publications (1)

Publication Number Publication Date
KR20210116488A true KR20210116488A (ko) 2021-09-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217022783A Pending KR20210116488A (ko) 2018-12-20 2019-12-19 액티빈 수용체-유사 키나제-2의 억제제로서의 이미다조피리다진 및 이미다조피리딘 화합물

Country Status (20)

Country Link
US (3) US11459329B2 (enExample)
EP (1) EP3898627A1 (enExample)
JP (2) JP7414827B2 (enExample)
KR (1) KR20210116488A (enExample)
CN (2) CN120208959A (enExample)
AU (1) AU2019401649B2 (enExample)
BR (1) BR112021011948A2 (enExample)
CA (1) CA3124088A1 (enExample)
CL (1) CL2021001656A1 (enExample)
CO (1) CO2021008117A2 (enExample)
CR (1) CR20210336A (enExample)
EC (1) ECSP21044843A (enExample)
IL (2) IL318278A (enExample)
MA (1) MA54551A (enExample)
MX (1) MX2021007426A (enExample)
PE (1) PE20220277A1 (enExample)
PH (1) PH12021551446A1 (enExample)
SG (1) SG11202106582YA (enExample)
TW (2) TW202504901A (enExample)
WO (1) WO2020132197A1 (enExample)

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KR20240078812A (ko) 2022-11-28 2024-06-04 계명대학교 산학협력단 신규한 pim 키나아제 억제제 및 이의 용도

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KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
CA3184811A1 (en) 2020-06-12 2021-12-16 Incyte Corporation Imidazopyridazine compounds with activity as alk2 inhibitors
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
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Publication number Priority date Publication date Assignee Title
KR20240078812A (ko) 2022-11-28 2024-06-04 계명대학교 산학협력단 신규한 pim 키나아제 억제제 및 이의 용도

Also Published As

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CA3124088A1 (en) 2020-06-25
CO2021008117A2 (es) 2021-09-20
EP3898627A1 (en) 2021-10-27
TW202039502A (zh) 2020-11-01
SG11202106582YA (en) 2021-07-29
US20200199131A1 (en) 2020-06-25
JP2022514650A (ja) 2022-02-14
JP2024045155A (ja) 2024-04-02
CL2021001656A1 (es) 2021-12-17
WO2020132197A1 (en) 2020-06-25
IL318278A (en) 2025-03-01
PE20220277A1 (es) 2022-02-25
IL284139B2 (en) 2025-06-01
ECSP21044843A (es) 2021-09-30
IL284139B1 (en) 2025-02-01
IL284139A (en) 2021-08-31
MX2021007426A (es) 2021-09-08
CN114787160A (zh) 2022-07-22
JP7414827B2 (ja) 2024-01-16
JP7723068B2 (ja) 2025-08-13
US11459329B2 (en) 2022-10-04
BR112021011948A2 (pt) 2021-09-08
CN120208959A (zh) 2025-06-27
US12030889B2 (en) 2024-07-09
US20240309008A1 (en) 2024-09-19
MA54551A (fr) 2021-10-27
AU2019401649B2 (en) 2025-08-28
US20220315595A1 (en) 2022-10-06
TWI852968B (zh) 2024-08-21
CN114787160B (zh) 2025-03-25
AU2019401649A1 (en) 2021-07-08
CR20210336A (es) 2021-12-06
PH12021551446A1 (en) 2021-12-06
TW202504901A (zh) 2025-02-01

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