KR20210061397A - 키메라 항원 수용체-변형된 면역 세포의 활성화 및 확장을 위한 단백질 l - Google Patents

키메라 항원 수용체-변형된 면역 세포의 활성화 및 확장을 위한 단백질 l Download PDF

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KR20210061397A
KR20210061397A KR1020217011444A KR20217011444A KR20210061397A KR 20210061397 A KR20210061397 A KR 20210061397A KR 1020217011444 A KR1020217011444 A KR 1020217011444A KR 20217011444 A KR20217011444 A KR 20217011444A KR 20210061397 A KR20210061397 A KR 20210061397A
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cells
car
immune cells
protein
cell
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막심 보디아니크
이단 맥러드
신 장
원 보 왕
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후지필름 셀룰러 다이내믹스, 인코포레이티드
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KR1020217011444A 2018-09-19 2019-09-19 키메라 항원 수용체-변형된 면역 세포의 활성화 및 확장을 위한 단백질 l Pending KR20210061397A (ko)

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US201862733291P 2018-09-19 2018-09-19
US62/733,291 2018-09-19
PCT/US2019/051832 WO2020061256A1 (en) 2018-09-19 2019-09-19 Protein l for activation and expansion of chimeric antigen receptor-modified immune cells

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KR20210061397A true KR20210061397A (ko) 2021-05-27

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US (1) US12533414B2 (https=)
EP (1) EP3853351A1 (https=)
JP (2) JP7716976B2 (https=)
KR (1) KR20210061397A (https=)
CN (1) CN112739816B (https=)
AU (1) AU2019345052B2 (https=)
CA (1) CA3110706A1 (https=)
IL (1) IL281413B2 (https=)
SG (1) SG11202102654UA (https=)
WO (1) WO2020061256A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL297697A (en) * 2020-06-17 2022-12-01 Tiziana Life Sciences Plc Preparations and methods for improving chimeric antigen receptor t cell therapies
WO2022216624A1 (en) 2021-04-07 2022-10-13 Century Therapeutics, Inc. Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells
BR112023018844A2 (pt) 2021-04-07 2023-10-10 Century Therapeutics Inc Composições e métodos para geração de células t gama-delta de células-tronco pluripotentes induzidas
JP7738826B2 (ja) * 2021-10-29 2025-09-16 東ソー株式会社 遺伝子改変t細胞の製造方法
CN113980901B (zh) * 2021-12-28 2022-06-17 上海惠盾因泰生物科技有限公司 一种制备高纯度的成熟人树突状细胞的方法及应用
EP4717765A1 (en) * 2023-05-22 2026-04-01 Kyoto University Method for producing cell population containing cd4 single positive helper t cells from pluripotent stem cells

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1147186A4 (en) 1999-01-28 2002-05-15 Palmetto Health Alliance D B A In vitro activated gamma delta lymphocytes
US20030235908A1 (en) 2000-02-24 2003-12-25 Xcyte Therapies, Inc. Activation and expansion of cells
CA2534639C (en) 2003-07-31 2013-07-30 Immunomedics, Inc. Anti-cd19 antibodies
JP5156382B2 (ja) * 2005-09-30 2013-03-06 タカラバイオ株式会社 T細胞集団の製造方法
US20110158954A1 (en) * 2007-03-09 2011-06-30 Mitsuko Ideno Method for producing gamma delta t cell population
EP2267118A4 (en) * 2008-03-27 2013-08-28 Takara Bio Inc METHOD FOR PRODUCING A TRANSFICED CELL
KR101720961B1 (ko) 2009-02-27 2017-03-29 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 다능성 세포의 분화
JP6509724B2 (ja) 2012-04-20 2019-05-08 アプティーボ リサーチ アンド デベロップメント エルエルシー Cd3結合ポリペプチド
CN102816734A (zh) 2012-05-09 2012-12-12 阮润生 一种肿瘤抗原特异性t细胞的获取方法
MX370148B (es) 2012-10-02 2019-12-03 Memorial Sloan Kettering Cancer Center Composiciones y su uso para inmunoterapia.
JP6961490B2 (ja) * 2015-04-08 2021-11-05 ノバルティス アーゲー Cd20療法、cd22療法、およびcd19キメラ抗原受容体(car)発現細胞との併用療法
WO2017050428A1 (en) * 2015-09-25 2017-03-30 Flechsig Patent Company Llc Novel plant protecting compositions and uses thereof
US10947502B2 (en) 2015-10-20 2021-03-16 FUJIFILM Cellular Dynamics, Inc. Methods for directed differentiation of pluripotent stem cells to immune cells
SG11201803419PA (en) 2015-10-30 2018-05-30 The Regents Of The Universtiy Of California Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
SG11201803145RA (en) * 2015-11-04 2018-05-30 Fate Therapeutics Inc Methods and compositions for inducing hematopoietic cell differentiation
WO2017079400A1 (en) 2015-11-04 2017-05-11 The Trustees Of The University Of Pennsylvania Methods and compositions for gene editing in hematopoietic stem cells
JP7016098B2 (ja) * 2016-03-16 2022-02-21 ネクシミューン インコーポレイテッド 抗原特異的t細胞の生成
EP3548055A4 (en) * 2016-12-02 2020-08-19 University of Southern California SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE
JPWO2021200901A1 (https=) * 2020-03-31 2021-10-07

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