SG11202102654UA - Protein l for activation and expansion of chimeric antigen receptor-modified immune cells - Google Patents

Protein l for activation and expansion of chimeric antigen receptor-modified immune cells

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Publication number
SG11202102654UA
SG11202102654UA SG11202102654UA SG11202102654UA SG11202102654UA SG 11202102654U A SG11202102654U A SG 11202102654UA SG 11202102654U A SG11202102654U A SG 11202102654UA SG 11202102654U A SG11202102654U A SG 11202102654UA SG 11202102654U A SG11202102654U A SG 11202102654UA
Authority
SG
Singapore
Prior art keywords
activation
protein
expansion
immune cells
antigen receptor
Prior art date
Application number
SG11202102654UA
Other languages
English (en)
Inventor
Maksym Vodyanyk
Ethan Mcleod
Xin Zhang
Wen Wang
Original Assignee
Fujifilm Cellular Dynamics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Cellular Dynamics Inc filed Critical Fujifilm Cellular Dynamics Inc
Publication of SG11202102654UA publication Critical patent/SG11202102654UA/en

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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SG11202102654UA 2018-09-19 2019-09-19 Protein l for activation and expansion of chimeric antigen receptor-modified immune cells SG11202102654UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862733291P 2018-09-19 2018-09-19
PCT/US2019/051832 WO2020061256A1 (en) 2018-09-19 2019-09-19 Protein l for activation and expansion of chimeric antigen receptor-modified immune cells

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SG11202102654UA true SG11202102654UA (en) 2021-04-29

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US (1) US12533414B2 (https=)
EP (1) EP3853351A1 (https=)
JP (2) JP7716976B2 (https=)
KR (1) KR20210061397A (https=)
CN (1) CN112739816B (https=)
AU (1) AU2019345052B2 (https=)
CA (1) CA3110706A1 (https=)
IL (1) IL281413B2 (https=)
SG (1) SG11202102654UA (https=)
WO (1) WO2020061256A1 (https=)

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JPWO2024242080A1 (https=) * 2023-05-22 2024-11-28

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