KR20210015770A - 감소된 간 향성을 갖는 AAV9과 AAVrh74의 하이브리드 재조합 아데노-관련 바이러스 세로타입 - Google Patents
감소된 간 향성을 갖는 AAV9과 AAVrh74의 하이브리드 재조합 아데노-관련 바이러스 세로타입 Download PDFInfo
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18305399.0 | 2018-04-05 | ||
| EP18305399 | 2018-04-05 | ||
| PCT/EP2019/058560 WO2019193119A1 (en) | 2018-04-05 | 2019-04-04 | HYBRID RECOMBINANT ADENO-ASSOCIATED VIRUS SEROTYPE BETWEEN AAV9 AND AAVrh74 WITH REDUCED LIVER TROPISM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210015770A true KR20210015770A (ko) | 2021-02-10 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207032024A Ceased KR20210015770A (ko) | 2018-04-05 | 2019-04-04 | 감소된 간 향성을 갖는 AAV9과 AAVrh74의 하이브리드 재조합 아데노-관련 바이러스 세로타입 |
| KR1020217031502A Withdrawn KR20210153047A (ko) | 2018-04-05 | 2019-10-04 | 감소된 간 향성 및 증가된 근육 형질도입을 갖는 AAV9와 AAVrh74 간의 펩티드-변형된 하이브리드 재조합 아데노-관련 바이러스 세로타입 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217031502A Withdrawn KR20210153047A (ko) | 2018-04-05 | 2019-10-04 | 감소된 간 향성 및 증가된 근육 형질도입을 갖는 AAV9와 AAVrh74 간의 펩티드-변형된 하이브리드 재조합 아데노-관련 바이러스 세로타입 |
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| EP (2) | EP3775173A1 (https=) |
| JP (2) | JP7374119B2 (https=) |
| KR (2) | KR20210015770A (https=) |
| CN (2) | CN112004925B (https=) |
| AU (2) | AU2019249890B2 (https=) |
| BR (2) | BR112020020223A2 (https=) |
| CA (2) | CA3093347A1 (https=) |
| IL (2) | IL277740A (https=) |
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| TN (1) | TN2020000187A1 (https=) |
| WO (2) | WO2019193119A1 (https=) |
| ZA (1) | ZA202005422B (https=) |
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| US12466864B2 (en) | 2019-03-25 | 2025-11-11 | Genethon | Production of large-sized quasidystrophins using overlapping AAV vectors |
| CN114127088B (zh) * | 2019-04-23 | 2024-05-14 | 国家医疗保健研究所 | 变体衣壳蛋白和腺相关病毒aav变体及其药物组合物 |
| JP7651562B2 (ja) | 2019-09-19 | 2025-03-26 | ジェネトン | Fkrpの心毒性を軽減する遺伝子治療発現系 |
| AU2020368539A1 (en) | 2019-10-16 | 2022-04-28 | Massachusetts Institute Of Technology | Engineered muscle targeting compositions |
| US12188039B2 (en) | 2019-11-08 | 2025-01-07 | The Board Of Regents Of The University Of Texas System | Recombinant adeno-associated viral vector for gene delivery |
| EP4073257A1 (en) * | 2019-12-09 | 2022-10-19 | UCL Business Ltd | Gene therapy composition and treatment for myh7-linked cardiomyopathy |
| EP4077684A1 (en) | 2019-12-18 | 2022-10-26 | Genethon | Production of recombinant viral vectors from plant hairy roots |
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| CN116322790A (zh) | 2020-06-09 | 2023-06-23 | 吉尼松公司 | 用于治疗扩张型心肌病的nrf2激活剂 |
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| WO2021250076A1 (en) | 2020-06-09 | 2021-12-16 | Genethon | Treatment of genetic dilated cardiomyopathies |
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| CA3187635A1 (en) | 2020-07-03 | 2022-01-06 | Genethon | Method for engineering novel hybrid aav capsids through hypervariable regions swapping |
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| US20240115734A1 (en) * | 2021-02-09 | 2024-04-11 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
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| WO2022226301A1 (en) * | 2021-04-23 | 2022-10-27 | The University Of North Carolina At Chapel Hill | Chimeric heart tropic aav capsids |
| EP4381077A1 (en) | 2021-08-04 | 2024-06-12 | Genethon | Hybrid promoters for gene expression in muscles and in the cns |
| CN115232818B (zh) * | 2021-09-18 | 2025-10-21 | 南京启真基因工程有限公司 | 构建dok7基因突变的先天性肌无力模型猪核移植供体细胞的基因编辑系统及其应用 |
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| CN114276419B (zh) * | 2021-12-30 | 2023-11-17 | 上海勉亦生物科技有限公司 | 肌肉高亲和性的新型腺相关病毒衣壳蛋白及其应用 |
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| WO2025072698A2 (en) * | 2023-09-27 | 2025-04-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Aav9 vectors and capsid polypeptides for use in treating cns disorders |
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| WO2025232917A1 (en) * | 2024-05-10 | 2025-11-13 | Hangzhou Jiayin Biotech Ltd. | Novel liver detargeted aav variants and uses thereof |
| WO2026017727A1 (en) | 2024-07-16 | 2026-01-22 | Genethon | Alternative barcoding method to assess transduction efficiency of aav vectors |
| WO2026041758A1 (en) | 2024-08-22 | 2026-02-26 | Genethon | Modified aav capsid with enhanced transduction efficiency |
| WO2026064736A1 (en) * | 2024-09-23 | 2026-03-26 | Carbon Biosciences, Inc. | Parvovirus compositions and related methods for gene therapy |
| WO2026064739A1 (en) * | 2024-09-23 | 2026-03-26 | Carbon Biosciences, Inc. | Parvovirus compositions and related methods for gene therapy |
| CN120842333A (zh) * | 2025-06-20 | 2025-10-28 | 上海朗昇生物科技有限公司 | 工程化的腺相关病毒衣壳蛋白和载体及其用途 |
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| ES2525067T3 (es) | 2005-04-07 | 2014-12-17 | The Trustees Of The University Of Pennsylvania | Método de incremento de la función de un vector de AAV |
| TR201908020T4 (tr) | 2011-02-17 | 2019-06-21 | Univ Pennsylvania | Doku özgüllüğünü değiştirmek ve aav9-aracılı gen transferini geliştirmek için bileşimler ve yöntemler. |
| MX367100B (es) | 2012-02-17 | 2019-08-05 | The Children´S Hospital Of Philadelphia | Composiciones del vector aav y metodos para su transferencia genetica a celulas, organos y tejidos. |
| NZ701693A (en) | 2012-04-18 | 2017-02-24 | The Children’S Hospital Of Philadelphia | Composition and methods for highly efficient gene transfer using aav capsid variants |
| EP2660325A3 (en) | 2012-05-02 | 2014-02-12 | Christian Medical College | AAV vectors and corresponding nucleotide sequences and methods |
| HK1220488A1 (zh) * | 2013-03-15 | 2017-05-05 | The Children's Hospital Of Philadelphia | 含有填充者/填充物多核苷酸序列的载体及其使用方法 |
| MX388221B (es) * | 2013-04-20 | 2025-03-19 | Res Institute At Nationwide Children´S Hospital | ADMINISTRACIÓN DE VIRUS ADENO-ASOCIADO RECOMBINANTE DE CONSTRUCCIONES DE POLINUCLÉOTIDOS U7snRNA DIRIGIDA AL EXÓN 2. |
| HK1222673A1 (zh) | 2013-07-12 | 2017-07-07 | The Children's Hospital Of Philadelphia | Aav载体和用於抗aav(腺相关病毒)中和抗体的检测 |
| IL297919A (en) | 2013-07-22 | 2023-01-01 | Childrens Hospital Philadelphia | Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues |
| EP3151866B1 (en) | 2014-06-09 | 2023-03-08 | Voyager Therapeutics, Inc. | Chimeric capsids |
| AU2015320694B2 (en) | 2014-09-24 | 2021-11-11 | City Of Hope | Adeno-associated virus vector variants for high efficiency genome editing and methods thereof |
| EP3384034B1 (en) | 2015-12-02 | 2020-07-08 | The Board of Trustees of the Leland Stanford Junior University | Novel recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism |
| WO2017161273A1 (en) | 2016-03-18 | 2017-09-21 | The Children's Hospital Of Philadelphia | Therapeutic for treatment of diseases including the central nervous system |
| IL305149A (en) * | 2016-07-26 | 2023-10-01 | Biomarin Pharm Inc | Novel adeno-associated virus capsid proteins |
| MX2020010465A (es) * | 2018-04-03 | 2021-01-08 | Vectores de virus para direccionamiento a tejidos oftalmicos. |
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| MA51353B1 (fr) | 2022-09-30 |
| AU2019249890B2 (en) | 2024-10-10 |
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| US12037362B2 (en) | 2024-07-16 |
| RU2020136195A (ru) | 2022-05-06 |
| MA51353A1 (fr) | 2021-09-30 |
| CA3134183A1 (en) | 2020-10-08 |
| ZA202005422B (en) | 2023-03-29 |
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| US20210107948A1 (en) | 2021-04-15 |
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| CN112004925A (zh) | 2020-11-27 |
| US20240317814A1 (en) | 2024-09-26 |
| TN2020000187A1 (en) | 2022-04-04 |
| IL277740A (en) | 2020-11-30 |
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