ZA202005422B - Hybrid recombinant adeno-associated virus serotype between aav9 and aavrh74 with reduced liver tropism - Google Patents

Hybrid recombinant adeno-associated virus serotype between aav9 and aavrh74 with reduced liver tropism

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Publication number
ZA202005422B
ZA202005422B ZA2020/05422A ZA202005422A ZA202005422B ZA 202005422 B ZA202005422 B ZA 202005422B ZA 2020/05422 A ZA2020/05422 A ZA 2020/05422A ZA 202005422 A ZA202005422 A ZA 202005422A ZA 202005422 B ZA202005422 B ZA 202005422B
Authority
ZA
South Africa
Prior art keywords
aavrh74
aav9
associated virus
recombinant adeno
virus serotype
Prior art date
Application number
ZA2020/05422A
Other languages
English (en)
Inventor
Isabelle Richard
Evelyne Gicquel
Mingozzi Federico
Original Assignee
Genethon
Inst Nat Sante Rech Med
Univ Devry Val Dessonne
Univ Sorbonne
Association Inst De Myologie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genethon, Inst Nat Sante Rech Med, Univ Devry Val Dessonne, Univ Sorbonne, Association Inst De Myologie filed Critical Genethon
Publication of ZA202005422B publication Critical patent/ZA202005422B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14171—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA2020/05422A 2018-04-05 2020-08-31 Hybrid recombinant adeno-associated virus serotype between aav9 and aavrh74 with reduced liver tropism ZA202005422B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18305399 2018-04-05
PCT/EP2019/058560 WO2019193119A1 (en) 2018-04-05 2019-04-04 HYBRID RECOMBINANT ADENO-ASSOCIATED VIRUS SEROTYPE BETWEEN AAV9 AND AAVrh74 WITH REDUCED LIVER TROPISM

Publications (1)

Publication Number Publication Date
ZA202005422B true ZA202005422B (en) 2023-03-29

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ZA2020/05422A ZA202005422B (en) 2018-04-05 2020-08-31 Hybrid recombinant adeno-associated virus serotype between aav9 and aavrh74 with reduced liver tropism

Country Status (13)

Country Link
US (3) US12037362B2 (https=)
EP (2) EP3775173A1 (https=)
JP (2) JP7374119B2 (https=)
KR (2) KR20210015770A (https=)
CN (2) CN112004925B (https=)
AU (2) AU2019249890B2 (https=)
BR (2) BR112020020223A2 (https=)
CA (2) CA3093347A1 (https=)
IL (2) IL277740A (https=)
MA (1) MA51353B1 (https=)
TN (1) TN2020000187A1 (https=)
WO (2) WO2019193119A1 (https=)
ZA (1) ZA202005422B (https=)

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CA3093347A1 (en) 2019-10-10
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