KR20200013758A - 피라졸로피리미딘 pde9 억제제 - Google Patents

피라졸로피리미딘 pde9 억제제 Download PDF

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Publication number
KR20200013758A
KR20200013758A KR1020207000123A KR20207000123A KR20200013758A KR 20200013758 A KR20200013758 A KR 20200013758A KR 1020207000123 A KR1020207000123 A KR 1020207000123A KR 20207000123 A KR20207000123 A KR 20207000123A KR 20200013758 A KR20200013758 A KR 20200013758A
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KR
South Korea
Prior art keywords
ethyl
pyrimidine
pyrazolo
oxo
carbonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
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KR1020207000123A
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English (en)
Korean (ko)
Inventor
아쇽 아라사판
제이슨 엠. 콕스
존 에스. 디벤햄
주얀 구아
지아팡 헤
자히드 후세인
종 라이
더룬 리
동팡 멩
수바레카 라가반
스리람 티아가라잔
Original Assignee
머크 샤프 앤드 돔 코포레이션
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Publication of KR20200013758A publication Critical patent/KR20200013758A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020207000123A 2017-06-08 2018-06-06 피라졸로피리미딘 pde9 억제제 Withdrawn KR20200013758A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762516903P 2017-06-08 2017-06-08
US62/516,903 2017-06-08
US201862665840P 2018-05-02 2018-05-02
US62/665,840 2018-05-02
PCT/US2018/036172 WO2018226771A1 (en) 2017-06-08 2018-06-06 Pyrazolopyrimidine pde9 inhibitors

Publications (1)

Publication Number Publication Date
KR20200013758A true KR20200013758A (ko) 2020-02-07

Family

ID=62779024

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207000123A Withdrawn KR20200013758A (ko) 2017-06-08 2018-06-06 피라졸로피리미딘 pde9 억제제

Country Status (13)

Country Link
US (2) US10934294B2 (https=)
EP (1) EP3634964B1 (https=)
JP (1) JP2020523309A (https=)
KR (1) KR20200013758A (https=)
CN (1) CN111051308A (https=)
AU (1) AU2018281131B2 (https=)
BR (1) BR112019025813A2 (https=)
CA (1) CA3064938A1 (https=)
MA (1) MA53841A (https=)
MX (1) MX2019014597A (https=)
RU (1) RU2019144010A (https=)
TW (1) TW201902898A (https=)
WO (1) WO2018226771A1 (https=)

Cited By (1)

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KR20230022982A (ko) * 2020-06-15 2023-02-16 노파르티스 아게 Cav1.2 활성제로서의 메틸 2-(플루오로메틸)-5-옥소-4-페닐-4,5,6,7-테트라하이드로-1h-시클로펜타[b]피리딘-3-카르복실레이트 및 메틸 2-(플루오로메틸)-5-옥소-4-페닐-1,4,5,7-테트라하이드로푸로[3,4-b]피리딘-3-카르복실레이트

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RU2019144010A (ru) * 2017-06-08 2021-07-13 Мерк Шарп И Доум Корп. Пиразолопиримидиновые ингибиторы pde9
EP3893881B1 (en) * 2018-12-12 2024-10-09 Merck Sharp & Dohme LLC Cyclobutyl pyrazolopyrimidine pde9 inhibitors
WO2020123272A1 (en) * 2018-12-12 2020-06-18 Merck Sharp & Dohme Corp. Pyrazolopyrimidine pde9 inhibitors
SG11202109781QA (en) 2019-03-08 2021-10-28 Transthera Sciences Nanjing Inc Uses of phosphodiesterase inhibitors
CN114773256B (zh) * 2022-03-23 2024-05-03 中国农业大学 一种4-氰基哌啶的合成方法
CN117582909B (zh) * 2024-01-19 2024-04-02 天津凯莱英医药科技发展有限公司 一种连续生产5-单硝酸异山梨酯的系统和方法
CN120329388B (zh) * 2025-04-30 2025-09-26 中日友好医院(中日友好临床医学研究所) 一种双靶点多肽及其在心衰治疗中的应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230022982A (ko) * 2020-06-15 2023-02-16 노파르티스 아게 Cav1.2 활성제로서의 메틸 2-(플루오로메틸)-5-옥소-4-페닐-4,5,6,7-테트라하이드로-1h-시클로펜타[b]피리딘-3-카르복실레이트 및 메틸 2-(플루오로메틸)-5-옥소-4-페닐-1,4,5,7-테트라하이드로푸로[3,4-b]피리딘-3-카르복실레이트

Also Published As

Publication number Publication date
US11028092B2 (en) 2021-06-08
US10934294B2 (en) 2021-03-02
BR112019025813A2 (pt) 2020-07-07
RU2019144010A (ru) 2021-07-13
AU2018281131B2 (en) 2022-01-20
US20180354955A1 (en) 2018-12-13
RU2019144010A3 (https=) 2021-10-01
EP3634964B1 (en) 2022-02-23
US20200140445A1 (en) 2020-05-07
CN111051308A (zh) 2020-04-21
WO2018226771A1 (en) 2018-12-13
MA53841A (fr) 2021-09-22
TW201902898A (zh) 2019-01-16
CA3064938A1 (en) 2018-12-13
EP3634964A1 (en) 2020-04-15
JP2020523309A (ja) 2020-08-06
AU2018281131A1 (en) 2019-12-05
MX2019014597A (es) 2020-02-05

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