CN111051308A - 吡唑并嘧啶pde9抑制剂 - Google Patents

吡唑并嘧啶pde9抑制剂 Download PDF

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Publication number
CN111051308A
CN111051308A CN201880037972.4A CN201880037972A CN111051308A CN 111051308 A CN111051308 A CN 111051308A CN 201880037972 A CN201880037972 A CN 201880037972A CN 111051308 A CN111051308 A CN 111051308A
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CN
China
Prior art keywords
ethyl
pyrimidine
pyrazolo
dihydro
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880037972.4A
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English (en)
Chinese (zh)
Inventor
A·阿拉萨潘
J·M·科克斯
J·S·德本汉姆
郭竹艳
贺家芳
Z·侯赛因
赖中
李德润
孟东方
S·拉格哈范
S·特亚加亚詹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of CN111051308A publication Critical patent/CN111051308A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880037972.4A 2017-06-08 2018-06-06 吡唑并嘧啶pde9抑制剂 Pending CN111051308A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762516903P 2017-06-08 2017-06-08
US62/516,903 2017-06-08
US201862665840P 2018-05-02 2018-05-02
US62/665,840 2018-05-02
PCT/US2018/036172 WO2018226771A1 (en) 2017-06-08 2018-06-06 Pyrazolopyrimidine pde9 inhibitors

Publications (1)

Publication Number Publication Date
CN111051308A true CN111051308A (zh) 2020-04-21

Family

ID=62779024

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880037972.4A Pending CN111051308A (zh) 2017-06-08 2018-06-06 吡唑并嘧啶pde9抑制剂

Country Status (13)

Country Link
US (2) US10934294B2 (https=)
EP (1) EP3634964B1 (https=)
JP (1) JP2020523309A (https=)
KR (1) KR20200013758A (https=)
CN (1) CN111051308A (https=)
AU (1) AU2018281131B2 (https=)
BR (1) BR112019025813A2 (https=)
CA (1) CA3064938A1 (https=)
MA (1) MA53841A (https=)
MX (1) MX2019014597A (https=)
RU (1) RU2019144010A (https=)
TW (1) TW201902898A (https=)
WO (1) WO2018226771A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114773256A (zh) * 2022-03-23 2022-07-22 中国农业大学 一种4-氰基哌啶的合成方法
CN117582909A (zh) * 2024-01-19 2024-02-23 天津凯莱英医药科技发展有限公司 一种连续生产5-单硝酸异山梨酯的系统和方法
CN120329388A (zh) * 2025-04-30 2025-07-18 中日友好医院(中日友好临床医学研究所) 一种双靶点多肽及其在心衰治疗中的应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2019144010A (ru) * 2017-06-08 2021-07-13 Мерк Шарп И Доум Корп. Пиразолопиримидиновые ингибиторы pde9
EP3893881B1 (en) * 2018-12-12 2024-10-09 Merck Sharp & Dohme LLC Cyclobutyl pyrazolopyrimidine pde9 inhibitors
WO2020123272A1 (en) * 2018-12-12 2020-06-18 Merck Sharp & Dohme Corp. Pyrazolopyrimidine pde9 inhibitors
SG11202109781QA (en) 2019-03-08 2021-10-28 Transthera Sciences Nanjing Inc Uses of phosphodiesterase inhibitors
WO2021253180A1 (en) * 2020-06-15 2021-12-23 Novartis Ag Methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-4, 5, 6, 7-tetrahydro-1h-cyclopenta [b] pyridine-3-carboxylate and methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-1, 4, 5, 7-tetrahydrofuro [3, 4-b] pyridine-3-carboxylate as cav1.2 activators

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114773256A (zh) * 2022-03-23 2022-07-22 中国农业大学 一种4-氰基哌啶的合成方法
CN114773256B (zh) * 2022-03-23 2024-05-03 中国农业大学 一种4-氰基哌啶的合成方法
CN117582909A (zh) * 2024-01-19 2024-02-23 天津凯莱英医药科技发展有限公司 一种连续生产5-单硝酸异山梨酯的系统和方法
CN117582909B (zh) * 2024-01-19 2024-04-02 天津凯莱英医药科技发展有限公司 一种连续生产5-单硝酸异山梨酯的系统和方法
CN120329388A (zh) * 2025-04-30 2025-07-18 中日友好医院(中日友好临床医学研究所) 一种双靶点多肽及其在心衰治疗中的应用
CN120329388B (zh) * 2025-04-30 2025-09-26 中日友好医院(中日友好临床医学研究所) 一种双靶点多肽及其在心衰治疗中的应用

Also Published As

Publication number Publication date
US11028092B2 (en) 2021-06-08
US10934294B2 (en) 2021-03-02
BR112019025813A2 (pt) 2020-07-07
RU2019144010A (ru) 2021-07-13
AU2018281131B2 (en) 2022-01-20
US20180354955A1 (en) 2018-12-13
RU2019144010A3 (https=) 2021-10-01
EP3634964B1 (en) 2022-02-23
US20200140445A1 (en) 2020-05-07
WO2018226771A1 (en) 2018-12-13
MA53841A (fr) 2021-09-22
TW201902898A (zh) 2019-01-16
CA3064938A1 (en) 2018-12-13
EP3634964A1 (en) 2020-04-15
JP2020523309A (ja) 2020-08-06
AU2018281131A1 (en) 2019-12-05
KR20200013758A (ko) 2020-02-07
MX2019014597A (es) 2020-02-05

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