KR20200009824A - An anti-drunkenness and hangover-alleviating composition and its preparation method - Google Patents

Abstract

The present invention relates to a composition for removing drunkenness and alleviating hangover and to a production method thereof. The composition for removing drunkenness and alleviating hangover comprises a major ingredient including one or more selected from a flavanone extract of the whole watermelon skin, a flavanone extract of the whole Moutan Radicis Cortex and a flavanone extract of the whole Schisandra chinensis.

Description

{An anti-drunkenness and hangover-alleviating composition and its preparation method}

The present invention relates to the pharmaceutical field, in particular to compositions having anti-drunkenness and hangover-alleviating functions and methods for their preparation.

Moderate drinking is beneficial to a person's physical health. However, excessive drinking can cause odor and dizziness, headaches, hangovers, and the appearance of rude behavior after drinking, and can affect normal work and interpersonal relationships. More seriously, excessive drinking can also damage body tissues and organs. For example, persistent excessive drinking can damage liver cells, interfere with normal metabolism of the liver, and can further cause alcoholic hepatitis and cirrhosis. In addition, frequent drinking may lead to alcohol dependence, that is, various uncomfortable physical symptoms will occur after sudden stop drinking or reducing alcohol intake, also known as alcohol withdrawal syndrome.

Thus, a person adopts various methods to alleviate the inconvenience caused by drinking, and there are also many commercially available products on the market, but most products have an inaccurate therapeutic effect.

In order to solve the above problems, the present invention proposes a new odor-removing and hangover-releasing composition based on a number of experiments. The composition can significantly improve the drinking threshold value of the drinker, can prevent physical discomfort such as dizziness, uncontrollable behaviors caused by odor and odor, and prevent alcohol withdrawal syndrome of the subject Can be mitigated. The composition also contains a liver-protective component that can promote the breakdown of alcohol and mitigate the damage of alcohol in liver cells, and is an ideal odor-removing and hangover-releasing product.

Summary of the Invention

In order to achieve the above technical object, the present invention adopts the following technical solution:

The odor-removing and hangover-releasing composition comprises at least one selected from flavanone extract of whole watermelon peel, flavanone extract of whole Cortex Moutan and flavanone extract of whole Schisandra chinensis. Contains the main ingredient.

Preferably, the main component comprises 0-40 parts by weight of flavanone extract of the whole watermelon peel, 0-40 parts by weight of flavanone extract of the whole bark and 20-100 parts by weight of flavanone extract of the whole Schisandra chinensis.

Preferably, the total flavanone content in the flavanone extract of the whole watermelon peel is> 50%, the total flavanone content in the flavanone extract of the whole bark skin is> 80%, and the total flavanone content in the flavanone extract of the whole Schizandra chinensis Is> 80%.

The flavanone extract of the whole watermelon peel, the flavanone extract of the whole bark, and the flavanon extract of the whole Schisandra chinensis were prepared by the following method:

Pulverizing watermelon peel, bark skin and schizandra; Extracting the milled product with water or ethanol, respectively, at a concentration of less than 70%; Recovering the extracted solution; Centrifuging; Performing extraction, macroporous resin column chromatography or recrystallization; Vacuum drying at 40-50 ° C .; And detecting to ensure that the contents of each extract meet the requirements.

The odor-removing and hangover-releasing composition of the present invention further comprises an auxiliary component comprising one or more selected from β-cyclodextrin, maltodextrin and stevioside.

Preferably, the weight ratio of the main component and the auxiliary component is 1: (0-3).

The present invention also discloses a method of preparing a composition for odor-removing and hangover-relieving, comprising the following steps:

(1) crushed watermelon peel, bark skin and schizandra; The ground product was extracted with water or ethanol, respectively, at a concentration of less than 70%; Recovering the extracted solution; Centrifugation; Extraction, sedimentation, macroporous resin column chromatography or recrystallization; Vacuum dried at 40-50 ° C .; Detection to obtain that the content of each extract satisfies the requirements to obtain a flavanone extract of the whole watermelon peel, a flavanone extract of the whole bark and a flavanone extract of the whole Schisandra chinensis; Milling each extract and sieving with a 60-mesh sieve;

(2) Weighing 0-40 parts by weight of flavanone extract of whole watermelon peel, 0-40 parts by weight of flavanone extract of whole Schisandra chinensis, and 20-100 parts by weight of flavanone extract of whole Schisandra chinensis, and mixing them uniformly To obtain a main component;

(3) 0-100 parts by weight of β-cyclodextrin and 0-100 parts by weight of maltodextrin, weighed and mixed uniformly with the main components, and repeatedly grinding by adding 10-50% water based on the total weight. ), Vacuum dried, milled and sieved to a 60-mesh sieve; And

(4) Add 0-20 parts by weight of stevioside, mix uniformly, sterilize, pelletize, and prepare into capsules, tablets or electuary.

The odor-removing and hangover-releasing composition described in the present invention comprises Schizandra as a main component and watermelon peel and Schizandra as auxiliary components. Based on the observation of the effect on volunteers, the compositions for odor-removing and hangover-relieving are proven to have an effect of improving drinking thresholds and alleviating or reducing drinking symptoms.

Hereinafter, the present invention will be further described in combination with specific examples, but the present invention will not be limited to these examples.

Example 1

Preparation of Flavanone Extract of Whole Watermelon Peel, Flavanone Extract of Whole Bark Skin and Flavanone Extract of Schizandra chinensis

The flavanone extract of the entire watermelon peel is crushed watermelon peel; The crushed watermelon skin was heated to reflux with 60% ethanol; Recovering the extracted solution; Centrifugation; Supernatant is collected; Macroporous resin column chromatography is performed to obtain a whole flavone concentrated portion; Recover the solvent; Concentrate; Vacuum dried at 40-50 ° C .; Prepared by detection to confirm that the total flavone content is> 50%.

Flavanone extracts of the whole bark of the subject pulverize the bark; The pulverized neck skin was ultrasonically extracted with 40% ethanol; Recovering the extracted solution; Centrifugation; Supernatant is collected; Extraction with ethyl acetate is carried out to obtain the entire flavone concentrate; Recover the solvent; Concentrate; Vacuum dried at 40-50 ° C .; Prepared by detection to confirm that the total flavone content is> 80%.

Flavanone extracts of the whole Schizandra chinensis are crushed Schizandra; Milled Schizandra chinensis was heated to reflux with 60% ethanol; Recovering the extracted solution; Centrifugation; Supernatant is collected; Recrystallization is carried out to obtain a whole flavone enriched portion; Vacuum dried at 40-50 ° C .; Prepared by detection to confirm that the total flavone content is> 80%.

Example 2

The odor-removing and hangover-releasing capsules include, as main components, flavanon extracts of whole watermelon peel, flavanon extracts of whole bark, and flavanon extracts of whole Schisandra chinensis, and β-cyclodextrin as a secondary component; It is prepared through the following steps:

(1) Weighing 500 g of flavanone extract of whole Purerariae lobatae, 500 g of flavanone extract of whole bark skin prepared in Example 1, and 5000 g of flavanone extract of whole Schisandra chinensis, pulverized, and sieved with a 60-mesh sieve; Weighing 4000 g β-cyclodextrin and mixing the materials uniformly.

(2) adding 3000 ml of water, grinding repeatedly, vacuum drying at 40-50 ° C. until the moisture content is <5%, pulverizing and sieving with a 60-mesh sieve;

(3) after performing sterilization, pelletizing in an environment of 20-40% humidity to obtain 20-40 mesh of particles; And

(4) filling the capsules with the particles under an environment having a humidity of 50% or less to obtain capsules each having a weight of 0.5 g.

Method of administration and dose: Oral administration, 2 capsules each time, 30 minutes before drinking with warm water.

Example 3

The odor-removing and hangover-relieving softeners include flavanone extracts of whole Schisandra chinensis as main components and β-cyclodextrin, maltodextrin and stevioside as auxiliary components; Prepared through the following steps:

(1) Weighing 5000 g of the total flavanone extract prepared in Example 1, weighing 5000 g of β-cyclodextrin and 5000 g of maltodextrin and mixing the materials uniformly.

(2) adding 5000 ml of water, grinding repeatedly, vacuum drying at 40-50 ° C. until the moisture content is <5%, grinding and sieving with a 60-mesh sieve;

(3) adding 1000 g of stevioside, mixing uniformly, and performing sterilization, then pelletizing in an environment of 20-40% humidity to obtain 20-40 mesh of particles; And

(4) filling the bags into bags under an environment having a humidity of 50% or less to obtain a sealed softener having a weight of 2 g each.

Method of administration and dose: Oral administration, 2 bags each time, 30 minutes after drinking or after drinking (after the soft solution is dissolved in boiled water).

Example 4

Odor-removing and hangover-relieving tablets include, as main components, flavanone extracts of whole bark skin and flavanone extracts of whole Schisandra chinensis, and β-cyclodextrin and maltodextrin as auxiliary components; Prepared through the following steps:

(1) Weigh 300 g of the entire flavonone extract and 2500 g of the whole flavonone extract prepared in Example 1; Weighing 2500 g of β-cyclodextrin and 2500 g of maltodextrin and mixing the materials uniformly.

(2) after performing sterilization, pelletizing in an environment of 20-40% humidity to obtain 20-40 mesh of particles; Tableting to obtain each tablet having a weight of 0.3 g.

Dosage method and dose: Oral administration, 2-3 tablets each time, 30 minutes before or after drinking.

Test Example 1

Observation on the effect of the odor-removing hangover-releasing capsule prepared in Example 2

Capsules were tested by 30 volunteers. They were given two capsules 30 minutes before drinking and dizziness and drinking symptoms were observed after drinking. All 30 volunteers gave the following feedback: Capsules were effective, could significantly increase the amount of alcohol causing alcohol drinkers, dizziness and control-induced behaviors caused by alcohol and alcohol The discomfort of the body could be prevented. Typical examples are as follows:

A 40-year-old male volunteer (Shen's last name), who usually had dizziness after drinking a small amount of beer, received two capsules 30 minutes before drinking, dizziness after drinking 52 g of 100% white wine. Did not detect it.

A 22-year-old male volunteer (having Fu's last name), who usually had dizziness after drinking four bottles of beer, received two capsules 30 minutes before drinking, and had dizziness after drinking seven bottles of beer. Did not detect.

Test Example 2

Observation on the effect of the odor-removing hangover-relaxing softener prepared in Example 3.

The soft was tested by five volunteers. After detecting dizziness caused by alcohol, they received two bags of soft medicine and alleviated dizziness symptoms. All five volunteers gave feedback: weakness was effective, relieved dizziness and shortened drinking time.

Test Example 3

Observation on the effect of the odor-removing hangover-relieving tablet prepared in Example 4

Capsules were tested by 16 volunteers. They were given two capsules 30 minutes before drinking and dizziness and drinking symptoms were observed after drinking. Of these, 15 volunteers gave feedback: tablets were effective, could significantly increase the amount of alcohol that causes the drinker's drinking, and increased the body's body, such as dizziness and loss of control-induced behavior caused by drinking and drinking. Discomfort could be prevented. Typical examples are as follows:

A 31-year-old male volunteer (with Gao's last name), who usually drank a lot of alcohol and immediately detected dizziness, was given two tablets 30 minutes before drinking and 52% of 100% white wine. Did not detect dizziness.

A 36-year-old male volunteer (who had sex with Zhang) who had dizziness after drinking a maximum of one bottle of beer without drinking white wine at all, received two tablets 30 minutes before drinking, 52% After drinking 100g of white wine, did not detect dizziness.

Claims (7)

Anti-deodorant comprising an active ingredient comprising one or more selected from flavanone extract of whole watermelon peel, flavanone extract of whole Cortex Moutan and flavanone extract of whole Schisandra chinensis drunkenness and hangover-alleviating composition.
According to claim 1, wherein the main ingredient is a flavour-containing 0-40 parts by weight of flavanon extract of the whole watermelon peel, 0-40 parts by weight of flavanone extract of the whole bark skin and 20-100 parts by weight of flavanone extract of the whole Schisandra chinensis Removal and hangover-relieving composition.
The total flavanone content of the flavanone extract of the whole watermelon peel is> 50%, the total flavanone content of the flavanone extract of the whole bark skin is> 80%, and the whole of Schisandra chinensis The total flavanone content in the flavanone extract is> 80%.
The odor-removing and hangover-relieving composition according to claim 3, wherein the flavanone extract of the whole watermelon peel, the flavanone extract of the whole bark and the whole flavanone extract of Schizandra chinensis are prepared by the following method:
Pulverizing watermelon peel, bark skin and schizandra; Extracting the pulverized resultant with water or ethanol, respectively, at a concentration of less than 70%; Recovering the extracted solution; Centrifuging; Performing extraction, macroporous resin column chromatography or recrystallization; Vacuum drying at 40-50 ° C .; And detecting to confirm that the content of each extract meets the requirements.
4. The odor-removing agent of claim 3, further comprising an adjuvant ingredient comprising at least one selected from β-cyclodextrin, maltodextrin and stevioside. And hangover-relieving compositions.
The composition for odor-removing and hangover-relieving according to claim 5, wherein the weight ratio of the main component and the auxiliary component is 1: (0-3).
A method for preparing a odor-removing and hangover-releasing composition comprising the following steps:
(1) crushed watermelon peel, bark skin and schizandra; The ground product was extracted with water or ethanol, respectively, at a concentration of less than 70%; Recovering the extracted solution; Centrifugation; Extraction, macroporous resin column chromatography or recrystallization is carried out; Vacuum dried at 40-50 ° C .; Detecting to obtain that the content of each extract satisfies the requirements to obtain a flavanone extract of the whole watermelon peel, a flavanone extract of the whole bark and a flavanone extract of the whole Schisandra chinensis; Milling each extract and sieving with a 60-mesh sieve;
(2) Weighing 0-04 parts by weight of flavanone extract of whole watermelon peel, 0-40 parts by weight of flavanone extract of whole Schisandra chinensis, and 20-100 parts by weight of flavanone extract of whole Schisandra chinensis, and mixing them uniformly To obtain a main component;
(3) Weighing 0-100 parts by weight of β-cyclodextrin and 0-100 parts by weight of maltodextrin, mixing them uniformly with the main ingredients, and repeatedly grinding by adding 10-50% water based on the total weight. ), Vacuum dried, milled and sieved to a 60-mesh sieve; And
(4) Add 0-20 parts by weight of stevioside, mix uniformly, sterilize, pelletize, and prepare into capsules, tablets or electuary.