KR20230058792A - An anti-drunkenness and hangover-alleviating composition and its preparation method - Google Patents

Abstract

According to the present invention, disclosed are an anti-intoxication and hangover-alleviating composition and a manufacturing method thereof. The main ingredient includes one or more selected from a bezoa total flavanone extract, a pseudoginseng total flavanone extract, and a green tea total flavanone extract. The anti-intoxication and hangover-alleviating composition improves an intoxication threshold and alleviates or reduces the symptoms of intoxication.

Description

An anti-drunkenness and hangover-alleviating composition and its preparation method}

The present invention relates to the field of medicine, particularly to a composition having anti-drunk and hangover-relieving functions and a method for preparing the same.

Moderate drinking is beneficial to people's physical health. However, excessive drinking causes drunkenness, dizziness, headache, hangover, and misbehavior after drinking, which can interfere with normal work and interpersonal communication. Even worse, excessive drinking can damage body tissues and organs. For example, continuous heavy drinking can damage liver cells and disrupt normal metabolism in the liver, leading to alcoholic hepatitis and cirrhosis. Also, frequent drinking can lead to alcohol dependence. In other words, when you suddenly stop drinking or reduce the amount of drinking, various unpleasant physical symptoms appear, which is also called alcohol withdrawal syndrome.

Therefore, people use various methods to alleviate the discomfort caused by drinking, and there are many corresponding products on the market. However, most products have imprecise therapeutic effects.

In order to solve the above problems, the present invention proposes a new anti-drunk and hangover-relieving composition through many experiments. The composition can significantly improve the intoxication threshold of a drinker, prevent intoxication and physical discomfort such as dizziness and uncontrollable behavior due to intoxication, and alleviate alcohol withdrawal syndrome in a subject. In addition, the composition is an ideal anti-drunk and anti-hangover product, including a liver-protecting component capable of accelerating the decomposition of alcohol and mitigating the damage of alcohol to hepatocytes.

To achieve the above technical objectives, the present invention adopts the following technical solutions:

The composition for anti-drinking and relieving hangover is selected from Bezoar total flavanone extract, pseudo-ginseng total flavanone extract, and green tea total flavanone extract. contain one or more as main constituents.

Preferably, the main ingredients include bezoa total flavanone extract 0-40, ginseng total flavanone extract 0-40 and green tea total flavanone extract 20-100 by weight part.

Preferably, the total flavanone content of the bezoa total flavanone extract is >50%, the total flavanone content of the pseudoginseng total flavanone extract is >80%, and the total flavanone content of the green tea total flavanone extract is > It is 80%.

Bezoa total flavanone extract, pseudoginseng total flavanone extract and green tea total flavanone extract were prepared by the following methods:

Grinding bezoa, pseudo ginseng and green tea; Extracting the pulverized product with water or ethanol at a concentration of less than 70%, respectively; recovering the extracted solution; centrifugation step; performing extraction, macroporous resin column chromatography or recrystallization; vacuum drying at 40-50 ° C; and inspecting to ensure that the content of each extract meets the requirements.

The anti-drunk and hangover-relieving composition of the present invention further includes an auxiliary component including at least one selected from β-cyclodextrin, maltodextrin, and stevioside.

Preferably, the weight ratio of the main component to the auxiliary component is 1:(0-3).

The present invention also discloses a method for preparing an anti-drunk and hangover-relieving composition comprising the following steps:

(1) crushing bezoa, ginseng pseudoginseng and green tea; Extracting the pulverized product with water or ethanol at a concentration of less than 70%, respectively; recovering the extracted solution; centrifuged; performing extraction, sedimentation, macroporous resin column chromatography or recrystallization; vacuum drying at 40-50 ° C; verifying whether the content of each extract meets the requirements to obtain bezoa total flavanone extract, pseudoginseng total flavanone extract and green tea total flavanone extract; And crushing each extract and sieving through a 60 mesh sieve;

(2) weighing 0-40 parts of bezoa total flavanone extract, 0-40 green tea total flavanone extract and 20-100 green tea total flavanone extract by weight, and mixing them uniformly to obtain a main component;

(3) Weigh 0-100 β-cyclodextrin and 0-100 maltodextrin by weight, mix them uniformly with the main component, add 10-50% of water based on the total weight, and grind, vacuum dry, and grind and sieving through a 60 mesh sieve; and

(4) Adding 0 to 20 parts by weight of stevioside, mixing uniformly, sterilizing, and pelletizing to prepare capsules, tablets or soft medicines.

The anti-drunk and hangover-relieving composition according to the present invention contains green tea as a main component and the bezoa and green tea as auxiliary components. As a result of observing the effect on volunteers, it was proved that the anti-drunk and hangover-relieving composition has an effect of improving the threshold of intoxication and alleviating or reducing symptoms of intoxication.

Hereinafter, the present invention will be further described with reference to specific examples, but the present invention is not limited to these examples.

Example 1

The preparation of Bezoar total flavanone extract, Pseudo-ginseng total flavanone extract and Green tea total flavanone extract

The desired bezoa total flavanone extract is:

crushing bezoa; The pulverized bezoa was extracted by heating under reflux with 60% ethanol; recovering the extracted solution; centrifuged; Collect the supernatant; Macroporous resin column chromatography was performed to obtain total flavone enrichment fractions; recover the solvent; concentrate; vacuum dried at 40-50° C.; It is prepared by a step of testing to ensure that the total flavone content is >50%.

The target ginseng-like total flavanone extract is:

Grinding pseudo ginseng; Ultrasonic extraction of pulverized pseudo ginseng with 40% ethanol; recovering the extracted solution; centrifuged; Collect the supernatant; Extraction with ethyl acetate to obtain total flavone enrichment; recover the solvent; concentrate; vacuum dried at 40-50° C.; and testing to ensure that the total flavone content is >80%.

The desired green tea total flavanone extract is:

grinding green tea; The ground green tea was extracted by heating under reflux with 60% ethanol; recovering the extracted solution; centrifuged; Collect the supernatant; Recrystallization is performed to obtain the total flavone enrichment fraction; vacuum dried at 40-50°C; and testing to ensure that the total flavone content is >80%.

Example 2

Anti-drunk and hangover-relieving capsules containing bezoa total flavanone extract, pseudoginseng total flavanone extract and green tea total flavanone extract as main components and beta-cyclodextrin as auxiliary ingredient are prepared through the following steps:

(1) 500 g of the total flavanone extract of Bezoa, 500 g of the total flavanone extract of Panax ginseng, and 5000 g of total flavanone extract of green tea prepared in Example 1 were weighed and ground, and sieved through a 60 mesh; Weighing 4000 g of β-cyclodextrin and uniformly mixing the above materials;

(2) adding 3000 ml of water, repeating grinding, vacuum drying at 40-50° C. until the moisture content is <5%, crushing, and sieving through a 60 mesh sieve;

(3) sterilization and then pelletizing in a 20-40% humidity environment to obtain particles of 20-40 mesh; and

(4) obtaining capsules each weighing 0.5 g by filling the particles into capsules in an environment of 50% or less humidity.

Administration method and usage: Oral administration, 2 capsules at a time, administration with warm water 30 minutes before drinking.

Example 3

An anti-drunk and anti-hangover electuary containing green tea total flavanone extract as a main component and β-cyclodextrin, maltodextrin and stevioside as auxiliary components is prepared through the following steps:

(1) weighing 5000 g of the total flavanone extract of green tea prepared in Example 1, weighing 5000 g of β-cyclodextrin and 5000 g of maltodextrin, and mixing them uniformly;

(2) adding 5000 ml of water, repeating milling, vacuum drying at 40-50° C. until the moisture content is <5%, milling, and sieving through a 60-metre sieve;

(3) adding 1000 g of stevioside, mixing uniformly, and then pelletizing in a 20-40% humidity environment after sterilization to obtain particles of 20-40 mesh; and

(4) Filling the bag with particles under an environment of 50% or less humidity, and obtaining pills contained in the bag each weighing 2 g.

Administration method and usage: Oral administration, 2 packets at a time, administered 30 minutes before or after drinking (after dissolving the branch in boiling water).

Example 4

The anti-drunk and hangover-relieving tablets containing pseudoginseng total flavanone extract and green tea total flavanone extract as main components and β-cyclodextrin and maltodextrin as auxiliary components are prepared through the following steps:

(1) 300 g of pseudoginseng total flavanone extract and 2500 g of green tea total flavanone extract prepared in Example 1 were weighed; Weighing 2500 g of β-cyclodextrin and 2500 g of maltodextrin and mixing the materials uniformly;

(2) After performing sterilization, pelletizing in a 20-40% humidity environment to obtain particles of 20-40 mesh and tableting them to obtain tablets each having a weight of 0.3 g.

Administration method and usage: Oral administration, 2-3 tablets at a time, orally administered before or after drinking for 30 days.

Experimental Example 1

Observation of the effect of anti-drunk hangover relief capsules prepared in Example 2

The capsule was tested by 30 volunteers. Two capsules were administered 30 minutes before drinking, and dizziness and intoxication symptoms were observed after drinking. All 30 volunteers received feedback that the capsules were effective, significantly increased the amount of alcohol that made drinkers intoxicated, and prevented drunkenness and physical discomforts such as dizziness and loss of control behavior. caused by drinking. Representative examples include:

A 40-year-old male volunteer (surname "Shen") who usually complained of dizziness after drinking a very small amount of beer was administered 2 capsules 30 minutes before drinking, and did not feel dizzy even after drinking 100g of 52% wine.

A 22-year-old male volunteer (surname "Fu") who complained of dizziness after drinking 4 bottles of beer was administered 2 capsules 30 minutes before drinking, and did not feel dizzy even after drinking 7 bottles of beer.

Test Example 2

Observation of the effects of the anti-drunk and hangover pills prepared in Example 3

The drug of the present invention was tested by 5 volunteers. As a result of administering 2 packets of Earth Medicine after feeling dizzy due to drinking, the effect of alleviating the symptoms of dizziness was observed. All five volunteers provided the following feedback:

The pill was effective, relieved symptoms of dizziness, and shortened the intoxication time.

Test Example 3

Observation of the effect of anti-drunk hangover relief tablets prepared in Example 4

The tablets of the present invention were tested by 16 volunteers. Two tablets were administered 30 minutes before drinking, and dizziness and intoxication symptoms were observed after drinking. Among them, 15 volunteers gave feedback that the tablets are effective, can significantly increase the amount of alcohol that causes drinkers to become intoxicated, prevent drunkenness and physical discomfort such as dizziness and loss of control behavior caused by drinking. gave Representative examples include:

A 31-year-old male volunteer (surname "Gao") who drank a lot and felt dizzy soon took 2 tablets 30 minutes before drinking, and did not feel dizzy even after drinking 100g of 52% white wine.

A 36-year-old male volunteer (surname "Zhang") who usually suffered from dizziness after drinking only a bottle of beer without drinking white wine was given two tablets 30 minutes before drinking. As a result, he did not feel dizzy after drinking 100g of 52% white wine. .

Claims (7)

Characterized in that it contains at least one selected from bezoa total flavanone extract, pseudoginseng total flavanone extract and green tea total flavanone extract as a main component,
Anti-drinking and hangover-relieving composition. According to claim 2,
The main component includes bezoa total flavanone extract 0-40, pseudo ginseng total flavanone extract 0-40 and green tea total flavanone extract 20-100 by weight,
composition According to claim 1 or 2,
The total flavanone content of the Bezoa total flavanone extract was >50%, the total flavanone content of the pseudoginseng total flavanone extract was >80%, and the total flavanone content of the green tea total flavanone extract was >80%. %person,
composition. According to claim 3,
The Bezoa total flavanone extract, the pseudoginseng total flavanone extract, and the green tea total flavanone extract are:
Grinding bezoa, pseudo ginseng and green tea;
Extracting the pulverized product with water or ethanol at a concentration of less than 70%, respectively; recovering the extracted solution;
centrifugation step;
performing extraction, macroporous resin column chromatography or recrystallization;
vacuum drying at 40-50°C; and
manufactured by a method comprising the step of inspecting the content of each extract to ensure that it meets the requirements;
composition. According to claim 3,
Further comprising an auxiliary component comprising at least one selected from β-cyclodextrin, maltodextrin and stevioside,
composition. According to claim 5,
The weight ratio of the main component and the auxiliary component is 1: (0-3),
composition. A method for preparing an anti-drunk and hangover-relieving composition, the method comprising:
(1) crushing bezoa, ginseng pseudoginseng and green tea; Extracting the pulverized product with water or ethanol at a concentration of less than 70%, respectively; recovering the extracted solution; centrifuged; performing extraction, macroporous resin column chromatography or recrystallization; vacuum dried at 40-50°C; verifying whether the content of each extract meets the requirements to obtain bezoa total flavanone extract, pseudoginseng total flavanone extract and green tea total flavanone extract; And crushing each extract and sieving through a 60 mesh sieve;
(2) weighing 0-40 parts of bezoa total flavanone extract, 0-40 green tea total flavanone extract and 20-100 green tea total flavanone extract by weight, and mixing them uniformly to obtain a main component;
(3) Weigh 0-100 β-cyclodextrin and 0-100 maltodextrin by weight, mix them uniformly with the main component, add 10-50% of water based on the total weight, and grind, vacuum dry, and grind and sieving with a 60 mesh sieve; and
(4) adding 0 to 20 parts by weight of stevioside, mixing uniformly, sterilizing, and pelletizing to prepare capsules, tablets or soft medicines;
including,
method.