KR20200020287A - An anti-drunkenness and hangover-alleviating composition and its preparation method - Google Patents

Abstract

Disclosed is a composition for preventing intoxication and alleviating hangover and a manufacturing method thereof. The composition for preventing intoxication and alleviating hangover contains, as a main ingredient, at least one selected from a flavanone extract derived from Morus alba, a flavanone extract derived from Pueraria montana flower, and a flavanone extract derived from Schisandra chinensis.

Description

Odor prevention and hangover relief composition and preparation method thereof {AN ANTI-DRUNKENNESS AND HANGOVER-ALLEVIATING COMPOSITION AND ITS PREPARATION METHOD}

TECHNICAL FIELD The present invention relates to the pharmaceutical field, and more particularly, to a composition having a odor preventing function and a hangover relieving function and a method for preparing the same.

Moderate drinking helps people's physical health. Excessive drinking, however, can cause odors and dizziness, headaches, abnormal behavior after hangovers and alcohol, and normal work and interpersonal relationships. More seriously, excessive drinking can damage body tissues and organs. For example, excessive drinking can damage liver cells, interfere with the normal metabolism of the liver, and can further cause alcoholic liver disease and cirrhosis. In addition, frequent drinking may cause alcohol dependence, that is, after sudden stop drinking or reducing alcohol consumption, various uncomfortable physical symptoms, also known as alcohol withdrawal syndrome, will appear.

Thus, people apply various methods to alleviate the discomfort associated with drinking, and there are many corresponding products on the market also correspondingly; However, most products have an indeterminate therapeutic effect.

In order to solve the above problems, the present invention proposes a new odor prevention and hangover relief composition based on a number of experiments. The composition can significantly improve the alcohol odor threshold, prevent physical discomfort and odor such as dizziness, uncontrollable behavior caused by odor, and alleviate alcohol withdrawal syndrome of the subject. In addition, the composition contains a liver protection component that can promote the decomposition of alcohol and alleviate the damage of alcohol in liver cells, and is an ideal odor preventing and hangover relief product.

In order to achieve the above technical object, the present invention adopts the following technical solution:

The anti-odor and hangover relief composition comprises a main ingredient comprising one or more selected from Mulberry Total Flavanone Extract, Echinacea Total Flavanone Extract, and Schisandra chinensis Flavanone Extract.

Preferably, the main component comprises 0-40 parts by weight of the total mulberry flavanone extract, 0-40 parts by weight of the total flower flavonone extract and 20-100 parts by weight of Schizandra chinensis flavanone extract.

Preferably, the total flavanone content of the mulberry total flavanone extract is> 50%, the total flavanone content of the ragweed total flavanone extract is> 80%, and the total flavanone content of the Schizandra chinensis flavanone extract is> 80% %to be.

Mulberry Total Flavanone Extract, Echinacea Total Flavanone Extract, and Schisandra chinensis Flavanone Extract are prepared by the following method:

Ground root (Radix Puerariae lobatae), aspen and schizandra; The milled product is extracted with water or ethanol at a concentration of less than 70%, respectively; Recovering the extracted solution; Centrifugation; Extraction, macroporous resin column chromatography or recrystallization is performed; Vacuum dried at 40-50 ° C .; Detect and verify that the content of each extract meets the requirements.

The anti-odor and hangover relief composition of the present invention further comprises an auxiliary component comprising at least one selected from β-cyclodextrin, maltodextrin and stevioside.

Preferably, the weight ratio of the main component to the auxiliary component is 1: (0-3).

The present invention also discloses a process for preparing an odor preventing and hangover relief composition comprising the following steps:

(1) grinding Radix Puerariae lobatae, hyacinth and Schizandra chinensis; The milled product is extracted with water or ethanol at a concentration of less than 70%, respectively; Recovering the extracted solution; Centrifugation; Extraction, sedimentation, macroporous resin column chromatography or recrystallization; Vacuum dried at 40-50 ° C .; Detect and confirm that the content of each extract meets the requirements, to obtain a mulberry total flavanone, a ragweed total flavanone extract and a schizandra total flavanone extract; Grinding each extract and sieving to 60 mesh sieve;

(2) weighing 0-40 parts by weight of the Mulberry Total Flavanone Extract, 0-40 parts by weight of the Ester Flower Total Flavanone Extract and 20-100 parts by weight of the Schizandra chinensis Flavanone Extract, and mixing them uniformly to obtain a main ingredient;

(3) 0-100 parts by weight of β-cyclodextrin and 0-100 parts by weight of maltodextrin, mixed homogeneously with the main component, repeated grinding, vacuum drying, by adding 10 to 50% of water based on the total weight Pulverizing and sieving with a 60 mesh sieve; And

(4) Add 0-20 parts by weight of steviosides, mix uniformly, sterilize, pellet, and prepare into capsules, tablets or soft.

The anti-odor and hangover relief compositions described herein comprise Schizandra as a main ingredient and Radix Puerariae lobatae and Schizandra as auxiliary ingredients. Based on observing the effect on the participants, the odor preventing and hangover mitigating compositions have been demonstrated to have the effect of improving odor thresholds and alleviating or reducing drinking symptoms.

Hereinafter, the present invention will be further described in combination with specific examples, but the present invention is not limited to these examples.

Example 1

Preparation of Mulberry Total Flavanone Extract, Echinacea Total Flavanone Extract, and Schisandra chinensis Flavanone Extract

The subject mulberry total flavanone extract was ground milled Radix Puerariae lobatae; The milled root is heated to reflux with 60% ethanol; Recovering the extracted solution; Centrifugation; Supernatant is collected; The total flavone enrichment was obtained by performing macroporous resin column chromatography; Recover the solvent; Concentrate; Vacuum dried at 40-50 ° C .; It is prepared by detecting to confirm that the total flavone content is> 50%.

Subject sperm total flavanone extract, pulverize essence; Ultrasonically extracting the ground ragweed with 40% ethanol; Recovering the extracted solution; Centrifugation; Supernatant is collected; The total flavone concentrate was obtained by performing extraction with ethyl acetate; Recover the solvent; Concentrate; Vacuum dried at 40-50 ° C .; It is prepared by detecting to confirm that the total flavone content is> 80%.

Subject Schizandra chinensis flavanone extracts are milled Schizandra chinensis; Heating and refluxing the ground schizandra with 60% ethanol; Recovering the extracted solution; Centrifugation; Supernatant is collected; Recrystallization is performed to obtain a total flavone concentrate; Vacuum dried at 40-50 ° C .; It is prepared by detecting to confirm that the total flavone content is> 80%.

Example 2

Anti-odor and Hangover Relief Capsules comprise Mulberry Total Flavanone Extract, Echinacea Total Flavanone Extract, and Schisandra chinensis Flavanone Extract as main ingredients, and include β-cyclodextrin as an auxiliary ingredient, and are made through the following steps:

(1) 500 g of the root root total flavanone extract prepared in Example 1, 500 g of sesame flower total flavanone extract, and 5000 g of Schizandra chinensis flavanone extract were weighed, pulverized, sieved with a 60-mesh sieve, and 4000 g of β-cyclodextrin was weighed. Uniformly mixing the materials;

(2) adding 3000 ml of water, repeatedly grinding, vacuum drying at 40-50 ° C. until the moisture content is <5%, grinding and sieving with a 60-mesh sieve;

(3) after sterilization, pelleting in an environment of 20-40% humidity to obtain 20-40 mesh of particles; And

(4) filling the capsules with the particles in an environment of 50% humidity or less to obtain 0.5 g of capsules each.

Method of administration and dosage: Oral administration, 2 capsules each time, with warm water 30 minutes before drinking.

Example 3

Odor-preventing and hangover-relieving softeners include Schizandra chinensis flavanone extract as a main component and β-cyclodextrin, maltodextrin and stevioside as auxiliary components; Manufactured through the following steps:

(1) weighing 5000 g of Schizandra chinensis flavanone extract prepared in Example 1, weighing 5000 g β-cyclodextrin and 5000 g maltodextrin and mixing the materials uniformly;

(2) adding 5000 ml of water, repeatedly grinding, vacuum drying at 40-50 ° C. until the moisture content is <5%, pulverizing and sieving with a 60-mesh sieve;

(3) adding 1000 g of steviosides, mixing uniformly, and sterilizing, then pelleting in an environment of 20-40% humidity to obtain 20-40 mesh particles; And

(4) filling the bags in an environment with a humidity of 50% or less to obtain a soft bag contained in each bag having a weight of 2 g.

Dosage method and dosage: Oral administration, 2 bags each time, 30 minutes before drinking or 30 minutes after drinking (after the soft dissolve in boiled water).

Example 4

Odor-prevention and hangover relief tablets are included as the main components of the ragweed total flavanone extract and Schisandra chinensis flavanone extract, and include β-cyclodextrin and maltodextrin as auxiliary components, and are prepared through the following steps.

(1) weighing 300 g of the total flower flavanone extract and 2500 g of Schisandra chinensis flavanone extract prepared in Example 1, 2500 g of β-cyclodextrin and 2500 g of maltodextrin, and mixing the materials uniformly;

(2) after sterilization, pelleting in an environment of 20-40% humidity to obtain 20-40 mesh particles; Tableting to obtain tablets having a weight of 0.3 g each.

Dosage method and dosage: Oral administration, 2-3 tablets each time, 30 minutes before drinking or 30 minutes after drinking.

Experimental Example 1

Observation on the effect of the anti-odor hangover relief capsule prepared in Example 2

Capsules were tested by 30 participants. Two capsules were administered 30 minutes before drinking, and dizziness and odor symptoms were observed after drinking. All 30 participants gave the following opinion: The capsules were effective, significantly increased the amount of alcohol that causes the odor of the drinker, and prevented physical discomfort and odors such as dizziness and loss of control caused by odor. Could. Common examples are:

A 40-year-old male participant (Shen), who had dizziness after drinking a very small amount of beer, did not feel dizzy after taking two capsules 30 minutes before drinking and drinking 100 g of 52% white wine. Did.

A 22-year-old male participant (whose surname, Fu), who had had dizziness after drinking four bottles of beer, received two capsules 30 minutes before drinking and did not feel dizzy after drinking seven bottles of beer .

Experimental Example 2

Observation on the effect of the anti-odor hangover relief prepared in Example 3

The soft was tested by five participants. After feeling dizziness due to drinking, two doses of soft medicine were administered, and the relief effect of dizziness was observed. All five participants gave the following opinion: The weakness was effective and could alleviate the symptoms of dizziness and shorten bedtime.

Experimental Example 3

Observation on the Effects of the Anti-odor Hangover Relief Tablets Prepared in Example 4

Capsules were tested by 16 participants. They took 2 capsules 30 minutes before drinking and observed dizziness and odor symptoms after drinking. Of these, 15 participants gave the following opinion: Tablets were effective, significantly increased the amount of alcohol that causes the odor of the drinker, and odor and physical discomforts such as dizziness and loss of control caused by odor Could be prevented. Common examples are:

A 31-year-old male participant (who had sex with Gao), who usually drank a lot of alcohol and soon became dizzy, did not feel dizzy after taking two tablets 30 minutes before drinking and drinking 100 g of 52% white wine.

A 36-year-old male participant (who had the name of Chang) who took dizziness after drinking a bottle of beer at best and never drank white wine, took two tablets 30 minutes before drinking, and took 52 g of 100% white wine. Did not feel dizzy after drinking.

Claims (7)

An anti-odor and hangover relief composition comprising a main ingredient comprising at least one selected from mulberry total flavanone extract, ragweed total flavanone extract, and Schizandra chinensis flavanone extract.
The anti-odor and hangover relief composition according to claim 1, wherein the main component comprises 0-40 parts by weight of the total mulberry flavanone extract, 0-40 parts by weight of the total flower flavonone extract, and 20-100 parts by weight of the Schizandra chinensis flavanone extract. .
The total flavanone content of the total mulberry flavanone extract is> 50%, the total flavanone content of the total flower flavanone extract is> 80%, and the total flavanone content of Schizandra chinensis flavanone extract. Anti-odor and hangover relief composition being> 80%.
The anti-odor and hangover relief composition according to claim 3, wherein the mulberry total flavanone extract, the ragweed total flavanone extract, and the Schizandra chinensis flavanone extract are prepared by the following method:
Ground root (Radix Puerariae lobatae), aspen and schizandra; The milled product is extracted with water or ethanol at a concentration of less than 70%, respectively; Recovering the extracted solution; Centrifugation; Extraction, macroporous resin column chromatography or recrystallization is performed; Vacuum dried at 40-50 ° C .; Detect and verify that the content of each extract meets the requirements.
The anti-odor and hangover relief composition of claim 3, further comprising an auxiliary component comprising at least one selected from β-cyclodextrin, maltodextrin, and stevioside.
The odor preventing and hangover relief composition according to claim 5, wherein the weight ratio of the main component to the auxiliary component is 1: (0-3).
(1) grinding Radix Puerariae lobatae, hyacinth and Schizandra chinensis; The milled product is extracted with water or ethanol at a concentration of less than 70%, respectively; Recovering the extracted solution; Centrifugation; Extraction, macroporous resin column chromatography or recrystallization is performed; Vacuum dried at 40-50 ° C .; Detect and confirm that the content of each extract meets the requirements and obtain mulberry total flavanone extract, ragweed total flavanone extract and Schizandra chinensis flavanone extract; Grinding each extract and sieving to 60 mesh sieve;
(2) weighing and uniformly mixing 0-40 parts by weight of mulberry total flavanone extract, 0-40 parts by weight of Schizandra chinensis flavanone extract and 20-100 parts by weight of Schizandra chinensis flavanone extract, to obtain a main ingredient;
(3) 0-100 parts by weight of β-cyclodextrin and 0-100 parts by weight of maltodextrin, mixed with these main components uniformly, added 10 to 50% of water based on the total weight, repeated grinding, and vacuum drying Crushing and sieving with a 60 mesh sieve; And
(4) adding 0-20 parts by weight of steviosides, mixing uniformly, sterilizing, pelleting, and preparing capsules, tablets, or softeners.
Comprising, odor prevention and hangover relief compositions.