KR20200022771A - An anti-drunkenness and hangover-alleviating composition and its preparation method - Google Patents

Abstract

The present invention relates to an anti-drunkenness and hangover-alleviating composition, and to a production method thereof. The anti-drunkenness and hangover-alleviating composition comprises a main ingredient containing at least one selected from a total flavanone extract of Polygonum multiflorum, a total flavanone extract of Rhizoma corydalis, and a total flavanone extract of Ophiopogon japonicas.

Description

Anti-drunkenness and hangover-alleviating composition and its preparation method

TECHNICAL FIELD The present invention relates to the field of medicine, and more particularly, to a composition having an anti-drinking and hangover-relaxing function and a method for producing the same.

Drinking alcohol usually helps people's physical health. However, excessive drinking can lead to drunkiness and dizziness, headaches, hangovers, and bad behavior after drinking and can affect normal work and interpersonal relationships. More seriously, excessive drinking can damage body tissues and organs. For example, continuous excessive drinking can damage liver cells, interfere with normal metabolism of the liver, and further lead to alcoholic hepatitis and cirrhosis. In addition, frequent drinking may result in alcohol dependence, which, as it were, will lead to various uncomfortable physical symptoms, such as alcohol withdrawal syndrome, after suddenly stopping drinking or reducing alcohol consumption.

Thus, people are adopting various methods to alleviate the discomfort associated with drinking, and there are many corresponding products on the market; However, most products have inaccurate therapeutic effects.

In order to solve the above problem, the present invention proposes a new anti-fragrance and hangover-releasing composition based on a number of experiments. The composition can significantly improve the alcoholic beverage threshold (drunkenness threshold value), prevent bodily discomfort such as dizziness, uncontrollable behavior caused by alcohol and alcohol, and relieve alcohol withdrawal syndrome of the subject have. In addition, the compositions include liver protective ingredients that can promote the breakdown of alcohol and mitigate the damage of alcohol in hepatocytes, and are ideal anti-drink and hangover-relieving products.

In order to achieve the above technical object, the present invention adopts the following technical solution:

Anti-gonist, comprising a major component comprising one or more selected from Polygonum multiflorum total flavanone extract, Rhizoma corydalis total flavanone extract, and Ophiopogon japonicus total flavanone extract Alcohol and Hangover-Relieving Compositions.

Preferably, per part by weight, comprising a total amount of Daffodil total flavanone extract 0-40, corydalis total flavanone extract 0-40 and leaflet vegetation total flavanone extract 20-100.

Preferably, the total flavanone content in the dropwise total flavanone extract is> 50%, the total flavanone content in corydalis total flavanone extract is> 80%, and the total flavanone content in the leaflet vegetation total flavanone extract is> 80%.

The Total Drainage Total Flavanone Extract, Corydalis Radix Total Flavanone Extract and Leaflet Vegetation Total Flavanone Extract are prepared by the following method:

Pulverizing the drip, scallop and leaflet veins; Extracting each of the milled products with water or ethanol at a concentration of less than 70%; Recovering the extracted solution; Centrifuge; Performing extraction, macroporous resin column chromatography or recrystallization; Vacuum dried at 40-50 ° C .; And detecting that the content of each extract meets the requirements.

The anti-fragrance and hangover-releasing composition of the present invention further comprises an auxiliary component containing at least one selected from β-cyclodextrin, maltodextrin and stevioside.

Preferably, the weight ratio of the main and auxiliary components is 1: (0-3).

The present invention also discloses a method of preparing an anti-drunken and hangover-relaxing composition comprising the following steps:

 (1) crushed drip, sesame and leaflet veins; Extracting each of the milled products with water or ethanol at a concentration of less than 70%; Recovering the extracted solution; Centrifuge; Performing extraction, precipitation, macroporous resin chromatography or recrystallization; Vacuum dried at 40-50 ° C .; Detecting that the content of each extract satisfies the requirements, to obtain the above-mentioned drop total gland flavanone extract, corydalis gland total flavanone extract and leaflet vegetation total flavanone extract; And milling each extract and sieving with a 60-mesh sieve;

(2) Per 1 part by weight, weighing 20 to 100 parts of the total dropwise total flavanone extract, 0-40 of the leaflet vegetation extract, and 20-100 of the leaflet vegetation extract, and mixing them uniformly to obtain the main components. box;

(3) per part by weight, β-cyclodextrin 0-100 and maltodextrin 0-100, weighed, mixed them uniformly with the main ingredients, added 10-50% water to the total weight and repeatedly polished, vacuum dried, Grinding, and manure with a 60-mesh sieve; And

(4) 0-20 parts by weight of stevioside added, uniformly mixed, sterilized, pelletized, and prepared into capsules, tablets or soft medicines.

The anti-fragrance and hangover-relaxing compositions described in the present invention comprise the leaflet vein sinus and the main component of the dropping sesame and leaflet vein sinus as main components. Based on observations on the effect on volunteers, the anti-drunken and hang-over compositions have been demonstrated to have an effect of improving the alcohol threshold and alleviating or reducing the symptoms of alcohol.

Hereinafter, the present invention is further described in combination with specific examples, but the present invention is not limited to these examples.

Example 1

Preparation of Dripping Sewage Total Flavanone Extract, Corydalis Total Flavanone Extract, and Lobules Leaflet Total Flavanone Extract

Desired dripping total flavanone extracts pulverized dripping; Heating and refluxing the ground dropwise water with 60% ethanol; Recovering the extracted solution; Centrifuge; Collecting the supernatant; Performing macroporous resin chromatography to obtain a total flavone enriched portion; Recovering the solvent; Concentrated; Vacuum dried at 40-50 ° C .; And detecting to confirm that the total flavone content is> 50%.

Desired corydalis total flavanone extracts pulverize corydalis; Ultrasonically extracting the ground corydale with 40% ethanol; Recovering the extracted solution; Centrifuge; Collecting the supernatant; Extraction with ethyl acetate to give the total flavone concentrate portion; Recovering the solvent; Concentrated; Vacuum dried at 40-50 ° C .; And detecting to confirm that the total flavone content is> 80%.

Desired leaflet vein pulmonary total flavanone extract pulverize leaflet vein sinus; Extracting the pulverized leafy veins from the heated reflux with 60% ethanol; Recovering the extracted solution; Centrifuge; Collecting the supernatant; Recrystallization is performed to obtain a flavone concentrate portion; Vacuum dried at 40-50 ° C .; And detecting to confirm that the total flavone content is> 80%.

Example 2

The anti-drunken and hangover-relieving capsules contain a total of flavonoid extract, corydale total flavanone extract, and leaflet vegetation total flavanone extract as main components, and β-cyclodextrin as a secondary component and the next step. Is manufactured through:

(1) 500 g of Puerariae lobatae total flavanone extract prepared in Example 1, 500 g of corydalis total flavanone extract and 5000 g of lobular vegetation total flavanone extract were weighed, pulverized and filtered through a 60-mesh sieve; And 4000 g of β-cyclodextrin and mixing the materials uniformly.

(2) 3000 ml of water was added, repeatedly polished, vacuum dried at 40-50 ° C. until the water content was <5%, pulverized, and sieved through a 60-mesh sieve;

(3) after sterilization, pelleted under 20-40% humidity environment to obtain 20-40 mesh of particles; And

(4) Filling the particles into capsules under a humidity environment of 50% or less, to obtain capsules having a weight of 0.5 g each.

Method of administration and dosage: Oral administration, two capsules each time, with warm water 30 minutes before drinking.

Example 3

Anti-drinking and hangover-softening drugs include leaflet vegetation total flavanone extract as a main component and β-cyclodextrin, maltodextrin and stevioside as auxiliary components; And by the following steps:

(1) Weigh 5000 g of the leaflet vegetation total flavanone extract prepared in Example 1, weigh 5000 g of β-cyclodextrin and 5000 g maltodextrin, and mix the materials uniformly.

(2) 5000 ml of water is added, repeatedly polished, vacuum dried at 40-50 ° C. until the water content is <5%, pulverized, and filtered with a 60-mesh sieve;

(3) 1000 g of stevioside was added, mixed uniformly, and sterilized before being pelletized in a 20-40% humidity environment to obtain 20-40 mesh of particles; And

(4) Filling the particles into a bag under a humidity environment of 50% or less, to obtain a thermotropic drug having a weight of 2 g each.

Method of administration and dosage: Oral administration, two bags each time, 30 minutes before drinking or after drinking (after the soft medicine is dissolved in boiled water).

Example 4

Anti-drunken and hangover-relieving tablets comprise corydalis total flavanone extract and leaflet vegetation total flavanone extract as main components, and β-cyclodextrin and maltodextrin as auxiliary components; And by the following steps:

(1) Weigh 300 g of Corydalis gland total flavanon extract and 2500 g of leaflet vegetation total flavanone extract prepared in Example 1; And 2500 g of β-cyclodextrin and 2500 g maltodextrin, and mixing the materials uniformly.

 (2) after sterilization, pelleted under 20-40% humidity environment to obtain 20-40 mesh of particles; And tableting to give tablets having a weight of 0.3 g each.

Method of administration and dosage: Oral administration, 2-3 tablets each time, 30 minutes before or after drinking.

Experimental Example 1

Observation of the Effect of the Anti-Drunk Hangover-Relieving Capsules Prepared in Example 2

Capsules were tested by 30 volunteers. They were given two capsules 30 minutes before drinking and dizziness and intoxication were observed after drinking. All 30 volunteers gave the following feedback: The capsules were effective, significantly increased the amount of alcohol causing alcohol intoxication, and increased physical discomfort such as dizziness and loss of behavioral control caused by alcohol and intoxication. It can be prevented. Typical examples are as follows:

A 40-year-old male volunteer (who has a last name, Shen) who drank a very small amount of beer, received two capsules 30 minutes before drinking and felt dizzy after drinking 100g of 52% white wine Did.

A 22-year-old male volunteer (with a surname named Fu) who usually suffered from a microscope after drinking four bottles of beer, received two capsules 30 minutes before drinking, and did not feel dizzy after drinking seven bottles of beer .

Experimental Example 2

Observation of the effects of the anti-drunken hangover-softening agent prepared in Example 3

Soft pills were tested by five volunteers. After receiving dizziness caused by drinking, they received two hundred soft pills, and a mitigating effect on dizziness symptoms was observed. All five volunteers gave the following feedback: The soft medication was effective and could alleviate the dizziness symptoms and shorten the infusion time.

Experimental Example 3

Observing the Effect of the Anti-Drunk Hangover-Relieving Tablet Prepared in Example 4

Capsules were tested by 16 volunteers. They were given two capsules 30 minutes before drinking and dizziness and intoxication were observed after drinking. Of them, 15 volunteers gave the following feedback: The tablet was effective, significantly increased the amount of alcohol causing alcohol intoxication, and physical discomfort such as dizziness and loss of behavioral control caused by alcohol and intoxication Can be prevented. Typical examples are as follows:

A 31-year-old male volunteer (usually named Gao) who drank a lot of alcohol and soon became dizzy, did not feel dizzy after drinking two tablets 30 minutes before drinking and 52% white wine.

A 36-year-old male volunteer (who has a surname called Zhang) who is dizzy and doesn't drink white wine after drinking up to one bottle of beer, received two tablets 30 minutes before drinking, and received 100g of 52% white wine. Did not feel dizzy after drinking.

Claims (7)

Anti-Drunk and Hangover-Containing a major ingredient comprising at least one selected from Polygonum multiflorum total flavanone extract, Rhizoma corydalis total flavanone extract and Ophiopogon japonicas total flavanone extract Emollient composition. According to claim 1, wherein the main ingredient, anti-fraction including a total weight of flavanone extract 0-40, sage red total flavanone extract 0-40 and leaflet vegetation total flavanone extract 20-100 per weight part; Hangover-relaxing composition. According to claim 1 or 2, wherein the total flavanone content in the total drop of the total flavanone extract is> 50%, total flavanone content in the corydalis total flavanone extract is> 80%, total leaf in the leaflet vegetation total flavanone extract Anti-fragrance and hangover-relaxing composition having a flavanone content of> 80%. The anti-drinking and hangover-relaxing composition according to claim 3, wherein the total dropwise total flavanone extract, corydale total flavanone extract and leaflet vegetation total flavanone extract are prepared by the following method:
Pulverizing the drip, scallop and leaflet veins; Extracting each of the milled products with water or ethanol at a concentration of less than 70%; Recovering the extracted solution; Centrifuge; Performing extraction, macroporous resin column chromatography or recrystallization; Vacuum dried at 40-50 ° C .; And detecting that the content of each extract meets the requirements. The anti-fragrance and hangover-relaxing composition of claim 3 further comprising an auxiliary component containing at least one selected from β-cyclodextrin, maltodextrin and stevioside. The anti-fragrance and hangover-relaxing composition of claim 5 wherein the weight ratio of the main component and the auxiliary component is 1: (0-3). A method for preparing an anti-drink and hangover-releasing composition comprising the following steps:
(1) crushed drip, sesame and leaflet veins; Extracting each of the milled products with water or ethanol at a concentration of less than 70%; Recovering the extracted solution; Centrifuge; Performing extraction, macroporous resin column chromatography or recrystallization; Vacuum dried at 40-50 ° C .; Detecting that the content of each extract satisfies the requirements, to obtain the above-mentioned dulciflora total flavanone extract, corydalis total flavanone extract and leaflet vegetation total flavanone extract; And milling each extract and sieving with a 60-mesh sieve;
(2) per weight part, weighing 20 to 100 drops of the total dropwise total flavanone extract, 0-40 of the leaflet vegetation extract, and 20-100 of the leaflet vegetation extract, and mixing them uniformly to obtain the main components. box;
(3) per part by weight, β-cyclodextrin 0-100 and maltodextrin 0-100 are weighed, mix them uniformly with the main ingredients, add 10-50% water to the total weight and repeat polishing, vacuum drying, grinding , And 60-mesh sieve; And
(4) 0-20 parts by weight of stevioside added, uniformly mixed, sterilized, pelletized, and prepared into capsules, tablets or soft medicines.