CN104585469A - Chewing gum having protective effect on alcoholic liver injury and preparation method of chewing gum - Google Patents
Chewing gum having protective effect on alcoholic liver injury and preparation method of chewing gum Download PDFInfo
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Abstract
The invention relates to a chewing gum having a protective effect on alcoholic liver injury and a preparation method of the chewing gum, and belongs to the technical field of food therapy health products. The chewing gum prepared from the following raw materials in parts by weight: 2 to 4 parts of cloves, 8 to 14 parts of Hovenia dulcis Thunb, 30 parts of kudzuvine roots, 15 parts of milkvetch roots and a proper amount of a colloid material. The colloid material comprises the following components: 0.03 to 0.09 part of a sweetener, 0.3 to 0.8 part of caramel, 0.02 to 0.04 part of glycerin, and 0.02 to 0.04 part of essence. The preparation method comprises the following steps: 1. adding water in the cloves, Hovenia dulcis Thunb, kudzuvine roots and milkvetch roots for decocting for three times, combining decoctions, then concentrating to obtain a thick paste, and drying to obtain extract particles; and 2. after uniformly mixing the extract particles and a matrix, pressing into slices, slitting and packaging. The chewing gum containing the cloves, Hovenia dulcis Thunb, kudzuvine roots and milkvetch roots is convenient to chew by people, and can effectively play a protective role in the alcoholic liver injury.
Description
Technical field
The present invention relates to a kind of to alcoholic liver injury chewing gum with protective effect and preparation method thereof, belong to food therapeutic health technical field.
Background technology
Wine has long history in China, and has formed a kind of spirits culture.Traditional Chinese medicine is early recognized wine, Li Shizhen (1518-1593 A.D.) is pointed out in Compendium of Material Medica " wine; the clever Lu in sky is also; few drink then with blood, promoting the circulation of qi, strong god, keep out the cold, relieve the lonliness and grief; drink to one's heart content, overtax one's nerves, hematozemia, damage stomach, essence of dying, raw phlegm, to get angry ", think that responsible drinking is good for health, but excessive, internal organs can be caused to damage, also alcoholism can be caused, even dead, acute alcoholism, also known as drunk, refer to and once drinks beyond one's capacity and the damage process of the central nervous system, digestive system, respiratory system, cardio-cerebrovascular etc. that cause.The World Health Organization (WHO) points out, alcoholism is the first public hazards within the scope of the world today, to become in China and even world wide a serious public health problem gradually.Therefore the hangover-alleviating health-care food seeking a kind ofly conveniently to take, mouthfeel is good, fashion is fashionable becomes the task of top priority, is also needed for people ' s health.
Although relieve the effect of alcohol at present, goods can have various ways to relieve the effect of alcohol, and acute alcoholism is generally by glucose, Vit1B1, Vit1B6, quiet of nicotinic acid clinically, the metabolism of accelerating alcohol, with quiet of Allylnoroxymorphone under serious conditions, mainly to breathing and the inhibitory action of cardiovascular sympathetic function, reduce free radical to generate, block CNS inhibition caused by alcoholism, promote consciousness recovery.This illustrates that the infringement of excessive consumption of alcohol to body is general.
How on the books the side of relieving the effect of alcohol is in the ancient book such as Shennong's Herbal, " the southern regions of the Yunnan Province book on Chinese herbal medicine ", and according to the arrangement of Sun Longchuan, the sober-up function of Chinese herbal medicine can be summarized as following three classes: reducing fever and causing diuresis class (FI puerariae, watermelon, mung bean flour etc.); The class that promotes the production of body fluid to quench thirst (dried immature fruit of citron orange, orange, the fruit of Chinese magnoliavine etc.); Class of removing dampness by means of aromatics (in one's early teens, cloves, apple, Semen Lablab Album etc.).Wan Fang etc. analyze the side's of relieving the effect of alcohol medicine described in ancient doctor's mat, it are roughly divided into three major types: drink not liquor-saturated side, and the increase human body of clothes, to the dosis tolerata of wine, is drunk as dry gold and made us not liquor-saturated side; The side of sobering up, is suitable for the intoxicating person that drinks beyond one's capacity, as Shigao Tang, the angle side of sobering up etc.; The wine disease side of controlling, this type of side is used for the treatment of because of the many diseases caused by wine, and have the food and drink that disappears to be main person, dampness elimination of eliminating the phlegm is main person, has relieving alcoholism to be main person, and relieving heat and thirst is main person, and having except wine amasss is main person etc.
The goods also many functional components found prescription from ancient times in natural plants that relieve the effect of alcohol now, are divided into following two classes according to its function.
Strengthen scavenging free radicals enzymatic activity: what the goods research of relieving the effect of alcohol in enhancing scavenging free radicals enzymatic activity was more is Araliaceae, especially ginseng.By research, Lee etc. find that ginsenoside can lower the rising of serum glutaminic acid transferase caused by ethanol, improve serum and the oxidasic activity of liver GSH-PX activity, suppress the generation of Peroxidation Product MDA, remove the free radical that ethanol produces at hepatic tissue.The tea seed saponin(e of Japanese scholars research known structure can suppress the gastrointestinal absorption of ethanol, promotes the decomposition of ethanol and the acetaldehyde absorbed simultaneously.
Metabolism Reinforcing agent: these type of goods that relieve the effect of alcohol are mainly based on kudzuvine root isoflavone, and the brave time youth in new Pu have studied the pharmacological action of each extract part of FI puerariae, finds that methanolic extract and osajin composition can suppress alcohol induced mouse blood sugar to raise.Domestic scholars carries out the experiment of mouse liver ethanol In vitro metabolism to the health-care sobering product/Puerariae Flos Essence based on FI puerariae, prove that the metabolism amount of ethanol Puerariae Flos Essence group ethanol is 113 times of simple ethanol group metabolism amount, and FI puerariae can affect the gastrointestinal absorption of ethanol, show that FI puerariae can play a role in the absorption of ethanol and metabolism two links.The result of study of Pueraria Flavonid antialcoholism action shows, Pueraria Flavonid obviously can shorten the mouse sleep time that ethanol causes, and extends ethanol sleep latency to some extent.
Dunhuang ancient medical prescription has followed the theory of Chinese dietary therapy, preferably medicine and food are blended and use, medicine food is double to be executed, that makes clear the purpose and main theme from the very beginning in " auxiliary row rhymed formula internal organs drug regimen is wanted " especially points out " attacking pathogenic factor with poisonous drug; supplementing vital QI with five kinds of veg etables, assisting vital QI with five kinds of fruits, supporting vital QI with five kinds of grains; reinforcing vital QI with meats of five livestock ", and the viewpoint of this and interior warp is come down in a continuous line.If " the rescuing all strain sides " in " auxiliary row rhymed formula internal organs drug regimen is wanted " is with the side of eating, medicine food is double to be executed, and constitutes typical medicative diet for food therapy prescription." auxiliary row rhymed formula internal organs drug regimen is wanted " is also on the books for food therapy of relieving the effect of alcohol: " wine diaphragm wine amasss, and tell inverse ruffian completely, it is loose for smashing sieve with cloves, hoveniae semoveniae semen ".
Hoveniae semoveniae semen, with name honey raisin tree, is Rhamnaceae (Rhamnaceae) Hovenia (HoveniaThunb) plant.Medicinal effects is the fruits and seeds with meat carpopodium, and bronzing time ripe, Glabrous, fragrant and sweet good to eat, spherical fruit, includes three bronzing seeds.It is one of name fruit, is also a kind of rare medical, edible fruit.This plant begins to be loaded in the Tang Materia Medica fruit residence of a high official, and Li Shizhen (1518-1593 A.D.) claims it to be golden fruit tree, the sweet acid of nature and flavor is put down "." herbal Ran Xin " also says its " sweet acid of taste; property is put down; nontoxic ", " popular feeling, spleen two warp ", " the southern regions of the Yunnan Province book on Chinese herbal medicine " thinks that its " can solution spill poison ", supplement to the Herbal record can " relieving restlessness of quenching the thirst, moisturizing viscera; sharp stool and urine; go postcibal vomiting heat, function is as honey ", and " herbal guiding principle with " thinks its " preventing or arresting vomiting is inverse ".Modern medicine ovum research shows, the effects such as Semen Hoveniae (Fructus Hoveniae) extract can alleviate noxious material to hepatocellular damage, has anti peroxidation of lipid, stabilizing cell membrane, protection hepatocyte activity.
Cloves, another name flos caryophylli (Syzygium aromaticum), begins to be loaded in " property of medicine book on Chinese herbal medicine ".Temperature taste is pungent, people's spleen, stomach, kidney channel.There is warming middle energizer to descend adverse-rising qi, effect of warming kidney and enhancing yang.Be usually used in the cards such as stomach cold induced Vomiting, hiccup and impotence due to deficiency of the kidney." large bright book on Chinese herbal medicine " has the record controlled cold air, kill wine poison.Control the cards such as induced Vomiting of drinking, body be cold, can be alone, or with ginseng, ginger, method summer, calyx and receptacle of a persimmon adapted.Research is had to confirm, cloves crude extract has stronger antioxidation activity, DPPH radical scavenging activity is weaker than the VC of equal in quality concentration, be better than 2 of equal in quality concentration, 6-di-tert-butyl-4-methy phenol (BHT), the main matter basis of cloves antioxidation activity is total polyphenols and general flavone.
Summary of the invention
The object of the invention is: fall apart for research object with the dietotherapy side's medicine cloves hoveniae semoveniae semen that relieves the effect of alcohol that Dunhuang Medicine posthumous papers " auxiliary row rhymed formula internal organs drug regimen will " are recorded; development one is conveniently taken, the good hangover-alleviating health-care food of mouthfeel----a kind of chewing gum alcoholic liver injury to protective effect, to meet the demand of numerous alcohol users.
Dunhuang ancient medical prescription has followed the theory of Chinese dietary therapy, preferably medicine and food are blended and use, medicine food is double to be executed, that makes clear the purpose and main theme from the very beginning in " auxiliary row rhymed formula internal organs drug regimen is wanted " especially points out " attacking pathogenic factor with poisonous drug; supplementing vital QI with five kinds of veg etables, assisting vital QI with five kinds of fruits, supporting vital QI with five kinds of grains; reinforcing vital QI with meats of five livestock ", and the viewpoint of this and interior warp is come down in a continuous line." auxiliary row rhymed formula internal organs drug regimen is wanted " is also on the books for food therapy of relieving the effect of alcohol: " wine diaphragm wine amasss, and tell inverse ruffian completely, it is loose for smashing sieve with cloves, hoveniae semoveniae semen ".This research is on the basis that cloves, hoveniae semoveniae semen fall apart, and the Gansu genunie medicinal materials Radix Astragali and the root of kudzu vine composition that add integration of drinking and medicinal herbs have Dealcoholic sobering-up and alcoholic liver injury had to the prescription of protective effect.
Technical scheme:
Alcoholic liver injury is had to the chewing gum of protective effect, include following component by weight as raw material: cloves 2 ~ 4 parts, hoveniae semoveniae semen 8 ~ 14 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, colloidal materials; Described matrix comprises following component: sweetener 0.03 ~ 0.09 part, maltose 0.3 ~ 0.8 part, glycerine 0.02 ~ 0.04 part, 0.02 ~ 0.04 part, essence.
Preferably, component proportion is: cloves 3 parts, hoveniae semoveniae semen 12 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, sweetener 0.06 part, maltose 0.6 part, glycerine 0.03 part, 0.03 part, essence.
Preferably, superfine silica gel powder 0.1 ~ 0.2 part is also comprised in described colloidal materials.
Preferably, 0.04 ~ 0.06 part, sweet mellow wine, guar gum 0.08 ~ 0.12 part is also comprised in described colloidal materials.
According to another aspect of the present invention, alcoholic liver injury is had to the preparation method of the chewing gum of protective effect, comprise the steps:
1st step, get cloves, hoveniae semoveniae semen, the root of kudzu vine, the Radix Astragali, add the decocting three times of 8 times of weight, merge decocting liquid, be then concentrated into thick paste, dry, obtain extract particles;
2nd step, extract particles is mixed with matrix after, tabletted, cuts, packaging.
Preferably, the decocting time in the 1st step is 30 ~ 60 min.
Preferably, the mother-in-law U.S. degree of the thick paste in the 1st step at 80 DEG C is 4 °.
Preferably, the temperature in the operation mixed in the 2nd step controls at 50 ~ 60 DEG C.
Beneficial effect
Chewing gum containing cloves, hoveniae semoveniae semen, the root of kudzu vine, the Radix Astragali provided by the invention, is convenient for people to eat, can relieving alcoholism and protecting liver effectively, and plays a protective role to alcoholic liver injury.
Detailed description of the invention
Below by detailed description of the invention, the present invention is described in further detail.But it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted concrete technology or condition person in embodiment, according to the technology described by the document in this area or condition or carry out according to product description.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Approximate language used herein can be used for modifying the statement of any quantity in whole description and claims, and it can permit changing under the condition not causing its relevant basic function to change.Therefore, the value of being modified by the term of such as " about " is not limited to specified exact value.In at least some cases, approximate language can be corresponding with the precision of the instrument for measuring this value.Unless separately pointed out in context or statement, otherwise range limit can carry out combining and/or exchanging, and this scope is confirmed as and comprises included all subranges herein.Except in operation embodiment or except indicating in other places, the numeral of the amount, reaction condition etc. of all expression compositions used in description and claims or express the modification that all should be understood to be subject to word " about " in all cases.
Technical conceive of the present invention is by getting cloves, after hoveniae semoveniae semen, the root of kudzu vine, the Radix Astragali carry out decocting extraction, extract is made as chewing gum, extraction process can be carried out with reference to the technique of the natural drug extraction and concentration of routine, but preferred condition adds decocting three times to cloves and hoveniae semoveniae semen, the weight adding water in is at every turn 8 times of each taste Chinese medicine gross weight, and then merge decocting liquid, being concentrated into the mother-in-law U.S. degree of thick paste at 80 DEG C is 4 °.In this step, preferably cloves and hoveniae semoveniae semen are separately extracted, the mutual stripping of impurity can be prevented, solve the problem that tissue morphology is not good.After obtaining extract, after the preparation technology of extract thick paste photograph chewing gum is mixed with matrix, compression molding.The glycerine of maltose and lubricate is mainly included in the matrix of chewing gum.
In addition, the present invention can coordinate sweetener to give sweet taste in chewing gum main body.As this sweetener, preferably conventional sweetener, at least a kind that such as selects from maltitol, sucrose, glucose, glucan, invert sugar, fructose, granulated sugar, syrup, xylitol, erythrite, D-sorbite, mannitol, lactitol, bar sugar, isomalt, trehalose, compound sugar, reduction syrup, stevia rebaudianum, Sucralose (sucralose), asccharin, Aspartame, special in local flavor, preferably containing maltitol, Sucralose, xylitol, isomalt, erythrite.
In addition, also essence can be coordinated.As essence, preferably use grease essence and the powdered flavors such as one kind or two or more natural essence, compound essence, but be not particularly limited.Such as, natural essence can be enumerated: frankincense oil, parsley oil, oleum anisi, eucalyptus oil, wintergreen, cinnamon oil, menthol oil, oleum menthae viridis, peppermint oil, lemon oil, coriander oil, orange-seed oil, mandarin oil, lime oil, lavender oil, oreodaphene, chamomile oil, cardamom oil, caraway oil, bay tree leaf oil, lemongrass oil, pinke needle oil, neroli oil, attar of roses, jasmine oil, flag flower medicinal extract, Peppermint essential oil, rose essential oil, oranges and tangerines flower, tangerine oil, mixed fruit oil, arbusterol, Ceylon cinnamon oil, caryophyllus oil, grape wet goods.As simple essence, can enumerate: carvol, anethole, gaultherolin, cinnamic acid, linalool, linalyl-acetate, citrene, menthones, menthyl acetate, sobrerone, octanal, citral, pulegone, carvacryl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, cyclohexane allyl propionate, Anthranilate, ethyl anthranilate, vanilione, undecalactone, hexanal, ethanol, propyl alcohol, butanols, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate etc.As containing simple essence and/or containing the mixing essence of natural essence, can enumerate: strawberry is fragrant, apple is fragrant, banana incense, pineapple is fragrant, grape is fragrant, mango is fragrant, tropical fruit (tree) is fragrant, butter is fragrant, milk, Yoghourt are fragrant, fruit mixing is fragrant, dried peppermint leaf is fragrant.In addition, the form of essence has essential oil, extract, solids, also can be the powder obtained by their spraying dry.
In order to solve the chewing gum problem that chew time declines after long-term placement, preferably can add superfine silica gel powder again in colloidal materials, it can make other material in extract be adsorbed effectively, and after can playing and can preventing long-term placement, the problem that chewing gum easily hardens when chewing.In order to improve the tissue morphology of chewing gum, preferably in colloidal materials, add a certain amount of sweet mellow wine and guar gum again.
About the sensory evaluation method of chewing gum, please 100 taster (wherein male sex 50, women 50) the scoring group that forms, to color and luster, tissue morphology, mouthfeel, sweetness duration, hold fragrance, chew time project is evaluated, and with the green arrow chewing gum on market for control group.Color and luster is the uniformity from whether mainly, and the color whether having product originally to have is considered; Tissue morphology is mainly complete from block shape, and surfacing is smooth, neat in edge, and thickness is even, and viscosity after chewing and extensibility are considered; Mouthfeel is mainly considered from the viscosity after chewing and the aspect such as extensibility and palatability; Sweetness duration is mainly considered from sweet taste duration after entrance; Hold fragrance mainly from fragrance continue time and whether have the aspects such as peculiar smell to consider; Chew time determines the height of the total quality of chewing gum, and therefore shared score value is heavier.
This scoring adopts hundred-mark system, and because each project is different to the influence degree of product quality, the score value therefore shared by each project is also different.Wherein color and luster accounts for 15 points, and tissue morphology accounts for 20 points, and mouthfeel accounts for 25 points, and sweetness duration accounts for 10 points, and hold fragrance and account for 5 points, chew time accounts for 25 points, when adding up each embodiment chewing gum obatained score, first removes a best result and minimum point, finally gets its mean value.
Embodiment 1
Take following raw material: cloves 3 parts, hoveniae semoveniae semen 12 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, colloidal materials; Described matrix comprises following component: sweetener 0.06 part, maltose 0.6 part, glycerine 0.03 part, 0.03 part, essence.Preparation method comprises the steps: the 1st step, gets cloves, hoveniae semoveniae semen, the root of kudzu vine, the Radix Astragali, add decocting three times, the weight of the water at every turn added is 8 times of ingredients gross weight, the decocting time is 30 min, merge decocting liquid, be then concentrated into thick paste, the mother-in-law U.S. degree of thick paste at 80 DEG C is 4 °, drying, obtains extract particles; 2nd step, extract particles is mixed at 50 DEG C with matrix after, tabletted (every sheet heavy 5g), cuts, packaging.
Embodiment 2
Take following raw material: cloves 3 parts, hoveniae semoveniae semen 12 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, colloidal materials; Described matrix comprises following component: sweetener 0.06 part, maltose 0.6 part, glycerine 0.03 part, 0.03 part, essence, superfine silica gel powder 0.2 part.Preparation method comprises the steps: the 1st step, gets cloves, hoveniae semoveniae semen, the root of kudzu vine, the Radix Astragali, add decocting three times, the weight of the water at every turn added is 8 times of ingredients gross weight, the decocting time is 30 min, merge decocting liquid, be then concentrated into thick paste, the mother-in-law U.S. degree of thick paste at 80 DEG C is 4 °, drying, obtains extract particles; 2nd step, extract particles is mixed at 50 DEG C with matrix after, tabletted (every sheet heavy 5g), cuts, packaging.
Embodiment 3
Take following raw material: cloves 3 parts, hoveniae semoveniae semen 12 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, colloidal materials; Described matrix comprises following component: sweetener 0.06 part, maltose 0.6 part, glycerine 0.03 part, 0.03 part, essence, 0.06 part, sweet mellow wine, guar gum 0.12 part.Preparation method comprises the steps: the 1st step, gets cloves, hoveniae semoveniae semen, the root of kudzu vine, the Radix Astragali, add decocting three times, the weight of the water at every turn added is 8 times of ingredients gross weight, the decocting time is 30 min, merge decocting liquid, be then concentrated into thick paste, the mother-in-law U.S. degree of thick paste at 80 DEG C is 4 °, drying, obtains extract particles; 2nd step, extract particles is mixed at 50 DEG C with matrix after, tabletted (every sheet heavy 5g), cuts, packaging.
Embodiment 4
Take following raw material: cloves 3 parts, hoveniae semoveniae semen 12 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, colloidal materials; Described matrix comprises following component: sweetener 0.06 part, maltose 0.6 part, glycerine 0.03 part, 0.03 part, essence, superfine silica gel powder 0.2 part, 0.06 part, sweet mellow wine, guar gum 0.12 part.Preparation method comprises the steps: the 1st step, gets cloves, hoveniae semoveniae semen, the root of kudzu vine, the Radix Astragali, add decocting three times, the weight of the water at every turn added is 8 times of ingredients gross weight, the decocting time is 30min, merge decocting liquid, be then concentrated into thick paste, the mother-in-law U.S. degree of thick paste at 80 DEG C is 4 °, drying, obtains extract particles; 2nd step, extract particles is mixed at 50 DEG C with matrix after, tabletted (every sheet heavy 5g), cuts, packaging.
Embodiment 5
Take following raw material: cloves 3 parts, hoveniae semoveniae semen 12 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, colloidal materials; Described matrix comprises following component: sweetener 0.06 part, maltose 0.6 part, glycerine 0.03 part, 0.03 part, essence, superfine silica gel powder 0.2 part, 0.06 part, sweet mellow wine, guar gum 0.12 part.Preparation method comprises the steps: the 1st step, gets cloves and hoveniae semoveniae semen, adds decocting respectively three times, and the weight of the water at every turn added is 8 times of cloves and hoveniae semoveniae semen gross weight respectively, and the decocting time is 30 min; Get the root of kudzu vine and the Radix Astragali again, add decocting three times after mixing, the weight that adds water is 8 times of the root of kudzu vine and astragalus weight sum, and the decocting time is 30min, and merge decocting liquid, be then concentrated into thick paste, the mother-in-law U.S. degree of thick paste at 80 DEG C is 4 °, dry, obtains extract particles; 2nd step, extract particles is mixed at 50 DEG C with matrix after, tabletted (every sheet heavy 5g), cuts, packaging.
Sensory evaluation result
Table 1 sensory evaluation result
| Color and luster | Tissue morphology | Mouthfeel | Sweetness duration | Hold fragrance | Chew time | Comprehensive grading | |
| Embodiment 1 | 13.01 | 16.22 | 19.65 | 7.95 | 4.01 | 18.47 | 79.31 |
| Embodiment 2 | 13.04 | 16.86 | 19.85 | 8.22 | 4.02 | 21.56 | 83.55 |
| Embodiment 3 | 13.24 | 17.60 | 22.57 | 8.34 | 4.39 | 18.67 | 84.81 |
| Embodiment 4 | 13.75 | 17.63 | 22.61 | 8.41 | 4.44 | 21.67 | 88.51 |
| Embodiment 5 | 14.52 | 18.65 | 22.51 | 8.49 | 4.39 | 22.45 | 91.01 |
| Control group | 13.22 | 18.44 | 22.35 | 8.39 | 4.32 | 22.12 | 88.84 |
Analyze as can be seen from table, owing to the addition of superfine silica gel powder in embodiment 2,4,5, relative to embodiment 1 and embodiment 3, considerably improve the scoring of chew time.Owing to the addition of sweet mellow wine and guar gum in embodiment 3,4,5, relative to embodiment 1 and 2, considerably improve the scoring of tissue morphology.Owing to being that cloves and hoveniae semoveniae semen are separately extracted in embodiment 5, further improve relative to the scoring of embodiment 4 tissue morphology.
Pharmacodynamics test
This research by cloves hoveniae semoveniae semen aproll decocting liquid to the righting reflex of acute alcoholism mouse; the impact of whole blood concentration of alcohol and liver, gastric tissue alcohol dehydrogenase (ADH) etc. and verify its Dealcoholic sobering-up, preventing drunkenness effect and the protective effect to alcoholic liver injury thereof to the impact of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease activity in acute alcohol-induced hepatic injury rat model serum, for the fall apart exploitation of Antialcoholic liver-protecting chewing gum product of cloves hoveniae semoveniae semen provides theoretical foundation and curative effect basis.
Material
1.1 animal Kunming mouses, SPF level, male and female half and half, weight 20 ~ 22g, SD rat, SPF level, 180 ~ 220g, there is provided by Gansu Chinese of Traditional Chinese Medicine's animal used as test animal center, the Quality of Experimental Animals quality certification number: SCXK (sweet) 2011-0001, animal facility use certificate: SYXK (sweet) 2011-0001.
1.2 medicine cloves hoveniae semoveniae semen aproll decocting liquids are provided by Gansu Chinese of Traditional Chinese Medicine's scientific experiment center pharmaceutics of Chinese drugs making in laboratory.
1.3 instruments and reagent ultraviolet specrophotometer (Japanese Shimadzu Corporation model: UV-2401PC), gas chromatograph (Japanese model: GC-14B), automatic clinical chemistry analyzer (Switzerland model cobas311), ADH measures kit (Beijing Zhongsheng Beikong Biological Science & Technology Co., Ltd., lot number 121120), (bioengineering Co., Ltd is built up in Nanjing to glutamic-pyruvic transaminase (ALT) detection kit, lot number 121101), detect with glutamic-oxalacetic transaminease (AST) and determine kit (bioengineering Co., Ltd is built up in Nanjing, lot number 111224), Coomassie brilliant blue protein determination kit (Beijing Zhongsheng Beikong Biological Science & Technology Co., Ltd., lot number 121101).
Method and result
2.1 experimental technique
2.1.1 on the impact of glutamic-pyruvic transaminase glutamic-oxalacetic transaminease activity in acute alcoholism rat blood serum
30 SD male rats, adaptability is fed 1 week, is divided into three groups at random by table of random number, often organizes 10.Blank group: every day, timing was with 1.4ml/100g body weight physiological saline gavage, continuous 15 days; Model group: every day, timing was with 1.4ml/100g body weight strong, colourless liquor distilled from sorghum gavage, continuous 10 days; Treatment group: every day, timing was with cloves hoveniae semoveniae semen aproll decocting liquid 1.4ml/100g body weight gavage, gave strong, colourless liquor distilled from sorghum 1.4ml/100g body weight gavage, continuous 10 days after 45 minutes.10th day model group and treatment group are anaesthetized with chloraldurate hypodermic injection respectively at 60min after filling strong, colourless liquor distilled from sorghum, get Inferior Vena Cava Blood loads in sterile tube simultaneously, normal temperature centrifugal 4000 revs/min 5 minutes, detects glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease content in serum with automatic clinical chemistry analyzer.Experimental result is in table 2.
Table 2 cloves hoveniae semoveniae semen aproll decocting liquid is on the impact (n=10 of rat blood serum glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease content
± SD)
| Group | Dosage (g/kg) | ALT(U/L) | AST(U/L) |
| Blank group | —— | 24.1±4.2 | 60.4±9.7 |
| Model group | —— | 75.1±11.4 | 106.3±14.1 |
| Treatment group | 1.2 | 49.3±5.3 △△ | 82.6±11.1 △△ |
Note: compare with model group
△p < 0.05,
△ △p < 0.01
Model group compares with blank group, and glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminease (AST) concentration obviously increase, and treatment group reduction more obvious than model group, has significant difference (P<0.01) between group.
2.1.2 drunk prevention experiment: by 30 mouse (male and female half and half) precuring 3d, is divided into the heavy dose of group of model group, cloves hoveniae semoveniae semen aproll decocting liquid small dose group and cloves hoveniae semoveniae semen aproll decocting liquid, often organizes 10.Water 6h is prohibited in each group of first fasting of mouse, and cloves hoveniae semoveniae semen aproll decocting liquid small dose group presses 1.0g/kg gavage, and heavy dose of group presses 2.0g/kg gavage, and model group gavages equivalent 9.0g/L sodium chloride injection.After 30min, each group mouse is all by 18ml/kg gavage 560ml/L strong, colourless liquor distilled from sorghum white wine, and the time needed for record mouse righting reflex loss to righting reflex recovery, experimental result is in table 1.
2.1.3 drunk Experiment on therapy: number of mice, grouping and experimental technique are the same, but by perfusion time and the exchange of filling wine time, the time needed for record recovers to mouse righting reflex loss to righting reflex after drinking, experimental result is in table 3.
Table 3 cloves hoveniae semoveniae semen aproll decocting liquid extremely recovers the impact (n=10 of required time on drunk mouse righting reflex loss
± SD)
| Group | Dosage (g/kg) | Prevention experiment (min) | Experiment on therapy (min) |
| Model group | —— | 388.5±31.2 | 405.2±37.8 |
| Heavy dose of group | 2.0 | 311.5±32.9 △△ | 302.4±32.4 △△ |
| Small dose group | 1.0 | 329.2±40.1 △ | 341.2±40.2 △ |
Note: compare with model group
△p < 0.05,
△ △p < 0.01
Result shows, cloves hoveniae semoveniae semen aproll decocting liquid significantly can reduce the time needed for the drunk mouse righting reflex loss caused to righting reflex recovery, has statistical significance (P < 0.05 or P < 0.01) with model group comparing difference.
2.1.4 whole blood determining concentration of alcohol: small white mouse 20, is divided into each 10 of model group, treatment group at random.The first gavage 9.0g/L sodium chloride injection of model group, the same treatment group of volume; Treatment group gavages cloves hoveniae semoveniae semen aproll decocting liquid by 16.7g/kg.After 60min, two groups all gavage 560ml/L white wine by 16ml/kg.0.1ml liquaemin is added by each 5 ml ml headspace bottle, get each treated animal broken end respectively in 120 min after drinking and get blood, 0.6ml blood is accurately pipetted to ml headspace bottle with liquid-transfering gun, add 5 μ l n-butanols again as interior mark, sealed with bottle capper rapidly and shake up, gasify 20min in 80 DEG C of waters bath with thermostatic control, layer of air on 1ml is extracted with 1ml glass syringe, inject gas chromatograph, detect ethanol content, experimental result is in table 4.
Table 4 cloves hoveniae semoveniae semen aproll decocting liquid is to the mensuration (n=10 of drunk Mouse whole blood concentration of alcohol
± SD)
| Group | Dosage (g/kg) | Whole blood ethanol content (g/L) |
| Model group | —— | 0.5947±0.1204 |
| Heavy dose of group | 2.0 | 0.1567±0.0369 △△ |
| Small dose group | 1.0 | 0.3458±0.0452 △ |
Note: compare with model group
△p < 0.05,
△ △p < 0.01
Result shows, cloves hoveniae semoveniae semen aproll decocting liquid significantly can reduce drunk Mouse whole blood concentration of alcohol (P < 0.05 or P < 0.01).
2.1.5 liver, stomach ADH determination of activity: mouse 20, is divided into treatment group and each 10 of model group at random.The fasting of each group of mouse elder generation, taboo water 12 h.Treatment group gavages cloves hoveniae semoveniae semen aproll decocting liquid decoction by 2.0g/kg, and control group gavages equivalent 9.0g/L sodium chloride injection.After 60 min, two groups of mouse are all by 16ml/kg gavage 560ml/L white wine.Its liver and stomach is got after 120min, by ADH kit and Coomassie brilliant blue protein reagent box description preparation related reagent, the quality of mouse liver and stomach is accurately taken with ten thousand/precision balance, 9.0g/L sodium chloride injection is added by the mass volume ratio of 1:10, the tissue homogenate of 100g/L is prepared into glass homogenizer, centrifugal 10 min of 2500 r/min, use micro sample adding appliance Aspirate supernatant.Supernatant is divided into two parts, portion 9.0g/L sodium chloride injection is diluted to 10g/L tissue homogenate by 1: 9, measures ADH activity (unit is the units contained in every milligram of homogenate proteins) in supernatant with 7520 type ultraviolet specrophotometers; Another part is for measuring the protein content of liver, stomach.Experimental result is in table 5.
Table 5 cloves hoveniae semoveniae semen aproll decocting liquid is on the impact (n=10 of drunk mouse every milligram homogenate liver, stomach ADH activity
± SD)
| Group | Dosage (g/kg) | Liver (U) | Stomach (U) |
| Model group | —— | 32.22±6.21 | 37.13±5.22 |
| Heavy dose of group | 2.0 | 54.42±6.87 △△ | 57.47±7.02 △△ |
| Small dose group | 1.0 | 39.89±8.56 | 48.02±6.12 △△ |
Note: compare with model group
△p < 0.05,
△ △p < 0.01
Result shows, cloves hoveniae semoveniae semen aproll decocting liquid significantly can increase the activity (P < 0.05 or P < 0.01) of drunk Mouse Liver gastric tissue alcohol dehydrogenase.
Conclusion
Cloves hoveniae semoveniae semen aproll decocting liquid significantly can reduce the time needed for the drunk mouse righting reflex loss caused to righting reflex recovery, significantly can reduce drunk Mouse whole blood concentration of alcohol, prompting cloves hoveniae semoveniae semen aproll decocting liquid has obvious antialcoholism action; Significantly can increase the activity of acute alcohol-induced hepatic injury rats'liver gastric tissue alcohol dehydrogenase; enhance the first-pass metabolism effect of ethanol in stomach; thus reduce body to the bioavilability of ethanol; alleviate ethanol to organ injury effects such as livers, prompting cloves hoveniae semoveniae semen aproll decocting liquid has certain protective effect to alcoholic liver injury.
Claims (8)
1. alcoholic liver injury is had to a chewing gum for protective effect, it is characterized in that, include following component by weight as raw material: cloves 2 ~ 4 parts, hoveniae semoveniae semen 8 ~ 14 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, colloidal materials; Described matrix comprises following component: sweetener 0.03 ~ 0.09 part, maltose 0.3 ~ 0.8 part, glycerine 0.02 ~ 0.04 part, 0.02 ~ 0.04 part, essence.
2. chewing gum alcoholic liver injury to protective effect according to claim 1, is characterized in that: component proportion is: cloves 3 parts, hoveniae semoveniae semen 12 parts, the root of kudzu vine 30 parts, the Radix Astragali 15 parts, sweetener 0.06 part, maltose 0.6 part, glycerine 0.03 part, 0.03 part, essence.
3. chewing gum alcoholic liver injury to protective effect according to claim 1, is characterized in that: also comprise superfine silica gel powder 0.1 ~ 0.2 part in described colloidal materials.
4. chewing gum alcoholic liver injury to protective effect according to claim 1, is characterized in that: also comprise 0.04 ~ 0.06 part, sweet mellow wine, guar gum 0.08 ~ 0.12 part in described colloidal materials.
5. preparation method alcoholic liver injury to the chewing gum of protective effect described in any one of Claims 1-4, it is characterized in that, comprise the steps: the 1st step, get cloves, hoveniae semoveniae semen, the root of kudzu vine, the Radix Astragali, add the decocting three times of 8 times of weight, merge decocting liquid, then thick paste is concentrated into, dry, obtain extract particles; 2nd step, extract particles is mixed with colloidal materials after, tabletted, cuts, packaging.
6. preparation method alcoholic liver injury to the chewing gum of protective effect according to claim 5, is characterized in that: the decocting time in the 1st step is 30 ~ 60 min.
7. preparation method alcoholic liver injury to the chewing gum of protective effect according to claim 5, is characterized in that: the mother-in-law U.S. degree of the thick paste in the 1st step at 80 DEG C is 4 °.
8. preparation method alcoholic liver injury to the chewing gum of protective effect according to claim 5, is characterized in that: the temperature in the operation mixed in the 2nd step controls at 50 ~ 60 DEG C.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030731A (en) * | 2015-07-07 | 2015-11-11 | 柳华平 | Preparation method of microcapsule with protection effect on alcoholic liver injury |
| CN109258908A (en) * | 2018-10-31 | 2019-01-25 | 方林 | A kind of preparation method of rose chewing gum |
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| EP0126570A2 (en) * | 1983-05-13 | 1984-11-28 | Warner-Lambert Company | A powder filled chewing gum piece |
| CN1105526A (en) * | 1994-01-20 | 1995-07-26 | 李发前 | Chewing gum capable of preventing dozing |
| CN1528429A (en) * | 2003-10-20 | 2004-09-15 | 上海澳博海洋生物技术开发有限公司 | Chinese medicine preparation with accessory protection action to alcoholic liver injury and preparing method thereof |
| CN101919982A (en) * | 2009-06-12 | 2010-12-22 | 湖北中烟工业有限责任公司 | Medicinal combination for relieving alcoholism and protecting liver and functional chewing gum prepared therefrom |
| CN104171241A (en) * | 2014-07-28 | 2014-12-03 | 邱彩练 | Chewing gum with effect of dispelling effects of alcohol |
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2015
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0126570A2 (en) * | 1983-05-13 | 1984-11-28 | Warner-Lambert Company | A powder filled chewing gum piece |
| CN1105526A (en) * | 1994-01-20 | 1995-07-26 | 李发前 | Chewing gum capable of preventing dozing |
| CN1528429A (en) * | 2003-10-20 | 2004-09-15 | 上海澳博海洋生物技术开发有限公司 | Chinese medicine preparation with accessory protection action to alcoholic liver injury and preparing method thereof |
| CN101919982A (en) * | 2009-06-12 | 2010-12-22 | 湖北中烟工业有限责任公司 | Medicinal combination for relieving alcoholism and protecting liver and functional chewing gum prepared therefrom |
| CN104171241A (en) * | 2014-07-28 | 2014-12-03 | 邱彩练 | Chewing gum with effect of dispelling effects of alcohol |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030731A (en) * | 2015-07-07 | 2015-11-11 | 柳华平 | Preparation method of microcapsule with protection effect on alcoholic liver injury |
| CN105030731B (en) * | 2015-07-07 | 2017-07-11 | 柳华平 | A kind of preparation method of the microcapsules to alcoholic liver injury with protective effect |
| CN109258908A (en) * | 2018-10-31 | 2019-01-25 | 方林 | A kind of preparation method of rose chewing gum |
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