CN104489853B - A kind of preparation method alcoholic liver injury to the soda of protective effect - Google Patents
A kind of preparation method alcoholic liver injury to the soda of protective effect Download PDFInfo
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- CN104489853B CN104489853B CN201510014078.3A CN201510014078A CN104489853B CN 104489853 B CN104489853 B CN 104489853B CN 201510014078 A CN201510014078 A CN 201510014078A CN 104489853 B CN104489853 B CN 104489853B
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- hoveniae semoveniae
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- A23L2/38—Other non-alcoholic beverages
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/54—Mixing with gases
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/68—Acidifying substances
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of preparation method alcoholic liver injury to the soda of protective effect, belong to technical field of beverage. By weight, 15 parts of 40～80 parts of cloves, 50～90 parts of hoveniae semoveniae semens, 30 parts of the roots of kudzu vine, the Radix Astragali are added in the water of 200～400 parts, heating is extracted, and obtains leaching liquor; Leaching liquor is carried out, after Separation of Solid and Liquid, obtaining clear liquid, clear liquid is mixed with the carbonated water of 1～1.5 times of weight, to obtain final product. Cloves provided by the invention, the hoveniae semoveniae semen soda that relieves the effect of alcohol combines the antialcoholism action of cloves, hoveniae semoveniae semen; be aided with the refrigerant hot effect that disappears of soda simultaneously; can be better for alcohol user be relieved the effect of alcohol; in addition; by being aided with again the root of kudzu vine, the Radix Astragali, can effectively play a protective role to alcoholic liver injury.
Description
Technical field
The present invention relates to a kind of preparation method alcoholic liver injury to the soda of protective effect, belong to beverageTechnical field.
Background technology
Drinking beyond one's capacity and become gradually a serious public health problem in China and even world wide, is world today's modelThe first public hazards in enclosing, doctor trained in Western medicine there is no special efficacy antialcoholic drugs at present. When concentration of alcohol in blood reaches 0.05%, the work of alcoholAppear with starting, occur excitement and floaty euphoria; In the time that Ethanol concentration in rat blood reaches 0.1%, people will losing self-control. As reachTo 0.2% time, people has arrived as drunk as a sow stage; While reaching 0.4%, people just can lose consciousness, and remains unconscious, and even has lifeDangerous. The infringement of alcohol to people, the most important thing is central nervous system. It makes the inhibition of nervous system from excitement to height, tightNeural normal function is destroyed in important place. Excessive drinking is exactly to damage liver. Chronic alcoholism, can cause AlcoholicCirrhosis. In addition chronic alcoholism, also has many-sided infringement to health. As can cause polyneuritis, myocardium pathology,Cerebral lesion, hematopoietic disorder, pancreatitis, gastritis and canker etc., also can make the incidence of disease of high blood pressure raise. Somebody's noteMeaning arrives, and long-term heavy drinking, can endanger reproduction cell, causes offspring's feeblemindedness. People's laryngocarcinoma and the digestive system cancer of often drinkingThe incidence of disease obviously increases. Therefore the health food that, development has a Dealcoholic sobering-up effect receives much concern.
Soda, refer to the goods that are filled with carbon dioxide gas under certain condition, is CO 2 aerated refrigerant beverageGeneral name, is commonly called as carbonated drink. Do not comprise the beverage that is produced carbon dioxide gas by fermentation method self, the content of carbon dioxide gas in its finished product(20 DEG C time volume multiple) are not less than 2.0 times. The feature of soda is to be filled with carbon dioxide gas, makes goods have refrigerant senseFeel, hindered microbial growth, can from beverage, take flavor component out of and had comfortable mouthfeel, so, soda toolThere is appetizing ventilation, the effect of relieving summer heat and quenching one's thirst. For the person of drinking beyond one's capacity, drink soda and can take away too much heat in body,And can bring refrigerant sensation to alcohol user.
In addition, how on the books the side of relieving the effect of alcohol is in the ancient book such as Shennong's Herbal, " the southern regions of the Yunnan Province book on Chinese herbal medicine ", according to Sun Longchuan's [1]Arrange, the sober-up function of Chinese herbal medicine can be summarized as following three classes: reducing fever and causing diuresis class (FI puerariae, watermelon, mung bean flour etc.); Only promote the production of body fluidThirsty class (dried immature fruit of citron orange, orange, the fruit of Chinese magnoliavine etc.); The class of removing dampness by means of aromatics (cloves, apple, Semen Lablab Album etc. in one's early teens). Wan Fang etc. [2] pointsAnalyse the ancient doctor side of relieving the effect of alcohol that mat is recorded medicine, it is roughly divided into three major types: the not liquor-saturated side that drinks, the tolerance of the increase human body of clothes to wineAmount, drinks and makes us not liquor-saturated side as dry gold; The side of sobering up, the intoxicating person that is suitable for drinking beyond one's capacity, as Shigao Tang, the angle side of sobering up etc.; WineThe disease side of controlling, this type of side is used for the treatment of because of the many diseases due to wine, and having the food and drink of disappearing is main person, and the dampness elimination of eliminating the phlegm is main person, has solutionWine poison is main person, and relieving heat and thirst is main person, and having except wine amasss is main person etc. Dunhuang ancient medical prescription " auxiliary row rhymed formula internal organs drug regimen will " is rightAlso on the books in the food therapy of relieving the effect of alcohol: " wine diaphragm wine is long-pending, tells contrary ruffian completely, smashes sieve as loose taking cloves, hoveniae semoveniae semen ".
Hoveniae semoveniae semen, with name honey raisin tree, is Rhamnaceae (Rhamnaceae) Hovenia (HoveniaThunb) plant. Medicinal partFor the fruits and seeds with meat carpopodium, bronzing when ripe, Glabrous, fragrant and sweet good to eat, spherical fruit, includes threeBronzing seed. It is one of name fruit, is also a kind of rare medical, edible fruit. This plant begins to be loaded in Tang Materia Medica fruitThe residence of a high official, Li Shizhen (1518-1593 A.D.) claims that it is golden fruit tree, the sweet acid of nature and flavor flat ". " herbal Ran Xin " also says its " sweet acid of taste, property is flat, nontoxic ", " popular feeling, spleenTwo through ", " the southern regions of the Yunnan Province book on Chinese herbal medicine " think its " can solution spill poison ", supplement to the Herbal record can " relieving restlessness of quenching the thirst, moisturizing viscera, sharp stool and urine,Go postcibal vomiting heat, function is as honey ", " herbal guiding principle with " thinks its " preventing or arresting vomiting is contrary ". Modern times medicine ovum is studied and is shown, Semen Hoveniae (Fructus Hoveniae) extract can subtractLight noxious material, to hepatocellular damage, has anti peroxidation of lipid, stabilizing cell membrane, the effects such as protection hepatocyte activity.
Cloves, another name flos caryophylli (Syzygiumaromaticum), begins to be loaded in " property of medicine book on Chinese herbal medicine ". Temperature taste is pungent, people's spleen,Stomach, kidney channel. There is warming middle energizer to descend adverse-rising qi, effect of warming kidney and enhancing yang. Be usually used in the cards such as stomach cold induced Vomiting, hiccup and impotence due to deficiency of the kidney. " largeBright book on Chinese herbal medicine " there is a record of controlling cold air, killing wine poison. Control the cards such as the induced Vomiting of drinking, body be cold, can be alone, or with ginseng, ginger, methodSummer, calyx and receptacle of a persimmon adapted. Studies confirm that, cloves crude extract has stronger antioxidation activity, and DPPH radical scavenging activity is weaker thanThe VC of equal in quality concentration, is better than 2 of equal in quality concentration, 6-di-tert-butyl-4-methy phenol (BHT), the anti-oxidant work of clovesThe main matter basis of property is total polyphenols and general flavone.
Summary of the invention
The object of the invention is: a kind of preparation side alcoholic liver injury to the soda of protective effect is providedMethod, it has possessed the antialcoholism action of cloves, hoveniae semoveniae semen simultaneously, and utilizes the feature of soda to bring refrigerant to alcohol userSense.
Dunhuang ancient medical prescription has been followed the theory of the dietary therapy of Chinese medicine, preferably medicine and food blending used, and double the executing of medicine food,In " auxiliary row rhymed formula internal organs drug regimen want ", make clear the purpose and main theme from the very beginning especially point out " attacking pathogenic factor with poisonous drug, supplementing vital QI with five kinds of veg etables, assisting vital QI with five kinds of fruits, five cereals areSupport reinforcing vital QI with meats of five livestock ", the viewpoint of this and interior warp is come down in a continuous line. " auxiliary row rhymed formula internal organs drug regimen is wanted " also has note for the food therapy of relieving the effect of alcoholCarry: " wine diaphragm wine is long-pending, tells contrary ruffian completely, smashes sieve as loose taking cloves, hoveniae semoveniae semen ". This research, on the loose basis of cloves, hoveniae semoveniae semen, addsThe Gansu genunie medicinal materials Radix Astragali and the root of kudzu vine composition that enter integration of drinking and medicinal herbs have Dealcoholic sobering-up and alcoholic liver injury are had to protection workWith prescription.
Technical scheme:
Alcoholic liver injury is there is to the preparation method of the soda of protective effect, by weight, by cloves 40～15 parts of 80 parts, 50～90 parts of hoveniae semoveniae semens, 30 parts of the roots of kudzu vine, the Radix Astragali add in the water of 200～400 parts, and heating is extracted, and obtains lixiviateLiquid; Leaching liquor is carried out, after Separation of Solid and Liquid, obtaining clear liquid, clear liquid is mixed all with the carbonated water of 1～1.5 times of weightEven, to obtain final product.
Preferably, the pH of described carbonated water is between 4.0～5.0.
Preferably, in described carbonated water, also include sweetener, acidulant, tartaric acid, ascorbic acid, anti-One or several in bad hematic acid sodium, sodium acid carbonate, dextrin, spices, emulsifying agent, stabilizing agent.
Preferably, before extracting, hoveniae semoveniae semen is placed in to ethanol water and soaks, filter post-drying.
Preferably, the volumetric concentration of ethanol water is more than 90%; Soaking temperature is 20～30 DEG C; Soak time 0.5～3 hours.
Preferably, hoveniae semoveniae semen is preferably crushed to 200 order～400 orders.
Beneficial effect
Cloves provided by the invention, the hoveniae semoveniae semen soda that relieves the effect of alcohol combines the antialcoholism action of cloves, hoveniae semoveniae semen, simultaneously auxiliaryWith the refrigerant hot effect that disappears of soda, can be better for alcohol user be relieved the effect of alcohol, in addition, and by being aided with again the root of kudzu vine, the Radix Astragali, canEffectively alcoholic liver injury is played a protective role.
Detailed description of the invention
Below by detailed description of the invention, the present invention is described in further detail. But those skilled in the art will manageSeparate, the following example is only for the present invention is described, and should not be considered as limiting scope of the present invention. Unreceipted concrete skill in embodimentArt or condition person, according to the described technology of the document in this area or condition or carry out according to product description. Examination usedThe unreceipted person of production firm of agent or instrument, being can be by the conventional products of commercial acquisition.
The value of expressing with range format should using mode be flexibly interpreted as not only comprise clearly list as scopeThe numerical value of limit value, but also comprise all single numerical value or the subinterval that are encompassed within the scope of this, just as each numerical value and subareaBetween clearly listed. For example, the concentration range of " about 0.1% to approximately 5% " should be understood to not only comprise and clearly listsApproximately 0.1% to approximately 5% concentration, also include single concentration in institute's how (as, 1%, 2%, 3% and 4%) and subinterval (exampleAs, 0.1% to 0.5%, 1% to 2.2%, 3.3% to 4.4%).
The present invention, by after cloves and hoveniae semoveniae semen are extracted, is prepared into soda. For leaching process, for example canWith the extraction element using according to conventional methods, 15 parts of 40～80 parts of cloves, 50～90 parts of hoveniae semoveniae semens, 30 parts of the roots of kudzu vine, the Radix Astragali addEnter in the water of 200～400 parts, stir as required 1 time～for several times, under normal pressure, carry out the extraction of approximately 30 minutes～90 minutes,Realize liquid look from maintaining suitable fragrance when and change the viewpoint suppressing and consider, preferably 10～90 DEG C, particularly preferably in 20At～80 DEG C, extract. Wherein, to extracting method and extraction conditions etc. without particular limitation of, for example also can pressurize and carryGet. The water using in extraction, except pure water, can be also hard water, soft water, ion exchange water, natural water etc. In the present invention, addThe weight multiple of water refer to the weight adding water be ingredients weight and multiple.
After extracting, need to filter leaching liquor, to remove particle, fiber, impurity etc., the solid-liquid here dividesFrom, can be undertaken by filtration, centrifugation etc., remove impurity and obtain black tea extract. For example can adopt arbitrarily notRust steel filter, outing cloth, filter, extract present the adopted filter method of residue in order to remove other. In addition, according toNeed further to carry out centrifugation, diatomite filtration.
Extract is directly mixed with the water that contains carbon dioxide. Here the filling of carbon dioxide can be usedThe known methods such as premixed method or rear mixing method are carried out. In addition, deteriorated in order to suppress beverage of the present invention, can fill twoBefore carbon oxide gas, by the oxygen that solution is carried out to degassed processing, remove containing in solution. For fear of long term storage itAfter, the thing that becomes turbid in beverage, according to a preferred embodiment of the present invention, the pH of carbonated water be 4.0～5.0 between. In soda of the present invention, the adjusting of pH can be by being used the known pH adjusting agent that can be applied to foodAnd carry out. Typically, because the carbonic acid containing in soda is acidic materials, so in order to regulate carbonic acid drink of the present inventionMaterial within the scope of above-mentioned pH, for example, can add NaOH, dibastic sodium phosphate, potassium hydroxide, tetrapotassium pyrophosphate, pyrophosphoric acid threeThe alkaline agents such as potassium, calcium hydroxide, sodium acid carbonate, dipotassium hydrogen phosphate, tripotassium phosphate, arginine. Above-mentioned pH adjusting agent can make separatelyWith a kind, also can combine two or more and use.
In soda, can add fruit juice, other additive, for example sweetener, acidulant, tartaric acid or otherComplex, such as water (pure water, hard water, soft water, ion exchange water, natural water etc.), ascorbic acid, sodium ascorbate, carbonic acidHydrogen sodium, dextrin, essence, emulsifying agent, stabilizing agent or other be any one or two or more in them in taste raw material etc.Combination, mainly carry out pH adjustment, concentration adjustment, taste adjustment.
The carbohydrate coordinating in soda of the present invention, can be applied in food as limit, is not particularly limited,For example can enumerate glucose, sucrose, fructose, lactose, liquid carbohydrate (for example HFCS), starch syrup, caramel, indigestibilityDextrin, polydextrose, dextrin, sorbierite, isomaltoketose, maltitol, stevia rebaudianum, Momordica grosvenori etc. Above-mentioned carbohydrate can be independentUse a kind, also can combine two or more and use. Coordinate carbohydrate in soda of the present invention time, as its content,Be not particularly limited, for example, can enumerate in 0.1～30 % by weight, preferably in the scope of 1～20 % by weight.
In soda of the present invention, essence be can coordinate, one kind or two or more natural essence, compound essence preferably usedDeng grease essence and powdered flavor, but be not particularly limited. For example, natural essence can be enumerated: frankincense oil, parsley oil, oleum anisi,Eucalyptus oil, wintergreen, cinnamon oil, menthol oil, oleum menthae viridis, peppermint oil, lemon oil, coriander oil, orange-seed oil, mandarin oil, acidOrange oil, lavender oil, oreodaphene, chamomile oil, cardamom oil, caraway oil, bay tree leaf oil, lemongrass oil, pinke needle oil, flores aurantiiOil, attar of roses, jasmine oil, flag flower medicinal extract, peppermint essential oil, rose essential oil, oranges and tangerines flower, tangerine oil, mixed fruit oil, strawberryOil, Ceylon cinnamon oil, caryophyllus oil, grape wet goods. As simple essence, can enumerate: carvol, anethole, gaultherolin, meatCinnamic aldehyde, linalool, linalyl-acetate, citrene, menthones, menthyl acetate, sobrerone, octanal, citral, pulegone,Carvacryl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, cyclohexane allyl propionate, Anthranilate, the adjacent ammonia of ethylYl benzoic acid salt, vanilione, undecalactone, hexanal, ethanol, propyl alcohol, butanols, isoamyl alcohol, hexenol, dimethyl sulfide, methylCyclopentenolone, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate etc. As contain simple essence and/orThe mixing essence that contains natural essence, can enumerate: strawberry perfume (or spice), apple perfume (or spice), banana incense, pineapple perfume (or spice), grape perfume (or spice), mango perfume (or spice), the torrid zoneThat fruit perfume (or spice), butter perfume (or spice), milk, Yoghourt perfume (or spice), fruit mix is fragrant, dried peppermint leaf is fragrant etc. In addition, the form of essence have essential oil, extract,Solids, also can be by dry their sprayings powder obtaining.
After long-term storage, there is precipitation and muddy problem in order to solve further, according to an improvement of the present inventionEmbodiment, before extracting, is placed in ethanol water by hoveniae semoveniae semen and soaks, and filters post-drying. Do like thisObject is can make to produce muddy material to be removed by ethanol, and is unlikely to lose principal component. Preferably, ethanol waterVolumetric concentration is more than 90%; Soaking temperature is 20～30 DEG C, soak time 0.5～3 hour. Filter process in this step, alsoCan adopt the same solid-liquid separating method, not concrete restriction. Dry processing can adopt drying under reduced pressure, air-dry, heating is dryThe known method such as dry, but from the loss of useful nutrient less, maintain good mouthfeel and the viewpoint of local flavor is considered, preferably decompressionDry.
In order to improve further the effect of alcohol immersion, hoveniae semoveniae semen is preferably crushed to 200 order～400 orders. Pulverizing placeReason can be carried out with the various reducing mechanisms of using in powdered in the art. As the tool of described reducing mechanismStyle, can enumerate airslide disintegrating mill (airgrinder).
Soda of the present invention is filled in closed container and supplies with. In addition, fill soda of the present inventionClosed container is not particularly limited, and can be any in vial, plastic bottle, can container etc. As described closed container,For example can enumerate and cover bottle that henna vial makes etc. with shrink film. The sterilization treatment bar of soda of the present inventionPart is not particularly limited, and can carry out the sterilization treatment such as heat sterilization, can also adopt from being mixed to filling container of raw materialUse sterile working.
In the present invention, adopt Hash nephelometer 2100Q to characterize the clarity of beverage.
The detection of general flavone content in hoveniae semoveniae semen:
Adopt UV-2550 dual-beam ultraviolet specrophotometer to measure, Japanese Shimadzu instrument Co., Ltd..
The making of calibration curve: weigh 7.2g rutin, dissolve and be settled to 50mL with methyl alcohol, obtain the rutin of 0.144g/LStandard items, precision measures standard items 0,1,2,3,4,5mL in 25mL volumetric flask, adds 1% AlCl3Solution 3mL, uses75% ethanol constant volume, shakes up rear standing 30min, is labeled as respectively 0#、1#、2#、3#、4#、5#, with 0#For contrast, 800～Between 190nm, scan 5#Sample, detects rutin maximum absorption band at 412nm place, measures 1 at 412nm place#、2#、3#、4#、5#SampleLight absorption value, taking light absorption value as ordinate, mass concentration mg/L is abscissa drawing standard curve.
The preparation of need testing solution:
Drink material 100ml, vacuum deaerator, then decompression distillation is to dry, dissolves and is settled to 10mL with methyl alcohol, shakes up use0.45 μ m membrane filtration, for subsequent use.
Embodiment 1
Cloves 60Kg, hoveniae semoveniae semen 70Kg, root of kudzu vine 30Kg, Radix Astragali 15Kg are added in the water of 300Kg, be heated to approximately 70At DEG C, extract, extraction time 60min, obtains leaching liquor; After leaching liquor is carried out to sand filtration filtration, Separation of Solid and Liquid,Obtain clear liquid, clear liquid is mixed with the carbonated water of 1.5 times of weight (pH is respectively 3.0,4.0,4.5,5.0,5.5), to obtain final product.
In hoveniae semoveniae semen in the soda preparing under different condition, general flavone content and turbidity are as 1 of following tableShow.
Table 1 soda testing result
| pH | 3.0 | 4.0 | 4.5 | 5.0 | 5.5 |
| General flavone mg/L | 23 | 23 | 23 | 22 | 23 |
| Turbidity NTU | 113 | 104 | 101 | 105 | 117 |
Beverage is placed after 30 days at normal temperatures, redeterminated, result is as shown in table 2 below.
Table 2 is placed the soda testing result after 30 days
| pH | 3.0 | 4.0 | 4.5 | 5.0 | 5.5 |
| General flavone mg/L | 22 | 22 | 22 | 23 | 22 |
| Turbidity NTU | 218 | 167 | 169 | 162 | 201 |
As can be seen from the table, pH is controlled in less scope and can ensures that turbidity can significantly not increase.
Embodiment 2
With the difference of embodiment 1 be: hoveniae semoveniae semen is carried out to alcohol immersion processing in advance. Hoveniae semoveniae semen 70Kg is positioned overIn the ethanol water of 90v/v%, soak 1 hour, temperature is controlled at 23 DEG C, then residue is leached with sand filtering device, driesAdd in the water of 300Kg with cloves 60Kg, root of kudzu vine 30Kg, Radix Astragali 15Kg afterwards, be heated at approximately 70 DEG C and extract, carryGet time 60min, obtain leaching liquor; After leaching liquor is carried out to sand filtration filtration, Separation of Solid and Liquid, obtains clear liquid, by clear liquid withThe carbonated water of 1.5 times of weight mixes (pH is respectively 4.5), to obtain final product. General flavone content 20mg/L, turbidity 90.Normal temperature was placed after 1 month, general flavone content 20mg/L, turbidity 111NTU. Can find out, soak by hoveniae semoveniae semen is carried out to ethanolAfter bubble, can solve significantly the problem that beverage turbidity increases afterwards in placement.
Embodiment 3
With the difference of embodiment 2 be: hoveniae semoveniae semen is carried out, before alcohol immersion processing, being crushed to 200 order～400 in advanceOrder. Hoveniae semoveniae semen 70Kg is crushed to 200 order～400 orders, is positioned in the ethanol water of 90v/v% and soaks 1 hour, temperatureDegree is controlled at 23 DEG C, then residue is leached with sand filtering device, after drying and cloves 60Kg, root of kudzu vine 30Kg, Radix Astragali 15Kg addIn the water of 300Kg, be heated at approximately 70 DEG C and extract, extraction time 60min, obtains leaching liquor; Leaching liquor is enteredAfter row sand filtration is filtered, Separation of Solid and Liquid, obtains clear liquid, and clear liquid is mixed to (pH with the carbonated water of 1.5 times of weightBe respectively 4.5), to obtain final product. General flavone content 20mg/L, turbidity 87. Normal temperature was placed after 1 month, and general flavone content 24mg/L is turbidDegree 92NTU. Can find out, after hoveniae semoveniae semen is pulverized, can solve significantly beverage turbidity increases after placementProblem.
Pharmacodynamics test
This research by cloves hoveniae semoveniae semen aproll decocting liquid to the righting reflex of acute alcoholism mouse, whole blood concentration of alcohol andThe impact of liver, gastric tissue alcohol dehydrogenase (ADH) etc. and acute alcohol liver damage rat model serum two-story valley third is turned to ammoniaThe impact of enzyme and glutamic-oxalacetic transaminease activity is verified its Dealcoholic sobering-up, preventing drunkenness effect and the protection of alcoholic liver injury is doneWith, for the exploitation of the loose alcohol-dissolving liver-protecting drink of cloves hoveniae semoveniae semen provides theoretical foundation and curative effect basis.
Material
1.1 animal Kunming mouses, SPF level, male and female half and half, weight 20 ~ 22g, SD rat, SPF level, 180 ~220g, provides by Gansu Chinese of Traditional Chinese Medicine's animal used as test animal center, the Quality of Experimental Animals quality certification number: SCXK (sweet) 2011-0001, animal facility use certificate: SYXK (sweet) 2011-0001.
1.2 medicine cloves hoveniae semoveniae semen aproll decocting liquids are tested by Gansu Chinese of Traditional Chinese Medicine's scientific experiment center pharmaceutics of Chinese drugsChamber makes and provides.
1.3 instruments and reagent ultraviolet specrophotometer (Japanese Shimadzu company model: UV-2401PC), gas phase lookSpectrometer (Japanese model: GC-14B), automatic clinical chemistry analyzer (Switzerland model cobas311), ADH measures kit (northCapital Zhongsheng Beikong Biological Science & Technology Co., Ltd., lot number 121120), glutamic-pyruvic transaminase (ALT) detection kit (build up by NanjingBioengineering Co., Ltd, lot number 121101), (bioengineering is built up in Nanjing to be had to determine kit with glutamic-oxalacetic transaminease (AST) detectionLimit company, lot number 111224), Coomassie brilliant blue protein determination kit (Beijing Zhongsheng Beikong Biological Science & Technology Co., Ltd.,Lot number 121101).
Method and result
2.1 experimental technique
2.1.1 the impact on glutamic-pyruvic transaminase glutamic-oxalacetic transaminease activity in acute alcoholism rat blood serum
30 SD male rats, adaptability is fed 1 week, is divided at random three groups by table of random number, 10 every group. BlankGroup: every day, timing was with 1.4ml/100g body weight physiological saline gavage, continuous 15 days; Model group: every day, timing was with 1.4ml/100gBody weight strong, colourless liquor distilled from sorghum gavage, continuous 10 days; Treatment group: every day, timing was filled with cloves hoveniae semoveniae semen aproll decocting liquid 1.4ml/100g body weightStomach, gives strong, colourless liquor distilled from sorghum 1.4ml/100g body weight gavage, continuous 10 days after 45 minutes. The 10th day model group and treatment group respectively atAfter filling with strong, colourless liquor distilled from sorghum, 60min, with chloraldurate hypodermic injection anesthesia, gets Inferior Vena Cava Blood simultaneously and packs in sterile tube, and normal temperature is centrifugal4000 revs/min 5 minutes, detect glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease content in serum with automatic clinical chemistry analyzer. Experiment knotFruit is in table 3.
Impact (the n=10 of table 3 cloves hoveniae semoveniae semen aproll decocting liquid on rat blood serum glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease content±SD）
| Group | Dosage (g/kg) | ALT(U/L) | AST(U/L) |
| Blank group | —— | 24.1±4.2 | 60.4±9.7 |
| Model group | —— | 75.1±11.4 | 106.3±14.1 |
| Treatment group | 1.2 | 49.3±5.3△△ | 82.6±11.1△△ |
Note: with model group comparison△P＜0.05，△△P＜0.01
Model group compares with blank group, and glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminease (AST) concentration obviously increase, treatmentGroup, than the obvious reduction of model group, has significant difference (P < 0.01) between group.
2.1.2 drunk prevention experiment: by 30 mouse (male and female half and half) precuring 3d, be divided into model group, cloves hoveniae semoveniae semenThe heavy dose of group of aproll decocting liquid small dose group and cloves hoveniae semoveniae semen aproll decocting liquid, 10 every group. Water 6h is prohibited in the first fasting of each group mouse,Cloves hoveniae semoveniae semen aproll decocting liquid small dose group is pressed 1.0g/kg gavage, and heavy dose of group is pressed 2.0g/kg gavage, and model group gavages equivalent9.0g/L sodium chloride injection. After 30min, each group mouse, all by 18ml/kg gavage 560ml/L strong, colourless liquor distilled from sorghum white wine, is recorded mouse and turns overNormal reflection disappears to righting reflex and recovers the required time, and experimental result is in table 1.
2.1.3 drunk treatment experiment: number of mice, grouping and experimental technique are the same, but by perfusion time and filling wine timeExchange, record recovers the required time to mouse righting reflex loss to righting reflex after drinking, and experimental result is in table 4.
Table 4 cloves hoveniae semoveniae semen aproll decocting liquid on drunk mouse righting reflex loss to the impact (n=10 that recovers required time±SD）
| Group | Dosage (g/kg) | Prevention experiment (min) | Treatment experiment (min) |
| Model group | —— | 388.5±31.2 | 405.2±37.8 |
| Heavy dose of group | 2.0 | 311.5±32.9△△ | 302.4±32.4△△ |
| Small dose group | 1.0 | 329.2±40.1△ | 341.2±40.2△ |
Note: with model group comparison△P＜0.05，△△P＜0.01
Result shows, cloves hoveniae semoveniae semen aproll decocting liquid can significantly reduce the drunk mouse righting reflex loss causing extremelyRighting reflex recovers the required time, has statistical significance (P < 0.05 or P < 0.01) with model group comparing difference.
2.1.4 whole blood determining concentration of alcohol: 20 of small white mouses, are divided into each 10 of model group, treatment group at random. Model groupFirst gavage 9.0g/L sodium chloride injection, the same treatment group of volume; Treatment group gavages cloves hoveniae semoveniae semen aproll decocting liquid by 16.7g/kg.After 60min, two groups all gavage 560ml/L white wine by 16ml/kg. By adding 0.1ml liquaemin in each 5ml head space bottle, in wineRear 120min gets respectively each treated animal broken end and gets blood, accurately pipettes 0.6ml blood to head space bottle with liquid-transfering gun, more just adds 5 μ lButanols is as interior mark, rapidly with bottle capper by its sealing and shake up, the 20min that gasifies in 80 DEG C of waters bath with thermostatic control, with 1ml glass noteEmitter extracts the upper layer of air of 1ml, and inject gas chromatograph, detects ethanol content, and experimental result is in table 5.
Mensuration (the n=10 of table 5 cloves hoveniae semoveniae semen aproll decocting liquid to drunk mouse whole blood concentration of alcohol±SD）
| Group | Dosage (g/kg) | Whole blood ethanol content (g/L) |
| Model group | —— | 0.5947±0.1204 |
| Heavy dose of group | 2.0 | 0.1567±0.0369 △△ |
| Small dose group | 1.0 | 0.3458±0.0452 △ |
Note: with model group comparison△P＜0.05，△△P＜0.01
Result shows, cloves hoveniae semoveniae semen aproll decocting liquid can significantly reduce drunk mouse whole blood concentration of alcohol (P < 0.05Or P < 0.01).
2.1.5 liver, stomach ADH determination of activity: 20 of mouse, are divided into each 10 for the treatment of group and model group at random. Each group is littleThe first fasting of mouse, taboo water 12h. Treatment group gavages cloves hoveniae semoveniae semen aproll decocting liquid decoction by 2.0g/kg, and control group gavages equivalent9.0g/L sodium chloride injection. After 60min, two groups of mouse are all by 16ml/kg gavage 560ml/L white wine. After 120min, get its liverAnd stomach, by ADH kit and Coomassie brilliant blue protein reagent box description preparation related reagent, by ten thousand/accurately balance standardReally take the quality of mouse liver and stomach, add 9.0g/L sodium chloride injection by the mass volume ratio of 1:10, use glass homogenateDevice is prepared into the tissue homogenate of 100g/L, and the centrifugal 10min of 2500r/min draws supernatant with micro sample adding appliance. By supernatantLiquid is divided into two parts, and portion was diluted to 10g/L tissue homogenate with 9.0g/L sodium chloride injection by 1: 9, with 7520 type ultraviolet spectrometriesADH activity in photometric determination supernatant (unit is the units containing in every milligram of homogenate albumen); Another part is for measuringThe protein content of liver, stomach. Experimental result is in table 6.
Impact (the n=10 of table 6 cloves hoveniae semoveniae semen aproll decocting liquid on every milligram of homogenate liver of drunk mouse, stomach ADH activity±SD）
| Group | Dosage (g/kg) | Liver (U) | Stomach (U) |
| Model group | —— | 32.22±6.21 | 37.13±5.22 |
| Heavy dose of group | 2.0 | 54.42±6.87△△ | 57.47±7.02△△ |
| Small dose group | 1.0 | 39.89±8.56 | 48.02±6.12△△ |
Note: with model group comparison△P＜0.05，△△P＜0.01
Result shows, cloves hoveniae semoveniae semen aproll decocting liquid can significantly increase drunk Mouse Liver gastric tissue alcohol dehydrogenaseActive (P < 0.05 or P < 0.01).
Conclusion
Cloves hoveniae semoveniae semen aproll decocting liquid can significantly reduce the drunk mouse righting reflex loss causing to righting reflexRecover the required time, can significantly reduce drunk mouse whole blood concentration of alcohol, prompting cloves hoveniae semoveniae semen aproll decocting liquid hasSignificantly antialcoholism action; Can significantly increase the activity of acute alcohol liver damage rats'liver gastric tissue alcohol dehydrogenase, increaseThe strong first-pass metabolism effect of ethanol in stomach, thus the bioavilability of body to ethanol reduced, alleviate ethanol to liver etc.Organ injury effect, prompting cloves hoveniae semoveniae semen aproll decocting liquid has certain protective effect to alcoholic liver injury.
Claims (1)
1. pair alcoholic liver injury has the preparation method of the soda of protective effect, it is characterized in that: by weight, and will15 parts of 40～80 parts of cloves, 50～90 parts of hoveniae semoveniae semens, 30 parts of the roots of kudzu vine, the Radix Astragali add in the water of 200～400 parts, and heating is extracted,To leaching liquor; Leaching liquor is carried out, after Separation of Solid and Liquid, obtaining clear liquid, by the carbonated water of clear liquid and 1～1.5 times of weightMix, to obtain final product: the pH of described carbonated water is between 4.0～5.0; In described carbonated waterAlso include sweetener; Before extracting, hoveniae semoveniae semen is placed in to ethanol water and soaks, filter post-drying; SecondThe volumetric concentration of alcohol solution is more than 90%; Soaking temperature is 20～30 DEG C; Soak time 0.5～3 hour; And by trifoliate orange DulcisSon carries out before alcohol immersion processing in advance, and hoveniae semoveniae semen is to be crushed to 200 order～400 orders.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1238148A (en) * | 1999-05-27 | 1999-12-15 | 张荣生 | Sobering-up health-care beverage |
| CN1509731A (en) * | 2002-12-26 | 2004-07-07 | 武汉东保科技开发有限责任公司 | Instant plant composition for sobering up and preparing method thereof |
| CN1515192A (en) * | 2003-08-22 | 2004-07-28 | 朱军真 | Health-care beverage for relieving acute alcoholism |
| CN1528429A (en) * | 2003-10-20 | 2004-09-15 | 上海澳博海洋生物技术开发有限公司 | Chinese medicine preparation with accessory protection action to alcoholic liver injury and preparing method thereof |
| CN103250947A (en) * | 2012-04-23 | 2013-08-21 | 乔德京 | Liver protection assisting health food |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1238148A (en) * | 1999-05-27 | 1999-12-15 | 张荣生 | Sobering-up health-care beverage |
| CN1509731A (en) * | 2002-12-26 | 2004-07-07 | 武汉东保科技开发有限责任公司 | Instant plant composition for sobering up and preparing method thereof |
| CN1515192A (en) * | 2003-08-22 | 2004-07-28 | 朱军真 | Health-care beverage for relieving acute alcoholism |
| CN1528429A (en) * | 2003-10-20 | 2004-09-15 | 上海澳博海洋生物技术开发有限公司 | Chinese medicine preparation with accessory protection action to alcoholic liver injury and preparing method thereof |
| CN103250947A (en) * | 2012-04-23 | 2013-08-21 | 乔德京 | Liver protection assisting health food |
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