CN108541846A - A kind of beverage with liver-protecting and alcoholism-relieving function - Google Patents
A kind of beverage with liver-protecting and alcoholism-relieving function Download PDFInfo
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- CN108541846A CN108541846A CN201810176596.9A CN201810176596A CN108541846A CN 108541846 A CN108541846 A CN 108541846A CN 201810176596 A CN201810176596 A CN 201810176596A CN 108541846 A CN108541846 A CN 108541846A
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- 235000015097 nutrients Nutrition 0.000 description 1
- YZNWXXJZEDHRKB-UHFFFAOYSA-N octadecyl 2-hydroxypropanoate;sodium Chemical compound [Na].CCCCCCCCCCCCCCCCCCOC(=O)C(C)O YZNWXXJZEDHRKB-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229930182496 polymethoxyflavone Natural products 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- OVSQVDMCBVZWGM-DTGCRPNFSA-N quercetin 3-O-beta-D-galactopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-DTGCRPNFSA-N 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- BBFYUPYFXSSMNV-UHFFFAOYSA-N quercetin-7-o-galactoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 BBFYUPYFXSSMNV-UHFFFAOYSA-N 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000028527 righting reflex Effects 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000003335 steric effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/62—Clouding agents; Agents to improve the cloud-stability
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to food technology fields, and in particular to a kind of beverage with liver-protecting and alcoholism-relieving function.The beverage includes component：Pueraria lobata, hoveniae semoveniae semen, dried hawthorn, dried orange peel, pulled figs, red bayberry fresh fruit, vine tea, the product that this component obtains in mouse modeling experiment is with good anti-intoxication alcohol neutralizing effect and to alcoholic fatty liver with certain protective effect.
Description
Technical field
The present invention relates to food technology fields, and in particular to a kind of beverage with liver-protecting and alcoholism-relieving function.
Background technology
Specific use beverage refers to the ingredient and content by adjusting nutrient in beverage, or be added have specific function at
The beverage that the certain special populations of adaptation divided need.With the improvement of living standards, demand of the consumer to beverage also presents
Diversified trend.Fig is Moraceae Ficus, containing abundant flavones and polysaccharide functional components, has prevention of cardiovascular disease
Disease, the effect for adjusting immunity, polysaccharide are considered as the antioxidant of natural safety.Pueraria lobata (Radix Puerariae) is
A kind of dry root of legume pueraria lobata has the good reputation of " ginseng in thousand ".It contains Multiple components, main physiological activity at
It is divided into isoflavone compound.The isoflavone compound extracted from Radix Puerariae at present has Puerarin, daidzin, daidzein
More than 20 kinds.What it had promote the production of body fluid to quench thirst, be hypoglycemic, reducing blood lipid, and the characteristics such as clearing and activating the channels and collaterals also have application in Chinese medicine, such as
For relieving alcoholism.Hawthorn is the economic plants that rose family hawthorn (Crataegus pinnatifada) has integration of drinking and medicinal herbs, main
It is flavonoids and glycoside, flavone compound such as epicatechin, anthocyanidin, Hyperoside, rutin, Quercetin to want active constituent
Deng, have the function of reduce blood fat.Dried orange peel (Pericarpium Citri Reticulatae) is rutaceae orange and other
The dry mature skin of variety (such as citrus reticulata"Chachi”, clovershrub, satsuma orange, tangerine produced in fujian province) has regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm
Function.The Flavonoid substances wherein contained contain unique polymethoxyflavone (polymethoxylated in dried orange peel
Flavones, PMFs), have the function of reducing serum cholesterol.Hoveniae semoveniae semen (Hovenia acerba Lindl.) is Rhamnaceae
Trifoliate orange Dulcis belongs to the ripening fruits of trifoliate orange Dulcis, containing bioactive ingredients such as alkaloid, flavonoids, triterpenoid saponins, has reducing fever and causing diuresis, solution
The effect of wine poison.Red bayberry is Myruca ceas Myrica(Myrica) (Myrica L.), and China is the main production country of red bayberry, and Zhejiang Province red bayberry not only exists
Quality, area, ranks first in the country in yield at kind.What it had helps digestion, keeps out the cold, relieving summer heat, antidiarrheal, diuresis, controlling dysentery and life
A variety of drug effects such as Tianjin quenches the thirst, gut purge stomach.Vine tea, also known as Sweet tea rattan, hair rock certain kind of berries tea etc. are a kind of medicinal plants of the Yao nationality of China
Object.It is vitaceae ampelopsis grossdentata, there is clearing heat and detoxicating, antibacterial anti-inflammatory, blood pressure lowering, hepatoprotective effect, the activity contained
Flavones ingredient --- dihydromyricetin has the survival rate for reducing acute alcoholism mice, and the tolerance to alcohol
The effect of.Wherein, hawthorn, hoveniae semoveniae semen, pueraria lobata be all defend planning commission announcement be both food and the Chinese medicine of drug, in food hygiene
Field is widely used.
Using the vegetable raw material of above-mentioned a variety of active functional components, by flooding, production has clearing heat and removing internal heat,
Improve the specific use beverage of immunity and liver-protecting and alcoholism-relieving poison.It is starch, more but due to complicated component in natural plant product
The presence of the Multiple components such as sugar, protein, influences its item property at the phenomenon that leading to Precipitation in ingredient.To increase beverage
The stability of product, using stabilizer common in being produced in beverage, including sodium carboxymethylcellulose (CMC-Na), xanthans
(xanthan), pectin (pectin), sodium alginate (sodium alginate) etc. and emulsifier stearoyl lactylates
(sodium stearyl lactate, SSL), diacetyl tartarate list double glyceride (diacetyl tartaric acid
Ester of mono (di) glycerides, DATEM) and propylene glycol alginate (propylene glycol alginate,
PGA) etc., by the Effect study to drink sample stabilizer, the stabilizer formula with good result is found, to increase sample
Acceptable degree, improve the sensory experience of product and the utilization rate etc. of plant material innate efficacy.
Invention content
In order to solve the problems in the existing technology, the present invention provides a kind of beverage with liver-protecting and alcoholism-relieving function,
The beverage includes ingredient：Pueraria lobata, hoveniae semoveniae semen, dried hawthorn, dried orange peel, pulled figs, red bayberry fresh fruit, vine tea.
Beverage containing these ingredients can be obviously prolonged mouse sleeping duration (P in mouse model experiment<
0.01), significantly shorten drunk time (P<0.01)；After drunk mouse gives sample, drunk time (P is significantly shortened<0.01).
In a preferred embodiment, each component is according to quality proportioning：
Pueraria lobata 25%
Hoveniae semoveniae semen 25%
Dried hawthorn 12.5%
Dried orange peel 8.3%
Pulled figs 8.3%
Red bayberry fresh fruit 16.7%
Vine tea 4.2%.
In a preferred embodiment, each component is according to the additive amount of quality in the beverage：
Pueraria lobata 6%
Hoveniae semoveniae semen 6%
Dried hawthorn 3%
Dried orange peel 2%
Pulled figs 2%
Red bayberry fresh fruit 4%
Vine tea 1%.
The preparation process of the beverage is proportionally to mix 7 kinds of raw materials, adds above-mentioned all raw material gross masses 3
Times deionized water, boiling water extracts 60min, and the deionized water of 2 times of raw material original quality is added in filter residue for four layers of filtered through gauze,
Boiling water extracts 30min again, and merging filtrate is concentrated or supplemented using cryogenic vacuum deionized water and quantifies extracting solution to raw material
3 times of gross mass cross 200 mesh filter clothes, high-pressure homogeneous (20MPa, 10min), and filling, sterilizing saves backup.
In order to find the stabilizer formula with good result, to increase the acceptable degree of sample, the sense of product is improved
Official experiences and the utilization rate of plant material innate efficacy, and preferably following ingredient is also added in beverage of the present invention, such as steady
Determine agent, the stabilizer is preferably the combination of one or more of CMC-Na, pectin, xanthans, sodium alginate；It is further excellent
Choosing, the stabilizer is pectin, xanthans and the combination of CMC-Na three.
In a preferred embodiment, emulsifier is further added in the beverage, the emulsifier is preferably
SSL, DATEM or PGA, it is preferred that the emulsifier is PGA.
In a preferred embodiment, three kinds of CMC-Na, pectin, xanthans stabilizations are preferably added in the beverage
Agent is compounded with emulsifier PGA.In a preferred embodiment, pectin 0.005% in the compounding；Xanthans 0.035%；
CMC-Na0.035%, PGA0.03%.
It is good that storage stability test has confirmed the performance of optimization of C/C composites sample appearance, and storage 2 weeks or more does not occur cotton-shaped
Precipitation illustrates that compound stabilizer has good stablizing effect to the specific use beverage, therefore applies valence with comparable
Value.
Description of the drawings
Fig. 1 extraction process flow charts；
Fig. 2 normally organizes 1 × 400 times of electron microscope of liver cell；
1 × 400 times of electron microscope of Fig. 3 model groups liver cell；
Fig. 4 Anti-A low dose groups 1 × 400 times of electron microscope of liver cell；
Fig. 5 Anti-A high dose groups 1 × 400 times of electron microscope of liver cell；
Fig. 6 is influence line chart of four kinds of stabilizer additive amounts to beverage stability；
Fig. 7 is that emulsifier SSL, DATEM and PGA change light transmittance line chart with concentration；
Influence line chart of Fig. 8 combined additives to beverage stability；
Influence column diagram of the tri- kinds of emulsifier compounded combinations of Fig. 9 to beverage stability.
Specific implementation mode
In order to be better understood by present disclosure, present disclosure is done in detail with reference to specific embodiment
Explanation, but specific embodiment is not the limitation to the content of present invention.
Embodiment 1：The manufacture craft of specific use beverage
By pueraria lobata (Radix Puerariae), hoveniae semoveniae semen (Hovenia acerba Lindl.), hawthorn (Crataegus
Pinnatifada it) does, dried orange peel (Pericarpium Citri Reticulatae), fig (Pericarpium Citri
Reticulatae it) does, red bayberry (Myrica L.) fresh fruit, vine tea (Ampelopsis grossedentata) this 7 kinds of raw materials are pressed
It is mixed according to following ratio：
Pueraria lobata 25%
Hoveniae semoveniae semen 25%
Dried hawthorn 12.5%
Dried orange peel 8.3%
Pulled figs 8.3%
Red bayberry fresh fruit 16.7%
Vine tea 4.2%.
Add the deionized water of above-mentioned 3 times of all raw material gross masses, boiling water extracts 60min, four layers of filtered through gauze, in filter residue
Be added the deionized water of 2 times of raw material original quality, boiling water extracts 30min again, merging filtrate, using cryogenic vacuum concentration or
Supplement deionized water quantifies extracting solution to 3 times of raw material gross mass, crosses 200 mesh filter clothes, high-pressure homogeneous (20MPa, 10min),
Filling, sterilizing saves backup to obtain the purposes beverage of ratio shown in table 1, and production technology is shown in Fig. 1.
The place of production of 1 specific use beverage raw material of table and its additive amount (the ratio product labelling is Anti-A)
Laboratory apparatus used in the present invention：Assay balance (METTLER TOLEDO), centrifuge (NEW
BRUNSWICK), spectrophotometer (SHIZUMA UV-1800), homogenizer (NANO HOMOGINISE MACHINE,
CANADA)；It is used in the present invention：Reagent C MC-Na, sodium alginate, pectin, xanthans (providing for oneself in laboratory), SSL, DATEM
(food-grade) (Henan Province Yuanyang Chemical Co., Ltd.), PGA (food-grade) (Zhejiang Renhe bio tech ltd).
Reference examples 1：The manufacture craft of specific use beverage (raw material type reduces or increases)
By pueraria lobata (Radix Puerariae), hoveniae semoveniae semen (Hovenia acerba Lindl.), hawthorn (Crataegus
Pinnatifada it) does, dried orange peel (Pericarpium Citri Reticulatae), fig (Pericarpium Citri
Reticulatae it) does, red bayberry (Myrica L.) fresh fruit, vine tea (Ampelopsis grossedentata) this 7 kinds of raw materials are pressed
It is mixed according to certain proportion, adds the deionized water of above-mentioned 3 times of all raw material gross masses, boiling water extracts 60min, four layers of gauze
It filters, the deionized water of 2 times of raw material original quality is added in filter residue, boiling water extracts 30min, merging filtrate, using low temperature again
It is concentrated in vacuo or supplement deionized water quantifies extracting solution to 3 times of raw material gross mass, cross 200 mesh filter clothes, it is high-pressure homogeneous
(20MPa, 10min), filling, sterilizing save backup to obtain the purposes beverage of ratio shown in table 2.
The place of production of 2 specific use beverage raw material of table and its additive amount (do not add red bayberry, product labelling Bayberry-
less)
The place of production of 3 specific use beverage raw material of table and its additive amount (not adding vine tea, product labelling Vine-less)
The place of production of 4 specific use beverage raw material of table and its additive amount (in addition add navel orange, product labelling Orange-
add)
All formulas add the deionized water of above-mentioned 3 times of all raw material gross masses, and boiling water extracts 60min, four layers of gauze mistake
It filters, the deionized water of 2 times of raw material original quality is added in filter residue, boiling water extracts 30min again, and merging filtrate is true using low temperature
Sky concentration or supplement deionized water quantify extracting solution to 3 times of raw material gross mass, cross 200 mesh filter clothes, high-pressure homogeneous
(20MPa, 10min), filling, sterilizing save backup.
Embodiment 2：Anti-intoxication alcohol neutralizing is tested
Mice drunk model is established using 56 degree of disposable administration by gavage of Beijing Erguotou wine, to study specific use beverage
Antialcoholism action.Mouse gives sample 5g/kg dosage, it is drunk to acute ethanol to observe it before to wine and to gavage is distinguished after drinking
Influence.The result shows that：Sample prevention administration can be obviously prolonged mouse sleeping duration (P<0.01), significantly shorten
Drunk time (P<0.01)；After drunk mouse gives sample, drunk time (P is significantly shortened<0.01) it is good, to illustrate that sample has
Good anti-intoxication alcohol neutralizing effect.
1. test objective
The anti-intoxication alcohol neutralizing effect of specific use beverage (sample Anti-A) is observed, the disintoxicating product to research and develop new provides centainly
Reference.
2. test medicine and reagent
Sample Anti-A, Bayberry-less, Vine-less, Orange-add dosage is 5g/kg；" thousand glasss
It is not liquor-saturated " antialcoholism capsule (Zhejiang Province Zhuji City Chaoyang Lu 78)；56 degree of Beijing Erguotou wines (Hongxing Co., Ltd. Beijing,
Product standard：GB/T10781.2).
3. experimental animal
ICR mouse 60, weight 18-22g, gender male.It is provided by Shanghai Slac Experimental Animal Co., Ltd.,
Production licence:SCXK (Zhejiang) 2014-0001.Rearing conditions：Checkout procedure completes (air cleaning in barrier system laboratory
≤ 1 ten thousand grade of degree, 10~20 time/hour of air exchange number, 20~26 DEG C of temperature, temperature difference per day≤3 DEG C, relative humidity 40~
70%), using licensing：SYXK2012-0178.Mouse feed 60 DEG C sterilizing big and small mouse upgrowth breeding feeds, by Shanghai this
Lake experimental animal Co., Ltd provides, and Shanghai, which is raised, examines (2014) 04001.Free diet drinking-water, cage utensil, bedding and padding etc. pass through
121 DEG C of high pressure sterilizations sterilize 20 minutes.
4. method
The anti-intoxication experiment of 4.1 samples takes male mice 30, is randomly divided into 3 groups, every group 10, respectively model group, the positive
Control group (" " thousand glasss not liquor-saturated " antialcoholism capsule " 0.4g/KG), Anti-A groups (5.0g/kg).Each group mouse with fed standard chow,
Free water, adaptable fed are tested after 1 week.Volume 10mL/kg, mould is administered in each group mouse fasting 12h before experiment, each group
Type control group gavage gives the drinking water of equivalent, and sample sets and positive controls distinguish the corresponding test liquid of gavage.After 15min,
Each group fills 56 degree of Beijing Erguotou wines with the capacity for liquor of 0.18mL/10g.The case where mouse is filled after drinking is observed, record mouse rights
The time and recovery time of areflexia, calculate tolerance time and drunk time.
4.2 samples relieve the effect of alcohol experimental animal grouping and adaptability raising it is the same, before experiment, each group mouse fasting 12h, first with
56 degree of Beijing Erguotou wines of capacity for liquor gavage of 0.16mL/10g, after 15min, model control group gavage gives drinking water, positive right
Distinguish the corresponding test liquid of gavage according to group and sample sets, volume 10mL/kg is administered in each group.Observe the case where mouse is filled after drinking, note
Time (drunk time) and the recovery time (sobering up the time) for recording mouse righting reflex loss, when calculating tolerance time and maintaining
Between.
4.3 statistical method measurement datas are indicated with " mean ± standard deviation " (M+SD).With SPSS V17.0 statistical packages
It carries out homogeneity test of variance and t is examined.
5. result
Anti-A prevention administrations can be obviously prolonged mouse sleeping duration (P<0.01) when, significantly shortening drunk
Between (P<0.01).After drunk mouse gives Anti-A, significantly extend mouse sleeping duration (P<0.01), shorten mouse
Drunk time (P<0.01), illustrate that Anti-A has good anti-intoxication alcohol neutralizing effect.Bayberry-less and Vine-less groups
Without significant difference compared with model group, illustrate after reducing red bayberry or vine tea, the anti-drunk function unobvious of beverage；Orange-add
Group there were significant differences compared with model group (P<0.05), but poorer (P than Anti-A groups<0.01), show to increase raw material, not necessarily
Anti-intoxication effect can be increased.Bayberry-less and Vine-less groups, without significant difference, illustrate to reduce poplar compared with model group
After plum or vine tea, the anti-drunk function unobvious of beverage；Orange-add groups there were significant differences compared with model group (P<0.01),
But it is poorer than Anti-A groups, in addition to it is cost-effective, it is advisable in addition not increasing raw material.
Anti-drunk functions of 5 Anti-A of table to ICR mouse
* (the P that shows compared with model group that there were significant differences<0.05), the * * (P that show compared with model group that there were significant differences<0.01)
Antialcoholism actions of 6 Anti-A of table to ICR mouse
* shows compared with model group that there were significant differences (P<0.01)
Embodiment 3：Liver protection is tested
Using 56 degree of Beijing Erguotou wine gavages one week, acute liver model is established, to study specific use drink
Expect the hepatoprotective effect of Anti-A.The mouse gavage Erguotou wine 12ml/kg/d before administration daily, gives respectively to 30min after drinking
Anti-A samples are low, high dose, observe its protective effect to acute liver damage.The result shows that：Anti-A, which has, mitigates liver weight
Amount and organ coefficient improve globulin, reduce albumin, reduce total bilirubin, promote alcohol dehydrogenase and acetaldehyde dehydrogenase point
The effect secreted, and have certain protective effect to alcoholic fatty liver.
1. test objective
The liver protection effect for observing Anti-A, the antialcoholic drug to research and develop new provide certain reference.
2. test medicine and reagent
Sample Anti-A is provided by Zhejiang Academy of Agricultural Science, and high and low dose is configured to 0.5g/mL and 0.25g/mL respectively
Solution for later use；56 degree of Beijing Erguotou wines (Hongxing Co., Ltd. Beijing, product standards：GB/T10781.2).ELISA is tried
Agent box is purchased from the Shanghai bio tech ltd Lang Dun.
3. instrument
8000 full automatic biochemical apparatus of Roche cobas, thermo companies varioskan flash microplate reader, Leica
EG1150H embedding machines, 2235 paraffin slicing machines of Leica RM, Leica HI1220 bake piece machine, and Leica HI1210 spread out piece machine,
Leica ASP300 dewaterers, 5010 full-automatic dyeing machines of Leica ST.Olympus CX21 type microscopes.
4. experimental animal
ICR mouse 60, weight 25-27g, gender male.It is provided by Shanghai Slac Experimental Animal Co., Ltd.,
Production licence:SCXK (Zhejiang) 2014-0001.Rearing conditions：Checkout procedure completes (air cleaning in barrier system laboratory
≤ 1 ten thousand grade of degree, 10~20 time/hour of air exchange number, 20~26 DEG C of temperature, temperature difference per day≤3 DEG C, relative humidity 40~
70%), using licensing：SYXK2012-0178.Mouse feed 60 DEG C sterilizing big and small mouse upgrowth breeding feeds, by Shanghai this
Lake experimental animal Co., Ltd provides, and Shanghai, which is raised, examines (2014) 04001.Free diet drinking-water, cage utensil, bedding and padding etc. pass through
121 DEG C of high pressure sterilizations sterilize 20 minutes.
5. method
5.1 take mouse 60, are randomly divided into 6 groups, respectively Normal group, model group, Anti-A high dose groups,
Anti-A low dose groups, daily according to 12ml/kg/ days 52 ° of Red Star strong, colourless liquor distilled from sorghum of dosage gavage, fill 30min after drinking by every group 10
Anti-A gastric infusions, one week experimental period, after a week, mouse fasting 12h, take a blood sample centrifuging and taking supernatant, survey ALT, AST, TP,
ALB, total bilirubin and alcohol dehydrogenase, acetaldehyde dehydrogenase, zootomy take liver, measure liver coefficient, and carry out HE dyeing,
Observe hepatic injury situation.
5.2 statistical method measurement datas are indicated with " mean ± standard deviation " (M+SD).With SPSS V17.0 statistical packages
It carries out homogeneity test of variance and t is examined.
6. result
Influence of 6.1 samples to ICR mouse weights and liver coefficient
Modeling each group mouse liver is below normal group again, and administration each group liver is less than model group, wherein Anti-A high again
Dosage group and the more significant difference of model group (P ＜ 0.05), liver organ coefficient significantly reduces compared with model group, wherein
Anti-A high and low dose group P ＜ 0.05.
Influence of 7 sample of table to ICR mouse weights and liver coefficient
* (the P that shows compared with model group that there were significant differences<0.05) the * * (P that show compared with model group that there were significant differences<0.01).
Influence of 6.2 samples to ICR mouse blood biochemical indicators
Model Histaglobin significantly reduces, and albumin significantly increases (P ＜ 0.05), and Anti-A high and low doses group can carry
High globulin, reduces albumin, and high dose group can also significantly reduce total bilirubin (P<0.05).
Influence of 8 sample of table to ICR mouse blood biochemical indicators
Δ shows compared with normal group that there were significant differences (P<0.05), the * (P that show compared with model group that there were significant differences<
0.05) the * * (P that show compared with model group that there were significant differences<0.01).
Influence of 6.3 samples to ICR mouse alcohol dehydrogenase, acetaldehyde dehydrogenase
Modeling can induce body alcohol dehydrogenase significantly to be increased with acetaldehyde dehydrogenase, be to reach within the scope of test dose
The level of signifiance.
Influence of 9 sample of table to ICR mouse alcohol dehydrogenase, acetaldehyde dehydrogenase
Δ Δ shows compared with normal group that there were significant differences (P<0.01), the * * (P that show compared with model group that there were significant differences<
0.01)。
Protective effect of 6.4 samples to ICR mouse liver injuries
Normal group liver liver Cable Structure is complete, fat-free cavity and inflammatory infiltration, compared with normal group, model group liver cell
Diffusivity fat becomes, and swelling of liver cell deformation, cytoplasm are muddy, have reticular structure, a small number of karyopycnosis inflammatory infiltration occur, with model
Group compares, and Anti-A group fat cavity is reduced, and liver Cable Structure is apparent, and swelling mitigates.
7. conclusion
Using 56 degree of Beijing Erguotou wine gavages one week, acute liver model is established, to study specific use drink
Expect the hepatoprotective effect of Anti-A.The mouse gavage Erguotou wine 12ml/kg/d before administration daily, gives respectively to 30min after drinking
Anti-A samples are low, high dose, observe its protective effect to acute liver damage.The result shows that：Anti-A, which has, mitigates liver weight
Amount and organ coefficient improve globulin, reduce albumin, reduce total bilirubin, promote alcohol dehydrogenase and acetaldehyde dehydrogenase point
The effect secreted, and have certain protective effect to alcoholic fatty liver.
Embodiment 4：The adding method of stabilizer
According to required ratio to be added, corresponding additive is weighed, uniformly mixes with dispersant sucrose, quickly stirs respectively
It mixes and is added in 70 DEG C of hot water, and stir the case where being completely dissolved to colloid, avoid the occurrence of conglomeration in boiling water bath.With 100mL
Beverage stoste is uniformly mixed, concentrated, is settled to 100mL, spare after 100 DEG C of sterilization treatment 10min, while will be not added with stabilization
After the sample sterilization treatment of agent as a contrast, more stable effect, each sample do three Duplicate Samples.
Embodiment 3：Process optimization test method
The screening and optimization of compound stabilizer：By single factor analysis CMC-Na, pectin, xanthans, sodium alginate, SSL,
DATEM, PGA and additive combine the stabilization to specific use beverage.Determine the preferable three kinds of thickeners of stablizing effect
Orthogonal is optimized with PGA (0.03%) compoundings, factor level is shown in Table 10.
10 factor of table and horizontal analysis
Embodiment 5：Method for estimating stability
Food additives are to the assay method of beverage stability, according to different needs, have different detection methods, such as
Clear beverage, detected using acetes chinensis, clarity etc.；The method used to the evaluation of beverage stability has：Sedimentation rate,
Subjective appreciation, coefficient of stabilization, viscosity, color density, the coefficient of stability, HLB value, shelf life, vertical scanning macroscopic analysis, light transmittance etc..
In comprehensive consideration this research the characteristics of sample, using the light transmittance and storage stability of centrifuged supernatant as evaluation method.
(1) light transmittance of supernatant
Sample is weighed into 10g in centrifuge tube, centrifugation 15min (4000rpm) takes its supernatant under 540nm wavelength, surveys
The light transmittance of random sample product.
(2) sample storage Detection of Stability
Sample is placed in room temperature, placement sees whether phenomena such as layering, be precipitated occur in 1 day -2 week, and record layering when
Between (day).
Orthogonal：Using SPSS19.0 analysis softwares, the orthogonal test of Three factors-levels is designed, and to experiment
As a result variance analysis is carried out, determines p<0.05 has statistical significance.
Embodiment 6：As a result with analysis
(1) influences of the CMC-Na to beverage stability
Fig. 6 is shown in influences of the CMC-Na to beverage stability of the present invention.In the range of added：0.0075%-0.05%,
Light transmittance present ascendant trend, illustrate add CMC-Na amount for the beverage precipitation crosslinked action unobvious, exist instead
Under low concentration, beverage presents preferable stability.Detection of the sample Jing Guo storage stability, the result is shown in tables 11, store 3 days
Later, all occur precipitation and deposited phenomenon in various degree in sample.After 5 days, in the sample of low concentration addition, precipitation is more
It is apparent.May be Polysaccharide due to being added in system after the macromolecular particles such as package protein, since shakiness occurs
Further precipitation, causes sample observation to layering and precipitation phenomenon, is added to acidic milk drink in CMC-Na with low concentration
When, with casein since there is a situation where bridge flocculations to cause unstability similar.
The additive amount of 11 CMC-Na of table is detected with storage stability
Note：+ sample appearance is uniform, without apparent lamination.Sample has visible delamination phenomenon.-- sample layering is apparent, sinks
Shallow lake amount is more.
(2) influence of the sodium alginate to beverage stability
Sodium alginate is added in beverage according to a certain percentage, within the scope of 0.0025%-0.1%, the stabilization of solution
Property present increase trend, only relatively good stability is presented between 0.0025-0.0075% (see Fig. 6).Additive is added
The storage stability testing result of sample is shown in Table 12.It is layered after placing 3 days, it is seen that apparent Precipitation, by 5 days
Afterwards, the precipitation in sample obviously increases, and illustrates that its shelf-stability is bad.Its reason may be due to the addition work in additive
Skill, to sodium alginate formed heat irreversible gel influence caused by.
The additive amount of 12 sodium alginate of table is detected with storage stability
Note：+ sample appearance is uniform, without apparent lamination.Sample has visible delamination phenomenon.-- sample layering is apparent, sinks
Shallow lake amount is more.
(3) influence of the pectin to beverage stability
Pectin is added in beverage according to a certain percentage, the results showed that, downward trend is integrally presented in addition range,
Within the scope of 0.0025-0.0075%, the additive amount between 0.0075-0.01% is better than on stablizing beverage characteristics (see figure
6).In storage stability detects (table 13), also there is layering after 3 days in pectin, compares, the layering after 5 days, sinks
Shallow lake thickness is slightly less than the sample of sodium alginate addition.
The additive amount of 13 pectin of table is detected with storage stability
Note：+ sample appearance is uniform, without apparent lamination.Sample has visible delamination phenomenon.
Pectin is a kind of higher anion polysaccharide of branching content, and molecule is soft, in the solution can be with band in beverage just
The macromolecular complex qualitative response of charge, and due to the presence of its more branch, protective film is formed on the surface of macromolecular, to drop
The low sedimentation of macromolecular substances, plays the role of stablizing solution.
(4) influence of the xanthans to beverage stability
Influence of the yellow Yuan glue proportionally added to the stability of beverage be shown in Fig. 6, with the amount of the xanthans of addition
Increase, translucency is declined slightly between 0.0075%-0.05%, there is certain stabilization, later to adding between 0.01%
Influence of the dosage to stability is smaller, it may be possible to after adding xanthans, affect protein in solution system and polysaccharide it
Between interaction, to affect the stability of product.And the testing result of storage stability is shown in Table 14, occurs after 3 days
Precipitation increase phenomenon with precipitation with the layering that occurs after 5 days, have with the supernatant light transmittance measured using 540nm similar
Trend illustrates to use the two Testing index have specific aim to adding the stability study of specific use beverage of stabilizer
And reference significance.
The additive amount of 14 xanthans of table is detected with storage stability
Note：+ sample appearance is uniform, without apparent lamination.Sample has visible delamination phenomenon.-- sample layering is apparent, sinks
Shallow lake amount is more.
Effect of four kinds of food stabilizers to the stability of specific use beverage, it may be possible to due to its respective molecule knot
Result caused by structure.And precipitated in storage stability detection, it may be possible to due to complicated component in beverage, be limited to add
The characteristic of amount or additive itself, is insufficient to allow macromolecular substances to be in stable state, leads to the Precipitation for still having different degrees of.
(5) influence of emulsifier
It using three kinds of emulsifiers, is respectively added in beverage, measures its light transmittance, as a result see Fig. 7：Two kinds of emulsifiers with
The increase of additive amount, light transmittance are increased slightly, and wherein SSL ratio DATEM measured value highers illustrate both emulsifiers to special use
The stability of way beverage is less than the stability of PGA.
In the experiment of storage stability, the stability of three kinds of emulsifier addition samples is shown in Table 15.The result shows that according to 5
Three kinds of emulsifiers that kind different proportion individually adds, the influence to stability of solution are followed successively by：PGA>DATEM>SSL.
15 emulsifier of table adds the storage stability detection of sample
Note：+ sample appearance is uniform, without apparent lamination.Sample has visible delamination phenomenon.-- sample layering is apparent, sinks
Shallow lake amount is more.
(6) influence of the combinative stability agent to beverage stability
(i) influence of the compounding of two kinds of stabilizers to stability
Aforementioned stable agent is compounded by the way of combination of two, as a result sees Fig. 8.One of which stabilizer respectively and
Other two kinds coordinate, additive amount 0.02%, 0.04%, 0.06%, and the proportioning in combination is 1:1.In addition every group of addition
0.05% emulsifier DATEM.It is seen that in three combinations containing sodium alginate, light transmittance is all higher than other
Combination illustrates in cooperation is stablized, poor compared with other three groups of combinations；In being combined at latter three kinds, the combination of CMC+ pectin is with additive amount
Light transmittance is presented with the increase of additive amount in the combination of influence unobvious to stability, CMC+ xanthans and pectin+xanthans
Downward trend illustrates there is certain stabilization to the stability of solution.
Combined additive storage stability experimental result is shown in Table 16, the time (day) of sample layering occurs, with concentration by small
To big trend：Addition concentration is higher, and separation time is longer, wherein the combination of addition CMC-Na+ xanthans, pectin+xanthans,
To the stability of specific use beverage better than CMC-Na+ pectin, better than CMC-Na+ sodium alginates, pectin and xanthans respectively with
The combination of sodium alginate is added.This is almost the same (see Fig. 8) with the stability trend of addition sample centrifuged supernatant.
The additive amount of 16 combined additive of table is detected with storage stability
(ii) emulsifier and comparison of the thickening agent combination to beverage stability
From storage stability measuring result (table 17), it can be seen that in the combination of three kinds of thickeners, CMC+ pectin, CMC+
The stability of xanthans is better than the combination of CMC+ sodium alginates.Shown in Fig. 9 and table 17, three kinds of various combinations of emulsifier are added
In, the additive containing emulsifier PGA in combination combines the stability of solution better than SSL and DATEM.
17 compound stabilizer of table (a kind of two kinds of thickeners+emulsifier) storage stability measures
The process optimization of 2.3 compound stabilizers is tested
According to above-mentioned single factor analysis as a result, determine pectin, xanthans, CMC be used as thickener, while selection to solution
Stability better than DATEM and SSL PGA as compounding raw material, result when according to single factor analysis determine its level, design
The orthogonal test (being shown in Table 18) of Three factors-levels.Wherein consider PGA in national standard GB 2760-2014《Food additives use
Standard》In addition limitation be 0.3g/kg (in beverage), determine usage amount be 0.03%.
The orthogonal test of 18 specific use beverage stability of table
L9(34) Optimal Experimental of Orthogonal Experiment and Design the results are shown in Table 18.In compounding Optimal Experimental, three factors are to sample
Stability influence not significantly (p<0.05) (19 are shown in Table).Therefore optimal experimental group is intuitively selected from experimental result
It closes：(the wherein pectin 0.005% of complex additive additive amount 0.105%；Xanthans 0.035%；CMC-Na0.035%,
PGA0.03%), by 540nm determination of light transmittance, as a result most preferably.It is tested simultaneously by storage-stable, optimum process compounding addition
The solution appearance of agent addition is in filbert, and liquid is uniform, and no layering is without precipitation.After placing 2 weeks or more, overall appearance does not become
Change, compared with the drink sample for being not added with additive, liquid stabilising, and the beverage stoste compareed therewith, bottom have one layer it is close
The flocculent deposit of 1mm is precipitated.The additive amount of the compound stabilizer (0.105%) of optimization is less than the additive amount of single factor test, but stablizes
Effect is best.
Table 19 compounds orthogonal test analysis of variance table
CMC-Na, pectin, PGA, xanthans are all anion polysaccharides, are hydrated to form hydrophilic colloid, when encountering in solution
When positively charged macromolecular substances, it may improve the viscosity in solution by complex reaction form occurs, cause visible
Light transmittance under light is relatively low；Or by space steric effect, or act on simultaneously with electrostatic repulsion, reduces in beverage and divide greatly
The precipitation of sub- substance is assembled, to improve the stability of beverage.Simultaneously by the additive amount of compound stabilizer with individually and/or
The stabilization of combined additive relatively from the point of view of, compounded formula have synergistic function.
Conclusion
(1) single factor analysis is used, by adding 4 kinds of polysaccharide stabilisers --- CMC-Na, pectin, xanthans, alginic acid
Sodium, it is descending to the stabilization of specific use beverage：Pectin>Yellow Yuan glue>CMC-Na>Sodium alginate.This is likely to be
Due to result caused by its respective molecular structure.But using it is single without a kind of stabilizer can continual and steady beverage it is molten
Liquid is detected by storage stability, is all precipitated, this may be and the single addition since ingredient is complex in beverage
The stabilization that agent rises is insufficient to allow all components to be in stable state, leads to still have partly precipitated precipitation.
(2) single factor analysis is used, three kinds of emulsifiers are compared --- SSL, DATEM, PGA, to specific use beverage
Stable influence, effect is descending to be：PGA>DATEM>SSL, storage stability the result shows that, the addition of three kinds of emulsifiers
There is Precipitation in sample.
(3) it is added in beverage by the way of compound additive, proportioning is each 0.01%+ emulsifiers of two kinds of stabilizers
0.05%, the results showed that, although in terms of the transmittance data that 540nm is measured, different compound additives shows different steady
Qualitative, difference is not too much apparent.In storage stability detection, there is the Precipitation that degree is different, and when single factor analysis
Sample is compared, and compound additive is more excellent.In the sample for the compound additive for being added to PGA, the transmitance of centrifuged supernatant with
And storage stability, it is better than the sample of other SSL and DATEM groups, system is relatively stable, and precipitation is less.
In summary measurement result is selected CMC-Na, pectin, three kinds of stabilizers of xanthans and emulsifier PGA and is compounded, passes through
Orthogonal test obtains optimization formula：(the wherein pectin 0.005% of complex additive additive amount 0.105%；Xanthans 0.035%；
CMC-Na0.035%, PGA0.03%).Storage stability test has also confirmed the performance of optimization of C/C composites sample appearance well, storage 2
Do not occur flocculent deposit precipitation more than all, illustrate that compound stabilizer has good stablizing effect to the specific use beverage, has
There is comparable application value.
Claims (10)
1. a kind of beverage with liver-protecting and alcoholism-relieving function, including component：Pueraria lobata, hoveniae semoveniae semen, dried hawthorn, dried orange peel, pulled figs, poplar
Plum fresh fruit, vine tea.
2. beverage according to claim 1, each component are according to quality proportioning：
Pueraria lobata 25%
Hoveniae semoveniae semen 25%
Dried hawthorn 12.5%
Dried orange peel 8.3%
Pulled figs 8.3%
Red bayberry fresh fruit 16.7%
Vine tea 4.2%.
3. beverage according to claim 1, each component are according to the additive amount of quality in the beverage：
Pueraria lobata 6%
Hoveniae semoveniae semen 6%
Dried hawthorn 3%
Dried orange peel 2%
Pulled figs 2%
Red bayberry fresh fruit 4%
Vine tea 1%.
4. beverage according to claim 3, be further added to stabilizer, the stabilizer be preferably CMC-Na, pectin,
The combination of one or more of xanthans, sodium alginate.
5. beverage according to claim 4, the stabilizer is pectin, xanthans and the combination of CMC-Na three.
6. beverage according to claim 5, is further added to emulsifier, the emulsifier is SSL, DATEM or PGA.
7. beverage according to claim 6, the emulsifier is PGA.
8. beverage according to claim 7, wherein pectin 0.005%；Xanthans 0.035%；CMC-Na0.035%,
PGA0.03%.
9. a kind of preparation process of the beverage with liver-protecting and alcoholism-relieving function, including by component as claimed in claim 1 or 2 according to than
Example is mixed, the method extracted at twice using boiling water, collects the filtrate after extraction, using high pressure homogenizer homogeneous, filling,
Sterilizing saves backup.
10. preparation process according to claim 9, including component as claimed in claim 1 or 2 is proportionally mixed
It closes, the deionized water of 3 times of addition all components gross mass, boiling water extraction 60min, four layers of filtered through gauze, raw material is added in filter residue
The deionized water that 2 times of original quality, boiling water extract 30min again, merging filtrate, concentrated or supplemented using cryogenic vacuum go from
Sub- water quantifies extracting solution to 3 times of raw material gross mass, crosses 200 mesh filter clothes, high-pressure homogeneous under the conditions of 20MPa, 10min, fills
Dress, sterilizing save backup.
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Application publication date: 20180918 |