KR20200005217A - An anti-drunkenness and hangover-alleviating composition and its preparation method - Google Patents

Abstract

Disclosed in the present invention are a composition for preventing drunkenness and relieving hangover, and a method for manufacturing the same. The composition for preventing drunkenness and relieving hangover contains a main component containing at least one selected from a total flavanone extract of Lonicera japonica, a total flavanone extract of pachyman, and a total flavanone extract of Cornus controversa.

Description

Prevention of hangover and hangover elimination composition and its manufacturing method {AN ANTI-DRUNKENNESS AND HANGOVER-ALLEVIATING COMPOSITION AND ITS PREPARATION METHOD}

FIELD OF THE INVENTION The present invention relates to the pharmaceutical field, and in particular to compositions having a odor preventing and hangover relieving action and methods for their preparation.

Proper drinking can help your health. However, excessive drinking can lead to the occurrence of alcohol and dizziness, headaches, hangovers and misdeeds after drinking and affect normal work and interpersonal communication. More seriously, excessive drinking can damage body tissues and organs. For example, excessive excessive drinking can damage liver cells, interfere with normal metabolism of the liver, and further cause alcoholic hepatitis and cirrhosis. In addition, frequent drinking may lead to alcohol dependence, that is, various unpleasant physical symptoms after sudden stop drinking or reducing alcohol consumption will also occur, which is also known as alcohol withdrawal syndrome.

Therefore, people adopt various methods to solve the discomfort caused by drinking, and there are many products on sale in the market. However, most products have inaccurate therapeutic effects.

In order to solve the above problems, the present invention proposes a novel alcohol prevention and hangover composition based on a number of experiments. Such compositions can significantly improve the alcohol intoxication threshold, prevent bodily discomfort caused by alcohol and intoxication such as dizziness, uncontrollable behavior, and alleviate the subject's alcohol withdrawal syndrome. In addition, such compositions include liver protection ingredients that can accelerate the breakdown of alcohol and mitigate alcohol damage to liver cells, making it an ideal anti-drinking and hangover product.

In order to achieve the above technical object, the present invention adopts the following technical solution:

Prevention of intoxication containing a main ingredient comprising at least one selected from total flavanone extract of Lonicera japonica, total flavanone extract of Pachyman and total flavanone extract of Dogwood And hangover relief compositions.

Preferably, the main component comprises a total flavanone extract 0-40 of Phosphorus by weight, a total flavanone extract 0-40 of Pachyman and a total flavanone extract 20-100 of Dogwood.

Preferably, the total flavanone content in the total flavanone extract of Phosphorus is> 50%, the total flavanone content in the total flavanone extract of Pakiman is> 80%, and the total flavanone in the total flavanone extract of the dogwood The content is> 80%.

Total flavanone extract of honeysuckle, total flavanone extract of pachyman and total flavanone extract of dogwood are prepared by the following method: grinding the phosphorus, pachyman and dogwood; The milled products were each extracted with water or ethanol at a concentration of less than 70%; Recover the extracted solution; Centrifugation; Extraction, macroporous resin column chromatography or recrystallization; Vacuum dried at 40-50 ° C .; Detection is made to ensure that the content of each extract meets the requirements.

The alcohol prevention and hangover composition of the present invention further comprises an adjuvant component comprising at least one selected from β-cyclodextrin, maltodextrin and stevioside.

Preferably, the weight ratio of the main component and the adjuvant component is 1: (0-3).

The present invention also discloses a process for the preparation of a hangover prevention and hangover relief composition comprising the following steps.

(1) grinding copper, pachyman and dogwood; The milled product was each extracted with water or ethanol at a concentration of less than 70%; Recover the extracted solution; Centrifugation; Extraction, settling, macroporous resin column chromatography or recrystallization; Vacuum dried at 40-50 ° C .; Detecting to obtain that the content of each extract meets the requirements to obtain a total flavanone extract of phosphorus, a total flavanone extract of pakiman and a total flavanone extract of dogwood; Milling each extract and sieving with a 60-mesh sieve;

(2) weighing the total flavanone extract 0-40 of Phosphorus, the total flavanone extract 0-40 of Pakiman and the total flavanone extract 20-100 of the dogwood by weight, and mixing them uniformly to obtain a main component;

(3) Weigh out β-cyclodextrin 0-100 and maltodextrin 0-100 by weight, mix it uniformly with the main component, add 10-50% water based on the total weight, repeat milling, vacuum Drying, grinding and sieving with a 60-mesh sieve; And

(4) adding 0-20 parts by weight of stevioside, uniformly mixing, sterilizing and pelletizing to prepare into capsules, tablets or electuary.

The alcohol-prevention and hangover-resolving composition described in this invention contains dogwood as a main component, and phosphorus and dogwood as an adjuvant component. Based on the observation of the effect on the volunteers, the alcohol-induced and hang-over composition has been proven to have an effect of improving the alcohol threshold and alleviating or reducing alcohol syndrome.

Hereinafter, the present invention will be further described in combination with specific examples, but the present invention will not be limited to such examples.

Example  One

Human  gun Flavanon  extract, Pakiman  gun Flavanon  Preparation and Preparation of Total Flavanone Extract of Dogwood

Total flavanone extract of the target phosphorus crushes the phosphorus; The ground phosphor was extracted by reflux with 60% ethanol; Recover the extracted solution; Centrifugation; The supernatant was collected and subjected to macroporous resin column chromatography to obtain a total flavanone enriched portion; Recover the solvent; Centrifugation; Vacuum dried at 40-50 ° C .; Detected to produce a total flavanone content of> 50%.

Total flavanone extract of target pachyman pulverizes pachyman; Only the pulverized paki was extracted with 40% ethanol; Recover the extracted solution; Centrifugation; Collect the supernatant; Extraction is performed with ethyl acetate to obtain a total flavanone concentrated portion; Recover the solvent; Concentrated; Vacuum dried at 40-50 ° C .; Detected to produce a total flavanone content of> 80%.

The total flavanone extract of the target dogwood crushed the dogwood; The ground dogwood was extracted by heating under reflux with 60% ethanol; Recover the extracted solution; Centrifugation; Collect the supernatant; Recrystallization is performed to obtain a total flavanone enriched portion; Vacuum dried at 40-50 ° C. and detected to produce a total flavanone content of> 80%.

Example  2

Alcohol Prevention and Hangover Relief Capsules include the total flavanone extract of Phosphorus, the total flavanone extract of Pachyman and the total flavanone extract of Dogwood, and β-cyclodextrin as the adjuvant component; It is created through the following steps:

(1) Weighing 500 g of phosphorus total flavanone extract, 500 g pachyman's total flavanone extract and 5,000 g of dogwood's total flavanone extract produced in Example 1, pulverized and 60-mesh Sifted through a sieve; Weighing 4,000 g of β-cyclodextrin and mixing the material uniformly;

(2) adding 3,000 ml of water, milling repeatedly, vacuum drying at 40-50 ° C. until the water content is <5%, grinding and sieving with a 60-mesh sieve;

(3) after sterilization, pelletizing in an environment of 20-40% humidity to obtain 20-40 mesh of particles; And

(4) filling the capsules with the particles under an environment having a humidity of 50% or less to obtain capsules each having a weight of 0.5 g.

Dosage method and dosage: Oral administration, 2 capsules each time, with warm water 30 minutes before drinking.

Example  3

Odor prevention and hangover aids include total flavanone extract of dogwood as a main component and β-cyclodextrin, maltodextrin and stevioside as adjuvant components; It is created through the following steps:

(1) weighing the total flavanone extract of 5,000 g of the dogwood produced in Example 1, weighing 5,000 g of β-cyclodextrin and 5,000 g of maltodextrin and mixing the material uniformly;

(2) adding 5,000 ml of water, milling repeatedly, vacuum drying at 40-50 ° C. until the water content is <5%, pulverizing and sieving with 60-mesh sieve;

(3) adding 1,000 g of stevioside, mixing uniformly, and performing sterilization to pellet in an environment with 20-40% humidity to obtain 20-40 mesh of particles; And

(4) packing the particles into a bag under an environment having a humidity of 50% or less to obtain a paper placed in a bag each having a weight of 2 g.

Dosage method and dosage: Oral administration, two bags each time, 30 minutes before or after drinking (after dissolving the paper in boiled water).

Example  4

Anti-Drinking and Hangover Refining Tablets include Pachyman's Total Flavanone Extract and Dogwood's Total Flavanone Extract as main components, and β-cyclodextrin and Maltodextrin as Adjuvant components; It is created through the following steps:

(1) 300 g of Pachyman's total flavanone extract and 2,500 g of Dogwood's total flavanone extract produced in Example 1 were weighed, 2,500 g of β-cyclodextrin and 2,500 g of maltodextrin were weighed Uniformly mixing the material;

 (2) after sterilization, pelletized under an environment with 20-40% humidity to obtain 20-40 mesh of particles; Produced by the steps of obtaining tablets each having a weight of 0.3 g.

Dosing method and dosage: Oral administration, 2-3 tablets each time, 30 minutes before or after drinking.

Test Example  One

Example  Generated in 2 Alcohol  Prevention hangover elimination capsule Observation of the effect

Capsules were tested by 30 volunteers. They received two capsules 30 minutes before drinking and observed their dizziness and intoxication after drinking. All 30 volunteers provide feedback that capsules are effective, can significantly increase the amount of alcohol causing alcohol intoxication, and prevent physical discomfort, such as dizziness and uncontrollable behavior caused by alcohol and alcohol It was. Representative examples are as follows:

A 40-year-old male volunteer (having a surname, Sen), who had a dizziness after drinking a very small amount of beer, received two capsules 30 minutes before drinking and did not feel dizzy after drinking 100 g of 52% white wine. Did.

After drinking four bottles of beer, a 22-year-old male volunteer (having a surname named Fu), who was generally dizzy, received two capsules 30 minutes before drinking and did not feel dizzy after drinking seven bottles of beer.

Test Example  2

Example  Generated in 3 Alcohol  Prevention of hangover Paper Observation of the effect

Papers were tested by five volunteers. After receiving dizziness caused by alcohol, they were given two paper bags, and the alleviation effect on dizziness symptoms was observed. All five volunteers provided feedback that the paper was effective, relieved dizziness, and reduced infusion time.

Test Example  3

Example  Generated in 4 Alcohol  Prevention hangover elimination tablet Observation of the effect

Capsules were tested on 16 volunteers. They received two capsules 30 minutes before drinking and observed dizziness and intoxication after their drinking. Among them, 15 volunteers found that tablets were effective, significantly increased the amount of alcohol causing alcohol intoxication, and prevented physical discomfort, such as dizziness and out of control behavior caused by alcohol and alcohol Feedback was provided. Representative examples are as follows:

In general, two 31-year-old male volunteers (who have sex with Gao) who received a lot of alcohol and soon became dizzy were given two tablets 30 minutes before drinking and dizziness after drinking 100 g of 52% white wine. I didn't feel it.

White wine was not drunk at all and was given two tablets 30 minutes before drinking alcohol to a 36-year-old male volunteer (whose name was Zhang) who generally had dizziness after drinking a bottle of beer at most, 52% of 100 g After drinking white wine did not feel dizzy.

Claims (7)

Alcoholic beverage, comprising a main component comprising one or more selected from total flavanone extract of Lonicera japonica, total flavanone extract of Pachyman and total flavanone extract of Dogwood Preventive and hangover composition. According to claim 1, wherein the main component, by weight, including a total flavanone extract 0-40 of Phosphorus, Pachyman's total flavanone extract 0-40 and a dogwood tree total flavanone extract 20-100, prevention and hangover Relieving composition. The total flavanone content in the total flavanone extract of the phosphorus is> 50%, the total flavanone content in the total flavanone extract of Pakiman is> 80%, and the dogwood And a hangover preventing and hangover composition having a total flavanone content of> 80%. The total flavanone extract of the phosphorus, the total flavanone extract of pakiman and the total flavanone extract of the dogwood,
Grinding copper, pachyman and dogwood; The milled products were each extracted with water or ethanol at a concentration of less than 70%; Recover the extracted solution; Centrifugation; Extraction, macroporous resin column chromatography or recrystallization is carried out; Vacuum dried at 40-50 ° C .; The anti-drinking and hangover composition produced by the method of detecting to confirm that the content of each extract meets the requirements. 4. The anti-drink and hangover composition according to claim 3, further comprising an adjuvant component comprising at least one selected from β-cyclodextrin, maltodextrin and stevioside. According to claim 5, wherein the weight ratio of the main component and the adjuvant component is 1: (0-3) alcohol prevention and hangover relief composition. In the manufacturing method of the alcohol prevention and hangover relief composition,
(1) grinding copper, pachyman and dogwood; The milled product was each extracted with water or ethanol at a concentration of less than 70%; Recover the extracted solution; Centrifugation; Extraction, macroporous resin column chromatography or recrystallization is carried out; Vacuum dried at 40-50 ° C .; Detecting to obtain that the content of each extract meets the requirements to obtain a total flavanone extract of phosphorus, a total flavanone extract of pakiman and a total flavanone extract of dogwood; Milling each extract and sieving with a 60-mesh sieve;
(2) weighing the total flavanone extract 0-40 of Phosphorus, the total flavanone extract 0-40 of Pakiman and the total flavanone extract 20-100 of the dogwood by weight, and uniformly mixing them to obtain a main component;
(3) weighing β-cyclodextrin 0-100 and maltodextrin 0-100 by weight, mixing it uniformly with the main ingredients, adding 10-50% water based on the total weight, repeatedly milling, Performing vacuum drying, grinding and sieving using a 60-mesh sieve; And
(4) 0-20 parts by weight of steviosides are added, uniformly mixed, sterilized, pelletized, and prepared into capsules, tablets or electuary.