KR20200017870A - An anti-drunkenness and hangover-alleviating composition and its preparation method - Google Patents

Abstract

The present invention discloses a composition for preventing drunkenness and alleviating hangover and a method for manufacturing the same. The composition for preventing drunkenness and alleviating hangover comprises one or more selected from a Hovenia dulcis total flavanone extract, a strong Prunus mume total flavanone extract, and a Panax pseudoginseng total flavanone extract as a main ingredient.

Description

Drunkenness prevention and hangover relief composition and its manufacturing method {AN ANTI-DRUNKENNESS AND HANGOVER-ALLEVIATING COMPOSITION AND ITS PREPARATION METHOD}

FIELD OF THE INVENTION The present invention relates to the medical field, in particular to compositions having a drunkenness-preventing and hangover-relieving function and methods for their preparation.

Moderate drinking is beneficial to a person's physical health. However, excessive drinking can cause dizziness, headaches, hangovers and misbehavior that appear after drunkenness and drinking, which can affect normal work and interpersonal communication. More seriously, drinking too much can damage body tissues and organs. For example, persistent heavy drinking can damage liver cells and interfere with normal liver metabolism and further lead to alcoholic liver disease and cirrhosis. Frequent drinking can also cause alcohol dependence, ie various uncomfortable physical symptoms may occur after sudden abstinence or diminishing alcohol, also known as alcohol withdrawal syndrome.

Therefore, people adopt various methods to alleviate the discomfort caused by drinking, and there are many corresponding products on the market, but most of the products have inaccurate therapeutic effects.

In order to solve the above problems, the present invention proposes a new anti-drunken and hangover relief composition based on a number of experiments. The composition can greatly improve the drunkenness threshold of the drinker, prevent physical discomfort, such as dizziness, uncontrollable behaviors caused by drunkenness and drunkenness, and alleviate the subject's alcohol withdrawal syndrome. In addition, the compositions contain liver protection ingredients that can accelerate the breakdown of alcohol and mitigate alcohol damage to liver cells and are ideal anti-drunken and hangover relief products.

In order to achieve the above technical object, the present invention adopts the following technical solutions.

The anti-drunken and hangover relieving composition comprises a main ingredient comprising one or more selected from Hovenia acerba total flavanone extract, dark plum total flavanone extract, and Himalayan ginseng (Pseudo-ginseng total flavanone extract). It includes.

Preferably, the main components comprise 0 to 40 of the total tree flavanone extract, 0 to 40 thick plum total flavanone extract and 20 to 100 Himalayan ginseng total flavanone extract on a weight part basis.

Preferably, the total flavanone content of the total flavanone extract of Ravensis is> 50%, the total flavanone content of the concentrated plum total flavanon extract is> 80%, and the total flavanone content of the Himalayan ginseng total flavanone extract is> 80%.

Raspberry Total Flavanone Extract, Dark Plum Total Flavanone Extract and Himalayan Ginseng Total Flavanone Extract

Prune, thick plum and Himalayan ginseng are ground and extracted with water or ethanol at a concentration of less than 70%, respectively, the extracted solution is recovered, centrifuged, extracted, macroporous resin column chromatography or Recrystallization is carried out, vacuum dried at 40 ° C. to 50 ° C., and prepared by a method of detection to ensure that the content of each extract meets the requirements.

In addition, the drunkenness prevention and hangover relief compositions of the present invention comprise an auxiliary component comprising at least one selected from β-cyclodexscreen, maltodextrin and stevioside.

Preferably, the weight ratio of the main and auxiliary components is from 1: 0 to 1: 3.

In addition, the present invention discloses a method for preparing a drunkenness prevention and hangover relief composition, the method comprising

(1) pulverize hawthorn, thick plum and Himalayan ginseng, extract the pulverized products with water or ethanol at a concentration of less than 70%, respectively, recover the extracted solution, centrifuge, extract, precipitate, macroporous Resin column chromatography or recrystallization is carried out, vacuum dried at 40 ° C. to 50 ° C., and detected to ensure that the content of each extract meets the requirements, and extracted from hawthorn total flavanone extract, dark plum total flavanone extract, and Obtaining Himalayan ginseng total flavanone extract and sieving with 60 mesh sieve;

(2) on the basis of the weight part, to measure the total content of the barberry total flavanone extract 0-40, the concentrated plum total flavanone extract 0-40 and the Himalayan ginseng total flavanone extract 20-100, and uniformly mixing them to obtain the main components ;

(3) Based on the weight part, β-cyclodextrin 0 to 100 and maltodextrin 0 to 100 were weighed, and they were mixed uniformly with the main component, 10% to 50% water was added based on the total weight, and repeated Grinding, vacuum drying, grinding and sieving to 60 mesh sieves; And

(4) adding 0 to 20 parts by weight of stevioside, mixing uniformly, sterilizing, pelletizing and preparing into capsules, pills or soft.

The drunkenness-prevention and hangover relief compositions described herein comprise Himalayan ginseng as a main ingredient and hawthorn and thick plums as auxiliary ingredients. Based on observations of the effects on volunteers, the anti-drunken and hangover-relieving compositions have been found to have the effect of improving the drunkenness threshold and alleviating or reducing drunken symptoms.

In the following, the invention is further described in conjunction with the specific embodiments, but the invention will not be limited to these embodiments.

Example 1

Hut  gun Flavanon  Extract, dark plum gun Flavanon  Extract and Preparation of Himalayan Ginseng Total Flavanone Extract

The target barn tree total flavanone extract is a step of pulverizing the barn tree, heating and refluxing the barn tree ground with 60% ethanol, recovering the extracted solution, centrifuging, collecting the supernatant, giant Performing porous resin column chromatography to obtain a total flavanone concentrated portion, recovering the solvent, concentrating, centrifuging, vacuum drying at 40 ° C. to 50 ° C., and a total flavanone content of> Prepared by the detecting step to confirm that it is 50%.

The target thick plum total flavanone extract is a step of pulverizing the concentrated plum, ultrasonic extraction of the concentrated pulverized plum with 40% ethanol, recovering the extracted solution, centrifugation, collecting the supernatant, ethyl acetate Extracting to obtain a total flavanone concentrated portion, recovering the solvent, concentrating, vacuum drying at 40 ° C. to 50 ° C., and detecting to confirm that the total flavanone content is> 80%. It is manufactured by the step.

The target Himalayan ginseng total flavanone extract is a step of grinding the Himalayan ginseng, heating and refluxing the Himalayan ginseng ground with 60% ethanol, recovering the extracted solution, centrifuging, collecting the supernatant, recrystallization To obtain the total flavanone enriched portion, vacuum drying at 40 ° C. to 50 ° C., and detecting to confirm that the total flavanone content is> 80%.

Example 2

The anti-drunken and hangover-relieving capsules include hawthorn total flavanone extract, dark plum total flavanone extract and Himalayan ginseng total flavanone extract as main ingredients, β-cyclodextrin as a secondary component,

(1) 500 g of the total tree flavanone extract prepared in Example 1, 500 g of the concentrated plum total flavanone extract and 5000 g of the Himalayan ginseng total flavanone extract were stocked, pulverized, filtered through a 60 mesh sieve, and 4000 g of β-cyclodextrin was stocked. Uniformly mixing the materials;

(2) adding 3000 ml of water, grinding repeatedly, vacuum drying at 40 ° C. to 50 ° C. until the water content is less than 5%, pulverizing and sieving with a 60 mesh sieve;

(3) after performing sterilization, pelletizing in an environment having a humidity of 20% to 40% to obtain particles of 20 to 40 mesh, and

(4) Prepared by filling the capsules in an environment with a humidity of 50% or less to obtain capsules each having a weight of 0.5 g.

Dosage and Dosage: Oral, 2 capsules each time, with warm water 30 minutes before drinking.

Example 3

Anti-drunken and hangover softeners include Himalayan ginseng total flavanone extract as a main component, β-cyclodextrin, maltodextrin and stevioside as auxiliary components,

(1) weighing 5000 g of the Himalayan ginseng total flavanone extract prepared in Example 1, 5000 g of β-cyclodextrin and 5000 g of maltodextrin, and mixing the materials uniformly;

(2) adding 5000 ml of water, repeatedly grinding, vacuum drying at 40 ° C. to 50 ° C. until the water content is less than 5%, pulverizing and sieving with a 60 mesh sieve;

(3) adding 1000 g of stevioside, mixing uniformly, and performing sterilization, and then pelletizing in an environment having a humidity of 20% to 40% to obtain particles of 20 to 40 mesh; And

(4) Prepared through the steps of filling the bags in an environment having a humidity of 50% or less to obtain a softener contained in a bag each having a weight of 2 g.

Directions for use and doses: Oral, 2 bags each time, 30 minutes before drinking or after drinking (after dissolving the soft flames in a boiled fire).

Example 4

The anti-drunken and hangover-relieving pill comprises dark plum total flavanone extract and Himalayan ginseng total flavanone extract as main components, and β-cyclodextrin and maltodextrin as auxiliary components,

(1) weighing 300 g of concentrated plum total flavanone extract and 2500 g of Himalayan ginseng total flavanone extract prepared in Example 1, 2500 g of β-cyclodextrin and 2500 g of maltodextrin, and mixing the materials uniformly;

(2) after sterilization, pelletized under an environment having a humidity of 20% to 40% to obtain particles of 20 to 40 mesh, and then pelletized to obtain pellets each having a weight of 0.3 g. do.

Dosage and Dosage: Oral, 2 to 3 pills each time, 30 minutes before or after drinking.

Test Example 1

Observation of the effects of anti-drunken and hangover-relieving capsules prepared in Example 2

Capsules were tested by 30 volunteers. Volunteers took two capsules 30 minutes before drinking and observed dizziness and drunkenness of volunteers after drinking. All 30 volunteers reported that the capsules were effective, significantly increased the amount of alcohol causing drunkenness of the drinker, and prevented discomfort such as dizziness and loss of control behavior caused by drunkenness and drunkenness. gave. A typical example is as follows.

A 40-year-old male volunteer (who had the last name of Chen) who had dizziness after drinking a very small amount of beer usually took two capsules 30 minutes before drinking and did not feel dizzy after drinking 100 g of 52% white wine.

A 22-year-old male volunteer (who was named Fu) who had dizziness after drinking four bottles of beer usually took two capsules 30 minutes before drinking and did not feel dizzy after drinking seven bottles of beer.

Test Example 2

Observation of the effects of the anti-drunken and hangover softening prepared in Example 3

The soft was tested by five volunteers. Volunteers took two bags of soft medicine after dizziness caused by drinking, and observed the alleviation of dizziness symptoms. All five volunteers gave feedback that the weakness was effective and could alleviate dizziness and reduce drunkenness.

Test Example 3

Observation of the Effects of the Anti-Drunk Hangover Relief Pills Prepared in Example 4

Capsules were tested by 16 volunteers. Volunteers took two capsules 30 minutes before drinking and observed volunteer drowsiness and drunkenness. Of the volunteers, 15 volunteers were effective in pilling, significantly increasing the amount of alcohol that caused the drunkenness of the drinker, and prevent physical discomfort, such as dizziness and loss of control behavior caused by drunkenness and drunkenness. Gave feedback. A typical example is as follows.

Usually, a 31-year-old male volunteer (who had a sex called Gao) who drank a lot of alcohol and soon became dizzy took two pills 30 minutes before drinking and did not feel dizzy after drinking 100 g of 52% white wine.

Usually, a 36-year-old male volunteer (who had sex with Zhang) who had dizziness after drinking up to a bottle of beer without drinking white wine at all took two pills 30 minutes before drinking and drank 100 g of 52% white wine. I didn't feel dizzy afterwards.

Claims (7)

An anti-drunken and hangover-relieving composition comprising: a main ingredient comprising at least one selected from liana total flavanone extract, dark plum total flavanone extract, and Himalayan ginseng total flavanone extract. According to claim 1, wherein the main ingredient is drunken prevention comprising a total weight of flannel extract 0 to 40, total plum flanone extract 0 to 40 and Himalayan ginseng total flavanone extract 20 to 100 and based on the weight part Hangover Relief Composition. According to claim 1 or 2, wherein the total flavanone content of the total flavanone extract of the bark tree is> 50%, the total flavanone content of the concentrated plum total flavanone extract is> 80%, the Himalayan ginseng total The anti-drunken and hangover relief composition of the flavanone extract has a total flavanone content of> 80%. According to claim 3, The total banyan total flavanone extract, the total plum total flavanone extract and the Himalayan ginseng total flavanone extract
Crushed barnwood, dark plums, and Himalayan ginseng; Extracting each of the results triturated with water or ethanol at a concentration of less than 70%; Recovering the extracted solution; Centrifugation; Extraction, macroporous resin column chromatography or recrystallization; Vacuum dried at 40 ° C. to 50 ° C .; An anti-drunken and hangover relieving composition prepared by a method of detection to ensure that the content of each extract meets the requirements. 4. The anti-drunken and hangover relief composition of claim 3, further comprising an auxiliary component comprising at least one selected from β-cyclodextrin, maltodextrin, and stevioside. The anti-drinking and hangover relief composition according to claim 5, wherein the weight ratio of the main component to the auxiliary component is 1: 0 to 1: 3. A method of preparing an anti-drunken and hangover relieving composition,
(1) grinding hawthorn, thick plum and Himalayan ginseng, extracting the resultant which was crushed with water or ethanol at a concentration of less than 70%, respectively, recovering the extracted solution, centrifuging, extracting, macroporous resin Perform column chromatography or recrystallization, vacuum dry at 40 ° C. to 50 ° C., detect to see if the content of each extract meets the requirements, and extract the hawthorn total flavanone extract, the concentrated plum total flavanone extract And obtaining the Himalayan ginseng total flavanone extract, pulverizing each extract to a 60 mesh sieve;
(2) Based on the weight part, 0 to 40 of the total content of the banyan tree flavanone extract, 0 to 40 of the concentrated plum total flavanone extract and 20 to 100 of the Himalayan ginseng total flavanone extract, and evenly mixed them to the main components Obtaining;
(3) on the basis of parts by weight, β-cyclodextrin 0 to 100 and maltodextrin 0 to 100 were weighed, mixed them uniformly with the main components, and 10% to 50% water was added based on the total weight Repeatedly grinding, vacuum drying, grinding and sieving to 60 mesh sieves; And
(4) A method for preparing an anti-drunken and hangover relieving composition comprising adding 0 to 20 parts by weight of stevioside, mixing uniformly, sterilizing, pelletizing and preparing into capsules, pills, or softs.