KR20190107761A - 모노클로날 항체를 생성하는 방법 및 시약 - Google Patents

모노클로날 항체를 생성하는 방법 및 시약 Download PDF

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KR20190107761A
KR20190107761A KR1020197026655A KR20197026655A KR20190107761A KR 20190107761 A KR20190107761 A KR 20190107761A KR 1020197026655 A KR1020197026655 A KR 1020197026655A KR 20197026655 A KR20197026655 A KR 20197026655A KR 20190107761 A KR20190107761 A KR 20190107761A
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antigen
immunoglobulin
nucleic acid
acid sequence
way
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Korean (ko)
Inventor
로베르토 폴라키에위츠
원 청 청
존 에드워드 러쉬
션 앙드레 보솔레이
Original Assignee
셀 시그널링 테크놀러지, 인크.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081DNA viruses
    • C07K16/082Hepadnaviridae (F), e.g. hepatitis B virus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197026655A 2011-03-09 2012-03-09 모노클로날 항체를 생성하는 방법 및 시약 Ceased KR20190107761A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161450922P 2011-03-09 2011-03-09
US61/450,922 2011-03-09
US201161560006P 2011-11-15 2011-11-15
US61/560,006 2011-11-15
US201161566876P 2011-12-05 2011-12-05
US61/566,876 2011-12-05
US201261594729P 2012-02-03 2012-02-03
US61/594,729 2012-02-03
PCT/US2012/028501 WO2012122484A1 (en) 2011-03-09 2012-03-09 Methods and reagents for creating monoclonal antibodies

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KR1020197000660A Division KR20190006083A (ko) 2011-03-09 2012-03-09 모노클로날 항체를 생성하는 방법 및 시약

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KR20190107761A true KR20190107761A (ko) 2019-09-20

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KR1020197026655A Ceased KR20190107761A (ko) 2011-03-09 2012-03-09 모노클로날 항체를 생성하는 방법 및 시약
KR1020197000660A Ceased KR20190006083A (ko) 2011-03-09 2012-03-09 모노클로날 항체를 생성하는 방법 및 시약
KR1020137026647A Active KR101938343B1 (ko) 2011-03-09 2012-03-09 모노클로날 항체를 생성하는 방법 및 시약

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KR1020137026647A Active KR101938343B1 (ko) 2011-03-09 2012-03-09 모노클로날 항체를 생성하는 방법 및 시약

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US (2) US9920110B2 (enExample)
EP (2) EP3345922A1 (enExample)
JP (3) JP6211931B2 (enExample)
KR (3) KR20190107761A (enExample)
CN (2) CN108220297A (enExample)
AU (3) AU2012225310B2 (enExample)
CA (1) CA2829606C (enExample)
DK (1) DK2683736T3 (enExample)
ES (1) ES2666301T3 (enExample)
HK (1) HK1256304A1 (enExample)
HU (1) HUE037095T2 (enExample)
WO (1) WO2012122484A1 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3059337T3 (da) 2009-01-15 2019-07-22 Adaptive Biotechnologies Corp Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier
EP2783214A2 (en) 2011-11-23 2014-10-01 The Board of Regents of The University of Texas System Proteomic identification of antibodies
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
EP3091089B1 (en) 2012-05-08 2019-01-23 Adaptive Biotechnologies Corporation Method for measuring and calibrating amplification bias in multiplexed pcr reactions
EP2861760B1 (en) 2012-06-15 2020-01-01 The Board of Regents of The University of Texas System High throughput sequencing of multiple transcripts of a single cell
US10150996B2 (en) 2012-10-19 2018-12-11 Adaptive Biotechnologies Corp. Quantification of adaptive immune cell genomes in a complex mixture of cells
WO2014145992A1 (en) * 2013-03-15 2014-09-18 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
EP3023777B1 (en) * 2013-09-09 2017-11-15 Shimadzu Corporation Method for preparing peptide fragments, kit for preparing peptide fragments to be used therein, and analysis method
GB201316644D0 (en) * 2013-09-19 2013-11-06 Kymab Ltd Expression vector production & High-Throughput cell screening
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US20170212130A1 (en) * 2014-06-25 2017-07-27 The Rockefeller University Compositions and methods for rapid production of versatile nanobody repertoires
CN105277638A (zh) * 2014-07-22 2016-01-27 沈鹤霄 一种单克隆抗体IgG质谱测序方法
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
CN104560979B (zh) * 2015-01-20 2017-04-05 中国人民解放军第三军医大学 基于高通量测序构建鼠bcr重链文库的多重pcr引物和方法
CN104560980B (zh) * 2015-01-20 2017-04-05 中国人民解放军第三军医大学 基于高通量测序构建鼠BCR轻链Lamda文库的多重PCR引物和方法
US11047008B2 (en) 2015-02-24 2021-06-29 Adaptive Biotechnologies Corporation Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
EP3265823B1 (en) 2015-03-06 2020-05-06 Micromass UK Limited Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
WO2016142693A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited In vivo endoscopic tissue identification tool
GB2552602B (en) * 2015-03-06 2020-12-30 Micromass Ltd Desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of swabs
CA2981085A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Spectrometric analysis
GB2554206B (en) 2015-03-06 2021-03-24 Micromass Ltd Spectrometric analysis of microbes
GB2556436B (en) 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
US11289320B2 (en) 2015-03-06 2022-03-29 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
WO2017044885A1 (en) * 2015-09-09 2017-03-16 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with cerebro-craniofacial health
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
CN106047857B (zh) * 2016-06-01 2020-04-03 苏州金唯智生物科技有限公司 一种发掘特异性功能抗体的方法
CN107525934A (zh) * 2016-06-21 2017-12-29 张效龙 一种测定血液中抗体氨基酸序列的方法
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
CN110382696B (zh) * 2017-03-07 2024-04-19 豪夫迈·罗氏有限公司 发现替代性抗原特异性抗体变体的方法
CN111201238B (zh) * 2017-07-21 2023-09-08 诺夫免疫股份有限公司 产生多特异性抗体混合物及其使用方法
CN109425662A (zh) * 2017-08-23 2019-03-05 深圳华大基因研究院 一种鉴定蛋白的方法及系统
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2019183334A1 (en) 2018-03-21 2019-09-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
CN108713136B (zh) * 2018-03-29 2020-10-09 深圳达闼科技控股有限公司 物质检测方法、装置、电子设备及计算机可读存储介质
CN108530533B (zh) * 2018-04-13 2020-09-04 吉林大学 猪瘟病毒单克隆抗体hk24及医用用途
US20220034902A1 (en) * 2018-12-11 2022-02-03 Merck Sharp & Dohme Corp. Method for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of b-cell and hybridoma libraries
WO2020246617A1 (ja) * 2019-06-07 2020-12-10 中外製薬株式会社 情報処理システム、情報処理方法、プログラム、及び、抗原結合分子或いはタンパク質を製造する方法
CN110452296A (zh) * 2019-07-16 2019-11-15 福州精锐生物技术有限公司 一种兔单克隆抗体制备方法
EP4031878A1 (en) * 2019-09-16 2022-07-27 Regeneron Pharmaceuticals, Inc. Lc-ms methods for antibody isotyping and quantification
EP4074725A4 (en) * 2019-12-09 2024-02-28 Optolane Technologies Inc. SWITCH BINDER, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION, ASSAY KIT, AND METHOD FOR DOSING ANTIGEN AND ANTIBODY, EACH USING THE SAME
JP7765090B2 (ja) * 2020-05-01 2025-11-06 ユニバーシティ オブ ピッツバーグ -オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション ナノボディ及びナノボディ親和性を同定するための組成物及び方法
WO2022216795A1 (en) * 2021-04-09 2022-10-13 Abterra Biosciences, Inc. Method for antibody identification from protein mixtures
IT202100019334A1 (it) * 2021-07-21 2023-01-21 Univ Degli Studi Di Pavia Metodo per l’identificazione dell’intera sequenza della regione variabile delle catene pesanti e leggere di immunoglobuline
CN115894687B (zh) * 2022-03-31 2024-06-07 台州恩泽医疗中心(集团) 一种抗hla-g1,-g2,-g5及hla-g6异构体分子的单克隆抗体及其用途
CN116779037B (zh) * 2022-07-27 2025-08-05 北京理工大学 一种基于从头测序和同源标签图论的抗体序列鉴定方法
CN119490586A (zh) * 2023-08-15 2025-02-21 东莞市朋志生物科技有限公司 一种抗n末端b型利钠肽原的抗体及其应用
CN117849159B (zh) * 2024-01-09 2025-01-07 融智生物科技(青岛)有限公司 M蛋白的检测方法、电子设备及存储介质
CN120214310B (zh) * 2025-05-20 2025-08-19 中国农业大学 一种禽白血病抗原检测试剂盒及其制备方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6673776B1 (en) 1989-03-21 2004-01-06 Vical Incorporated Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
ES2284161T3 (es) 1990-01-12 2007-11-01 Amgen Fremont Inc. Generacion de anticuerpos xenogenicos.
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
AU3328493A (en) 1991-12-17 1993-07-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
NZ261259A (en) 1993-01-12 1996-12-20 Biogen Inc Humanised recombinant anti-vla4 antibody and diagnostic compositions and medicaments
US6436908B1 (en) 1995-05-30 2002-08-20 Duke University Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US6376471B1 (en) 1997-10-10 2002-04-23 Johns Hopkins University Gene delivery compositions and methods
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
CA2330673C (en) 1998-05-01 2009-05-26 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
US7300753B2 (en) 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
ATE508361T1 (de) 2001-08-14 2011-05-15 Harvard College Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie
CA2467509A1 (en) * 2001-12-14 2003-06-26 Eli Lilly And Company Recombinant bovine thrombin
GB0130267D0 (en) 2001-12-19 2002-02-06 Neutec Pharma Plc Focussed antibody technology
US7485291B2 (en) 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
CA2526120A1 (en) 2003-06-03 2005-02-24 Cell Genesys, Inc. Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US8512959B2 (en) 2004-02-09 2013-08-20 Northwestern University Monoclonal antibody based biomarker discovery and development platform
AU2005216549A1 (en) 2004-02-27 2005-09-09 President And Fellows Of Harvard College Polony fluorescent in situ sequencing beads
US20070161001A1 (en) 2004-03-04 2007-07-12 Dena Leshkowitz Quantifying and profiling antibody and t cell receptor gene expression
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
AU2006256763B2 (en) * 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
US7678373B2 (en) 2006-02-10 2010-03-16 Genentech, Inc. Anti-FGF19 antibodies and methods using same
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
US20090209737A1 (en) * 2006-07-07 2009-08-20 Pall Corporation Use of denaturing agents during affinity capture
WO2008079914A1 (en) 2006-12-21 2008-07-03 Novartis Ag Antibody quantitation
NZ597466A (en) 2007-03-01 2013-08-30 Symphogen As Recombinant anti-epidermal growth factor receptor antibody compositions
MX2009009226A (es) * 2007-03-06 2009-10-28 Symphogen As Anticuerpos recombinantes para el tratamiento de infecciones con el virus respiratorio sincitial.
SG196697A1 (en) 2007-03-22 2014-02-13 Biogen Idec Inc Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof
CA2688834C (en) 2007-06-01 2020-01-07 Ronald Buelow Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies
US7887801B2 (en) 2007-07-13 2011-02-15 Topotarget Germany Ag Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins
EP2220116B1 (en) * 2007-11-12 2012-09-05 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
RU2476886C2 (ru) 2007-11-22 2013-02-27 Симфоген А/С Способ характеризации рекомбинантного поликлонального белка
EP2088432A1 (en) 2008-02-11 2009-08-12 MorphoSys AG Methods for identification of an antibody or a target
WO2010002911A2 (en) 2008-06-30 2010-01-07 H. Lee Moffitt Cancer Center And Research Institute, Inc. Methods and materials for monitoring myeloma using quantitative mass spetrometry
WO2010039900A2 (en) 2008-09-30 2010-04-08 Aliva Biopharmaceuticals, Inc. Non-human mammals for the production of chimeric antibodies
CA2747534C (en) 2008-12-18 2020-08-18 Erasmus University Medical Center Rotterdam Non-human transgenic animals expressing humanised antibodies and use therof
DK3059337T3 (da) 2009-01-15 2019-07-22 Adaptive Biotechnologies Corp Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier
ES2700442T3 (es) 2009-02-25 2019-02-15 Ucb Biopharma Sprl Método para producir anticuerpos
CN102638971B (zh) 2009-07-08 2015-10-07 科马布有限公司 动物模型及治疗分子
US20110045534A1 (en) 2009-08-20 2011-02-24 Cell Signaling Technology, Inc. Nucleic Acid Cassette For Producing Recombinant Antibodies
US8293483B2 (en) 2009-09-11 2012-10-23 Epitomics, Inc. Method for identifying lineage-related antibodies
PL3251503T3 (pl) 2010-03-31 2024-07-08 Ablexis, Llc Modyfikacja myszy metodami inżynierii genetycznej w celu wytworzenia przeciwciał chimerycznych
WO2011140433A2 (en) 2010-05-07 2011-11-10 The Board Of Trustees Of The Leland Stanford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
EP2572203B1 (en) * 2010-05-17 2017-10-25 The Board of Regents of The University of Texas System Determination of antigen-specific antibody sequences in blood circulation
CN103228130B (zh) 2010-06-17 2016-03-16 科马布有限公司 动物模型及治疗分子

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US9920110B2 (en) 2018-03-20
AU2012225310A1 (en) 2013-09-26
ES2666301T3 (es) 2018-05-03
KR101938343B1 (ko) 2019-01-14
JP2018027090A (ja) 2018-02-22
WO2012122484A1 (en) 2012-09-13
AU2017245395A2 (en) 2017-11-23
CA2829606A1 (en) 2012-09-13
HK1256304A1 (en) 2019-09-20
AU2017245395A1 (en) 2017-11-02
AU2019216660A1 (en) 2019-09-05
JP2014509853A (ja) 2014-04-24
AU2012225310B2 (en) 2017-08-03
JP2019195335A (ja) 2019-11-14
CN108220297A (zh) 2018-06-29
AU2017245395B2 (en) 2019-05-16
EP2683736B1 (en) 2018-01-17
HUE037095T2 (hu) 2018-08-28
JP6211931B2 (ja) 2017-10-11
EP2683736A1 (en) 2014-01-15
EP3345922A1 (en) 2018-07-11
CN103842379A (zh) 2014-06-04
US20120308555A1 (en) 2012-12-06
KR20190006083A (ko) 2019-01-16
CA2829606C (en) 2020-06-02
KR20140010436A (ko) 2014-01-24
US20190002532A1 (en) 2019-01-03
DK2683736T3 (en) 2018-04-23
JP6557709B2 (ja) 2019-08-07

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