KR20180132626A - 글리코시다제 저해제 - Google Patents
글리코시다제 저해제 Download PDFInfo
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- KR20180132626A KR20180132626A KR1020187025755A KR20187025755A KR20180132626A KR 20180132626 A KR20180132626 A KR 20180132626A KR 1020187025755 A KR1020187025755 A KR 1020187025755A KR 20187025755 A KR20187025755 A KR 20187025755A KR 20180132626 A KR20180132626 A KR 20180132626A
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- 0 CC1(C)C2C1CC*2 Chemical compound CC1(C)C2C1CC*2 0.000 description 2
- IFMHNXABCSMTFF-UHFFFAOYSA-N C1c(cccn2)c2OC1 Chemical compound C1c(cccn2)c2OC1 IFMHNXABCSMTFF-UHFFFAOYSA-N 0.000 description 1
- PJVQPPHJEYPUDB-UHFFFAOYSA-N C1c2ncccc2OC1 Chemical compound C1c2ncccc2OC1 PJVQPPHJEYPUDB-UHFFFAOYSA-N 0.000 description 1
- KLCUJOSOGXFJCQ-VQHVLOKHSA-N CC(C)/C(/C)=C/c1nccnc1N=C Chemical compound CC(C)/C(/C)=C/c1nccnc1N=C KLCUJOSOGXFJCQ-VQHVLOKHSA-N 0.000 description 1
- CRDQTKQNAYTZIA-UHFFFAOYSA-N CC(C)c(cc1)nc2c1[s]cn2 Chemical compound CC(C)c(cc1)nc2c1[s]cn2 CRDQTKQNAYTZIA-UHFFFAOYSA-N 0.000 description 1
- XFAZBYIUQLRNCO-UHFFFAOYSA-N CC(C)c(cn1)cc2c1[s]c(C)n2 Chemical compound CC(C)c(cn1)cc2c1[s]c(C)n2 XFAZBYIUQLRNCO-UHFFFAOYSA-N 0.000 description 1
- WKXGHQBJBZAEHT-UHFFFAOYSA-N CC(Nc1nnc(N2CCNCC2)[s]1)=O Chemical compound CC(Nc1nnc(N2CCNCC2)[s]1)=O WKXGHQBJBZAEHT-UHFFFAOYSA-N 0.000 description 1
- VRILYBNDQYDVGM-UHFFFAOYSA-N CC(c(cc1)cc(OC)c1OC)N(CC1)CCN1c(cc1)nc(OC)c1Br Chemical compound CC(c(cc1)cc(OC)c1OC)N(CC1)CCN1c(cc1)nc(OC)c1Br VRILYBNDQYDVGM-UHFFFAOYSA-N 0.000 description 1
- VKKXFZSVWGVTHA-UHFFFAOYSA-N CC(c(cc1)cc2c1nccn2)N(CC1)CCC1C(O1)=NNC1=O Chemical compound CC(c(cc1)cc2c1nccn2)N(CC1)CCC1C(O1)=NNC1=O VKKXFZSVWGVTHA-UHFFFAOYSA-N 0.000 description 1
- FBJJITQFGMPRSV-UHFFFAOYSA-N CC(c(cc1)cc2c1nccn2)N(CC1)CCN1c1cccc(C(OC)=O)n1 Chemical compound CC(c(cc1)cc2c1nccn2)N(CC1)CCN1c1cccc(C(OC)=O)n1 FBJJITQFGMPRSV-UHFFFAOYSA-N 0.000 description 1
- TUZNGHDZMBETBG-UHFFFAOYSA-N CC(c(cc1)cc2c1nccn2)N(CC1)CCN1c1ncc(C(C(F)(F)F)O)cn1 Chemical compound CC(c(cc1)cc2c1nccn2)N(CC1)CCN1c1ncc(C(C(F)(F)F)O)cn1 TUZNGHDZMBETBG-UHFFFAOYSA-N 0.000 description 1
- KEPBBALEVLHKQC-UHFFFAOYSA-N CC(c(cc1)cc2c1nccn2)N(CC1)CCN1c1ncc(C2(CCOCC2)O)cn1 Chemical compound CC(c(cc1)cc2c1nccn2)N(CC1)CCN1c1ncc(C2(CCOCC2)O)cn1 KEPBBALEVLHKQC-UHFFFAOYSA-N 0.000 description 1
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- NYDMAWVHTYZHTO-UHFFFAOYSA-N CC(c1cc(OCC2)c2cc1)N(CC1)CCC1[n]1ncc(C(F)(F)F)c1 Chemical compound CC(c1cc(OCC2)c2cc1)N(CC1)CCC1[n]1ncc(C(F)(F)F)c1 NYDMAWVHTYZHTO-UHFFFAOYSA-N 0.000 description 1
- RJKCTCJUOLSAEW-UHFFFAOYSA-N CC(c1cc(OCC2)c2cc1)N(CC1)CCN1c(cc1)ncc1C(N(C)C)=O Chemical compound CC(c1cc(OCC2)c2cc1)N(CC1)CCN1c(cc1)ncc1C(N(C)C)=O RJKCTCJUOLSAEW-UHFFFAOYSA-N 0.000 description 1
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- KOVYKKXRTWGGDK-UHFFFAOYSA-N CC(c1cc(OCC2)c2cc1)N(CC1)CCN1c1ncc(C)cn1 Chemical compound CC(c1cc(OCC2)c2cc1)N(CC1)CCN1c1ncc(C)cn1 KOVYKKXRTWGGDK-UHFFFAOYSA-N 0.000 description 1
- RVWDLLHXXXPKOX-UHFFFAOYSA-N CC(c1cc(OCC2)c2cc1)N(CC1)CCN1c1ncc(CNCC2)c2n1 Chemical compound CC(c1cc(OCC2)c2cc1)N(CC1)CCN1c1ncc(CNCC2)c2n1 RVWDLLHXXXPKOX-UHFFFAOYSA-N 0.000 description 1
- FCONYVAYFJDBDI-UHFFFAOYSA-N CC(c1cc2nccnc2cc1)Cl Chemical compound CC(c1cc2nccnc2cc1)Cl FCONYVAYFJDBDI-UHFFFAOYSA-N 0.000 description 1
- JSJYGWRQINRPCZ-UHFFFAOYSA-N CC(c1ccc(CCO2)c2c1)Cl Chemical compound CC(c1ccc(CCO2)c2c1)Cl JSJYGWRQINRPCZ-UHFFFAOYSA-N 0.000 description 1
- NJOVFHNALRRZCD-UHFFFAOYSA-N CC(c1ccc(CCO2)c2c1)N(CC1)CCN1c1ncc(C(C)(C)O)cn1 Chemical compound CC(c1ccc(CCO2)c2c1)N(CC1)CCN1c1ncc(C(C)(C)O)cn1 NJOVFHNALRRZCD-UHFFFAOYSA-N 0.000 description 1
- TVQWEOIECDKZMD-UHFFFAOYSA-N CC(c1ccc2[s]cnc2c1)N(CC1)CCN1c(nc1)ncc1C(N(C)C)=O Chemical compound CC(c1ccc2[s]cnc2c1)N(CC1)CCN1c(nc1)ncc1C(N(C)C)=O TVQWEOIECDKZMD-UHFFFAOYSA-N 0.000 description 1
- HHIQELQYWXPAEA-UHFFFAOYSA-N CC(c1ccc2[s]cnc2c1)N(CC1)CCN1c(nc1)ncc1C(OC)=O Chemical compound CC(c1ccc2[s]cnc2c1)N(CC1)CCN1c(nc1)ncc1C(OC)=O HHIQELQYWXPAEA-UHFFFAOYSA-N 0.000 description 1
- YUNACVOBOJKTSI-UHFFFAOYSA-N CC(c1nnc(N(CC2)CCN2C(C)c(cc2)cc3c2nccn3)[s]1)O Chemical compound CC(c1nnc(N(CC2)CCN2C(C)c(cc2)cc3c2nccn3)[s]1)O YUNACVOBOJKTSI-UHFFFAOYSA-N 0.000 description 1
- VBVILWHQIWQAQA-UHFFFAOYSA-N Cc1n[n](cccn2)c2n1 Chemical compound Cc1n[n](cccn2)c2n1 VBVILWHQIWQAQA-UHFFFAOYSA-N 0.000 description 1
- QHFLHFHJVNMPBL-UHFFFAOYSA-N Cc1nc(nc(C)cc2)c2[s]1 Chemical compound Cc1nc(nc(C)cc2)c2[s]1 QHFLHFHJVNMPBL-UHFFFAOYSA-N 0.000 description 1
- CGSWTRTYXLGAFI-UHFFFAOYSA-N Cc1nc(nccc2)c2[s]1 Chemical compound Cc1nc(nccc2)c2[s]1 CGSWTRTYXLGAFI-UHFFFAOYSA-N 0.000 description 1
- DSCYVCLBSVVQDH-UHFFFAOYSA-N Fc1c2nccnc2ccc1 Chemical compound Fc1c2nccnc2ccc1 DSCYVCLBSVVQDH-UHFFFAOYSA-N 0.000 description 1
- YPZCLMPOXZWSJI-UHFFFAOYSA-N Fc1ccnc2c1cccn2 Chemical compound Fc1ccnc2c1cccn2 YPZCLMPOXZWSJI-UHFFFAOYSA-N 0.000 description 1
- ZPWVMEBCBJNTNY-UHFFFAOYSA-N OC1(CCCC1)c(cc1)cnc1Cl Chemical compound OC1(CCCC1)c(cc1)cnc1Cl ZPWVMEBCBJNTNY-UHFFFAOYSA-N 0.000 description 1
- NYBJDWOMBJJWSN-UHFFFAOYSA-N OC1(CCOCC1)c(cn1)cnc1Cl Chemical compound OC1(CCOCC1)c(cn1)cnc1Cl NYBJDWOMBJJWSN-UHFFFAOYSA-N 0.000 description 1
- DMHMRXBMODHZGL-UHFFFAOYSA-N OC1(COCC1)c(cn1)cnc1Cl Chemical compound OC1(COCC1)c(cn1)cnc1Cl DMHMRXBMODHZGL-UHFFFAOYSA-N 0.000 description 1
- VMLKTERJLVWEJJ-UHFFFAOYSA-N c1cc2ncccc2nc1 Chemical compound c1cc2ncccc2nc1 VMLKTERJLVWEJJ-UHFFFAOYSA-N 0.000 description 1
- YEYHFKBVNARCNE-UHFFFAOYSA-N c1cnc2nccnc2c1 Chemical compound c1cnc2nccnc2c1 YEYHFKBVNARCNE-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07—ORGANIC CHEMISTRY
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Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1311316A (fr) | 1961-04-12 | 1962-12-07 | Science Union Et Compagnie Soc | Nouveaux dérivés de la pipérazine et leurs préparations |
| NL127996C (https=) | 1963-11-19 | |||
| US3485757A (en) | 1964-11-23 | 1969-12-23 | Atomic Energy Commission | Thermoelectric composition comprising doped bismuth telluride,silicon and boron |
| DE1595923A1 (de) | 1965-02-20 | 1969-11-27 | Merck Ag E | 1-Aralkyl-4-(thiazolyl-2)-piperazine und Verfahren zu ihrer Herstellung |
| GB1165283A (en) | 1967-01-17 | 1969-09-24 | Science Union & Cie | New Purine Derivatives and processes for prepararing them |
| US4600025A (en) | 1982-11-18 | 1986-07-15 | Grigg Ronald E | Smoking products comprising nicotine substitutes |
| WO1993021181A1 (en) | 1992-04-15 | 1993-10-28 | Merck Sharp & Dohme Limited | Azacyclic compounds |
| IL118768A (en) | 1995-07-12 | 2000-10-31 | Akzo Nobel Nv | Diphenylmethane piperidine derivatives pharmaceutical compositions containing them and a method for their preparation |
| TW504510B (en) | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
| EP0975624A1 (en) | 1997-04-17 | 2000-02-02 | Takeda Chemical Industries, Ltd. | Thermogenic composition and benzazepine thermogenics |
| DE69829989T2 (de) | 1997-10-24 | 2006-02-23 | Neurogen Corp., Branford | 1-(2-naphthyl) und 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazine als dopamin d4 subtype liganden |
| IL158941A0 (en) * | 2001-05-22 | 2004-05-12 | Neurogen Corp | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
| US6982259B2 (en) | 2002-04-30 | 2006-01-03 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
| CA2488635C (en) | 2002-06-12 | 2012-10-23 | Abbott Laboratories | Antagonists of melanin concentrating hormone receptor |
| BR0312023A (pt) | 2002-06-27 | 2005-03-22 | Novo Nordisk As | Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica |
| WO2004005293A2 (en) | 2002-07-05 | 2004-01-15 | Targacept, Inc. | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof |
| NZ538307A (en) | 2002-09-09 | 2008-04-30 | Janssen Pharmaceutica Nv | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
| MXPA05011223A (es) | 2003-04-18 | 2006-01-26 | Lilly Co Eli | Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas 5-htif. |
| CN100448870C (zh) | 2003-05-21 | 2009-01-07 | 万有制药株式会社 | 2-氨基喹啉衍生物 |
| JP4834840B2 (ja) | 2004-01-06 | 2011-12-14 | ノヴォ ノルディスク アー/エス | ヘテロアリール尿素およびグルコキナーゼ活性化剤としてのその使用 |
| WO2005110982A2 (en) * | 2004-04-07 | 2005-11-24 | Neurogen Corporation | Substituted 1-benzyl-4-substituted piperazine analogues |
| HU227119B1 (en) | 2004-07-29 | 2010-07-28 | Richter Gedeon Nyrt | Indole and benzimidazole carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| HUP0401522A2 (en) | 2004-07-29 | 2006-04-28 | Richter Gedeon Vegyeszet | New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation |
| CA2599843C (en) | 2005-03-01 | 2013-08-27 | Simon Fraser University | Selective glycosidase inhibitors, methods of making inhibitors, and uses thereof |
| US7582769B2 (en) | 2005-07-08 | 2009-09-01 | Novo Nordisk A/S | Dicycloalkyl urea glucokinase activators |
| EP2004613A2 (en) | 2006-03-31 | 2008-12-24 | AstraZeneca AB | Bicyclic benzimidazole compounds and their use as metabotropic glutamate receptor potentiators |
| WO2007135398A1 (en) | 2006-05-22 | 2007-11-29 | Astrazeneca Ab | Indole derivatives |
| US20080051387A1 (en) | 2006-06-09 | 2008-02-28 | Yuelian Xu | Tetrahydropyrido[3,4-d]pyrimidines and related analogues |
| WO2008012623A1 (en) | 2006-07-25 | 2008-01-31 | Pfizer Products Inc. | Benzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor |
| AU2007291870B2 (en) | 2006-08-31 | 2012-12-06 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| US20100022517A1 (en) | 2006-12-18 | 2010-01-28 | Richards Lori A | Ophthalmic formulation of rho kinase inhibitor compound |
| US8148369B2 (en) | 2007-05-10 | 2012-04-03 | Janssen Pharmaceutica Nv | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2009011904A1 (en) | 2007-07-19 | 2009-01-22 | Renovis, Inc. | Compounds useful as faah modulators and uses thereof |
| US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| EP2276738A1 (en) | 2008-04-17 | 2011-01-26 | Pfizer Inc. | Ether benzylidene piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors |
| US20110060012A1 (en) | 2008-04-17 | 2011-03-10 | Pfizer Inc. | 4-[3-(aryloxy)benzylidene]-3-methyl piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors |
| US7863291B2 (en) | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
| AU2009261248A1 (en) | 2008-06-19 | 2009-12-23 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
| JP2010065024A (ja) | 2008-08-14 | 2010-03-25 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリミジン誘導体又はその塩を含有する有害生物防除剤 |
| WO2010021381A1 (ja) | 2008-08-22 | 2010-02-25 | 武田薬品工業株式会社 | 縮合複素環誘導体およびその用途 |
| CA2735269C (en) | 2008-08-29 | 2018-10-16 | Saint Mary's University | Use of gluconacetobacter with reduced use of nitrogen fertilizer to improve beet crop production |
| JP5549592B2 (ja) | 2008-09-02 | 2014-07-16 | 日産化学工業株式会社 | オルト置換ハロアルキルスルホンアニリド誘導体及び除草剤 |
| TW201030007A (en) | 2009-02-06 | 2010-08-16 | Gruenenthal Gmbh | Substituted spiro-amides as b1r modulators |
| BRPI1011477A2 (pt) | 2009-03-02 | 2016-03-22 | Sirtris Pharmaceuticals Inc | quinolinas 8-substituidas e analogos relacionados como moduladores de sirtuina |
| US20100240720A1 (en) | 2009-03-20 | 2010-09-23 | Burnham Institute For Medical Research | Allosteric jnk inhibitors |
| WO2010108268A1 (en) | 2009-03-23 | 2010-09-30 | Merck Frosst Canada Ltd. | Heterocyclic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| JP2010270034A (ja) | 2009-05-20 | 2010-12-02 | Sumitomo Chemical Co Ltd | アミド化合物並びにその植物病害防除用途 |
| US9096518B2 (en) | 2009-06-22 | 2015-08-04 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| DE102009049679A1 (de) | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
| WO2011140640A1 (en) | 2010-05-11 | 2011-11-17 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| JP2013537233A (ja) | 2010-09-17 | 2013-09-30 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 脂肪酸合成酵素阻害剤 |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| US8933040B2 (en) | 2010-11-08 | 2015-01-13 | Craig A. Coburn | Selective glycosidase inhibitors and uses thereof |
| WO2012061972A1 (en) | 2010-11-08 | 2012-05-18 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| RU2609210C2 (ru) | 2010-12-23 | 2017-01-31 | Алектос Терапьютикс Инк. | Селективные ингибиторы гликозидазы и их применение |
| GB201103526D0 (en) | 2011-03-02 | 2011-04-13 | Summit Corp Plc | Selective glycosidase inhibitors and uses thereof |
| WO2012124744A1 (ja) | 2011-03-14 | 2012-09-20 | 大正製薬株式会社 | 含窒素縮合複素環化合物 |
| ES2568603T3 (es) | 2011-08-25 | 2016-05-03 | Merck Patent Gmbh | Pirano[3,2-d][1,3]tiazol como inhibidores de glicosidasas |
| WO2013066729A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Aminopyrimidinones as interleukin receptor-associated kinase inhibitors |
| JP6233855B2 (ja) | 2012-08-08 | 2017-11-22 | ノバルティス・ティーアゲズントハイト・アクチェンゲゼルシャフトNovartis Tiergesundheit Ag | 殺虫剤としての置換されたアジン類 |
| US9522883B2 (en) | 2012-08-31 | 2016-12-20 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| RS58768B1 (sr) | 2013-03-14 | 2019-06-28 | Merck Patent Gmbh | Inhibitori glikozidaze |
| CN103435606A (zh) | 2013-08-22 | 2013-12-11 | 中国药科大学 | CDK2与GSK3β双重抑制剂及用途 |
| MX368464B (es) | 2013-12-05 | 2019-10-02 | Pfizer | Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinil o y pirrolo[2,3-d]piridinilo. |
| EP2913330A1 (en) | 2014-02-27 | 2015-09-02 | Laboratoire Biodim | Condensed derivatives of imidazole useful as pharmaceuticals |
| DK3134413T3 (da) | 2014-04-23 | 2019-10-14 | Dart Neuroscience Cayman Ltd | Substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer |
| KR102043337B1 (ko) | 2014-08-28 | 2019-11-11 | 아셰뉴론 에스아 | 글리코시다제 저해제 |
| UA125171C2 (uk) | 2015-07-02 | 2022-01-26 | Янссен Саєнсиз Айрленд Юсі | Антибактеріальні сполуки |
| CN108349979B (zh) | 2015-11-02 | 2021-04-09 | 詹森药业有限公司 | [1,2,4]三唑并[1,5-a]嘧啶-7-基化合物 |
| US10323038B2 (en) | 2015-11-20 | 2019-06-18 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| WO2017087858A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| WO2017091818A1 (en) | 2015-11-25 | 2017-06-01 | Lieber Institute For Brain Development | Comt inhibiting methods and compositions |
| EP3389658B1 (en) | 2015-12-18 | 2020-11-25 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| KR20180132629A (ko) | 2016-02-25 | 2018-12-12 | 아셰뉴론 에스아 | 글리코시다제 저해제 |
| AU2017222964B2 (en) | 2016-02-25 | 2020-01-02 | Asceneuron S. A. | Glycosidase inhibitors |
| EP3585783A2 (en) | 2016-02-25 | 2020-01-01 | Asceneuron SA | Sulfoximine glycosidase inhibitors |
| CA3014572C (en) | 2016-02-25 | 2023-10-03 | Asceneuron S.A. | Acid addition salts of piperazine derivatives |
| US10344021B2 (en) | 2016-02-25 | 2019-07-09 | Asceneuron S A | Process for the separation of enantiomers of piperazine derivatives |
| US11186564B2 (en) | 2016-08-04 | 2021-11-30 | Sunovion Pharmaceuticals Inc. | Dual NAV1.2/5HT2a inhibitors for treating CNS disorders |
| US20190359609A1 (en) | 2016-12-16 | 2019-11-28 | Janssen Pharmaceutica Nv | Bicyclic oga inhibitor compounds |
| CA3045957A1 (en) | 2016-12-16 | 2018-06-21 | Janssen Pharmaceutica Nv | Monocyclic oga inhibitor compounds |
| TWI654978B (zh) | 2017-01-27 | 2019-04-01 | 美商美國禮來大藥廠 | 5-甲基-1,2,4-二唑-3-基化合物 |
| CN110267961A (zh) | 2017-02-06 | 2019-09-20 | 詹森药业有限公司 | Oga抑制剂化合物 |
| WO2018154133A1 (en) | 2017-02-27 | 2018-08-30 | Janssen Pharmaceutica Nv | [1,2,4]-triazolo [1,5-a]-pyrimidinyl derivatives substituted with piperidine, morpholine or piperazine as oga inhibitors |
| TWI669302B (zh) | 2017-05-25 | 2019-08-21 | 美商美國禮來大藥廠 | 5-甲基-1,3,4-<img align="absmiddle" height="18px" width="27px" file="d10999.TIF" alt="其他非圖式 ed10999.png" img-content="tif" orientation="portrait" inline="yes" giffile="ed10999.png"></img>二唑-2-基化合物 |
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2017
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- 2017-02-24 JP JP2018544555A patent/JP2019506430A/ja not_active Withdrawn
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- 2017-02-24 US US16/078,155 patent/US10556902B2/en active Active
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- 2017-02-24 CA CA3012624A patent/CA3012624A1/en not_active Withdrawn
- 2017-02-24 KR KR1020187025755A patent/KR20180132626A/ko not_active Withdrawn
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- 2017-02-24 MX MX2018010191A patent/MX2018010191A/es unknown
- 2017-02-24 MA MA043680A patent/MA43680A/fr unknown
- 2017-08-24 KR KR1020197027278A patent/KR20190118184A/ko not_active Abandoned
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2019
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| CN108884078A (zh) | 2018-11-23 |
| IL268501B1 (en) | 2026-01-01 |
| BR112019017514A2 (pt) | 2020-03-31 |
| KR102620279B1 (ko) | 2024-01-03 |
| MX2018010191A (es) | 2019-05-20 |
| CA3053200A1 (en) | 2018-08-30 |
| MA47573A (fr) | 2021-04-28 |
| CA3012624A1 (en) | 2017-08-31 |
| US10556902B2 (en) | 2020-02-11 |
| KR20190118184A (ko) | 2019-10-17 |
| MA47574A (fr) | 2020-01-01 |
| US10995090B2 (en) | 2021-05-04 |
| EP3419972A1 (en) | 2019-01-02 |
| AU2017222964A1 (en) | 2018-08-02 |
| IL268501A (en) | 2019-09-26 |
| AU2017222964B2 (en) | 2020-01-02 |
| EP3419972B1 (en) | 2023-07-26 |
| WO2017144639A1 (en) | 2017-08-31 |
| MA43680A (fr) | 2018-11-28 |
| US20190055239A1 (en) | 2019-02-21 |
| US20190388415A1 (en) | 2019-12-26 |
| JP2019506430A (ja) | 2019-03-07 |
| CA3053200C (en) | 2023-03-14 |
| KR20230026541A (ko) | 2023-02-24 |
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