KR20180093078A - 단백질 제제를 위한 트립토판 유도체의 용도 - Google Patents

단백질 제제를 위한 트립토판 유도체의 용도 Download PDF

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KR20180093078A
KR20180093078A KR1020187021448A KR20187021448A KR20180093078A KR 20180093078 A KR20180093078 A KR 20180093078A KR 1020187021448 A KR1020187021448 A KR 1020187021448A KR 20187021448 A KR20187021448 A KR 20187021448A KR 20180093078 A KR20180093078 A KR 20180093078A
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formulation
antibody
tryptophan
polypeptide
oxidation
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Korean (ko)
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비카스 샤르마
다니엘 라이스케
리디아 함부르크
클레오 살리스버리
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제넨테크, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
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    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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KR1020187021448A 2015-12-30 2016-12-28 단백질 제제를 위한 트립토판 유도체의 용도 Withdrawn KR20180093078A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562273273P 2015-12-30 2015-12-30
US62/273,273 2015-12-30
US201662321636P 2016-04-12 2016-04-12
US62/321,636 2016-04-12
PCT/US2016/069039 WO2017117304A1 (en) 2015-12-30 2016-12-28 Use of tryptophan derivatives for protein formulations

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KR20180093078A true KR20180093078A (ko) 2018-08-20

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US (2) US20170239355A1 (cg-RX-API-DMAC7.html)
EP (1) EP3397243A1 (cg-RX-API-DMAC7.html)
JP (1) JP7046814B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180093078A (cg-RX-API-DMAC7.html)
CN (1) CN108430455A (cg-RX-API-DMAC7.html)
AU (1) AU2016381694A1 (cg-RX-API-DMAC7.html)
BR (1) BR112018013071A2 (cg-RX-API-DMAC7.html)
CA (1) CA3007491A1 (cg-RX-API-DMAC7.html)
IL (1) IL259952A (cg-RX-API-DMAC7.html)
MX (1) MX2018008063A (cg-RX-API-DMAC7.html)
SG (2) SG11201804951SA (cg-RX-API-DMAC7.html)
WO (1) WO2017117304A1 (cg-RX-API-DMAC7.html)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2020101125A1 (ko) * 2018-11-12 2020-05-22 씨제이제일제당 (주) N-아세틸-l-트립토판을 유효성분으로 포함하는 젖소용 사료첨가제

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EP4509831A3 (en) 2018-07-27 2025-03-19 Waters Technologies Corporation Liquid chromatography/mass spectrometry methods for the analysis of polar molecules
KR102898177B1 (ko) 2018-08-08 2025-12-10 제넨테크, 인크. 단백질 제제를 위한 트립토판 유도체 및 l-메티오닌의 용도
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
AU2021248641A1 (en) 2020-04-03 2022-10-27 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
CN114441699B (zh) * 2020-10-30 2024-07-26 江苏正大丰海制药有限公司 同时测定注射液中葡萄糖酸钙与葡萄糖二酸钙含量的方法
WO2023053891A1 (ja) * 2021-09-29 2023-04-06 富士フイルム株式会社 製薬支援装置、製薬支援装置の作動方法、および製薬支援装置の作動プログラム
WO2023053892A1 (ja) * 2021-09-29 2023-04-06 富士フイルム株式会社 製薬支援装置、製薬支援装置の作動方法、および製薬支援装置の作動プログラム
JPWO2023053893A1 (cg-RX-API-DMAC7.html) * 2021-09-29 2023-04-06

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