KR20180085814A - 치환된 5,6-디히드로-6-페닐벤조[f]이소퀴놀린-2-아민의 제조 방법 - Google Patents
치환된 5,6-디히드로-6-페닐벤조[f]이소퀴놀린-2-아민의 제조 방법 Download PDFInfo
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- C07—ORGANIC CHEMISTRY
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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| US201562268758P | 2015-12-17 | 2015-12-17 | |
| US62/268,758 | 2015-12-17 | ||
| PCT/US2016/067161 WO2017106639A1 (en) | 2015-12-17 | 2016-12-16 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
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| KR20180085814A true KR20180085814A (ko) | 2018-07-27 |
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| EP3390368A4 (en) * | 2015-12-17 | 2019-07-03 | ArQule, Inc. | PROCESS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYL BENZO [F] ISOCHINOLINE-2-AMINE |
| JP2018537499A (ja) | 2015-12-17 | 2018-12-20 | アークル インコーポレイテッド | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態 |
| CN110669015A (zh) * | 2018-07-03 | 2020-01-10 | 上海喀露蓝科技有限公司 | 一种fgfr抑制剂的制备方法 |
| US10878412B2 (en) * | 2019-05-13 | 2020-12-29 | Truist Bank | In-line verification of transactions |
| WO2022053708A1 (en) | 2020-09-14 | 2022-03-17 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| JP2001507349A (ja) * | 1996-12-23 | 2001-06-05 | セルテック セラピューティックス リミテッド | 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用 |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| CN101115749B (zh) * | 2004-12-17 | 2011-06-22 | 安姆根有限公司 | 氨基嘧啶化合物和使用方法 |
| ES2656496T3 (es) | 2006-12-29 | 2018-02-27 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos útiles como inhibidores de AXL |
| GB2449293A (en) * | 2007-05-17 | 2008-11-19 | Evotec | Compounds having Hsp90 inhibitory activity |
| EP2379506B1 (en) | 2008-12-30 | 2015-09-02 | ArQule, Inc. | Substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds |
| CN103476770B (zh) | 2010-11-25 | 2017-02-15 | 拉蒂欧制药有限责任公司 | 阿法替尼盐和多晶型物 |
| WO2012177852A1 (en) * | 2011-06-24 | 2012-12-27 | Arqule, Inc | Substituted imidazopyridinyl compounds |
| WO2015150900A2 (en) * | 2014-03-31 | 2015-10-08 | Debiopharm International Sa | Fgfr fusions |
| EP3390368A4 (en) | 2015-12-17 | 2019-07-03 | ArQule, Inc. | PROCESS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYL BENZO [F] ISOCHINOLINE-2-AMINE |
| JP2018537499A (ja) | 2015-12-17 | 2018-12-20 | アークル インコーポレイテッド | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミン化合物の固体形態 |
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2016
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- 2016-12-16 KR KR1020187020433A patent/KR20180085814A/ko not_active Ceased
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- 2016-12-16 WO PCT/US2016/067161 patent/WO2017106639A1/en not_active Ceased
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- 2016-12-16 CN CN202210565751.2A patent/CN114874149A/zh active Pending
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- 2016-12-16 HK HK18114135.7A patent/HK1255014A1/zh unknown
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