CA3006077A1 - Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine - Google Patents

Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine Download PDF

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Publication number
CA3006077A1
CA3006077A1 CA3006077A CA3006077A CA3006077A1 CA 3006077 A1 CA3006077 A1 CA 3006077A1 CA 3006077 A CA3006077 A CA 3006077A CA 3006077 A CA3006077 A CA 3006077A CA 3006077 A1 CA3006077 A1 CA 3006077A1
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Canada
Prior art keywords
compound
slurry
mixture
optionally
hours
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Pending
Application number
CA3006077A
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English (en)
French (fr)
Inventor
Craig Bates
David P. Reed
Jianmin Mao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arqule Inc
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Arqule Inc
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Application filed by Arqule Inc filed Critical Arqule Inc
Publication of CA3006077A1 publication Critical patent/CA3006077A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA3006077A 2015-12-17 2016-12-16 Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine Pending CA3006077A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268758P 2015-12-17 2015-12-17
US62/268,758 2015-12-17
PCT/US2016/067161 WO2017106639A1 (en) 2015-12-17 2016-12-16 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

Publications (1)

Publication Number Publication Date
CA3006077A1 true CA3006077A1 (en) 2017-06-22

Family

ID=59057623

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3006077A Pending CA3006077A1 (en) 2015-12-17 2016-12-16 Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine

Country Status (16)

Country Link
US (4) US9834519B2 (enExample)
EP (2) EP4015508A1 (enExample)
JP (2) JP6940504B2 (enExample)
KR (1) KR20180085814A (enExample)
CN (2) CN114874149A (enExample)
AU (2) AU2016369520B2 (enExample)
BR (1) BR112018012325A2 (enExample)
CA (1) CA3006077A1 (enExample)
EA (1) EA201891431A1 (enExample)
HK (1) HK1255014A1 (enExample)
IL (1) IL259557A (enExample)
MX (2) MX385672B (enExample)
NZ (1) NZ742785A (enExample)
SG (1) SG11201804601TA (enExample)
TW (1) TWI748972B (enExample)
WO (1) WO2017106639A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA036295B1 (ru) 2015-12-17 2020-10-22 Аркьюл, Инк. Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений
CA3006077A1 (en) * 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine
CN110669015A (zh) * 2018-07-03 2020-01-10 上海喀露蓝科技有限公司 一种fgfr抑制剂的制备方法
US10878412B2 (en) * 2019-05-13 2020-12-29 Truist Bank In-line verification of transactions
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JP2001507349A (ja) * 1996-12-23 2001-06-05 セルテック セラピューティックス リミテッド 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
CN101115749B (zh) * 2004-12-17 2011-06-22 安姆根有限公司 氨基嘧啶化合物和使用方法
CN101622252B (zh) 2006-12-29 2015-04-22 里格尔制药公司 用作axl抑制剂的取代三唑
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
KR101714799B1 (ko) * 2008-12-30 2017-03-09 아르퀼 인코포레이티드 치환된 5,6-디히드로-6-페닐벤조［ｆ］이소퀴놀린-2-아민 화합물
US9012464B2 (en) 2010-11-25 2015-04-21 Ratiopharm Gmbh Salts and polymorphic forms of Afatinib
US8815854B2 (en) * 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
JP2017516463A (ja) * 2014-03-31 2017-06-22 デバイオファーム インターナショナル エスエイ Ｆｇｆｒ融合体
EA036295B1 (ru) 2015-12-17 2020-10-22 Аркьюл, Инк. Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений
CA3006077A1 (en) * 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine

Also Published As

Publication number Publication date
US10093632B2 (en) 2018-10-09
AU2016369520A1 (en) 2018-06-07
US11279679B2 (en) 2022-03-22
AU2021202610B2 (en) 2022-06-02
CN108602779A (zh) 2018-09-28
US20180065937A1 (en) 2018-03-08
CN114874149A (zh) 2022-08-09
MX385672B (es) 2025-03-18
US9834519B2 (en) 2017-12-05
US10766868B2 (en) 2020-09-08
JP2018537495A (ja) 2018-12-20
TWI748972B (zh) 2021-12-11
MX2018007415A (es) 2018-11-09
US20190241527A1 (en) 2019-08-08
BR112018012325A2 (pt) 2018-12-04
EP4015508A1 (en) 2022-06-22
AU2016369520B2 (en) 2021-02-18
NZ742785A (en) 2023-06-30
IL259557A (en) 2018-07-31
SG11201804601TA (en) 2018-07-30
US20170174637A1 (en) 2017-06-22
EP3390368A4 (en) 2019-07-03
US20200102276A1 (en) 2020-04-02
KR20180085814A (ko) 2018-07-27
TW201733992A (zh) 2017-10-01
HK1255014A1 (zh) 2019-08-02
AU2021202610A1 (en) 2021-05-27
EA201891431A1 (ru) 2018-11-30
JP6940504B2 (ja) 2021-09-29
WO2017106639A1 (en) 2017-06-22
MX2020012771A (es) 2022-10-04
EP3390368A1 (en) 2018-10-24
JP2021191782A (ja) 2021-12-16

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