TWI748972B - 製備經取代5,6-二氫-6-苯基苯并[f]異喹啉-2-胺之方法 - Google Patents

製備經取代5,6-二氫-6-苯基苯并[f]異喹啉-2-胺之方法 Download PDF

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TWI748972B
TWI748972B TW105141874A TW105141874A TWI748972B TW I748972 B TWI748972 B TW I748972B TW 105141874 A TW105141874 A TW 105141874A TW 105141874 A TW105141874 A TW 105141874A TW I748972 B TWI748972 B TW I748972B
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compound
acetone
scope
patent application
dihydrochloride
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TW105141874A
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Chinese (zh)
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TW201733992A (zh
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克雷格 貝茨
大衛 瑞德
毛建民
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美商亞闊股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW105141874A 2015-12-17 2016-12-16 製備經取代5,6-二氫-6-苯基苯并[f]異喹啉-2-胺之方法 TWI748972B (zh)

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US201562268758P 2015-12-17 2015-12-17
US62/268,758 2015-12-17

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TW201733992A TW201733992A (zh) 2017-10-01
TWI748972B true TWI748972B (zh) 2021-12-11

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TW105141874A TWI748972B (zh) 2015-12-17 2016-12-16 製備經取代5,6-二氫-6-苯基苯并[f]異喹啉-2-胺之方法

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US (4) US9834519B2 (enExample)
EP (2) EP3390368A4 (enExample)
JP (2) JP6940504B2 (enExample)
KR (1) KR20180085814A (enExample)
CN (2) CN108602779A (enExample)
AU (2) AU2016369520B2 (enExample)
BR (1) BR112018012325A2 (enExample)
CA (1) CA3006077A1 (enExample)
EA (1) EA201891431A1 (enExample)
HK (1) HK1255014A1 (enExample)
IL (1) IL259557A (enExample)
MX (2) MX385672B (enExample)
NZ (1) NZ742785A (enExample)
SG (1) SG11201804601TA (enExample)
TW (1) TWI748972B (enExample)
WO (1) WO2017106639A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201804670PA (en) * 2015-12-17 2018-07-30 Arqule Inc Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
JP6940504B2 (ja) * 2015-12-17 2021-09-29 アークル インコーポレイテッド 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法
CN110669015A (zh) * 2018-07-03 2020-01-10 上海喀露蓝科技有限公司 一种fgfr抑制剂的制备方法
US10878412B2 (en) * 2019-05-13 2020-12-29 Truist Bank In-line verification of transactions
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102325755A (zh) * 2008-12-30 2012-01-18 阿奎利公司 取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JP2001507349A (ja) * 1996-12-23 2001-06-05 セルテック セラピューティックス リミテッド 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
MX2007007032A (es) 2004-12-17 2007-07-04 Amgen Inc Compuestos de aminopirimidina y metodos de uso.
AU2007342007A1 (en) 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as Axl inhibitors
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
WO2012121764A1 (en) 2010-11-25 2012-09-13 Ratiopharm Gmbh Novel salts and polymorphic forms of afatinib
WO2012177852A1 (en) 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
CN106459993A (zh) * 2014-03-31 2017-02-22 德彪药业国际股份公司 Fgfr融合体
SG11201804670PA (en) 2015-12-17 2018-07-30 Arqule Inc Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
JP6940504B2 (ja) * 2015-12-17 2021-09-29 アークル インコーポレイテッド 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102325755A (zh) * 2008-12-30 2012-01-18 阿奎利公司 取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物

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Publication number Publication date
SG11201804601TA (en) 2018-07-30
JP2021191782A (ja) 2021-12-16
US11279679B2 (en) 2022-03-22
AU2016369520B2 (en) 2021-02-18
JP2018537495A (ja) 2018-12-20
CN114874149A (zh) 2022-08-09
AU2021202610A1 (en) 2021-05-27
WO2017106639A1 (en) 2017-06-22
US20170174637A1 (en) 2017-06-22
JP6940504B2 (ja) 2021-09-29
US20180065937A1 (en) 2018-03-08
AU2021202610B2 (en) 2022-06-02
NZ742785A (en) 2023-06-30
EP3390368A4 (en) 2019-07-03
KR20180085814A (ko) 2018-07-27
TW201733992A (zh) 2017-10-01
MX2018007415A (es) 2018-11-09
EA201891431A1 (ru) 2018-11-30
HK1255014A1 (zh) 2019-08-02
MX385672B (es) 2025-03-18
EP3390368A1 (en) 2018-10-24
AU2016369520A1 (en) 2018-06-07
CN108602779A (zh) 2018-09-28
US20190241527A1 (en) 2019-08-08
CA3006077A1 (en) 2017-06-22
US10093632B2 (en) 2018-10-09
US10766868B2 (en) 2020-09-08
MX2020012771A (es) 2022-10-04
BR112018012325A2 (pt) 2018-12-04
US9834519B2 (en) 2017-12-05
IL259557A (en) 2018-07-31
EP4015508A1 (en) 2022-06-22
US20200102276A1 (en) 2020-04-02

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