KR20180051676A - 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 - Google Patents
항미생물성 화합물 및 이의 제조 방법 및 사용 방법 Download PDFInfo
- Publication number
- KR20180051676A KR20180051676A KR1020187013069A KR20187013069A KR20180051676A KR 20180051676 A KR20180051676 A KR 20180051676A KR 1020187013069 A KR1020187013069 A KR 1020187013069A KR 20187013069 A KR20187013069 A KR 20187013069A KR 20180051676 A KR20180051676 A KR 20180051676A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- group
- unsaturated
- membered saturated
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CCC=C(*)CNOCC Chemical compound CCC=C(*)CNOCC 0.000 description 8
- SRRPEZQNZGHKTA-UHFFFAOYSA-N CCOC(COc(ccc(Br)c1)c1[N+]([O-])=O)=O Chemical compound CCOC(COc(ccc(Br)c1)c1[N+]([O-])=O)=O SRRPEZQNZGHKTA-UHFFFAOYSA-N 0.000 description 2
- UVUUCYFYHJSQSI-UHFFFAOYSA-N CC(C)(C)c(cc1)cc(NC2=N3)c1OC2=CNC3=O Chemical compound CC(C)(C)c(cc1)cc(NC2=N3)c1OC2=CNC3=O UVUUCYFYHJSQSI-UHFFFAOYSA-N 0.000 description 1
- WFUWTMWCMSBHTL-UHFFFAOYSA-N O=C1Nc(cc(CCc2cccc(F)c2)cc2)c2OC1 Chemical compound O=C1Nc(cc(CCc2cccc(F)c2)cc2)c2OC1 WFUWTMWCMSBHTL-UHFFFAOYSA-N 0.000 description 1
- CUTFAPGINUFNQM-UHFFFAOYSA-N [O-][N+](c(cc(cc1)Br)c1O)=O Chemical compound [O-][N+](c(cc(cc1)Br)c1O)=O CUTFAPGINUFNQM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6862—Stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25247809P | 2009-10-16 | 2009-10-16 | |
| US61/252,478 | 2009-10-16 | ||
| US31428710P | 2010-03-16 | 2010-03-16 | |
| US61/314,287 | 2010-03-16 | ||
| US35820110P | 2010-06-24 | 2010-06-24 | |
| US61/358,201 | 2010-06-24 | ||
| PCT/US2010/052924 WO2011047320A2 (en) | 2009-10-16 | 2010-10-15 | Antimicrobial compounds and methods of making and using the same |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127012702A Division KR101857694B1 (ko) | 2009-10-16 | 2010-10-15 | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180051676A true KR20180051676A (ko) | 2018-05-16 |
Family
ID=44343889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187013069A Ceased KR20180051676A (ko) | 2009-10-16 | 2010-10-15 | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9023843B2 (enExample) |
| EP (2) | EP3421476A1 (enExample) |
| JP (1) | JP6274723B2 (enExample) |
| KR (1) | KR20180051676A (enExample) |
| CN (1) | CN102712657A (enExample) |
| AU (3) | AU2010306647B9 (enExample) |
| BR (1) | BR112012008759A2 (enExample) |
| CA (1) | CA2777739A1 (enExample) |
| DK (1) | DK2488532T3 (enExample) |
| EA (1) | EA201270568A1 (enExample) |
| ES (1) | ES2683311T3 (enExample) |
| IL (2) | IL219134B (enExample) |
| MX (2) | MX2012004341A (enExample) |
| NZ (1) | NZ599289A (enExample) |
| PH (2) | PH12012500734A1 (enExample) |
| WO (1) | WO2011047320A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9216979B2 (en) | 2009-10-16 | 2015-12-22 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| PH12012500734A1 (en) | 2009-10-16 | 2012-11-26 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| EP3039025A4 (en) | 2013-09-09 | 2017-05-31 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| AU2014315045A1 (en) | 2013-09-09 | 2016-03-24 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| WO2015064714A1 (ja) * | 2013-10-31 | 2015-05-07 | 国立大学法人東京大学 | オートタキシン阻害活性を有する１－置換イミダゾピリミジノン誘導体 |
| KR20180015114A (ko) | 2015-03-11 | 2018-02-12 | 멜린타 테라퓨틱스, 인크. | 항미생물 화합물 및 이의 제조 및 사용 방법 |
| JP2017061430A (ja) * | 2015-09-25 | 2017-03-30 | 芳男 ▲浜▼田 | 新規なプロドラッグ |
| EP3452479A1 (en) * | 2016-05-06 | 2019-03-13 | Melinta Therapeutics, Inc. | Antimicrobials and methods of making and using same |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| WO2025233837A1 (en) | 2024-05-07 | 2025-11-13 | Takeda Pharmaceutical Company Limited | 4h-pyrimido[1,2-a]pyrimidin-4-one derivatives for use as nlrp3 inflammasome inhibitors for the treatment of neurodegenerative disorder |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2624731A (en) | 1953-01-06 | S-phenylpyrimidkn e x derivativesx | ||
| US3980781A (en) | 1966-03-31 | 1976-09-14 | Imperial Chemical Industries Limited | Fungicidal composition and method containing 2-amino-pyrimidines |
| US3673184A (en) * | 1970-09-02 | 1972-06-27 | Dainippon Pharmaceutical Co | Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives |
| JPS5821681B2 (ja) | 1974-12-05 | 1983-05-02 | 株式会社三井三池製作所 | 電磁探傷装置によるワイヤロ−プ位置判別検出装置 |
| US4361557A (en) | 1980-01-28 | 1982-11-30 | Schering Corporation | 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| ZA835684B (en) | 1982-08-27 | 1985-03-27 | Roussel Uclaf | Imidazo(1,2-a)pyrimidines |
| US5332835A (en) | 1984-02-03 | 1994-07-26 | Zambon S.P.A. | Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process |
| JPS6191184A (ja) | 1984-10-08 | 1986-05-09 | Morishita Seiyaku Kk | ２−アニリノ−５−（１ｈ−テトラゾ−ル−５−イル）ピリミジン−４（３ｈ）−オン誘導体 |
| DE3446812A1 (de) | 1984-12-21 | 1986-06-26 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| JP2873340B2 (ja) | 1988-04-29 | 1999-03-24 | 武田薬品工業株式会社 | 抗生物質ｔａｎ―１０５７，その製造法および用途 |
| JP2549931B2 (ja) | 1990-01-12 | 1996-10-30 | 株式会社大塚製薬工場 | ピリミドベンズイミダゾール誘導体 |
| JP2991382B2 (ja) * | 1990-07-18 | 1999-12-20 | 大日本製薬株式会社 | 縮合三環式化合物およびその塩 |
| US5208141A (en) | 1990-10-09 | 1993-05-04 | Konica Corporation | Silver halide color photographic light-sensitive material |
| JP2811230B2 (ja) | 1990-10-17 | 1998-10-15 | コニカ株式会社 | 新規な写真用カプラー |
| US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
| US6451968B1 (en) | 1991-05-24 | 2002-09-17 | Isis Pharmaceuticals, Inc. | Peptide nucleic acids |
| US5766855A (en) | 1991-05-24 | 1998-06-16 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity and sequence specificity |
| US5434257A (en) * | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| US5646163A (en) | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| FR2700086B1 (fr) | 1992-12-30 | 1995-04-28 | Alcatel Radiotelephone | Procédé de transmission d'informations à débit élevé par allocation multiple de blocs, procédé de réception associé et dispositif de réception pour sa mise en Óoeuvre. |
| EP0698013B1 (en) | 1993-05-12 | 2001-10-04 | E.I. Du Pont De Nemours And Company | Fungicidal fused bicyclic pyrimidinones |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| US5668127A (en) | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
| TW424090B (en) | 1995-08-18 | 2001-03-01 | Nat Science Council | Pyrimidines as folate antimetabolites with selective activity against human brain cancer |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| US7282327B2 (en) | 1996-01-23 | 2007-10-16 | Affymetrix, Inc. | Nucleic acid labeling compounds |
| GB9708611D0 (en) | 1997-04-28 | 1997-06-18 | Univ Cardiff | Chemical compounds |
| CA2297055A1 (en) | 1997-08-07 | 1999-02-18 | Research Corporation Technologies, Inc. | Antibiotic for methicillin resistant bacteria |
| ATE284407T1 (de) | 1997-11-07 | 2004-12-15 | Isis Pharmaceuticals Inc | Pyrimidinderivate als markierte bindungspartner |
| US6028183A (en) | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
| DE19838998A1 (de) | 1998-08-27 | 2000-03-09 | Bayer Ag | Neue Naturstoffderivate |
| SE9903894D0 (sv) | 1999-10-28 | 1999-10-28 | New Pharma Research Ab | Novel compounds |
| EP1113008A1 (en) | 1999-12-29 | 2001-07-04 | Pfizer Products Inc. | 4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidine derivatives useful as antibacterial and antiprotozoal agents |
| KR100358083B1 (ko) | 2000-02-17 | 2002-10-25 | 에스케이케미칼주식회사 | 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도 |
| KR101005299B1 (ko) | 2000-10-18 | 2011-01-04 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| DE10061538A1 (de) | 2000-12-11 | 2002-06-20 | Bayer Ag | Ureido-Dihydropyrimidinone |
| DE10061542A1 (de) | 2000-12-11 | 2002-06-13 | Bayer Ag | Alkanoylamino-pyrimidine |
| DE10061537A1 (de) | 2000-12-11 | 2002-06-20 | Bayer Ag | beta-Alanin-Derivate |
| DE10061541A1 (de) | 2000-12-11 | 2002-06-20 | Bayer Ag | Arylamino-Dihydropyrimidinone |
| HUP0303410A3 (en) * | 2000-12-14 | 2005-12-28 | Procter & Gamble | Antimicrobial quinolones, pharmaceutical compositions containing them and their use |
| US6900215B2 (en) | 2000-12-15 | 2005-05-31 | Merck Sharp & Dohme Ltd. | Imidazo-pyrimidine derivatives as ligands for gaba receptors |
| JP4542311B2 (ja) * | 2001-01-29 | 2010-09-15 | バイオ−ラッド ラボラトリーズ インコーポレイテッド | 核酸誘導体 |
| TWI248936B (en) | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
| US20030207804A1 (en) | 2001-05-25 | 2003-11-06 | Muthiah Manoharan | Modified peptide nucleic acids |
| CA2452458A1 (en) | 2001-07-03 | 2003-01-16 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| US20030158403A1 (en) | 2001-07-03 | 2003-08-21 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| DE10133277A1 (de) | 2001-07-09 | 2003-01-23 | Bayer Ag | ß-Alanin-Derivate |
| DE10141271A1 (de) | 2001-08-23 | 2003-03-06 | Bayer Ag | Neue Tetrahydro-1,3,5-triazin-2-on-Derivate und ihre Verwendung |
| JP4306206B2 (ja) | 2001-09-04 | 2009-07-29 | 住友化学株式会社 | イミダゾ［１，２−ａ］ピリミジン、その用途およびその製造中間体 |
| DE10208256A1 (de) | 2002-02-26 | 2003-09-04 | Bayer Ag | Piperidinouracile |
| GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| CN1649829A (zh) | 2002-03-08 | 2005-08-03 | 先灵-普劳有限公司 | 新型氟苯尼考类抗生素 |
| PA8595001A1 (es) | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
| AU2003225705A1 (en) | 2003-03-07 | 2004-09-30 | Ribapharm Inc. | Cytidine analogs and methods of use |
| EP1660500B1 (en) | 2003-07-30 | 2007-12-12 | Laboratorios S.A.L.V.A.T., S.A. | Substituted imidazopyrimidines for the prevention and treatment of cancer |
| WO2005019228A1 (en) | 2003-08-12 | 2005-03-03 | Achillion Pharmaceuticals, Inc. | Isothiazoloquinolones and related compounds as anti-infective agents |
| TW200509938A (en) | 2003-08-26 | 2005-03-16 | Teijin Pharma Ltd | Pyrrolopyrimidine thion derivatives |
| TW200524880A (en) | 2003-10-21 | 2005-08-01 | Sankyo Co | Pyrimidine compounds |
| EP1781788A2 (en) | 2004-06-30 | 2007-05-09 | ZGene A/S | Chicken deoxycytidine and deoxyadenosine kinase enzymes and their use |
| DK1913004T3 (da) * | 2005-07-27 | 2011-01-10 | Achillion Pharmaceuticals Inc | 8-methoxy-9h-isothiazolo[5,4-b]quinolin-3,4-dioner og beslægtede forbindelser som antiinfektive midler |
| CN101360720A (zh) | 2005-11-15 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | 新颖的2-氨基嘧啶酮衍生物及其用途 |
| NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| JP2007270087A (ja) | 2006-03-31 | 2007-10-18 | Fujifilm Corp | 硬化性組成物、インク組成物、インクジェット記録方法、印刷物、平版印刷版の製造方法、及び平版印刷版 |
| DE602007012161D1 (de) | 2006-03-03 | 2011-03-10 | Fujifilm Corp | Härtbare Zusammensetzung, Tintenzusammensetzung, Tintenstrahlaufzeichnungsverfahren und Flachdruckplatte |
| WO2007101871A1 (de) | 2006-03-08 | 2007-09-13 | Basf Se | Substituierte imidazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
| AU2007270276A1 (en) | 2006-07-03 | 2008-01-10 | Sk Chemicals Co., Ltd. | Salts of pyrrolopyrimidinone derivatives and process for preparing the same |
| KR20080003599A (ko) | 2006-07-03 | 2008-01-08 | 에스케이케미칼주식회사 | 피롤로피리미디논 유도체의 겐티세이트 염 및 이의제조방법 |
| US20100112561A1 (en) | 2006-08-25 | 2010-05-06 | Stefan Lutz | Fluorescent nucleoside analogues |
| ES2362805T3 (es) | 2006-09-07 | 2011-07-13 | Industrial Research Limited | Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas. |
| EP1964841A1 (en) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
| WO2008143730A2 (en) | 2007-02-28 | 2008-11-27 | Rib-X Pharmaceuticals, Inc. | Macrolide compounds and methods of making and using the same |
| CA2680177A1 (en) | 2007-03-07 | 2008-09-12 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors containing a heterocyclic moiety |
| JP2008222557A (ja) | 2007-03-08 | 2008-09-25 | Kotobuki Seiyaku Kk | ピロロ［３，２−ｄ］ピリミジン誘導体及びこれを有効成分とする医薬組成物 |
| CA2688432A1 (en) | 2007-05-30 | 2008-12-11 | Schering-Plough Ltd. | A process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol |
| WO2008154642A2 (en) | 2007-06-12 | 2008-12-18 | Achaogen, Inc. | Antibacterial agents |
| US20110046142A1 (en) | 2007-06-13 | 2011-02-24 | Northeastern University | Antibiotic compounds |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| KR20090098710A (ko) | 2008-03-14 | 2009-09-17 | 주식회사 씨티아이바이오 | 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체 |
| US20100190747A1 (en) | 2009-01-27 | 2010-07-29 | Hideo Suzuki | Fused ring compound and use thereof |
| WO2011017319A1 (en) | 2009-08-03 | 2011-02-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of treating disorders associated with protein polymerization |
| ES2620177T3 (es) | 2009-10-15 | 2017-06-27 | Guerbet | Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas |
| SG10201406634VA (en) | 2009-10-16 | 2014-11-27 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| AU2010306646B2 (en) | 2009-10-16 | 2016-09-01 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| PH12012500734A1 (en) | 2009-10-16 | 2012-11-26 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| US9216979B2 (en) | 2009-10-16 | 2015-12-22 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| CA2829993A1 (en) | 2011-03-15 | 2012-09-20 | Rib-X Pharmaceuticals, Inc. | Antimicrobial agents |
| JP6317669B2 (ja) | 2011-04-15 | 2018-04-25 | メリンタ セラピューティクス インコーポレイテッド | 抗菌化合物ならびにそれを作製および使用する方法 |
| JP5821681B2 (ja) | 2012-02-16 | 2015-11-24 | カシオ電子工業株式会社 | 画像形成装置 |
| EP3039025A4 (en) | 2013-09-09 | 2017-05-31 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| AU2014315045A1 (en) | 2013-09-09 | 2016-03-24 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| KR20180015114A (ko) | 2015-03-11 | 2018-02-12 | 멜린타 테라퓨틱스, 인크. | 항미생물 화합물 및 이의 제조 및 사용 방법 |
-
2010
- 2010-10-15 PH PH1/2012/500734A patent/PH12012500734A1/en unknown
- 2010-10-15 EP EP18166633.0A patent/EP3421476A1/en not_active Withdrawn
- 2010-10-15 NZ NZ599289A patent/NZ599289A/en not_active IP Right Cessation
- 2010-10-15 MX MX2012004341A patent/MX2012004341A/es active IP Right Grant
- 2010-10-15 AU AU2010306647A patent/AU2010306647B9/en not_active Ceased
- 2010-10-15 WO PCT/US2010/052924 patent/WO2011047320A2/en not_active Ceased
- 2010-10-15 DK DK10824204.1T patent/DK2488532T3/en active
- 2010-10-15 EP EP10824204.1A patent/EP2488532B1/en not_active Not-in-force
- 2010-10-15 CN CN2010800573380A patent/CN102712657A/zh active Pending
- 2010-10-15 MX MX2015009863A patent/MX359743B/es unknown
- 2010-10-15 US US13/501,836 patent/US9023843B2/en not_active Expired - Fee Related
- 2010-10-15 EA EA201270568A patent/EA201270568A1/ru unknown
- 2010-10-15 ES ES10824204.1T patent/ES2683311T3/es active Active
- 2010-10-15 JP JP2012534412A patent/JP6274723B2/ja not_active Expired - Fee Related
- 2010-10-15 BR BR112012008759-2A patent/BR112012008759A2/pt not_active IP Right Cessation
- 2010-10-15 CA CA2777739A patent/CA2777739A1/en not_active Abandoned
- 2010-10-15 KR KR1020187013069A patent/KR20180051676A/ko not_active Ceased
-
2012
- 2012-04-15 IL IL219134A patent/IL219134B/en not_active IP Right Cessation
-
2015
- 2015-04-08 US US14/681,806 patent/US9573962B2/en not_active Expired - Fee Related
- 2015-10-13 PH PH12015502375A patent/PH12015502375B1/en unknown
-
2016
- 2016-09-22 AU AU2016231569A patent/AU2016231569A1/en not_active Abandoned
-
2017
- 2017-01-05 US US15/399,159 patent/US10259825B2/en not_active Expired - Fee Related
-
2018
- 2018-03-04 IL IL257837A patent/IL257837A/en unknown
- 2018-03-22 AU AU2018202061A patent/AU2018202061A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101972992B1 (ko) | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 | |
| KR20180069098A (ko) | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 | |
| KR20180051676A (ko) | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 | |
| KR101857694B1 (ko) | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 | |
| WO2017193017A1 (en) | Antimicrobials and methods of making and using same | |
| EP3452479A1 (en) | Antimicrobials and methods of making and using same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20180508 Application number text: 1020127012702 Filing date: 20120516 |
|
| PG1501 | Laying open of application | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20180607 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20180618 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20190115 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20180618 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |