AU2010306647B9 - Antimicrobial compounds and methods of making and using the same - Google Patents

Antimicrobial compounds and methods of making and using the same Download PDF

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Publication number
AU2010306647B9
AU2010306647B9 AU2010306647A AU2010306647A AU2010306647B9 AU 2010306647 B9 AU2010306647 B9 AU 2010306647B9 AU 2010306647 A AU2010306647 A AU 2010306647A AU 2010306647 A AU2010306647 A AU 2010306647A AU 2010306647 B9 AU2010306647 B9 AU 2010306647B9
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AU
Australia
Prior art keywords
cr6r6
unsaturated
group
alkyl
member saturated
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2010306647A
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English (en)
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AU2010306647A1 (en
AU2010306647A8 (en
AU2010306647B2 (en
Inventor
Ashoke Bhattacharjee
Shili Chen
Marco Devivo
Erin M. Duffy
Rongliang Lou
Hardwin O'dowd
Brian T. Wimberly
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Melinta Subsidiary Corp
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Melinta Therapeutics Inc
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Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of AU2010306647A1 publication Critical patent/AU2010306647A1/en
Publication of AU2010306647A8 publication Critical patent/AU2010306647A8/en
Assigned to MELINTA THERAPEUTICS, INC. reassignment MELINTA THERAPEUTICS, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: RIB-X PHARMACEUTICALS, INC.
Priority to AU2016231569A priority Critical patent/AU2016231569A1/en
Publication of AU2010306647B2 publication Critical patent/AU2010306647B2/en
Application granted granted Critical
Publication of AU2010306647B9 publication Critical patent/AU2010306647B9/en
Priority to AU2018202061A priority patent/AU2018202061A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6862—Stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)
AU2010306647A 2009-10-16 2010-10-15 Antimicrobial compounds and methods of making and using the same Ceased AU2010306647B9 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2016231569A AU2016231569A1 (en) 2009-10-16 2016-09-22 Antimicrobial Compounds And Methods Of Making And Using The Same
AU2018202061A AU2018202061A1 (en) 2009-10-16 2018-03-22 Antimicrobial Compounds And Methods Of Making And Using The Same

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US25247809P 2009-10-16 2009-10-16
US61/252,478 2009-10-16
US31428710P 2010-03-16 2010-03-16
US61/314,287 2010-03-16
US35820110P 2010-06-24 2010-06-24
US61/358,201 2010-06-24
PCT/US2010/052924 WO2011047320A2 (en) 2009-10-16 2010-10-15 Antimicrobial compounds and methods of making and using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016231569A Division AU2016231569A1 (en) 2009-10-16 2016-09-22 Antimicrobial Compounds And Methods Of Making And Using The Same

Publications (4)

Publication Number Publication Date
AU2010306647A1 AU2010306647A1 (en) 2012-05-03
AU2010306647A8 AU2010306647A8 (en) 2012-05-17
AU2010306647B2 AU2010306647B2 (en) 2016-10-20
AU2010306647B9 true AU2010306647B9 (en) 2016-11-17

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2010306647A Ceased AU2010306647B9 (en) 2009-10-16 2010-10-15 Antimicrobial compounds and methods of making and using the same
AU2016231569A Abandoned AU2016231569A1 (en) 2009-10-16 2016-09-22 Antimicrobial Compounds And Methods Of Making And Using The Same
AU2018202061A Abandoned AU2018202061A1 (en) 2009-10-16 2018-03-22 Antimicrobial Compounds And Methods Of Making And Using The Same

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2016231569A Abandoned AU2016231569A1 (en) 2009-10-16 2016-09-22 Antimicrobial Compounds And Methods Of Making And Using The Same
AU2018202061A Abandoned AU2018202061A1 (en) 2009-10-16 2018-03-22 Antimicrobial Compounds And Methods Of Making And Using The Same

Country Status (16)

Country Link
US (3) US9023843B2 (enExample)
EP (2) EP3421476A1 (enExample)
JP (1) JP6274723B2 (enExample)
KR (1) KR20180051676A (enExample)
CN (1) CN102712657A (enExample)
AU (3) AU2010306647B9 (enExample)
BR (1) BR112012008759A2 (enExample)
CA (1) CA2777739A1 (enExample)
DK (1) DK2488532T3 (enExample)
EA (1) EA201270568A1 (enExample)
ES (1) ES2683311T3 (enExample)
IL (2) IL219134B (enExample)
MX (2) MX2012004341A (enExample)
NZ (1) NZ599289A (enExample)
PH (2) PH12012500734A1 (enExample)
WO (1) WO2011047320A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216979B2 (en) 2009-10-16 2015-12-22 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
PH12012500734A1 (en) 2009-10-16 2012-11-26 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
EP3039025A4 (en) 2013-09-09 2017-05-31 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
AU2014315045A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2015064714A1 (ja) * 2013-10-31 2015-05-07 国立大学法人東京大学 オートタキシン阻害活性を有する１－置換イミダゾピリミジノン誘導体
KR20180015114A (ko) 2015-03-11 2018-02-12 멜린타 테라퓨틱스, 인크. 항미생물 화합물 및 이의 제조 및 사용 방법
JP2017061430A (ja) * 2015-09-25 2017-03-30 芳男 ▲浜▼田 新規なプロドラッグ
EP3452479A1 (en) * 2016-05-06 2019-03-13 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
PH12022551379A1 (en) 2019-12-06 2023-05-03 Vertex Pharma Substituted tetrahydrofurans as modulators of sodium channels
DK4347031T3 (da) 2021-06-04 2025-12-01 Vertex Pharma N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler
WO2025233837A1 (en) 2024-05-07 2025-11-13 Takeda Pharmaceutical Company Limited 4h-pyrimido[1,2-a]pyrimidin-4-one derivatives for use as nlrp3 inflammasome inhibitors for the treatment of neurodegenerative disorder

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624731A (en) 1953-01-06 S-phenylpyrimidkn e x derivativesx
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US3673184A (en) * 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
JPS5821681B2 (ja) 1974-12-05 1983-05-02 株式会社三井三池製作所 電磁探傷装置によるワイヤロ−プ位置判別検出装置
US4361557A (en) 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
ZA835684B (en) 1982-08-27 1985-03-27 Roussel Uclaf Imidazo(1,2-a)pyrimidines
US5332835A (en) 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
JPS6191184A (ja) 1984-10-08 1986-05-09 Morishita Seiyaku Kk ２−アニリノ−５−（１ｈ−テトラゾ−ル−５−イル）ピリミジン−４（３ｈ）−オン誘導体
DE3446812A1 (de) 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
JP2873340B2 (ja) 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質ｔａｎ―１０５７，その製造法および用途
JP2549931B2 (ja) 1990-01-12 1996-10-30 株式会社大塚製薬工場 ピリミドベンズイミダゾール誘導体
JP2991382B2 (ja) * 1990-07-18 1999-12-20 大日本製薬株式会社 縮合三環式化合物およびその塩
US5208141A (en) 1990-10-09 1993-05-04 Konica Corporation Silver halide color photographic light-sensitive material
JP2811230B2 (ja) 1990-10-17 1998-10-15 コニカ株式会社 新規な写真用カプラー
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5434257A (en) * 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
US5646163A (en) 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
FR2700086B1 (fr) 1992-12-30 1995-04-28 Alcatel Radiotelephone Procédé de transmission d'informations à débit élevé par allocation multiple de blocs, procédé de réception associé et dispositif de réception pour sa mise en Óoeuvre.
EP0698013B1 (en) 1993-05-12 2001-10-04 E.I. Du Pont De Nemours And Company Fungicidal fused bicyclic pyrimidinones
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
TW424090B (en) 1995-08-18 2001-03-01 Nat Science Council Pyrimidines as folate antimetabolites with selective activity against human brain cancer
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
GB9708611D0 (en) 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
CA2297055A1 (en) 1997-08-07 1999-02-18 Research Corporation Technologies, Inc. Antibiotic for methicillin resistant bacteria
ATE284407T1 (de) 1997-11-07 2004-12-15 Isis Pharmaceuticals Inc Pyrimidinderivate als markierte bindungspartner
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
DE19838998A1 (de) 1998-08-27 2000-03-09 Bayer Ag Neue Naturstoffderivate
SE9903894D0 (sv) 1999-10-28 1999-10-28 New Pharma Research Ab Novel compounds
EP1113008A1 (en) 1999-12-29 2001-07-04 Pfizer Products Inc. 4-oxo-2-ureido-1,4,5,6-tetrahydro-pyrimidine derivatives useful as antibacterial and antiprotozoal agents
KR100358083B1 (ko) 2000-02-17 2002-10-25 에스케이케미칼주식회사 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도
KR101005299B1 (ko) 2000-10-18 2011-01-04 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
DE10061538A1 (de) 2000-12-11 2002-06-20 Bayer Ag Ureido-Dihydropyrimidinone
DE10061542A1 (de) 2000-12-11 2002-06-13 Bayer Ag Alkanoylamino-pyrimidine
DE10061537A1 (de) 2000-12-11 2002-06-20 Bayer Ag beta-Alanin-Derivate
DE10061541A1 (de) 2000-12-11 2002-06-20 Bayer Ag Arylamino-Dihydropyrimidinone
HUP0303410A3 (en) * 2000-12-14 2005-12-28 Procter & Gamble Antimicrobial quinolones, pharmaceutical compositions containing them and their use
US6900215B2 (en) 2000-12-15 2005-05-31 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for gaba receptors
JP4542311B2 (ja) * 2001-01-29 2010-09-15 バイオ−ラッド ラボラトリーズ インコーポレイテッド 核酸誘導体
TWI248936B (en) 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
US20030207804A1 (en) 2001-05-25 2003-11-06 Muthiah Manoharan Modified peptide nucleic acids
CA2452458A1 (en) 2001-07-03 2003-01-16 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
US20030158403A1 (en) 2001-07-03 2003-08-21 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
DE10133277A1 (de) 2001-07-09 2003-01-23 Bayer Ag ß-Alanin-Derivate
DE10141271A1 (de) 2001-08-23 2003-03-06 Bayer Ag Neue Tetrahydro-1,3,5-triazin-2-on-Derivate und ihre Verwendung
JP4306206B2 (ja) 2001-09-04 2009-07-29 住友化学株式会社 イミダゾ［１，２−ａ］ピリミジン、その用途およびその製造中間体
DE10208256A1 (de) 2002-02-26 2003-09-04 Bayer Ag Piperidinouracile
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
CN1649829A (zh) 2002-03-08 2005-08-03 先灵-普劳有限公司 新型氟苯尼考类抗生素
PA8595001A1 (es) 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
AU2003225705A1 (en) 2003-03-07 2004-09-30 Ribapharm Inc. Cytidine analogs and methods of use
EP1660500B1 (en) 2003-07-30 2007-12-12 Laboratorios S.A.L.V.A.T., S.A. Substituted imidazopyrimidines for the prevention and treatment of cancer
WO2005019228A1 (en) 2003-08-12 2005-03-03 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents
TW200509938A (en) 2003-08-26 2005-03-16 Teijin Pharma Ltd Pyrrolopyrimidine thion derivatives
TW200524880A (en) 2003-10-21 2005-08-01 Sankyo Co Pyrimidine compounds
EP1781788A2 (en) 2004-06-30 2007-05-09 ZGene A/S Chicken deoxycytidine and deoxyadenosine kinase enzymes and their use
DK1913004T3 (da) * 2005-07-27 2011-01-10 Achillion Pharmaceuticals Inc 8-methoxy-9h-isothiazolo[5,4-b]quinolin-3,4-dioner og beslægtede forbindelser som antiinfektive midler
CN101360720A (zh) 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶酮衍生物及其用途
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
JP2007270087A (ja) 2006-03-31 2007-10-18 Fujifilm Corp 硬化性組成物、インク組成物、インクジェット記録方法、印刷物、平版印刷版の製造方法、及び平版印刷版
DE602007012161D1 (de) 2006-03-03 2011-03-10 Fujifilm Corp Härtbare Zusammensetzung, Tintenzusammensetzung, Tintenstrahlaufzeichnungsverfahren und Flachdruckplatte
WO2007101871A1 (de) 2006-03-08 2007-09-13 Basf Se Substituierte imidazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
AU2007270276A1 (en) 2006-07-03 2008-01-10 Sk Chemicals Co., Ltd. Salts of pyrrolopyrimidinone derivatives and process for preparing the same
KR20080003599A (ko) 2006-07-03 2008-01-08 에스케이케미칼주식회사 피롤로피리미디논 유도체의 겐티세이트 염 및 이의제조방법
US20100112561A1 (en) 2006-08-25 2010-05-06 Stefan Lutz Fluorescent nucleoside analogues
ES2362805T3 (es) 2006-09-07 2011-07-13 Industrial Research Limited Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas.
EP1964841A1 (en) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]azine and their use as pharmaceuticals
WO2008143730A2 (en) 2007-02-28 2008-11-27 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
CA2680177A1 (en) 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
JP2008222557A (ja) 2007-03-08 2008-09-25 Kotobuki Seiyaku Kk ピロロ［３，２−ｄ］ピリミジン誘導体及びこれを有効成分とする医薬組成物
CA2688432A1 (en) 2007-05-30 2008-12-11 Schering-Plough Ltd. A process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
WO2008154642A2 (en) 2007-06-12 2008-12-18 Achaogen, Inc. Antibacterial agents
US20110046142A1 (en) 2007-06-13 2011-02-24 Northeastern University Antibiotic compounds
GB0724342D0 (en) 2007-12-13 2008-01-30 Prolysis Ltd Anitbacterial compositions
KR20090098710A (ko) 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
US20100190747A1 (en) 2009-01-27 2010-07-29 Hideo Suzuki Fused ring compound and use thereof
WO2011017319A1 (en) 2009-08-03 2011-02-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating disorders associated with protein polymerization
ES2620177T3 (es) 2009-10-15 2017-06-27 Guerbet Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas
SG10201406634VA (en) 2009-10-16 2014-11-27 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
AU2010306646B2 (en) 2009-10-16 2016-09-01 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
PH12012500734A1 (en) 2009-10-16 2012-11-26 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
US9216979B2 (en) 2009-10-16 2015-12-22 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
CA2829993A1 (en) 2011-03-15 2012-09-20 Rib-X Pharmaceuticals, Inc. Antimicrobial agents
JP6317669B2 (ja) 2011-04-15 2018-04-25 メリンタ セラピューティクス インコーポレイテッド 抗菌化合物ならびにそれを作製および使用する方法
JP5821681B2 (ja) 2012-02-16 2015-11-24 カシオ電子工業株式会社 画像形成装置
EP3039025A4 (en) 2013-09-09 2017-05-31 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
AU2014315045A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
KR20180015114A (ko) 2015-03-11 2018-02-12 멜린타 테라퓨틱스, 인크. 항미생물 화합물 및 이의 제조 및 사용 방법

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