KR20180004193A - Gpr52와 관련된 장애의 치료 또는 예방을 위한 gpr52 조절제로서 1-헤테로아릴-인돌린-4-카르복스아미드 - Google Patents
Gpr52와 관련된 장애의 치료 또는 예방을 위한 gpr52 조절제로서 1-헤테로아릴-인돌린-4-카르복스아미드 Download PDFInfo
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- KR20180004193A KR20180004193A KR1020177034516A KR20177034516A KR20180004193A KR 20180004193 A KR20180004193 A KR 20180004193A KR 1020177034516 A KR1020177034516 A KR 1020177034516A KR 20177034516 A KR20177034516 A KR 20177034516A KR 20180004193 A KR20180004193 A KR 20180004193A
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- pyridin
- carboxamide
- trifluoromethyl
- fluoro
- indoline
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201562154523P | 2015-04-29 | 2015-04-29 | |
| US62/154,523 | 2015-04-29 | ||
| PCT/US2016/030105 WO2016176571A1 (en) | 2015-04-29 | 2016-04-29 | 1-heteroaryl-indoline-4-carboxamides as modulators of gpr52 useful for the treatment or prevention of disorders related thereto |
Publications (1)
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| KR20180004193A true KR20180004193A (ko) | 2018-01-10 |
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| KR1020177034516A Withdrawn KR20180004193A (ko) | 2015-04-29 | 2016-04-29 | Gpr52와 관련된 장애의 치료 또는 예방을 위한 gpr52 조절제로서 1-헤테로아릴-인돌린-4-카르복스아미드 |
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| EP (1) | EP3292114B1 (https=) |
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| CN (1) | CN108174603B (https=) |
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| CN111792990A (zh) * | 2019-04-09 | 2020-10-20 | 中国科学院上海药物研究所 | 一种不饱和酮类化合物、其制备方法和用途 |
| AU2020381168A1 (en) * | 2019-11-08 | 2022-04-14 | Nxera Pharma Uk Limited | GPR52 modulator compounds |
| GB202003668D0 (en) | 2020-03-13 | 2020-04-29 | Heptares Therapeutics Ltd | GPR52 Modulator compounds |
| BR112022018996A2 (pt) * | 2020-03-30 | 2022-11-01 | Boehringer Ingelheim Int | 3-fenoxiazetidin-1-il-pirazinas substituídas apresentando atividade agonística do gpr52". |
| WO2021216705A1 (en) * | 2020-04-22 | 2021-10-28 | Neurocrine Biosciences, Inc. | Gpr52 modulators and methods of use |
| GB202013558D0 (en) | 2020-08-28 | 2020-10-14 | Heptares Therapeutics Ltd | GRP52 Modularor compounds |
| WO2022232017A1 (en) | 2021-04-26 | 2022-11-03 | Neurocrine Biosciences, Inc. | Gpr52 modulators and methods of use |
| JP2024533565A (ja) | 2021-09-14 | 2024-09-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ３－フェノキシアゼチジン－１－イル－ヘテロアリールピロリジン誘導体及び医薬としてのその使用 |
| GB202113186D0 (en) | 2021-09-15 | 2021-10-27 | Heptares Therapeutics Ltd | GPR52 Modulator compounds |
| WO2024091542A1 (en) * | 2022-10-26 | 2024-05-02 | Neurocrine Biosciences, Inc. | Compounds and compositions as gpr52 modulators |
| WO2024091541A1 (en) * | 2022-10-26 | 2024-05-02 | Neurocrine Biosciences, Inc. | Compounds and compositions as gpr52 modulators |
| AR130864A1 (es) * | 2022-10-26 | 2025-01-29 | Neurocrine Biosciences Inc | Compuestos y composiciones como moduladores de gpr52 |
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| EP2043744A2 (en) * | 2006-07-13 | 2009-04-08 | SmithKline Beecham Corporation | Chemical compounds |
| US20110009421A1 (en) * | 2008-02-27 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
| FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| JPWO2009157196A1 (ja) * | 2008-06-25 | 2011-12-08 | 武田薬品工業株式会社 | アミド化合物 |
| TW201010977A (en) | 2008-08-12 | 2010-03-16 | Takeda Pharmaceutical | Amide compound |
| US8481731B2 (en) * | 2009-06-24 | 2013-07-09 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| JP2012082175A (ja) * | 2010-10-14 | 2012-04-26 | Daiichi Sankyo Co Ltd | インドリン化合物を含有する医薬組成物 |
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Also Published As
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| EA034244B1 (ru) | 2020-01-21 |
| IL255185A0 (en) | 2017-12-31 |
| US20160318911A1 (en) | 2016-11-03 |
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| US9676758B2 (en) | 2017-06-13 |
| JP6673939B2 (ja) | 2020-04-01 |
| MX2017013853A (es) | 2018-06-07 |
| WO2016176571A1 (en) | 2016-11-03 |
| CL2017002738A1 (es) | 2018-06-01 |
| ES2784316T3 (es) | 2020-09-24 |
| JP2018519253A (ja) | 2018-07-19 |
| BR112017022987A2 (pt) | 2018-07-24 |
| CN108174603A (zh) | 2018-06-15 |
| EA201792375A1 (ru) | 2018-05-31 |
| CN108174603B (zh) | 2021-07-02 |
| PH12017501961A1 (en) | 2018-03-26 |
| MX373876B (es) | 2020-03-26 |
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