KR20170129191A - (4s)-4-[4-사이아노-2-(메틸설폰일)페닐]-3,6-다이메틸-2-옥소-1-[3-(트라이플루오로메틸)페닐]-1,2,3,4-테트라하이드로 피리미딘-5-카보나이트릴의 생성 방법 - Google Patents
(4s)-4-[4-사이아노-2-(메틸설폰일)페닐]-3,6-다이메틸-2-옥소-1-[3-(트라이플루오로메틸)페닐]-1,2,3,4-테트라하이드로 피리미딘-5-카보나이트릴의 생성 방법 Download PDFInfo
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- KR20170129191A KR20170129191A KR1020177029441A KR20177029441A KR20170129191A KR 20170129191 A KR20170129191 A KR 20170129191A KR 1020177029441 A KR1020177029441 A KR 1020177029441A KR 20177029441 A KR20177029441 A KR 20177029441A KR 20170129191 A KR20170129191 A KR 20170129191A
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- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 title abstract description 33
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| GB0520743D0 (en) | 2005-10-12 | 2005-11-23 | Argenta Discovery Ltd | Compounds and their use |
| WO2007067575A2 (en) | 2005-12-05 | 2007-06-14 | Wyeth | Process for preparing substituted aryl cycloalkanol derivatives |
| JP4999920B2 (ja) | 2006-05-04 | 2012-08-15 | プルマジェン セラピューティクス （インフラメーション） リミテッド | テトラヒドロピロロピリミジンジオン類およびヒト好中球エラスターゼ阻害薬としてのそれらの使用 |
| US20100010024A1 (en) | 2006-07-01 | 2010-01-14 | Bayer Healthcare Ag | Use of1,4-diaryl-dihydropyrimidine-2-on derivatives for treating pulmonary arterial hypertension |
| EP2064184A1 (en) | 2006-09-04 | 2009-06-03 | AstraZeneca AB | Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors |
| MX2010006033A (es) | 2007-12-20 | 2010-07-16 | Bayer Schering Pharma Ag | 4-(4-ciano-2-tioaril)dihidropirimidinonas y su uso. |
| DE102008022521A1 (de) | 2008-05-07 | 2009-11-12 | Bayer Schering Pharma Aktiengesellschaft | 1,4-Diaryl-pyrimidopyridazin-2,5-dione und ihre Verwendung |
| DE102009016553A1 (de) | 2009-04-06 | 2010-10-07 | Bayer Schering Pharma Aktiengesellschaft | Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung |
| CN110981815A (zh) | 2015-03-18 | 2020-04-10 | Ph制药有限公司 | 用于生产化合物的方法 |
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| Publication number | Publication date |
|---|---|
| JP2021138711A (ja) | 2021-09-16 |
| US20190248750A1 (en) | 2019-08-15 |
| ES2877583T3 (es) | 2021-11-17 |
| EP3271337B1 (de) | 2021-03-03 |
| CN110981815A (zh) | 2020-04-10 |
| JP7117415B2 (ja) | 2022-08-12 |
| JP2022145951A (ja) | 2022-10-04 |
| CA2980071A1 (en) | 2016-09-22 |
| JP7390100B2 (ja) | 2023-12-01 |
| EP3271337A1 (de) | 2018-01-24 |
| AU2016232270A1 (en) | 2017-10-19 |
| WO2016146607A1 (de) | 2016-09-22 |
| JP2018508549A (ja) | 2018-03-29 |
| JP7125450B2 (ja) | 2022-08-24 |
| CN107635972A (zh) | 2018-01-26 |
| US10316001B2 (en) | 2019-06-11 |
| US20180072685A1 (en) | 2018-03-15 |
| US10676443B2 (en) | 2020-06-09 |
| AU2016232270B2 (en) | 2020-09-03 |
| JP2020172529A (ja) | 2020-10-22 |
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