KR20160015333A - 분류가능한 정자를 갖는 동물을 만들기 위한 유전적 기술 - Google Patents

분류가능한 정자를 갖는 동물을 만들기 위한 유전적 기술 Download PDF

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Publication number
KR20160015333A
KR20160015333A KR1020157037264A KR20157037264A KR20160015333A KR 20160015333 A KR20160015333 A KR 20160015333A KR 1020157037264 A KR1020157037264 A KR 1020157037264A KR 20157037264 A KR20157037264 A KR 20157037264A KR 20160015333 A KR20160015333 A KR 20160015333A
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South Korea
Prior art keywords
sperm
marker
animal
chromosome
cells
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Korean (ko)
Inventor
다니엘 에프. 칼슨
스캇 씨. 파렌크루그
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리컴비네틱스 인코포레이티드
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Publication of KR20160015333A publication Critical patent/KR20160015333A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020157037264A 2013-05-31 2014-04-29 분류가능한 정자를 갖는 동물을 만들기 위한 유전적 기술 Withdrawn KR20160015333A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361829672P 2013-05-31 2013-05-31
US61/829,672 2013-05-31
US201361870586P 2013-08-27 2013-08-27
US61/870,586 2013-08-27
PCT/US2014/035851 WO2014193584A2 (en) 2013-05-31 2014-04-29 Genetic techniques for making animals with sortable sperm

Publications (1)

Publication Number Publication Date
KR20160015333A true KR20160015333A (ko) 2016-02-12

Family

ID=51986778

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157037264A Withdrawn KR20160015333A (ko) 2013-05-31 2014-04-29 분류가능한 정자를 갖는 동물을 만들기 위한 유전적 기술

Country Status (13)

Country Link
US (1) US20140359795A1 (enExample)
EP (1) EP3003021A4 (enExample)
JP (1) JP2016519955A (enExample)
KR (1) KR20160015333A (enExample)
CN (1) CN105658050A (enExample)
AP (1) AP2015008966A0 (enExample)
AU (1) AU2014272107A1 (enExample)
BR (1) BR112015029905A2 (enExample)
CA (1) CA2913412A1 (enExample)
MX (1) MX2015016383A (enExample)
PH (1) PH12015502646A1 (enExample)
RU (1) RU2015156824A (enExample)
WO (1) WO2014193584A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3456831T3 (da) 2013-04-16 2021-09-06 Regeneron Pharma Målrettet modifikation af rottegenom
US20140359796A1 (en) * 2013-05-31 2014-12-04 Recombinetics, Inc. Genetically sterile animals
ES2962492T3 (es) 2013-10-25 2024-03-19 Livestock Improvement Corporation Ltd Marcadores genéticos y usos de los mismos
CN111218447B (zh) 2013-11-07 2024-10-11 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
US10787684B2 (en) * 2013-11-19 2020-09-29 President And Fellows Of Harvard College Large gene excision and insertion
MX388127B (es) 2013-12-11 2025-03-19 Regeneron Pharma Metodos y composiciones para la modificacion dirigida de un genoma.
BR122023023211A2 (pt) 2014-04-28 2024-01-23 Recombinetics, Inc. Método de fazer edições de genes multiplex em uma célula de vertebrado ou de embrião primário não-humano
DK3161128T3 (en) 2014-06-26 2018-11-05 Regeneron Pharma METHODS AND COMPOSITIONS FOR TARGETED GENTICAL MODIFICATIONS AND PROCEDURES FOR USE THEREOF
EP3221457B1 (en) 2014-11-21 2019-03-20 Regeneron Pharmaceuticals, Inc. Methods and compositions for targeted genetic modification using paired guide rnas
CN108368502B (zh) 2015-06-03 2022-03-18 内布拉斯加大学董事委员会 使用单链dna的dna编辑
CN107315092B (zh) * 2017-07-11 2019-03-19 上海市第一人民医院 一种快速评估睾丸生精功能的免疫荧光染色法及其试剂盒
WO2020102565A2 (en) * 2018-11-14 2020-05-22 Flagship Pioneering Innovations V, Inc. Systems and methods for nondestructive testing of gametes
CN111500530A (zh) * 2020-04-30 2020-08-07 延安大学 一种通用型动物精子分选方法及x精子质控方法
CN114015705A (zh) * 2021-11-28 2022-02-08 华中科技大学同济医学院附属协和医院 一种小鼠体外受精繁育性别选择方法
WO2024249570A2 (en) * 2023-06-02 2024-12-05 New York University Single-sex chicken with toxin-antitoxin system
CN119498221B (zh) * 2024-11-12 2026-07-17 南京农业大学 一种公猪阴囊智能降温机器人及其工作方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000029602A1 (en) * 1998-11-13 2000-05-25 Cedars-Sinai Medical Center Transfection of male germ cells for generation of selectable transgenic stem cells
GB9916810D0 (en) * 1999-07-16 1999-09-22 Cancer Res Campaign Tech Killing cells
US20010041348A1 (en) * 1999-12-07 2001-11-15 Stan Blecher Sex-chromosome-specific proteins, species specific and sperm specific proteins and methods for their identification and isolation
CN1434678A (zh) * 1999-12-27 2003-08-06 刘成宇 通过将转基因靶向至性染色体上控制子代性别比例
CN101024829A (zh) * 2000-02-24 2007-08-29 马萨诸塞大学 只生育单一性别后代的哺乳动物的生产
US20050081256A1 (en) * 2001-03-22 2005-04-14 Forsberg Erik J. Sex- specific selection of sperm from transgenic animals
CN1313061C (zh) * 2002-03-11 2007-05-02 刘凤鸣 一种动物精子的性别分选方法
JP4271120B2 (ja) * 2003-10-14 2009-06-03 独立行政法人科学技術振興機構 Ｙ染色体標識トランスジェニック非ヒト動物
CN101014700B (zh) * 2004-03-29 2012-03-28 英格朗公司 用于分选带有x或y染色体富集群的精子悬浮液
US20060123489A1 (en) * 2004-12-03 2006-06-08 Envivo Pharmaceuticals, Inc. Sex-specific automated sorting of non-human animals
CA2793945A1 (en) * 2009-04-01 2011-10-21 Biocern, Inc. Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein
US8633348B2 (en) * 2009-08-28 2014-01-21 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Genetic vasectomy by overexpression of PRML-EGFP fusion protein in spermatids
MX363013B (es) * 2011-02-25 2019-03-04 Recombinetics Inc Animales genéticamente modificados y métodos para su obtención.
CN102199606B (zh) * 2011-03-09 2012-12-26 塔里木大学 一种筛选非人哺乳动物xy精子差异表达基因的方法

Also Published As

Publication number Publication date
CN105658050A (zh) 2016-06-08
AU2014272107A1 (en) 2016-01-21
WO2014193584A2 (en) 2014-12-04
AP2015008966A0 (en) 2015-12-31
WO2014193584A3 (en) 2015-08-06
EP3003021A2 (en) 2016-04-13
PH12015502646A1 (en) 2016-03-07
US20140359795A1 (en) 2014-12-04
MX2015016383A (es) 2016-09-29
RU2015156824A (ru) 2017-07-05
CA2913412A1 (en) 2014-12-04
JP2016519955A (ja) 2016-07-11
BR112015029905A2 (pt) 2017-09-26
EP3003021A4 (en) 2016-11-02

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PA0105 International application

Patent event date: 20151231

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid