CN105658050A - 用于制备具有可分选精子的动物的遗传技术 - Google Patents

用于制备具有可分选精子的动物的遗传技术 Download PDF

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Publication number
CN105658050A
CN105658050A CN201480042059.5A CN201480042059A CN105658050A CN 105658050 A CN105658050 A CN 105658050A CN 201480042059 A CN201480042059 A CN 201480042059A CN 105658050 A CN105658050 A CN 105658050A
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CN
China
Prior art keywords
sperm
animal
mark
cells
chromosome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480042059.5A
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English (en)
Chinese (zh)
Inventor
D.F.卡尔森
S.C.法伦克鲁格
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Recombinetics Inc
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Recombinetics Inc
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Application filed by Recombinetics Inc filed Critical Recombinetics Inc
Publication of CN105658050A publication Critical patent/CN105658050A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201480042059.5A 2013-05-31 2014-04-29 用于制备具有可分选精子的动物的遗传技术 Pending CN105658050A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361829672P 2013-05-31 2013-05-31
US61/829,672 2013-05-31
US201361870586P 2013-08-27 2013-08-27
US61/870,586 2013-08-27
PCT/US2014/035851 WO2014193584A2 (en) 2013-05-31 2014-04-29 Genetic techniques for making animals with sortable sperm

Publications (1)

Publication Number Publication Date
CN105658050A true CN105658050A (zh) 2016-06-08

Family

ID=51986778

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480042059.5A Pending CN105658050A (zh) 2013-05-31 2014-04-29 用于制备具有可分选精子的动物的遗传技术

Country Status (13)

Country Link
US (1) US20140359795A1 (enExample)
EP (1) EP3003021A4 (enExample)
JP (1) JP2016519955A (enExample)
KR (1) KR20160015333A (enExample)
CN (1) CN105658050A (enExample)
AP (1) AP2015008966A0 (enExample)
AU (1) AU2014272107A1 (enExample)
BR (1) BR112015029905A2 (enExample)
CA (1) CA2913412A1 (enExample)
MX (1) MX2015016383A (enExample)
PH (1) PH12015502646A1 (enExample)
RU (1) RU2015156824A (enExample)
WO (1) WO2014193584A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114015705A (zh) * 2021-11-28 2022-02-08 华中科技大学同济医学院附属协和医院 一种小鼠体外受精繁育性别选择方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX369747B (es) 2013-04-16 2019-11-20 Regeneron Pharma Modificación dirigida del genoma de rata.
US20140359796A1 (en) * 2013-05-31 2014-12-04 Recombinetics, Inc. Genetically sterile animals
EP3060682B1 (en) 2013-10-25 2023-08-30 Livestock Improvement Corporation Limited Genetic markers and uses therefor
CN111218447B (zh) 2013-11-07 2024-10-11 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
US10787684B2 (en) * 2013-11-19 2020-09-29 President And Fellows Of Harvard College Large gene excision and insertion
RU2685914C1 (ru) 2013-12-11 2019-04-23 Регенерон Фармасьютикалс, Инк. Способы и композиции для направленной модификации генома
CN111647627A (zh) 2014-04-28 2020-09-11 重组股份有限公司 多重基因编辑
WO2015200805A2 (en) 2014-06-26 2015-12-30 Regeneron Pharmaceuticals, Inc. Methods and compositions for targeted genetic modifications and methods of use
RU2734770C2 (ru) 2014-11-21 2020-10-23 Регенерон Фармасьютикалз, Инк. Способы и композиции для нацеленной генетической модификации с использованием парных гидовых рнк
WO2016196887A1 (en) 2015-06-03 2016-12-08 Board Of Regents Of The University Of Nebraska Dna editing using single-stranded dna
CN107315092B (zh) * 2017-07-11 2019-03-19 上海市第一人民医院 一种快速评估睾丸生精功能的免疫荧光染色法及其试剂盒
WO2020102565A2 (en) * 2018-11-14 2020-05-22 Flagship Pioneering Innovations V, Inc. Systems and methods for nondestructive testing of gametes
CN111500530A (zh) * 2020-04-30 2020-08-07 延安大学 一种通用型动物精子分选方法及x精子质控方法
WO2024249570A2 (en) * 2023-06-02 2024-12-05 New York University Single-sex chicken with toxin-antitoxin system

Citations (11)

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Publication number Priority date Publication date Assignee Title
WO2000029602A1 (en) * 1998-11-13 2000-05-25 Cedars-Sinai Medical Center Transfection of male germ cells for generation of selectable transgenic stem cells
WO2001062076A1 (en) * 2000-02-24 2001-08-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of mammals which produce progeny of a single sex
CN1414975A (zh) * 1999-12-07 2003-04-30 圭尔夫大学 性染色体特异性蛋白质,种特异性和精子特异性蛋白质以及它们的鉴定和分离方法
CN1434678A (zh) * 1999-12-27 2003-08-06 刘成宇 通过将转基因靶向至性染色体上控制子代性别比例
CN1443519A (zh) * 2002-03-11 2003-09-24 刘凤鸣 一种动物精子的性别分选方法
US20050081256A1 (en) * 2001-03-22 2005-04-14 Forsberg Erik J. Sex- specific selection of sperm from transgenic animals
CN101014700A (zh) * 2004-03-29 2007-08-08 孟山都技术公司 用于分选带有x或y染色体富集群的精子悬浮液
WO2010120518A2 (en) * 2009-04-01 2010-10-21 Biocern, Inc. Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein
WO2011023740A1 (en) * 2009-08-28 2011-03-03 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids
CN102199606A (zh) * 2011-03-09 2011-09-28 塔里木大学 一种筛选哺乳动物xy精子差异表达基因的方法
WO2012116274A2 (en) * 2011-02-25 2012-08-30 Recombinetics, Inc. Genetically modified animals and methods for making the same

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GB9916810D0 (en) * 1999-07-16 1999-09-22 Cancer Res Campaign Tech Killing cells
JP4271120B2 (ja) * 2003-10-14 2009-06-03 独立行政法人科学技術振興機構 Ｙ染色体標識トランスジェニック非ヒト動物
US20060123489A1 (en) * 2004-12-03 2006-06-08 Envivo Pharmaceuticals, Inc. Sex-specific automated sorting of non-human animals

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000029602A1 (en) * 1998-11-13 2000-05-25 Cedars-Sinai Medical Center Transfection of male germ cells for generation of selectable transgenic stem cells
CN1414975A (zh) * 1999-12-07 2003-04-30 圭尔夫大学 性染色体特异性蛋白质,种特异性和精子特异性蛋白质以及它们的鉴定和分离方法
CN1434678A (zh) * 1999-12-27 2003-08-06 刘成宇 通过将转基因靶向至性染色体上控制子代性别比例
WO2001062076A1 (en) * 2000-02-24 2001-08-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of mammals which produce progeny of a single sex
US20050081256A1 (en) * 2001-03-22 2005-04-14 Forsberg Erik J. Sex- specific selection of sperm from transgenic animals
CN1443519A (zh) * 2002-03-11 2003-09-24 刘凤鸣 一种动物精子的性别分选方法
CN101014700A (zh) * 2004-03-29 2007-08-08 孟山都技术公司 用于分选带有x或y染色体富集群的精子悬浮液
WO2010120518A2 (en) * 2009-04-01 2010-10-21 Biocern, Inc. Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein
WO2011023740A1 (en) * 2009-08-28 2011-03-03 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids
WO2012116274A2 (en) * 2011-02-25 2012-08-30 Recombinetics, Inc. Genetically modified animals and methods for making the same
CN102199606A (zh) * 2011-03-09 2011-09-28 塔里木大学 一种筛选哺乳动物xy精子差异表达基因的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAOYI WANG ET AL: ""TALEN-mediated editing of the mouse Y chromosome"", 《NATURE BIOTECHNOLOGY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114015705A (zh) * 2021-11-28 2022-02-08 华中科技大学同济医学院附属协和医院 一种小鼠体外受精繁育性别选择方法

Also Published As

Publication number Publication date
EP3003021A2 (en) 2016-04-13
BR112015029905A2 (pt) 2017-09-26
WO2014193584A3 (en) 2015-08-06
WO2014193584A2 (en) 2014-12-04
JP2016519955A (ja) 2016-07-11
AP2015008966A0 (en) 2015-12-31
EP3003021A4 (en) 2016-11-02
RU2015156824A (ru) 2017-07-05
CA2913412A1 (en) 2014-12-04
US20140359795A1 (en) 2014-12-04
AU2014272107A1 (en) 2016-01-21
PH12015502646A1 (en) 2016-03-07
MX2015016383A (es) 2016-09-29
KR20160015333A (ko) 2016-02-12

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