JP2016519955A - 選別可能な精子を有する動物を作製するための遺伝子技術 - Google Patents

選別可能な精子を有する動物を作製するための遺伝子技術 Download PDF

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Publication number
JP2016519955A
JP2016519955A JP2016516662A JP2016516662A JP2016519955A JP 2016519955 A JP2016519955 A JP 2016519955A JP 2016516662 A JP2016516662 A JP 2016516662A JP 2016516662 A JP2016516662 A JP 2016516662A JP 2016519955 A JP2016519955 A JP 2016519955A
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Prior art keywords
sperm
marker
animal
cells
chromosome
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JP2016516662A
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English (en)
Japanese (ja)
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JP2016519955A5 (enExample
Inventor
ダニエル・エフ・カールソン
スコット・シー・ファーレンクラッグ
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Recombinetics Inc
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Recombinetics Inc
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Application filed by Recombinetics Inc filed Critical Recombinetics Inc
Publication of JP2016519955A publication Critical patent/JP2016519955A/ja
Publication of JP2016519955A5 publication Critical patent/JP2016519955A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016516662A 2013-05-31 2014-04-29 選別可能な精子を有する動物を作製するための遺伝子技術 Pending JP2016519955A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361829672P 2013-05-31 2013-05-31
US61/829,672 2013-05-31
US201361870586P 2013-08-27 2013-08-27
US61/870,586 2013-08-27
PCT/US2014/035851 WO2014193584A2 (en) 2013-05-31 2014-04-29 Genetic techniques for making animals with sortable sperm

Publications (2)

Publication Number Publication Date
JP2016519955A true JP2016519955A (ja) 2016-07-11
JP2016519955A5 JP2016519955A5 (enExample) 2017-06-15

Family

ID=51986778

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016516662A Pending JP2016519955A (ja) 2013-05-31 2014-04-29 選別可能な精子を有する動物を作製するための遺伝子技術

Country Status (13)

Country Link
US (1) US20140359795A1 (enExample)
EP (1) EP3003021A4 (enExample)
JP (1) JP2016519955A (enExample)
KR (1) KR20160015333A (enExample)
CN (1) CN105658050A (enExample)
AP (1) AP2015008966A0 (enExample)
AU (1) AU2014272107A1 (enExample)
BR (1) BR112015029905A2 (enExample)
CA (1) CA2913412A1 (enExample)
MX (1) MX2015016383A (enExample)
PH (1) PH12015502646A1 (enExample)
RU (1) RU2015156824A (enExample)
WO (1) WO2014193584A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2986729T1 (sl) 2013-04-16 2019-02-28 Regeneron Pharmaceuticals, Inc. Ciljana sprememba genoma podgane
US20140359796A1 (en) * 2013-05-31 2014-12-04 Recombinetics, Inc. Genetically sterile animals
MX388563B (es) 2013-10-25 2025-03-20 Livestock Improvement Corporation Ltd Marcadores geneticos y usos de los mismos.
EP4372090A3 (en) 2013-11-07 2024-08-07 Editas Medicine, Inc. Crispr-related methods and compositions with governing grnas
US10787684B2 (en) * 2013-11-19 2020-09-29 President And Fellows Of Harvard College Large gene excision and insertion
CN110951779B (zh) 2013-12-11 2024-04-16 瑞泽恩制药公司 用于靶向修饰基因组的方法和组合物
MX2016014066A (es) 2014-04-28 2017-05-03 Recombinetics Inc Edicion de genes multiples en cerdos.
RU2771532C2 (ru) 2014-06-26 2022-05-05 Регенерон Фармасьютикалз, Инк. Способы и композиции для нацеленных генетических модификаций и способы их применения
BR112017010547A2 (pt) 2014-11-21 2018-02-27 Regeneron Pharma métodos para produção de uma modificação bialélica, modificação de um genoma dentro de uma célula, produção de uma geração f0 de um animal não humano e identificação de uma inserção de um inserto de ácido nucleico.
EP3303585A4 (en) 2015-06-03 2018-10-31 Board of Regents of the University of Nebraska Dna editing using single-stranded dna
CN107315092B (zh) * 2017-07-11 2019-03-19 上海市第一人民医院 一种快速评估睾丸生精功能的免疫荧光染色法及其试剂盒
WO2020102565A2 (en) * 2018-11-14 2020-05-22 Flagship Pioneering Innovations V, Inc. Systems and methods for nondestructive testing of gametes
CN111500530A (zh) * 2020-04-30 2020-08-07 延安大学 一种通用型动物精子分选方法及x精子质控方法
CN114015705A (zh) * 2021-11-28 2022-02-08 华中科技大学同济医学院附属协和医院 一种小鼠体外受精繁育性别选择方法
WO2024249570A2 (en) * 2023-06-02 2024-12-05 New York University Single-sex chicken with toxin-antitoxin system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003516134A (ja) * 1999-12-07 2003-05-13 ユニバーシティ オブ グェルフ 性染色体特異的タンパク質、種特異的および精子特異的タンパク質、ならびにそれらの同定および単離の方法
JP2003518927A (ja) * 1999-12-27 2003-06-17 チェニュー・リュウ 性染色体に対するトランス遺伝子の標的化による子孫の性別比の制御
US20050081256A1 (en) * 2001-03-22 2005-04-14 Forsberg Erik J. Sex- specific selection of sperm from transgenic animals
JP2005137367A (ja) * 2003-10-14 2005-06-02 Japan Science & Technology Agency Ｙ染色体標識トランスジェニック非ヒト動物
JP2008521441A (ja) * 2004-12-03 2008-06-26 エンビボ ファーマシューティカルズ インコーポレイテッド 非ヒト動物の性特異的自動化選別
WO2010120518A2 (en) * 2009-04-01 2010-10-21 Biocern, Inc. Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
CA2350829A1 (en) * 1998-11-13 2000-05-25 Cedars-Sinai Medical Center Transfection of male germ cells for generation of selectable transgenic stem cells
GB9916810D0 (en) * 1999-07-16 1999-09-22 Cancer Res Campaign Tech Killing cells
CN101024829A (zh) * 2000-02-24 2007-08-29 马萨诸塞大学 只生育单一性别后代的哺乳动物的生产
CN1313061C (zh) * 2002-03-11 2007-05-02 刘凤鸣 一种动物精子的性别分选方法
CN101014700B (zh) * 2004-03-29 2012-03-28 英格朗公司 用于分选带有x或y染色体富集群的精子悬浮液
EP2470557A1 (en) * 2009-08-28 2012-07-04 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids
EP3461898A1 (en) * 2011-02-25 2019-04-03 The University Court Of The University of Edinburgh Genetically modified animals and methods for making the same
CN102199606B (zh) * 2011-03-09 2012-12-26 塔里木大学 一种筛选非人哺乳动物xy精子差异表达基因的方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003516134A (ja) * 1999-12-07 2003-05-13 ユニバーシティ オブ グェルフ 性染色体特異的タンパク質、種特異的および精子特異的タンパク質、ならびにそれらの同定および単離の方法
JP2003518927A (ja) * 1999-12-27 2003-06-17 チェニュー・リュウ 性染色体に対するトランス遺伝子の標的化による子孫の性別比の制御
US20050081256A1 (en) * 2001-03-22 2005-04-14 Forsberg Erik J. Sex- specific selection of sperm from transgenic animals
JP2005137367A (ja) * 2003-10-14 2005-06-02 Japan Science & Technology Agency Ｙ染色体標識トランスジェニック非ヒト動物
JP2008521441A (ja) * 2004-12-03 2008-06-26 エンビボ ファーマシューティカルズ インコーポレイテッド 非ヒト動物の性特異的自動化選別
WO2010120518A2 (en) * 2009-04-01 2010-10-21 Biocern, Inc. Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. GENET. GENOMICS, AVAILABLE ONLINE 2013.04.12, VOL.40, P.281-289, JPN6018011569, ISSN: 0003946066 *

Also Published As

Publication number Publication date
BR112015029905A2 (pt) 2017-09-26
KR20160015333A (ko) 2016-02-12
EP3003021A4 (en) 2016-11-02
AP2015008966A0 (en) 2015-12-31
PH12015502646A1 (en) 2016-03-07
AU2014272107A1 (en) 2016-01-21
WO2014193584A3 (en) 2015-08-06
RU2015156824A (ru) 2017-07-05
US20140359795A1 (en) 2014-12-04
WO2014193584A2 (en) 2014-12-04
EP3003021A2 (en) 2016-04-13
MX2015016383A (es) 2016-09-29
CN105658050A (zh) 2016-06-08
CA2913412A1 (en) 2014-12-04

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