RU2015156824A - Генетические методики получения животных с поддающимися сортировке сперматозоидами - Google Patents
Генетические методики получения животных с поддающимися сортировке сперматозоидами Download PDFInfo
- Publication number
- RU2015156824A RU2015156824A RU2015156824A RU2015156824A RU2015156824A RU 2015156824 A RU2015156824 A RU 2015156824A RU 2015156824 A RU2015156824 A RU 2015156824A RU 2015156824 A RU2015156824 A RU 2015156824A RU 2015156824 A RU2015156824 A RU 2015156824A
- Authority
- RU
- Russia
- Prior art keywords
- marker
- sperm
- animal
- chromosome
- toxin
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title claims 22
- 238000000034 method Methods 0.000 title claims 3
- 230000002068 genetic effect Effects 0.000 title 1
- 239000003550 marker Substances 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 108700012359 toxins Proteins 0.000 claims 8
- 210000001766 X chromosome Anatomy 0.000 claims 7
- 210000002593 Y chromosome Anatomy 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000000975 dye Substances 0.000 claims 6
- 239000003053 toxin Substances 0.000 claims 6
- 231100000765 toxin Toxicity 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 231100000331 toxic Toxicity 0.000 claims 5
- 230000002588 toxic effect Effects 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108010016529 Bacillus amyloliquefaciens ribonuclease Proteins 0.000 claims 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 3
- 239000000729 antidote Substances 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- 239000011575 calcium Substances 0.000 claims 3
- 239000007850 fluorescent dye Substances 0.000 claims 3
- 238000009830 intercalation Methods 0.000 claims 3
- 238000012800 visualization Methods 0.000 claims 3
- 108090001008 Avidin Proteins 0.000 claims 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 2
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 2
- 101710163270 Nuclease Proteins 0.000 claims 2
- 108010039491 Ricin Proteins 0.000 claims 2
- 102000006601 Thymidine Kinase Human genes 0.000 claims 2
- 108020004440 Thymidine kinase Proteins 0.000 claims 2
- 230000001640 apoptogenic effect Effects 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 231100000518 lethal Toxicity 0.000 claims 2
- 230000001665 lethal effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229920002704 polyhistidine Polymers 0.000 claims 2
- 230000019100 sperm motility Effects 0.000 claims 2
- 102100030988 Angiotensin-converting enzyme Human genes 0.000 claims 1
- 101710183938 Barstar Proteins 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 102000016736 Cyclin Human genes 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 102000007327 Protamines Human genes 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 210000003495 flagella Anatomy 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000006543 gametophyte development Effects 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 229940048914 protamine Drugs 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829672P | 2013-05-31 | 2013-05-31 | |
| US61/829,672 | 2013-05-31 | ||
| US201361870586P | 2013-08-27 | 2013-08-27 | |
| US61/870,586 | 2013-08-27 | ||
| PCT/US2014/035851 WO2014193584A2 (en) | 2013-05-31 | 2014-04-29 | Genetic techniques for making animals with sortable sperm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015156824A true RU2015156824A (ru) | 2017-07-05 |
Family
ID=51986778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015156824A RU2015156824A (ru) | 2013-05-31 | 2014-04-29 | Генетические методики получения животных с поддающимися сортировке сперматозоидами |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20140359795A1 (enExample) |
| EP (1) | EP3003021A4 (enExample) |
| JP (1) | JP2016519955A (enExample) |
| KR (1) | KR20160015333A (enExample) |
| CN (1) | CN105658050A (enExample) |
| AP (1) | AP2015008966A0 (enExample) |
| AU (1) | AU2014272107A1 (enExample) |
| BR (1) | BR112015029905A2 (enExample) |
| CA (1) | CA2913412A1 (enExample) |
| MX (1) | MX2015016383A (enExample) |
| PH (1) | PH12015502646A1 (enExample) |
| RU (1) | RU2015156824A (enExample) |
| WO (1) | WO2014193584A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| US20140359796A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetically sterile animals |
| AU2014337790B2 (en) | 2013-10-25 | 2019-09-26 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US10787684B2 (en) * | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| US20160029604A1 (en) | 2014-04-28 | 2016-02-04 | Recombinetics, Inc. | Multiplex gene editing |
| PT3161128T (pt) | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| CA2968440A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| EP3303585A4 (en) | 2015-06-03 | 2018-10-31 | Board of Regents of the University of Nebraska | Dna editing using single-stranded dna |
| CN107315092B (zh) * | 2017-07-11 | 2019-03-19 | 上海市第一人民医院 | 一种快速评估睾丸生精功能的免疫荧光染色法及其试剂盒 |
| WO2020102565A2 (en) * | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Systems and methods for nondestructive testing of gametes |
| CN111500530A (zh) * | 2020-04-30 | 2020-08-07 | 延安大学 | 一种通用型动物精子分选方法及x精子质控方法 |
| CN114015705A (zh) * | 2021-11-28 | 2022-02-08 | 华中科技大学同济医学院附属协和医院 | 一种小鼠体外受精繁育性别选择方法 |
| WO2024249570A2 (en) * | 2023-06-02 | 2024-12-05 | New York University | Single-sex chicken with toxin-antitoxin system |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3563499A (en) * | 1998-11-13 | 2000-06-05 | Cedars-Sinai Medical Center | Transfection of male germ cells for generation of selectable transgenic stem cells |
| GB9916810D0 (en) * | 1999-07-16 | 1999-09-22 | Cancer Res Campaign Tech | Killing cells |
| CN1414975A (zh) * | 1999-12-07 | 2003-04-30 | 圭尔夫大学 | 性染色体特异性蛋白质,种特异性和精子特异性蛋白质以及它们的鉴定和分离方法 |
| CN1434678A (zh) * | 1999-12-27 | 2003-08-06 | 刘成宇 | 通过将转基因靶向至性染色体上控制子代性别比例 |
| CA2400292A1 (en) * | 2000-02-24 | 2001-08-30 | James M. Robl | Production of mammals which produce progeny of a single sex |
| US20050081256A1 (en) * | 2001-03-22 | 2005-04-14 | Forsberg Erik J. | Sex- specific selection of sperm from transgenic animals |
| CN1313061C (zh) * | 2002-03-11 | 2007-05-02 | 刘凤鸣 | 一种动物精子的性别分选方法 |
| JP4271120B2 (ja) * | 2003-10-14 | 2009-06-03 | 独立行政法人科学技術振興機構 | Ｙ染色体標識トランスジェニック非ヒト動物 |
| CN101014350A (zh) * | 2004-03-29 | 2007-08-08 | 孟山都技术公司 | 用于授精的精子悬浮液 |
| US20060123489A1 (en) * | 2004-12-03 | 2006-06-08 | Envivo Pharmaceuticals, Inc. | Sex-specific automated sorting of non-human animals |
| CA2793945A1 (en) * | 2009-04-01 | 2011-10-21 | Biocern, Inc. | Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein |
| US8633348B2 (en) * | 2009-08-28 | 2014-01-21 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Genetic vasectomy by overexpression of PRML-EGFP fusion protein in spermatids |
| BR112013021785A8 (pt) * | 2011-02-25 | 2018-07-03 | Recombinetics Inc | animais geneticamente modificados e métodos para fazer os mesmos |
| CN102199606B (zh) * | 2011-03-09 | 2012-12-26 | 塔里木大学 | 一种筛选非人哺乳动物xy精子差异表达基因的方法 |
-
2014
- 2014-04-28 US US14/263,431 patent/US20140359795A1/en not_active Abandoned
- 2014-04-29 CN CN201480042059.5A patent/CN105658050A/zh active Pending
- 2014-04-29 MX MX2015016383A patent/MX2015016383A/es unknown
- 2014-04-29 BR BR112015029905A patent/BR112015029905A2/pt not_active Application Discontinuation
- 2014-04-29 AP AP2015008966A patent/AP2015008966A0/xx unknown
- 2014-04-29 JP JP2016516662A patent/JP2016519955A/ja active Pending
- 2014-04-29 CA CA2913412A patent/CA2913412A1/en not_active Abandoned
- 2014-04-29 WO PCT/US2014/035851 patent/WO2014193584A2/en not_active Ceased
- 2014-04-29 RU RU2015156824A patent/RU2015156824A/ru not_active Application Discontinuation
- 2014-04-29 EP EP14804017.3A patent/EP3003021A4/en not_active Withdrawn
- 2014-04-29 KR KR1020157037264A patent/KR20160015333A/ko not_active Withdrawn
- 2014-04-29 AU AU2014272107A patent/AU2014272107A1/en not_active Abandoned
-
2015
- 2015-11-26 PH PH12015502646A patent/PH12015502646A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014272107A1 (en) | 2016-01-21 |
| PH12015502646A1 (en) | 2016-03-07 |
| CA2913412A1 (en) | 2014-12-04 |
| MX2015016383A (es) | 2016-09-29 |
| US20140359795A1 (en) | 2014-12-04 |
| WO2014193584A2 (en) | 2014-12-04 |
| BR112015029905A2 (pt) | 2017-09-26 |
| WO2014193584A3 (en) | 2015-08-06 |
| JP2016519955A (ja) | 2016-07-11 |
| EP3003021A4 (en) | 2016-11-02 |
| KR20160015333A (ko) | 2016-02-12 |
| EP3003021A2 (en) | 2016-04-13 |
| CN105658050A (zh) | 2016-06-08 |
| AP2015008966A0 (en) | 2015-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180604 |