KR20150125728A - 캡슐화된 피코플라틴 - Google Patents
캡슐화된 피코플라틴 Download PDFInfo
- Publication number
- KR20150125728A KR20150125728A KR1020157030498A KR20157030498A KR20150125728A KR 20150125728 A KR20150125728 A KR 20150125728A KR 1020157030498 A KR1020157030498 A KR 1020157030498A KR 20157030498 A KR20157030498 A KR 20157030498A KR 20150125728 A KR20150125728 A KR 20150125728A
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- KR
- South Korea
- Prior art keywords
- picoplatin
- water
- cancer
- dosage form
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Landscapes
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88920107P | 2007-02-09 | 2007-02-09 | |
| US60/889,201 | 2007-02-09 | ||
| US88967507P | 2007-02-13 | 2007-02-13 | |
| US60/889,675 | 2007-02-13 | ||
| US98415607P | 2007-10-31 | 2007-10-31 | |
| US60/984,156 | 2007-10-31 | ||
| US98902007P | 2007-11-19 | 2007-11-19 | |
| US60/989,020 | 2007-11-19 | ||
| PCT/US2008/001746 WO2008097658A1 (en) | 2007-02-09 | 2008-02-08 | Encapsulated picoplatin |
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| KR1020097018781A Division KR20090109130A (ko) | 2007-02-09 | 2008-02-08 | 캡슐화된 피코플라틴 |
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| KR20150125728A true KR20150125728A (ko) | 2015-11-09 |
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| KR1020097018781A Ceased KR20090109130A (ko) | 2007-02-09 | 2008-02-08 | 캡슐화된 피코플라틴 |
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| KR1020097018781A Ceased KR20090109130A (ko) | 2007-02-09 | 2008-02-08 | 캡슐화된 피코플라틴 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20100062056A1 (enExample) |
| EP (1) | EP2109451A4 (enExample) |
| JP (1) | JP2010518088A (enExample) |
| KR (2) | KR20150125728A (enExample) |
| CN (1) | CN101663040A (enExample) |
| AU (1) | AU2008214199A1 (enExample) |
| BR (1) | BRPI0806362A2 (enExample) |
| CA (1) | CA2677639A1 (enExample) |
| IL (1) | IL200261A0 (enExample) |
| MX (1) | MX2009008487A (enExample) |
| RU (1) | RU2009133447A (enExample) |
| WO (1) | WO2008097658A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168661B2 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| TW200920347A (en) * | 2007-07-16 | 2009-05-16 | Poniard Pharmaceuticals Inc | Oral formulations for picoplatin |
| JP2011511072A (ja) * | 2008-02-08 | 2011-04-07 | ポニアード ファーマシューティカルズ， インコーポレイテッド | 結腸直腸癌を治療するためのピコプラチンおよびベバシツマブの使用 |
| EP2418955A4 (en) * | 2009-04-15 | 2012-11-21 | Poniard Pharmaceuticals Inc | ORBIOTIC ANTICANCER THERAPY BASED ON HIGH BIODISIBILITY PICOPLATIN |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4419340A (en) * | 1969-03-24 | 1983-12-06 | University Of Delaware | Controlled release of anticancer agents from biodegradable polymers |
| US4302446A (en) * | 1979-10-02 | 1981-11-24 | Bristol-Myers Company | Pharmaceutical compositions |
| MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
| JP2657393B2 (ja) * | 1988-05-18 | 1997-09-24 | 日本化薬株式会社 | 化学塞栓療法剤 |
| WO1994028880A1 (en) * | 1993-06-14 | 1994-12-22 | Janssen Pharmaceutica N.V. | Extended release, film-coated tablet of astemizole and pseudoephedrine |
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5789000A (en) * | 1994-11-14 | 1998-08-04 | Bionumerik Pharmaceuticals, Inc. | Sterile aqueous parenteral formulations of cis-diammine dichloro platinum |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
| DE19847618A1 (de) * | 1998-10-15 | 2000-04-20 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| US6894049B1 (en) * | 2000-10-04 | 2005-05-17 | Anormed, Inc. | Platinum complexes as antitumor agents |
| SE0004671D0 (sv) * | 2000-12-15 | 2000-12-15 | Amarin Dev Ab | Pharmaceutical formulation |
| WO2003015707A2 (en) * | 2001-08-20 | 2003-02-27 | Transave, Inc. | Method for treating lung cancers |
| AU2003302314A1 (en) * | 2002-08-02 | 2004-07-09 | Transave, Inc. | Platinum aggregates and process for producing the same |
| EP1547596A4 (en) * | 2002-09-06 | 2008-11-19 | Western Therapeutics Inst Inc | MEDICAL COMPOSITION AND METHOD FOR THE TREATMENT OF MALIGNANT TUMORS AND THE USE THEREOF |
| DE10325989A1 (de) * | 2003-06-07 | 2005-01-05 | Glatt Gmbh | Verfahren zur Herstellung von und daraus resultierende Mikropellets sowie deren Verwendung |
| PT1720540E (pt) * | 2004-02-18 | 2008-09-10 | Gpc Biotech Ag | Métodos de tratamento de tumores resistentes ou refractários |
| BRPI0519466B8 (pt) * | 2004-12-30 | 2021-05-25 | Pf Medicament | dispersão sólida estável de um derivado de alcalóide de vinca e processo para a fabricação do mesmo |
| JP5106098B2 (ja) * | 2005-02-28 | 2012-12-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の抗癌剤との新規併用 |
| US8106033B2 (en) * | 2005-03-11 | 2012-01-31 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
| US8143236B2 (en) * | 2005-12-13 | 2012-03-27 | Bionumerik Pharmaceuticals, Inc. | Chemoprotective methods |
| US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) * | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| US7687487B2 (en) * | 2007-04-19 | 2010-03-30 | Bionumerik Pharmaceuticals, Inc. | Camptothecin-analog with a novel, “flipped” lactone-stable, E-ring and methods for making and using same |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| TW200920347A (en) * | 2007-07-16 | 2009-05-16 | Poniard Pharmaceuticals Inc | Oral formulations for picoplatin |
| JP2011511072A (ja) * | 2008-02-08 | 2011-04-07 | ポニアード ファーマシューティカルズ， インコーポレイテッド | 結腸直腸癌を治療するためのピコプラチンおよびベバシツマブの使用 |
-
2008
- 2008-02-08 AU AU2008214199A patent/AU2008214199A1/en not_active Abandoned
- 2008-02-08 RU RU2009133447/15A patent/RU2009133447A/ru not_active Application Discontinuation
- 2008-02-08 EP EP08725387A patent/EP2109451A4/en not_active Withdrawn
- 2008-02-08 JP JP2009549126A patent/JP2010518088A/ja active Pending
- 2008-02-08 KR KR1020157030498A patent/KR20150125728A/ko not_active Ceased
- 2008-02-08 BR BRPI0806362-1A patent/BRPI0806362A2/pt not_active IP Right Cessation
- 2008-02-08 CA CA002677639A patent/CA2677639A1/en not_active Abandoned
- 2008-02-08 MX MX2009008487A patent/MX2009008487A/es not_active Application Discontinuation
- 2008-02-08 CN CN200880011347A patent/CN101663040A/zh active Pending
- 2008-02-08 WO PCT/US2008/001746 patent/WO2008097658A1/en not_active Ceased
- 2008-02-08 KR KR1020097018781A patent/KR20090109130A/ko not_active Ceased
-
2009
- 2009-08-05 US US12/536,311 patent/US20100062056A1/en not_active Abandoned
- 2009-08-06 IL IL200261A patent/IL200261A0/en unknown
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2012
- 2012-09-27 US US13/629,108 patent/US20130202690A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101663040A (zh) | 2010-03-03 |
| US20130202690A1 (en) | 2013-08-08 |
| BRPI0806362A2 (pt) | 2011-09-06 |
| RU2009133447A (ru) | 2011-03-20 |
| MX2009008487A (es) | 2010-01-15 |
| JP2010518088A (ja) | 2010-05-27 |
| WO2008097658A1 (en) | 2008-08-14 |
| AU2008214199A1 (en) | 2008-08-14 |
| IL200261A0 (en) | 2010-04-29 |
| KR20090109130A (ko) | 2009-10-19 |
| EP2109451A1 (en) | 2009-10-21 |
| CA2677639A1 (en) | 2008-08-14 |
| EP2109451A4 (en) | 2012-12-19 |
| US20100062056A1 (en) | 2010-03-11 |
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